{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:48:38Z","timestamp":1761490118636},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","award":["IRMS\/13-14\/03"],"award-info":[{"award-number":["IRMS\/13-14\/03"]}],"id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hong Kong Research Grants Council","award":["GRF14114615 and C2014-14E"],"award-info":[{"award-number":["GRF14114615 and C2014-14E"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.talanta.2016.10.013","type":"journal-article","created":{"date-parts":[[2016,10,8]],"date-time":"2016-10-08T07:50:23Z","timestamp":1475913023000},"page":"285-292","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Determination of amino acids in colon cancer cells by using UHPLC-MS\/MS and [U-13C5]-glutamine as the isotope tracer"],"prefix":"10.1016","volume":"162","author":[{"given":"Xiaona","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Chun","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangfu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongwei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2016.10.013_bib1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.semcancer.2005.04.005","article-title":"Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?","volume":"15","author":"Fuchs","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.talanta.2016.10.013_bib2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0300-9084(92)90016-8","article-title":"Deviant energetic metabolism of glycolytic cancer cells","volume":"74","author":"Baggetto","year":"1992","journal-title":"Biochimie"},{"key":"10.1016\/j.talanta.2016.10.013_bib3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1126\/science.122.3168.501","article-title":"Nutrition needs of mammalian cells in tissue culture","volume":"122","author":"Eagle","year":"1955","journal-title":"Science"},{"key":"10.1016\/j.talanta.2016.10.013_bib4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tibs.2010.05.003","article-title":"Glutamine addiction: a new therapeutic target in cancer","volume":"35","author":"Wise","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.talanta.2016.10.013_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-1596-8-203","article-title":"Early detection of colon cancer by amino acid profiling using aminoindex technology: a case report","volume":"8","author":"Yatabe","year":"2013","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.talanta.2016.10.013_bib6","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1007\/s00216-008-2167-9","article-title":"Analysis of amino acids without derivatization in barley extracts by LC-MS-MS","volume":"391","author":"Thiele","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2016.10.013_bib7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.talanta.2015.07.066","article-title":"Study of sample preparation for quantitative analysis of amino acids in human sweat by liquid chromatography-tandem mass spectrometry","volume":"146","author":"Delgado-Povedano","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2016.10.013_bib8","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s00216-005-3083-x","article-title":"Amino acid analysis by using comprehensive two-dimensional gas chromatography","volume":"382","author":"Mayadunne","year":"2005","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2016.10.013_bib9","doi-asserted-by":"crossref","first-page":"8086","DOI":"10.1021\/ac051211v","article-title":"Extraction and GC\/MS analysis of the human blood plasma metabolome","volume":"77","author":"A","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2016.10.013_bib10","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.talanta.2014.07.101","article-title":"Capillary electrophoresis with laser-induced fluorescence detection for studying amino acid uptake by yeast during beer fermentation","volume":"131","author":"Turkia","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2016.10.013_bib11","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1021\/ac103245b","article-title":"Highly sensitive GC\/MS\/MS method for quantitation of amino and nonamino organic acids","volume":"83","author":"Kvitvang","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2016.10.013_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/elps.200900399","article-title":"Recent advances in amino acid analysis by CE","volume":"31","author":"Poinsot","year":"2010","journal-title":"Electrophoresis"},{"key":"10.1016\/j.talanta.2016.10.013_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jchromb.2013.06.026","article-title":"Analysis of chloroformate-derivatised amino acids, dipeptides and polyamines by LC-MS\/MS","volume":"934","author":"Ubhi","year":"2013","journal-title":"J. Chromatogr. B."},{"key":"10.1016\/j.talanta.2016.10.013_bib14","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.talanta.2013.07.009","article-title":"Development of a method for the analysis of underivatized amino acids by liquid chromatography\/tandem mass spectrometry: application on standard reference material 1649a (urban dust)","volume":"115","author":"Buiarelli","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2016.10.013_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jchromb.2012.07.029","article-title":"Comparison of amino acid derivatization reagents for LC-ESI-MS analysis. Introducing a novel phosphazene-based derivatization reagent","volume":"904","author":"Rebane","year":"2012","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.talanta.2016.10.013_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.talanta.2016.01.056","article-title":"Characterization of oncogene-induced metabolic alterations in hepatic cells by using ultrahigh performance liquid chromatography-tandem mass spectrometry","volume":"152","author":"Tang","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2016.10.013_bib17","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2016.07.011","article-title":"SLC25A22 promotes proliferation and survival of colorectal cancer cells with KRAS mutations, and xenograft tumor progression in mice, via intracellular synthesis of aspartate","author":"Wong","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.talanta.2016.10.013_bib18","unstructured":"Guidance for industry: bioanalytical method validation, Department of Health and Human Services, Food and Drug Administration, U.S. 2001."},{"key":"10.1016\/j.talanta.2016.10.013_bib19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jchromb.2013.10.005","article-title":"Liquid chromatographic-mass spectrometric method for simultaneous determination of small organic acids potentially contributing to acidosis in severe malaria","volume":"941","author":"Sriboonvorakul","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.talanta.2016.10.013_bib20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chroma.2015.12.031","article-title":"A strategy for the targeted metabolomics analysis of 11 gut microbiota-host co-metabolites in rat serum, urine and feces by ultra high performance liquid chromatography-tandem mass spectrometry","volume":"1429","author":"Hou","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2016.10.013_bib21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00216-011-5308-5","article-title":"Hydrophilic interaction liquid chromatography (HILIC)\u2014a powerful separation technique","volume":"402","author":"Buszewski","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2016.10.013_bib22","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nprot.2012.024","article-title":"A positive\/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue","volume":"7","author":"Yuan","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.talanta.2016.10.013_bib23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.chroma.2007.02.034","article-title":"Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography-mass spectrometry","volume":"1147","author":"Luo","year":"2007","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.talanta.2016.10.013_bib24","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00216-013-7456-2","article-title":"Metabolic profiling of amino acids in cellular samples via zwitterionic sub-2 mum particle size HILIC-MS\/MS and a uniformly 13C labeled internal standard","volume":"406","author":"Guerrasio","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2016.10.013_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.chroma.2014.10.040","article-title":"Analysis of free amino acids in natural waters by liquid chromatography-tandem mass spectrometry","volume":"1370","author":"How","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2016.10.013_bib26","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.jchromb.2010.12.010","article-title":"Free amino acid quantification by LC-MS\/MS using derivatization generated isotope-labelled standards","volume":"879","author":"Johnson","year":"2011","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.talanta.2016.10.013_bib27","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jchromb.2011.01.010","article-title":"Quantification of 22 plasma amino acids combining derivatization and ion-pair LC-MS\/MS","volume":"879","author":"Harder","year":"2011","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.talanta.2016.10.013_bib28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cca.2009.06.023","article-title":"Quantitative UPLC-MS\/MS analysis of underivatised amino acids in body fluids is a reliable tool for the diagnosis and follow-up of patients with inborn errors of metabolism","volume":"407","author":"Waterval","year":"2009","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.talanta.2016.10.013_bib29","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1007\/s00216-008-2167-9","article-title":"Analysis of amino acids without derivatization in barley extracts by LC-MS-MS","volume":"391","author":"Thiele","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2016.10.013_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cbf.1003","article-title":"Glutamine and glutamate--their central role in cell metabolism and function","volume":"21","author":"Newsholme","year":"2003","journal-title":"Cell. Biochem. Funct."},{"key":"10.1016\/j.talanta.2016.10.013_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/964321","article-title":"Key roles of glutamine pathways in reprogramming the cancer metabolism","volume":"2015","author":"Michalak","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.talanta.2016.10.013_bib32","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2015.07.016","article-title":"An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis","volume":"162","author":"Birsoy","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.talanta.2016.10.013_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.nutr.22.110801.140547","article-title":"Regulation of enzymes of the urea cycle and arginine metabolism","volume":"22","author":"Morris","year":"2002","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.talanta.2016.10.013_bib34","doi-asserted-by":"crossref","first-page":"314S","DOI":"10.1093\/jn\/136.1.314S","article-title":"Branched-chain amino acid-enriched nutritional support in surgical and cancer patients","volume":"136","author":"Choudry","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.talanta.2016.10.013_bib35","doi-asserted-by":"crossref","first-page":"9677","DOI":"10.1158\/0008-5472.CAN-07-1462","article-title":"Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation","volume":"67","author":"Sato","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.talanta.2016.10.013_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.nutr.27.061406.093749","article-title":"Protein turnover via autophagy: implications for metabolism","volume":"27","author":"Mizushima","year":"2007","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.talanta.2016.10.013_bib37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/humu.20813","article-title":"C. urea cycle disorder, genetic variation in the urea cycle: a model resource for investigating key candidate genes for common diseases","volume":"30","author":"Mitchell","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.talanta.2016.10.013_bib38","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s11306-011-0357-5","article-title":"Serum amino acid profiles and their alterations in colorectal cancer","volume":"8","author":"Leichtle","year":"2012","journal-title":"Metabolomics"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914016307500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914016307500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T11:17:20Z","timestamp":1568459840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914016307500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":38,"alternative-id":["S0039914016307500"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2016.10.013","relation":{},"ISSN":["0039-9140"],"issn-type":[{"type":"print","value":"0039-9140"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of amino acids in colon cancer cells by using UHPLC-MS\/MS and [U-13C5]-glutamine as the isotope tracer","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2016.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}