{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:49:53Z","timestamp":1792788593331,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503032"],"award-info":[{"award-number":["81503032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230079"],"award-info":[{"award-number":["81230079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81227802"],"award-info":[{"award-number":["81227802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National China Postdoctoral Science Foundation Funded Project","award":["2015M570844"],"award-info":[{"award-number":["2015M570844"]}],"id":[{"id":"https:\/\/ror.org\/0426zh255","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National China Postdoctoral Science Foundation Funded Project","award":["2016T90930"],"award-info":[{"award-number":["2016T90930"]}],"id":[{"id":"https:\/\/ror.org\/0426zh255","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2017JM8050"],"award-info":[{"award-number":["2017JM8050"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shaanxi Postdoctoral Science Foundation"},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.talanta.2018.09.053","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T02:06:04Z","timestamp":1537236364000},"page":"248-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Dual-mixed\/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors"],"prefix":"10.1016","volume":"192","author":[{"given":"Jia","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2018.09.053_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2174\/1570180814666170412124634","article-title":"Herbal medicines: application of a sequential voltammetric procedure to the determination of mercury, copper, lead, cadmium and zinc at trace level","volume":"15","author":"Melucci","year":"2018","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.talanta.2018.09.053_bib2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/1573407210666140716164321","article-title":"Toxic metals in herbal medicines. A review","volume":"10","author":"Locatelli","year":"2014","journal-title":"Curr. Bioact. Compd."},{"key":"10.1016\/j.talanta.2018.09.053_bib3","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.drudis.2008.07.004","article-title":"Natural products in drug discovery","volume":"13","author":"Harvey","year":"2008","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.talanta.2018.09.053_bib4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bmj.319.7203.160","article-title":"Review of randomised controlled trials of traditional Chinese medicine","volume":"319","author":"Tang","year":"1999","journal-title":"Br. Med. J."},{"key":"10.1016\/j.talanta.2018.09.053_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.tips.2006.04.006","article-title":"Angiogenesisi: from plants to blood vessels","volume":"27","author":"Fan","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.talanta.2018.09.053_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.molmed.2007.07.001","article-title":"From traditional Chinese medicine to rational cancer therapy","volume":"13","author":"Efferth","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.talanta.2018.09.053_bib7","first-page":"65","article-title":"A comparative study of Danshen injections from selected pharmacies using HPLC fingerprints","volume":"9","author":"Xu","year":"2007","journal-title":"Mod. Tradit. Chin. Med. Mater. Med."},{"key":"10.1016\/j.talanta.2018.09.053_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/0929867053363397","article-title":"Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza","volume":"12","author":"Jiang","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.talanta.2018.09.053_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.indcrop.2017.09.065","article-title":"Chemical composition and biological activities of extracts from three Salvia species: S. blepharochlaena, S. euphratica var. leiocalycina, and S. verticillata subsp. Amasiaca","volume":"111","author":"Zengin","year":"2018","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.talanta.2018.09.053_bib10","first-page":"389","article-title":"Advances in studies on antitumor activities of compounds in Salvia miltiorrhiza","volume":"35","author":"Zhang","year":"2010","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.talanta.2018.09.053_bib11","first-page":"4436","article-title":"Effects of component formula of Salviae Miltiorrhizae Radix et Rhizoma and Ginseng Radix et Rhizoma on cell proliferation, apoptosis and skeleton in lung cancer A549 cells","volume":"39","author":"Yan","year":"2014","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.talanta.2018.09.053_bib12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.7314\/APJCP.2012.13.2.407","article-title":"The socioeconomic burden of cancer in member countries of the Association of Southeast Asian Nations (ASEAN)-stakeholder meeting report","volume":"13","author":"Jan","year":"2012","journal-title":"Asian Pacific J. Cancer Prev."},{"key":"10.1016\/j.talanta.2018.09.053_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ctrv.2007.12.001","article-title":"Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review","volume":"34","author":"Gupta","year":"2008","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.talanta.2018.09.053_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1158\/1055-9965.EPI-15-0578","article-title":"Global cancer incidence and mortality rates and trends-an update","volume":"25","author":"Torre","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.talanta.2018.09.053_bib15","first-page":"108","article-title":"Vascular endothelial growth factor receptor-2 in breast cancer","volume":"1806","author":"Guo","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.talanta.2018.09.053_bib16","doi-asserted-by":"crossref","first-page":"11275","DOI":"10.1038\/srep11275","article-title":"Mannan-modified adenovirus targeting TERT and VEGFR-2: a universal tumour vaccine","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.talanta.2018.09.053_bib17","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1517\/13543784.2014.928283","article-title":"Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer","volume":"23","author":"Lee","year":"2014","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.talanta.2018.09.053_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijdevneu.2015.03.003","article-title":"Expression of vascular endothelial growth factor (VEGF) mRNA, VEGF receptor 2 (Flk-1) mRNA, and of VEGF co-receptor neuropilin (Nrp)-1 mRNA in brain tissue of aging Tg2576 mice by in situ hybridization","volume":"43","author":"Muche","year":"2015","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.talanta.2018.09.053_bib19","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1200\/JCO.2003.01.504","article-title":"Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer","volume":"21","author":"Mendelsohn","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.talanta.2018.09.053_bib20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1158\/2159-8290.CD-14-1029","article-title":"First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathway","volume":"5","author":"Hagel","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.talanta.2018.09.053_bib21","first-page":"8","article-title":"Cell membrane chromatography-a new method for studying the drug-receptor interactions","volume":"3","author":"He","year":"1996","journal-title":"New Prog. Biomed. Chromatogr."},{"key":"10.1016\/j.talanta.2018.09.053_bib22","doi-asserted-by":"crossref","first-page":"7081","DOI":"10.1016\/j.chroma.2009.08.062","article-title":"A vascular smooth muscle\/cell membrane chromatography-offline-gas chromatography\/mass spectrometry method for recognition, separation and identification of active components from traditional Chinese medicines","volume":"1216","author":"Hou","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2018.09.053_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jpba.2017.01.005","article-title":"Screening active compounds from Corydalis yanhusuo by combining high expression VEGF receptor HEK293 cell membrane chromatography with HPLC-ESI-IT-TOF-MSn method","volume":"136","author":"Wei","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.talanta.2018.09.053_bib24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jchromb.2016.01.001","article-title":"Cell membrane chromatography coupled with UHPLC-ESI-MS\/MS method to screen target components from Peucedanum praeruptorum Dunn acting on \u03b11A adrenergic receptor","volume":"1011","author":"Han","year":"2016","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.talanta.2018.09.053_bib25","unstructured":"L.C. He, W.J. Luo, X. Li, X.M. Xu, S.C. Wang, X.W. Ge, C. Li, A wild-type EGFR expression of recombinant HEK293 cells, Chinese Patent, 200910022565.9."},{"key":"10.1016\/j.talanta.2018.09.053_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jchromb.2012.10.029","article-title":"Combined fibroblast growth factor receptor 4 cell membrane chromatography online with high performance liquid chromatography\/mass spectrometry to screen active compounds in Brassica albla","volume":"912","author":"Zhang","year":"2013","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.talanta.2018.09.053_bib27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mex.2014.07.003","article-title":"Novel detection method for chemiluminescence derived from the Kinase-Glo luminescent Kinase assay platform: advantages over traditional microplate luminometers","volume":"1","author":"Bell","year":"2014","journal-title":"MethodsX"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914018309639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914018309639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T23:41:34Z","timestamp":1589931694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914018309639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":27,"alternative-id":["S0039914018309639"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2018.09.053","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-mixed\/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2018.09.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}