{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:03:17Z","timestamp":1793494997556,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ministerio del Interior-DGT","award":["SPIP2015-01838"],"award-info":[{"award-number":["SPIP2015-01838"]}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["AGL-2014-53647-R"],"award-info":[{"award-number":["AGL-2014-53647-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.talanta.2017.06.022","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T05:32:40Z","timestamp":1498023160000},"page":"454-461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"special_numbering":"C","title":["A fast bioanalytical method based on microextraction by packed sorbent and UPLC\u2013MS\/MS for determining new psychoactive substances in oral fluid"],"prefix":"10.1016","volume":"174","author":[{"given":"A.M.","family":"Ares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Regenjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Carro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2017.06.022_bib1","unstructured":"UNODC (United Nations Office on Drugs and Crime), Worlds Drug Report. New Psychoactive Substances: Concepts and Definitions, Vienna, 2013, pp. 60\u2013115. \u3008http:\/\/www.unodc.org\/unodc\/secured\/wdr\/wdr2013\/World_Drug_Report_2013.pdf\u3009. (Accessed in December 2016)."},{"key":"10.1016\/j.talanta.2017.06.022_bib2","unstructured":"European Monitoring Centre for Drugs and Drug Addiction, European Drug Report 2016: Trends and Developments, Publications Office of the European Union, Luxembourg, 2016. \u3008http:\/\/www.emcdda.europa.eu\/system\/files\/publications\/2637\/TDAT16001ENN.pdf\u3009. (Accessed in December 2016)."},{"key":"10.1016\/j.talanta.2017.06.022_bib3","unstructured":"European Monitoring Centre for Drugs and Drug Addiction, New Psychoactive Substances in Europe, An Update from the EU Early Warning System (March 2015), Publications Office of the European Union, Luxembourg, 2015. \u3008http:\/\/www.emcdda.europa.eu\/attachements.cfm\/att_235958_EN_TD0415135ENN.pdf\u3009 (Accessed in December 2016)."},{"key":"10.1016\/j.talanta.2017.06.022_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drugalcdep.2015.09.030","article-title":"Next generation of novel psychoactive substances on the horizon \u2013 a complex problem to face","volume":"157","author":"Zawilska","year":"2015","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.talanta.2017.06.022_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.scijus.2013.08.001","article-title":"Rapid determination of scopolamine in evidence of recreational and predatory use","volume":"53","author":"S\u00e1iz","year":"2013","journal-title":"Sci. Justice"},{"key":"10.1016\/j.talanta.2017.06.022_bib6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1373\/clinchem.2013.209676","article-title":"The potential role of oral fluid in antidoping testing","volume":"60","author":"Anizan","year":"2014","journal-title":"Clin. Chem."},{"key":"10.1016\/j.talanta.2017.06.022_bib7","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1002\/jssc.200700067","article-title":"Quantitative analysis of methadone in human urine samples by microextraction in packed syringe-gas chromatography-mass spectrometry (MEPS-GC-MS)","volume":"30","author":"El-Beqqali","year":"2007","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.talanta.2017.06.022_bib8","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.jchromb.2011.02.027","article-title":"A validated method for the detection and quantitation of 50 drugs of abuse and medicinal drugs in oral fluid by gas chromatography-mass spectrometry","volume":"879","author":"Langel","year":"2011","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.talanta.2017.06.022_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.forsciint.2015.07.040","article-title":"Detection of synthetic cathinones in victims of sexual assault","volume":"257","author":"Hagan","year":"2015","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.talanta.2017.06.022_bib10","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/jat\/bkv053","article-title":"Ethylone-related deaths: toxicological findings","volume":"39","author":"Lee","year":"2015","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.talanta.2017.06.022_bib11","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00216-012-6548-8","article-title":"Determination of 32 cathinone derivatives and other designer drugs in serum by comprehensive LC-QQQ-MS\/MS analysis","volume":"405","author":"Swortwood","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2017.06.022_bib12","doi-asserted-by":"crossref","first-page":"9437","DOI":"10.1007\/s00216-013-7386-z","article-title":"Simultaneous quantification of 28 synthetic cathinones and metabolites in urine by liquid chromatography- high resolution mass spectrometry","volume":"405","author":"Concheiro","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2017.06.022_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.forsciint.2011.03.019","article-title":"Identification and characterization of the new designer drug 4\u2032-methylethcathinone (4-MEC) and elaboration of a novel liquid chromatography-tandem mass spectrometry (LC-MS\/MS) screening method for seven different methcathinone analogs","volume":"210","author":"Jankovics","year":"2011","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.talanta.2017.06.022_bib14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/jat\/bkt080","article-title":"Quantitative measurement of synthetic cathinones in oral fluid","volume":"37","author":"Amaratunga","year":"2013","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.talanta.2017.06.022_bib15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/jat\/bkv011","article-title":"A fatal case of pentedrone and alpha-pyrrolidinovalerophenone poisoning","volume":"39","author":"Sykutera","year":"2015","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.talanta.2017.06.022_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.chroma.2014.11.024","article-title":"Liquid chromatography tandem mass spectrometry determination of selected synthetic cathinones and two piperazines in oral fluid. Cross reactivity study with an on-site immunoassay device","volume":"1374","author":"de Castro","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2017.06.022_bib17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.chroma.2015.04.002","article-title":"Simultaneous determination of 40 novel psychoactive stimulants in urine by liquid chromatography-high resolution mass spectrometry and library matching","volume":"1397","author":"Concheiro","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2017.06.022_bib18","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1007\/s00216-015-8583-8","article-title":"Determination of illicit drugs and metabolites in oral fluid by microextraction on packed sorbent coupled with LC-MS\/MS","volume":"407","author":"Montesano","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2017.06.022_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.chroma.2013.05.072","article-title":"Microextraction by packed sorbent coupled to liquid chromatography tandem mass spectrometry for the rapid and sensitive determination of cannabinoids in oral fluids","volume":"1301","author":"Sergi","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2017.06.022_bib20","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00216-012-6157-6","article-title":"A novel test using dried blood spots for the chromatographic assay of methadone","volume":"404","author":"Saracino","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2017.06.022_bib21","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.chroma.2014.06.058","article-title":"Utilization of micellar electrokinetic chromatography-tandem mass spectrometry employed volatile micellar phase in the analysis of cathinone designer drugs","volume":"1356","author":"Svidrnoch","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2017.06.022_bib22","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1002\/rcm.4692","article-title":"Toxicological determination and in vitro metabolism of designer drug methylenedioxypyrovalerone (MDPV) by gas chromatography \/ mass spectrometry and liquid chromatography \/ quadrupole time-of-flight mass spectrometry","volume":"24","author":"Strano. Rossi","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.talanta.2017.06.022_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.aca.2011.05.037","article-title":"Microextraction by packed sorbents (MEPS): a tutorial","volume":"701","author":"Abdel-Rehim","year":"2011","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2017.06.022_bib24","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.chroma.2009.09.053","article-title":"Recent advances in microextraction by packed sorbents for bioanalysis","volume":"1217","author":"Abdel-Rehim","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2017.06.022_bib25","first-page":"24","article-title":"Solid phase microextraction and related techniques for drugs in biological samples","author":"Mahdi Moein","year":"2014","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.talanta.2017.06.022_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.trac.2014.12.003","article-title":"Microextraction by packed sorbent (MEPS)","volume":"67","author":"Moein","year":"2015","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.talanta.2017.06.022_bib27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.chroma.2015.07.021","article-title":"An improved analytical strategy combining microextraction by packed sorbent combined with ultra-high pressure liquid chromatography for the determination of fluoxetine, clomipramine and their active metabolites in human urine","volume":"1408","author":"Alves","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2017.06.022_bib28","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/bmc.2946","article-title":"Molecularly imprinted polymer in microextraction by packed sorbent for the simultaneous determination of local anesthetics: lidocaine, ropivacaine, mepivacaine and bupivacaine in plasma and urine samples","volume":"27","author":"Mosaye Daryanavard","year":"2013","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.talanta.2017.06.022_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jchromb.2014.10.026","article-title":"Determination of parabens in urine samples by microextraction using packed sorbent and ultra-performance liquid chromatography coupled to tandem mass spectrometry","volume":"974","author":"Cristina Jardim","year":"2015","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.talanta.2017.06.022_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2014.09.034","article-title":"Microextraction by packed sorbent and high performance liquid chromatography determination of seven non-steroidal anti-inflammatory drugs in human plasma and urine","volume":"1367","author":"Locatelli M","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2017.06.022_bib31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chroma.2015.09.075","article-title":"Determination of ciprofloxacin and levofloxacin in human sputum collected from cystic fibrosis patients using microextraction by packed sorbent-high performance liquid chromatography photodiode array detector","volume":"1419","author":"Locatelli","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2017.06.022_bib32","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/14756366.2016.1209496","article-title":"Microextraction by packed sorbent and HPLC\u2013PDA quantification of multiple anti-inflammatory drugs and fluoroquinolones in human plasma and urine","volume":"31","author":"D\u2019Angelo","year":"2016","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.talanta.2017.06.022_bib33","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/jssc.201200466","article-title":"A simplified approach to direct SPE-MS","volume":"35","author":"Candish","year":"2012","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.talanta.2017.06.022_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jpba.2011.04.023","article-title":"Experimental designs and their recent advances in set-up, data interpretation, and analytical applications","volume":"56","author":"Dejaegher","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.talanta.2017.06.022_bib35","doi-asserted-by":"crossref","unstructured":"World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects, JAMA-J Am. Med. Assoc. 310, 2013, pp. 2191\u20132194.","DOI":"10.1001\/jama.2013.281053"},{"key":"10.1016\/j.talanta.2017.06.022_bib36","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration, Guidance for Industry: Bioanalytical Method Validation, Draft Guidance, U.S. Department of Health and Human Services Food and Drug Administration, 2013. \u3008http:\/\/www.fda.gov\/downloads\/Drugs\/%20GuidanceComplianceRegulatoryInformation\/Guidances\/UCM368107.pdf\u3009. (Accessed in December 2016)."},{"key":"10.1016\/j.talanta.2017.06.022_bib37","unstructured":"ICH Harmonized Tripartite Guideline: Validation of Analytical Procedures: Text and Methodology Q2(R1), International Conference of Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, 2005. \u3008http:\/\/www.fda.gov\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/ucm265700.htm\u3009. (Accessed in December 2016)."},{"key":"10.1016\/j.talanta.2017.06.022_bib38","series-title":"Eurachem Guide: The Fitness for Purpose of Analytical Methods \u2013 A Laboratory Guide to Method Validation and Related Topics","author":"Magnusson","year":"2014"},{"key":"10.1016\/j.talanta.2017.06.022_bib39","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1021\/ac020361s","article-title":"Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS\/MS","volume":"75","author":"Matuszewski","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2017.06.022_bib40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.aca.2015.02.016","article-title":"Tutorial review on validation of liquid chromatography\u2013mass spectrometry methods: part II","volume":"870","author":"Kruve","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2017.06.022_bib41","unstructured":"D. Mathieu, J. Nony, R. Phan-Tan-Luu, NemrodW\u00ae, Version 2011, LPRAI, Marseille."},{"key":"10.1016\/j.talanta.2017.06.022_bib42","series-title":"Pharmaceutical Experimental Design","author":"Lewis","year":"1999"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914017306549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914017306549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T12:16:23Z","timestamp":1758543383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914017306549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":42,"alternative-id":["S0039914017306549"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2017.06.022","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A fast bioanalytical method based on microextraction by packed sorbent and UPLC\u2013MS\/MS for determining new psychoactive substances in oral fluid","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2017.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}