{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:14:28Z","timestamp":1792638868366,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703579"],"award-info":[{"award-number":["81703579"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018ZX09711001-004-006"],"award-info":[{"award-number":["2018ZX09711001-004-006"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["81573410"],"award-info":[{"award-number":["81573410"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017BH082"],"award-info":[{"award-number":["ZR2017BH082"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.talanta.2019.120196","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T02:25:21Z","timestamp":1564539921000},"page":"120196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["A rapid-response and near-infrared fluorescent probe for imaging of nitroxyl in living cells"],"prefix":"10.1016","volume":"206","author":[{"given":"Hongyi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KeWei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2019.120196_bib1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1021\/tx0496800","article-title":"The physiological chemistry and biological activity of nitroxyl (HNO): the neglected, misunderstood, and enigmatic nitrogen oxide","volume":"18","author":"Fukuto","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.talanta.2019.120196_bib2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.pharmtox.45.120403.095959","article-title":"Nitroxyl (HNO): chemistry, biochemistry, and pharmacology","volume":"45","author":"Fukuto","year":"2005","journal-title":"Annu. Rev. Pharmacol."},{"key":"10.1016\/j.talanta.2019.120196_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ccr.2004.08.010","article-title":"The chemistry of nitroxyl (HNO) and implications in biology","volume":"249","author":"Miranda","year":"2005","journal-title":"Coordin. Chem. Rev."},{"key":"10.1016\/j.talanta.2019.120196_bib4","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1021\/jo100172t","article-title":"Computational investigation of the reaction mechanisms of nitroxyl and thiols","volume":"75","author":"Sherman","year":"2010","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.talanta.2019.120196_bib5","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1073\/pnas.1031571100","article-title":"Nitroxyl gets to the heart of the matter","volume":"100","author":"Feelisch","year":"2003","journal-title":"Proc. Nati. Acad. Sci. U. S. A."},{"key":"10.1016\/j.talanta.2019.120196_bib6","doi-asserted-by":"crossref","first-page":"14253","DOI":"10.1039\/C4CC07561G","article-title":"Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe","volume":"50","author":"Jing","year":"2014","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2019.120196_bib7","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1021\/acs.analchem.7b05172","article-title":"Recognition of exogenous and endogenous nitroxyl in living cells via a two-photon fluorescent probe","volume":"90","author":"Li","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2019.120196_bib8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/niox.1998.0166","article-title":"The reaction of nitroxyl (HNO) with nitrosobenzene gives cupferron (N-nitrosophenylhydroxylamine)","volume":"2","author":"Shoeman","year":"1998","journal-title":"Nitric. Oxide"},{"key":"10.1016\/j.talanta.2019.120196_bib9","doi-asserted-by":"crossref","first-page":"15272","DOI":"10.1021\/ja036370f","article-title":"Fast nitroxyl trapping by ferric porphyrins","volume":"125","author":"Bari","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2019.120196_bib10","doi-asserted-by":"crossref","first-page":"13188","DOI":"10.1002\/anie.201704084","article-title":"Fluorescent probes with multiple binding sites for the discrimination of Cys, hcy, and GSH","volume":"56","author":"Yin","year":"2017","journal-title":"Ange. Chem. Int. Edit."},{"key":"10.1016\/j.talanta.2019.120196_bib11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.aca.2017.04.020","article-title":"A single pH fluorescent probe for biosensing and imaging of extreme acidity and extreme alkalinity","volume":"975","author":"Chao","year":"2017","journal-title":"Anal. Chim. Acta."},{"key":"10.1016\/j.talanta.2019.120196_bib12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.aca.2018.11.030","article-title":"A ratiometric fluorescent probe for lysosomal hypochlorous acid based on through-bond energy transfer strategy","volume":"1052","author":"Shen","year":"2019","journal-title":"Anal. Chim. Acta."},{"key":"10.1016\/j.talanta.2019.120196_bib13","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1021\/acs.analchem.7b04957","article-title":"Activatable near-infrared fluorescent probe for dipeptidyl peptidase IV and its bioimaging applications in living cells and animals","volume":"90","author":"Liu","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2019.120196_bib14","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.talanta.2019.01.042","article-title":"A novel \u201cturn-on\u201d mitochondria-targeting near-infrared fluorescent probe for H2S detection and in living cells imaging","volume":"197","author":"Zhao","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2019.120196_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fchem.2019.00032","article-title":"A near-infrared ratiometric fluorescent probe for highly selective recognition and bioimaging of cysteine","volume":"7","author":"Zhang","year":"2019","journal-title":"Front. Chem."},{"key":"10.1016\/j.talanta.2019.120196_bib16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.talanta.2018.09.062","article-title":"Development of large Stokes shift, near-infrared fluorescence probe for rapid and bioorthogonal imaging of nitroxyl (HNO) in living cells","volume":"193","author":"Zhang","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2019.120196_bib17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.talanta.2019.01.016","article-title":"A turn-on reactive fluorescent probe for Hg2+ in 100% aqueous solution","volume":"197","author":"Zhang","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2019.120196_bib18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.talanta.2019.01.022","article-title":"A new double-emission fluorescent probe for fast detection of thiophenols in aqueous solution and living cells","volume":"197","author":"Lv","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2019.120196_bib19","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.talanta.2019.01.061","article-title":"A rhodamine-deoxylactam based fluorescent probe for fast and selective detection of nitric oxide in living cells","volume":"197","author":"Jiang","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2019.120196_bib20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.talanta.2019.01.084","article-title":"Developing a julolidine-fluorescein-based hybrid as a highly sensitive fluorescent probe for sensing and bioimaging cysteine in living cells","volume":"197","author":"Ji","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2019.120196_bib21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.talanta.2018.12.080","article-title":"Phosphinate-based mitochondria-targeted fluorescent probe for imaging and detection of endogenous superoxide in live cells and in vivo","volume":"197","author":"Huang","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2019.120196_bib22","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1021\/ja909148v","article-title":"Direct detection of nitroxyl in aqueous solution using a tripodal copper(II) BODIPY complex","volume":"132","author":"Rosenthal","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2019.120196_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jinorgbio.2012.08.025","article-title":"Physical and structural properties of [Cu(BOT1)Cl]Cl, a fluorescent imaging probe for HNO","volume":"118","author":"Royzen","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.talanta.2019.120196_bib24","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1021\/ol103077q","article-title":"Visualization of nitroxyl in living cells by a chelated copper(II) coumarin complex","volume":"13","author":"Zhou","year":"2011","journal-title":"Org. Lett."},{"key":"10.1016\/j.talanta.2019.120196_bib25","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1016\/j.bmc.2012.06.013","article-title":"Reduced glutathione-resisting 19F NMR sensors for detecting HNO","volume":"20","author":"Kitamura","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.talanta.2019.120196_bib26","doi-asserted-by":"crossref","first-page":"12690","DOI":"10.1021\/ja404757s","article-title":"A reductant-resistant and metal-free fluorescent probe for nitroxyl applicable to living cells","volume":"135","author":"Kawai","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2019.120196_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2018.04.564","article-title":"Fluorescent probes for the detection of nitroxyl (HNO)","volume":"128","author":"Smulik-Izydorczyk","year":"2018","journal-title":"Free. Radic. Bio. Med."},{"key":"10.1016\/j.talanta.2019.120196_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.dyepig.2016.03.046","article-title":"A mitochondria-targetable near-infrared fluorescent probe for imaging nitroxyl (HNO) in living cells","volume":"131","author":"Gong","year":"2016","journal-title":"Dyes. Pigments."},{"key":"10.1016\/j.talanta.2019.120196_bib29","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1039\/C4CC10382C","article-title":"A two-photon fluorescent turn-on probe for nitroxyl (HNO) and its bioimaging application in living tissues","volume":"51","author":"Zheng","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2019.120196_bib30","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/am508987v","article-title":"A FRET-based ratiometric fluorescent probe for nitroxyl detection in living cells","volume":"7","author":"Zhang","year":"2015","journal-title":"Acs. Appl. Mater. Inter."},{"key":"10.1016\/j.talanta.2019.120196_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bmcl.2014.11.041","article-title":"A selective phosphine-based fluorescent probe for nitroxyl in living cells","volume":"25","author":"Miao","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.talanta.2019.120196_bib32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.dyepig.2016.03.046","article-title":"A mitochondria-targetable near-infrared fluorescent probe for imaging nitroxyl (HNO) in living cells","volume":"131","author":"Gong","year":"2016","journal-title":"Dyes. Pigments."},{"key":"10.1016\/j.talanta.2019.120196_bib33","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1039\/C5AN00759C","article-title":"A near-infrared fluorescent probe for the selective detection of HNO in living cells and in vivo","volume":"140","author":"Liu","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2019.120196_bib34","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1021\/ja500315x","article-title":"A fast and selective near-infrared fluorescent sensor for multicolor imaging of biological nitroxyl (HNO)","volume":"136","author":"Wrobel","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2019.120196_bib35","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1039\/c4cc00980k","article-title":"A fast-response, highly sensitive and selective fluorescent probe for the ratiometric imaging of nitroxyl in living cells","volume":"50","author":"Liu","year":"2014","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2019.120196_bib36","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1021\/ic00219a017","article-title":"ChemInform abstract: evidence from the reaction between trioxodinitrat(II) and\\ 15\\ NO that trioxodinitrate(II) decomposes into nitrosyl hydride and nitrite in neutral aqueous solution","volume":"24","author":"Bazylinski D A","year":"1985","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.talanta.2019.120196_bib37","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1021\/acssensors.5b00271","article-title":"Two-photon near infrared fluorescent turn-on probe toward cysteine and its imaging applications","volume":"1","author":"Wang","year":"2016","journal-title":"ACS. Sensors."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003991401930829X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003991401930829X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T12:28:39Z","timestamp":1758544119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003991401930829X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":37,"alternative-id":["S003991401930829X"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2019.120196","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A rapid-response and near-infrared fluorescent probe for imaging of nitroxyl in living cells","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2019.120196","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120196"}}