{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:24:43Z","timestamp":1792898683854,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2018JQ2011"],"award-info":[{"award-number":["2018JQ2011"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2018JZ2001"],"award-info":[{"award-number":["2018JZ2001"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21605122"],"award-info":[{"award-number":["21605122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21874106"],"award-info":[{"award-number":["21874106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21545007"],"award-info":[{"award-number":["21545007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013149","name":"Science and Technology Innovation as a Whole Plan Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2013SZS18-K01"],"award-info":[{"award-number":["2013SZS18-K01"]}],"id":[{"id":"10.13039\/501100013149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012594","name":"Scientific Research Foundation of Shaanxi Provincial Key Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.talanta.2019.120310","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T10:02:57Z","timestamp":1567591377000},"page":"120310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Synthesis and optimization of SiO2@SiO2 core-shell microspheres by an improved polymerization-induced colloid aggregation method for fast separation of small solutes and proteins"],"prefix":"10.1016","volume":"207","author":[{"given":"Xiaohui","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangping","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanna","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2019.120310_bib1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.chroma.2011.07.082","article-title":"Fast high performance liquid chromatography separations for proteomic applications using fused-core\u00ae silica particles","volume":"1228","author":"Schuster","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2019.120310_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.chroma.2012.03.018","article-title":"Evaluation of a new wide pore core\u2013shell material (Aeris\u2122 WIDEPORE) and comparison with other existing stationary phases for the analysis of intact proteins","volume":"1236","author":"Fekete","year":"2012","journal-title":"J. Chromatogr. A"},{"issue":"5","key":"10.1016\/j.talanta.2019.120310_bib3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jpha.2013.02.005","article-title":"Fused-core particle technology in high-performance liquid chromatography: an overview","volume":"3","author":"Kirkland","year":"2013","journal-title":"J. Pharm. Anal."},{"issue":"1\u20132","key":"10.1016\/j.talanta.2019.120310_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.chroma.2007.05.090","article-title":"Monolithic columns in high-performance liquid chromatography","volume":"1168","author":"Guiochon","year":"2007","journal-title":"J. Chromatogr. A"},{"issue":"1\u20132","key":"10.1016\/j.talanta.2019.120310_bib5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.chroma.2007.11.118","article-title":"Particle packed columns and monolithic columns in high-performance liquid chromatography-comparison and critical appraisal","volume":"1184","author":"Unger","year":"2008","journal-title":"J. Chromatogr. A"},{"issue":"8","key":"10.1016\/j.talanta.2019.120310_bib6","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/jssc.200700026","article-title":"Fundamental and practical aspects of ultrahigh pressure liquid chromatography for fast separations","volume":"30","author":"Wu","year":"2007","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.talanta.2019.120310_bib7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.chroma.2014.05.010","article-title":"Core\u2013shell particles: preparation, fundamentals and applications in high performance liquid chromatography","volume":"1357","author":"Hayes","year":"2014","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.talanta.2019.120310_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jssc.201700850","article-title":"Core\u2013shell microspheres with porous nanostructured shells for liquid chromatography","volume":"41","author":"Ahmed","year":"2018","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.talanta.2019.120310_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.trac.2014.08.008","article-title":"Core-shell particles lead the way to renewing high-performance liquid chromatography","volume":"64","author":"Gonz\u00e1lez-Ruiz","year":"2015","journal-title":"Trac. Trends Anal. Chem."},{"key":"10.1016\/j.talanta.2019.120310_bib10","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1002\/jssc.200900091","article-title":"Fused\u00edn, Fused\u2010core, sub\u20102 \u03bcm packings, and monolithic HPLC columns: a comparative evaluation","volume":"32","author":"Brice","year":"2009","journal-title":"J. Sep. Sci."},{"issue":"2","key":"10.1016\/j.talanta.2019.120310_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/chromsci\/7.2.109","article-title":"Column design in high pressure liquid chromatography","volume":"7","author":"Horvath","year":"1969","journal-title":"J. Chromatogr. Sci."},{"issue":"10","key":"10.1016\/j.talanta.2019.120310_bib12","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/chromsci\/46.10.883","article-title":"Fused-core particles: a practical alternative to sub-2 micron particles","volume":"46","author":"Salisbury","year":"2008","journal-title":"J. Chromatogr. Sci."},{"issue":"21","key":"10.1016\/j.talanta.2019.120310_bib13","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1039\/b502065d","article-title":"Magnetic and optical tunable microspheres with a magnetite\/gold nanoparticle shell","volume":"15","author":"Spasova","year":"2005","journal-title":"J. Mater. Chem."},{"issue":"45","key":"10.1016\/j.talanta.2019.120310_bib14","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1002\/adma.201202810","article-title":"One\u2013pot synthesis of spheres-on-sphere silica particles from a single precursor for fast HPLC with low back pressure","volume":"24","author":"Ahmed","year":"2012","journal-title":"Adv. Mater."},{"issue":"26","key":"10.1016\/j.talanta.2019.120310_bib15","doi-asserted-by":"crossref","first-page":"13197","DOI":"10.1039\/c2jm31090b","article-title":"One-pot synthesis of silica core\u2013shell particles with double shells and different pore orientations from their nonporous counterparts","volume":"22","author":"Dong","year":"2012","journal-title":"J. Mater. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2019.120310_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0021-9673(00)00392-7","article-title":"Superficially porous silica microspheres for fast high-performance liquid chromatography of macromolecules","volume":"890","author":"Kirkland","year":"2000","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2019.120310_bib17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.chroma.2015.08.043","article-title":"Synthesis and optimization of wide pore superficially porous particles by a one-step coating process for separation of proteins and monoclonal antibodies","volume":"1414","author":"Chen","year":"2015","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.talanta.2019.120310_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cclet.2017.06.004","article-title":"Synthesis of SiO2@ SiO2 core-shell microspheres using urea-formaldehyde polymers as the templates for fast separation of small solutes and proteins","volume":"29","author":"Wan","year":"2018","journal-title":"Chin. Chem. Lett."},{"issue":"18","key":"10.1016\/j.talanta.2019.120310_bib19","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1039\/b617471j","article-title":"Synthesis of monodisperse spherical silica particles with solid core and mesoporous shell: mesopore channels perpendicular to the surface","volume":"17","author":"Yoon","year":"2007","journal-title":"J. Mater. Chem."},{"issue":"13","key":"10.1016\/j.talanta.2019.120310_bib20","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/(SICI)1521-4095(199809)10:13<1036::AID-ADMA1036>3.0.CO;2-Z","article-title":"Synthesis of monodis\u2013size solid core\/mesoporous shell silica spheres","volume":"10","author":"Yoon","year":"1998","journal-title":"Adv. Mater."},{"issue":"2","key":"10.1016\/j.talanta.2019.120310_bib21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00604-019-3229-8","article-title":"One-pot synthesis of SiO2@ SiO2 core-shell microspheres with controllable mesopore size as a new stationary phase for fast HPLC separation of alkyl benzenes and \u03b2-agonists","volume":"186","author":"Xia","year":"2019","journal-title":"Microchimica Acta"},{"issue":"9","key":"10.1016\/j.talanta.2019.120310_bib22","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/anie.201108748","article-title":"Highly ordered mesoporous silica films with perpendicular mesochannels by a simple st\u00f6ber\u2013solution growth approach","volume":"51","author":"Teng","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"issue":"7","key":"10.1016\/j.talanta.2019.120310_bib23","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/chromsci\/48.7.566","article-title":"Wider pore superficially porous particles for peptide separations by HPLC","volume":"48","author":"Schuster","year":"2010","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.talanta.2019.120310_bib24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.matlet.2017.01.055","article-title":"Preparation of superficially porous core-shell silica particle with controllable mesopore by a dual-templating approach for fast HPLC of small molecules","volume":"192","author":"Xia","year":"2017","journal-title":"Mater. Lett."},{"key":"10.1016\/j.talanta.2019.120310_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.matlet.2017.09.087","article-title":"Synthesis of core-shell silica spheres with tunable pore diameters for HPLC","volume":"211","author":"Qu","year":"2018","journal-title":"Mater. Lett."},{"key":"10.1016\/j.talanta.2019.120310_bib26","unstructured":"W. Chen, T.C. Wei, Superficially Porous Particles and Methods of Making and Using Same, Patent: US7846337B2."},{"issue":"19","key":"10.1016\/j.talanta.2019.120310_bib27a","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.1021\/ac201665e","article-title":"Integrated sample pretreatment system for N-linked glycosylation site profiling with combination of hydrophilic interaction chromatography and PNGase F immobilized enzymatic reactor via a strong cation exchange precolumn","volume":"83","author":"Qu","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2019.120310_bib27b","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.talanta.2018.07.061","article-title":"Thiol-radical-mediated polymerization for preparation of POSS-containing polyacrylate monoliths in capillary liquid chromatography","volume":"190","author":"Wang","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2019.120310_bib28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.chroma.2017.07.070","article-title":"Synthesis of polymeric monoliths via thiol-maleimide polymerization reaction for highly efficient chromatographic separation","volume":"1514","author":"Bai","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2019.120310_bib29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.aca.2017.05.004","article-title":"Preparation of open tubular capillary columns by in situ ring-opening polymerization and their applications in cLC-MS\/MS analysis of tryptic digest","volume":"979","author":"Wang","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2019.120310_bib30","doi-asserted-by":"crossref","first-page":"8789","DOI":"10.1021\/acs.analchem.5b01707","article-title":"Preparation of hybrid monolithic columns via \u201cOne-pot\u201d photoinitiated thiol-acrylate polymerization for retention-independent performance in capillary liquid chromatography","volume":"87","author":"Zhang","year":"2015","journal-title":"Anal. Chem."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914019309439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914019309439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:42:12Z","timestamp":1777444932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914019309439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":31,"alternative-id":["S0039914019309439"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2019.120310","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and optimization of SiO2@SiO2 core-shell microspheres by an improved polymerization-induced colloid aggregation method for fast separation of small solutes and proteins","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2019.120310","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120310"}}