{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:52:18Z","timestamp":1793015538192,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20876180"],"award-info":[{"award-number":["20876180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.talanta.2019.01.042","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T08:04:33Z","timestamp":1547453073000},"page":"326-333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["A novel \u201cturn-on\u201d mitochondria-targeting near-infrared fluorescent probe for H2S detection and in living cells imaging"],"prefix":"10.1016","volume":"197","author":[{"given":"Xiong-jie","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ren","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2019.01.042_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/152308603768295249","article-title":"The gasotransmitter role of hydrogen sulfide","volume":"5","author":"Wang","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.talanta.2019.01.042_bib2","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1021\/cr8005125","article-title":"Molecular regulation of tumor angiogenesis and perfusion via redox signaling","volume":"109","author":"Miller","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.talanta.2019.01.042_bib3","first-page":"348","article-title":"New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant","volume":"62","author":"Dominy","year":"2004","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.talanta.2019.01.042_bib4","doi-asserted-by":"crossref","first-page":"22457","DOI":"10.1074\/jbc.M109.010868","article-title":"Relative contributions of cystathionine \u03b2-synthase and \u03b3-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions","volume":"284","author":"Singh","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.talanta.2019.01.042_bib5","doi-asserted-by":"crossref","first-page":"11601","DOI":"10.1074\/jbc.M808026200","article-title":"H2S biogenesis by human cystathionine \u03b3-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia","volume":"284","author":"Chiku","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.talanta.2019.01.042_bib6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"111","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.talanta.2019.01.042_bib7","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1073\/pnas.1115634109","article-title":"Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production","volume":"109","author":"Fu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.talanta.2019.01.042_bib8","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1042\/bst0030316","article-title":"Inhibition of cytochrome c oxidase by sulphid","volume":"3","author":"Nicholls","year":"1975","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.talanta.2019.01.042_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.talanta.2019.01.042_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/science.1108581","article-title":"H2S induces a suspended animation\u2013like state in mice","volume":"308","author":"Blackstone","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.talanta.2019.01.042_bib11","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1073\/pnas.1005866107","article-title":"H2S mediates O2 sensing in the carotid body","volume":"107","author":"Peng","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.talanta.2019.01.042_bib12","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.talanta.2019.01.042_bib13","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.talanta.2019.01.042_bib14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1096\/fj.05-4712fje","article-title":"Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells","volume":"20","author":"Yang","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.talanta.2019.01.042_bib15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1113\/jphysiol.2005.097642","article-title":"Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms","volume":"569","author":"Yang","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.talanta.2019.01.042_bib16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through Nrf2 signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.talanta.2019.01.042_bib17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ajmg.a.10847","article-title":"Endogenous hydrogen sulfide overproduction in Down syndrome","volume":"116","author":"Kamoun","year":"2003","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.talanta.2019.01.042_bib18","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0006-291X(02)00422-9","article-title":"Brain hydrogen sulfide is severely decreased in Alzheimer's disease","volume":"293","author":"Eto","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.talanta.2019.01.042_bib19","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.1039\/b916476f","article-title":"Sulfide-selective chemosignaling by a Cu2+ complex of dipicolylamine appended fluorescein","volume":"47","author":"Choi","year":"2009","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2019.01.042_bib20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ab.2003.09.037","article-title":"Hydrogen sulfide consumption measured at low steady state concentrations using a sulfidostat","volume":"324","author":"Searcy","year":"2004","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.talanta.2019.01.042_bib21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0021-9673(98)00882-6","article-title":"Measurement of reduced sulphur compounds contained in aqueous matrices by direct injection into a gas chromatograph with a flame photometric detector","volume":"830","author":"B\u00e9rub\u00e9","year":"1999","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2019.01.042_bib22","first-page":"1930","article-title":"Reappraisal of H2S\/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling","volume":"294","author":"Whiteld","year":"2008","journal-title":"Am. J. Physiol.: Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.talanta.2019.01.042_bib23","first-page":"1479","article-title":"Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values","volume":"295","author":"Furne","year":"2008","journal-title":"Am. J. Physiol.: Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.talanta.2019.01.042_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/nmeth.1663","article-title":"Fluorescent probes for sensing and imaging","volume":"8","author":"Ueno","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.talanta.2019.01.042_bib25","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.talanta.2016.07.047","article-title":"A naphthalene-based two-photon fluorescent probe for selective and sensitive detection of endogenous hypochlorous acid","volume":"160","author":"Zhou","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2019.01.042_bib26","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1016\/j.tetlet.2017.06.084","article-title":"A novel AIEE and EISPT fluorescent probe for selective detection of cysteine","volume":"58","author":"Zhou","year":"2017","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.talanta.2019.01.042_bib27","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1039\/c2cc30730h","article-title":"Selective turn-on fluorescent probes for imaging hydrogen sulfide in living cells","volume":"48","author":"Montoya","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2019.01.042_bib28","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1021\/acssensors.8b00142","article-title":"A sensitive near-infrared fluorescent sensor for mitochondrial hydrogen sulfide","volume":"3","author":"Ji","year":"2018","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2019.01.042_bib29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.snb.2017.03.135","article-title":"A mitochondrial-targeted two-photon fluorescent probe for imaging hydrogen sulfide in the living cells and mouse liver tissues","volume":"248","author":"Deng","year":"2017","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.talanta.2019.01.042_bib30","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1039\/C8TB01070F","article-title":"A novel fret-based fluorescent probe for the selective detection of hydrogen sulfide (H2S) and its application for bioimaging","volume":"6","author":"Zhao","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.talanta.2019.01.042_bib31","doi-asserted-by":"crossref","first-page":"9213","DOI":"10.1021\/acs.analchem.6b02459","article-title":"Visualizing hydrogen sulfide in mitochondria and lysosome of living cells and in tumors of living mice with positively charged fluorescent chemosensors","volume":"88","author":"Wu","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2019.01.042_bib32","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bios.2016.09.093","article-title":"A near-infrared \u201cturn-on\u201d fluorescent probe with a self-immolative linker for the in vivo quantitative detection and imaging of hydrogen sulfide","volume":"89","author":"Park","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2019.01.042_bib33","doi-asserted-by":"crossref","first-page":"11757","DOI":"10.1039\/c2cc36088h","article-title":"A highly selective turn-on near-infrared fluorescent probe for hydrogen sulfide detection and imaging in living cells","volume":"48","author":"Wang","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2019.01.042_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/cbdd.12948","article-title":"A novel mitochondria-targeting fluorescent probe for hydrogen sulfde in living cells","volume":"90","author":"Shi","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.talanta.2019.01.042_bib35","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1039\/C7CC05339H","article-title":"A bioorthogonal fluorescent probe for mitochondrial hydrogen sulfide: new strategy for cancer cell labeling","volume":"53","author":"Velusamy","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2019.01.042_bib36","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1039\/c4ob00285g","article-title":"A colorimetric and ratiometric fluorescent probe for the imaging of endogenous hydrogen sulphide in living cells and sulphide determination in mouse hippocampus","volume":"12","author":"Zhang","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.talanta.2019.01.042_bib37","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2116\/analsci.29.1171","article-title":"A highly selective fluorescent probe for quantitative detection of hydrogen sulfide","volume":"29","author":"Ding","year":"2013","journal-title":"Anal. Sci."},{"key":"10.1016\/j.talanta.2019.01.042_bib38","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.saa.2018.09.022","article-title":"The design of hydrogen sulfide fluorescence probe based on dual nucleophilic reaction and its application for bioimaging","volume":"207","author":"Zhang","year":"2019","journal-title":"Spectrochim. Acta Part A"},{"key":"10.1016\/j.talanta.2019.01.042_bib39","doi-asserted-by":"crossref","DOI":"10.1039\/C8NJ04208J","article-title":"Naked-eye and ratiometric fluorescence probe for fast and sensitive detection of hydrogen sulfide and its application in bioimaging","author":"Ma","year":"2018","journal-title":"New J. Chem."},{"key":"10.1016\/j.talanta.2019.01.042_bib40","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1039\/C7CC01695F","article-title":"A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar esipt fluorophore bearing aie characteristics","volume":"53","author":"Chen","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2019.01.042_bib41","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1039\/c2cc34031c","article-title":"A near-infrared fluorescent turn-on probe for fluorescence imaging of hydrogen sulfide in living cells based on thiolysis of dinitrophenyl ether","volume":"48","author":"Cao","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2019.01.042_bib42","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.1039\/C7NJ04577H","article-title":"A novel fluorescent probe for selective detection of hydrogen sulfide in living cells","volume":"42","author":"Peng","year":"2018","journal-title":"New J. Chem."},{"key":"10.1016\/j.talanta.2019.01.042_bib43","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.bios.2016.12.055","article-title":"Molecular engineering of a mitochondrial-targeting two-photon in and near-infrared out fluorescent probe for gaseous signal molecules H2S in deep tissue bioimaging","volume":"91","author":"Zhou","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2019.01.042_bib44","doi-asserted-by":"crossref","DOI":"10.1039\/C8TB02218F","article-title":"fluorescent probe for the detection and visualization of hydrogen sulfide using aldehyde group assisted thiolysis of dinitrophenyl ether strategy","author":"Qian","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.talanta.2019.01.042_bib45","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.snb.2018.08.138","article-title":"A selective fluorescence probe for H2S from biothiols with a significant regioselective turn-on response and its application for H2S detection in living cells and in living Caenorhabditis elegans","volume":"276","author":"Yang","year":"2018","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.talanta.2019.01.042_bib46","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1039\/c3sc50369k","article-title":"A near-infrared ratiometric fluorescent probe for rapid and highly sensitive imaging of endogenous hydrogen sulfide in living cells","volume":"4","author":"Wang","year":"2013","journal-title":"Chem. Sci."},{"key":"10.1016\/j.talanta.2019.01.042_bib47","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nnano.2013.222","article-title":"In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes","volume":"8","author":"Iverson","year":"2013","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.talanta.2019.01.042_bib48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nbt.2468","article-title":"Targeted zwitterionic near-infrared fluorophores for improved optical imaging","volume":"31","author":"Choi","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.talanta.2019.01.042_bib49","series-title":"The Chemist's Companion. A Handbook of Practical Data, Techniques and References","author":"Gordon","year":"1972"},{"key":"10.1016\/j.talanta.2019.01.042_bib50","doi-asserted-by":"crossref","first-page":"9566","DOI":"10.1016\/j.biomaterials.2013.08.081","article-title":"Analogs of Changsha near-infrared dyes with large Stokes shifts for bioimaging","volume":"34","author":"Yuan","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.talanta.2019.01.042_bib51","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1021\/ja209292b","article-title":"A unique class of near-infrared functional fluorescent dyes with carboxylic-acid-modulated fluorescence ON\/OFF switching: rational design, synthesis, optical properties, theoretical calculations, and applications for fluorescence imaging in living animals","volume":"134","author":"Yuan","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2019.01.042_bib52","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.biomaterials.2016.05.029","article-title":"A novel near-infrared fluorescent probe for H2O2 in alkaline environment and the application for H2O2 imaging in vitro and in vivo","volume":"100","author":"Liu","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.talanta.2019.01.042_bib53","doi-asserted-by":"crossref","first-page":"11883","DOI":"10.1021\/ac503611f","article-title":"Ratiometric time-gated luminescence probe for hydrogen sulfide based on lanthanide complexes","volume":"86","author":"Dai","year":"2014","journal-title":"Anal. Chem."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914019300438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914019300438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T22:39:43Z","timestamp":1565217583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914019300438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":53,"alternative-id":["S0039914019300438"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2019.01.042","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel \u201cturn-on\u201d mitochondria-targeting near-infrared fluorescent probe for H2S detection and in living cells imaging","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2019.01.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}