{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T19:57:30Z","timestamp":1776715050525,"version":"3.51.2"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21575100"],"award-info":[{"award-number":["21575100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21621003"],"award-info":[{"award-number":["21621003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21727814"],"award-info":[{"award-number":["21727814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21922409"],"award-info":[{"award-number":["21922409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012612","name":"Tianjin Research Program of Application Foundation and Advanced Technology of China","doi-asserted-by":"publisher","award":["17JCYBJC20500"],"award-info":[{"award-number":["17JCYBJC20500"]}],"id":[{"id":"10.13039\/501100012612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.talanta.2020.120732","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T02:19:15Z","timestamp":1578536355000},"page":"120732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Evaluation of the accumulation of disulfiram and its copper complex in A549\u00a0cells using mass spectrometry"],"prefix":"10.1016","volume":"211","author":[{"given":"Xinling","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binxin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Ming","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.talanta.2020.120732_bib1","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA A Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.talanta.2020.120732_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"Ca-Cancer J. Clin."},{"issue":"23","key":"10.1016\/j.talanta.2020.120732_bib3","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1002\/cncr.29045","article-title":"Analysis of stage and clinical\/prognostic factors for lung cancer from SEER registries: AJCC staging and collaborative stage data collection system","volume":"120","author":"Chen","year":"2014","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.talanta.2020.120732_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1055\/s-0033-1342950","article-title":"Lung cancer staging: clinical and radiologic perspectives","volume":"30","author":"Chheang","year":"2013","journal-title":"Semin. Interv. Radiol."},{"issue":"10","key":"10.1016\/j.talanta.2020.120732_bib5","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1634\/theoncologist.2010-0322","article-title":"Future scenarios for the treatment of advanced non-small cell lung cancer: focus on taxane-containing regimens","volume":"15","author":"Grossi","year":"2010","journal-title":"The Oncologist"},{"issue":"3","key":"10.1016\/j.talanta.2020.120732_bib6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/clpt.2009.293","article-title":"Deconstructing the drug development process: the new face of innovation","volume":"87","author":"Kaitin","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.talanta.2020.120732_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/nrd3461","article-title":"Mining for therapeutic gold","volume":"10","author":"Collins","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7607","key":"10.1016\/j.talanta.2020.120732_bib8","first-page":"314","article-title":"Can you teach old drugs new tricks?","volume":"534","author":"Nosengo","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"11","key":"10.1016\/j.talanta.2020.120732_bib9","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/jama.1986.03380110055026","article-title":"Disulfiram treatment of alcoholism. a veterans administration cooperative study","volume":"256","author":"Fuller","year":"1986","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"10.1016\/j.talanta.2020.120732_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-0447.1992.tb03310.x","article-title":"A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites","volume":"86","author":"Johansson","year":"1992","journal-title":"Acta Psychiatr. Scand."},{"issue":"4","key":"10.1016\/j.talanta.2020.120732_bib11","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/15563650701636390","article-title":"Disulfiram neuropathy: two cases of distal axonopathy","volume":"46","author":"Filosto","year":"2008","journal-title":"Clin. Toxicol."},{"issue":"7684","key":"10.1016\/j.talanta.2020.120732_bib12","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature25016","article-title":"Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4","volume":"552","author":"Skrott","year":"2017","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.talanta.2020.120732_bib13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1634\/theoncologist.2014-0424","article-title":"A phase IIb trial assessing the addition of disulfiram to chemotherapy for the treatment of metastatic non-small cell lung cancer","volume":"20","author":"Nechushtan","year":"2015","journal-title":"The Oncologist"},{"issue":"1","key":"10.1016\/j.talanta.2020.120732_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF01877380","article-title":"Sodium dithiocarb as adjuvant immunotherapy for high risk breast cancer: a randomized study","volume":"6","author":"Dufour","year":"1993","journal-title":"Biotherapy"},{"issue":"19","key":"10.1016\/j.talanta.2020.120732_bib15","doi-asserted-by":"crossref","first-page":"6070","DOI":"10.1158\/1078-0432.CCR-09-1035","article-title":"High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth","volume":"15","author":"Iljin","year":"2009","journal-title":"Clin. Cancer Res."},{"issue":"21","key":"10.1016\/j.talanta.2020.120732_bib16","doi-asserted-by":"crossref","first-page":"10425","DOI":"10.1158\/0008-5472.CAN-06-2126","article-title":"Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity","volume":"66","author":"Chen","year":"2006","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.talanta.2020.120732_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/bjc.2013.19","article-title":"Reply: cytotoxic effect of disulfiram\/copper on human glioblastoma cell lines and ALDH-positive cancer-stern-like cells","volume":"108","author":"Liu","year":"2013","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.talanta.2020.120732_bib18","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1038\/s41598-018-19410-1","article-title":"Restrained management of copper level enhances the antineoplastic activity of imatinib in vitro and in vivo","volume":"8","author":"Hassan","year":"2018","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.talanta.2020.120732_bib19","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.molonc.2015.02.007","article-title":"Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer","volume":"9","author":"Allensworth","year":"2015","journal-title":"Mol. Oncol."},{"issue":"12","key":"10.1016\/j.talanta.2020.120732_bib20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0966-842X(99)01638-8","article-title":"Pipes and wiring: the regulation of copper uptake and distribution in yeast","volume":"7","author":"Labbe","year":"1999","journal-title":"Trends Microbiol."},{"issue":"4","key":"10.1016\/j.talanta.2020.120732_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000226722","article-title":"Serum and tissue trace metal levels in lung cancer","volume":"46","author":"Diez","year":"1989","journal-title":"Oncology"},{"issue":"2","key":"10.1016\/j.talanta.2020.120732_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0009-9120(98)00096-4","article-title":"Association between oxidative stress and changes of trace elements in patients with breast cancer","volume":"32","author":"Huang","year":"1999","journal-title":"Clin. Biochem."},{"issue":"6","key":"10.1016\/j.talanta.2020.120732_bib23","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1039\/c5tx00210a","article-title":"The cytotoxic mechanisms of disulfiram and copper(II) in cancer cells","volume":"4","author":"Tawari","year":"2015","journal-title":"Toxicol. Res."},{"issue":"1","key":"10.1016\/j.talanta.2020.120732_bib24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrc1781","article-title":"Predicting the future burden of cancer","volume":"6","author":"Bray","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.talanta.2020.120732_bib25","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1021\/acs.biomac.9b00367","article-title":"Highly stable, coordinated polymeric nanoparticles loading copper(II) diethyldithiocarbamate for combinational chemo\/chemodynamic therapy of cancer","volume":"20","author":"Peng","year":"2019","journal-title":"Biomacromolecules"},{"issue":"29","key":"10.1016\/j.talanta.2020.120732_bib26","doi-asserted-by":"crossref","first-page":"11531","DOI":"10.1021\/jacs.9b03503","article-title":"Enhanced tumor-specific disulfiram chemotherapy by in situ Cu2+ chelation-initiated nontoxicity-to-toxicity transition","volume":"141","author":"Wu","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2020.120732_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.msec.2016.12.024","article-title":"In vitro cytotoxicity effect and antibacterial performance of human lung epithelial cells A549 activity of Zinc oxide doped TiO2 nanocrystals: investigation of bio-medical application by chemical method","volume":"74","author":"Kaviyarasu","year":"2017","journal-title":"Mater. Sci. Eng. C-Mater. Biol. Appl."},{"key":"10.1016\/j.talanta.2020.120732_bib28","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1021\/ac200349g","article-title":"Analytical strategies for assessment of human metabolites in preclinical safety testing","volume":"83","author":"Ma","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2020.120732_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.talanta.2019.05.088","article-title":"Alteration of intracellular metabolome in osteosarcoma stem cells revealed by liquid chromatography-tandem mass spectrometry","volume":"204","author":"Zhong","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2020.120732_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.talanta.2018.08.016","article-title":"Near-physiological microenvironment simulation on chip to evaluate drug resistance of different loci in tumour mass","volume":"191","author":"Wang","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2020.120732_bib31","doi-asserted-by":"crossref","first-page":"6711","DOI":"10.1038\/s41388-019-0915-2","article-title":"Disulfiram's anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase","volume":"38","author":"Skrott","year":"2019","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.talanta.2020.120732_bib32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.tibs.2019.04.013","article-title":"DNA content, cell size, and cell senescence","volume":"44","author":"Veitia","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.talanta.2020.120732_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12906-018-2300-z","article-title":"Sotetsuflavone inhibits proliferation and induces apoptosis of A549 cells through ROS-mediated mitochondrial-dependent pathway","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.talanta.2020.120732_bib34","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jinorgbio.2012.08.010","article-title":"Copper(II) complexes of terpyridine derivatives: a footstep towards development of antiproliferative agent for breast cancer","volume":"117","author":"Rajalakshmi","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.talanta.2020.120732_bib35","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.saa.2014.02.197","article-title":"DNA binding, cytotoxicity and apoptosis induction activity of a mixed-ligand copper(II) complex with taurine Schiff base and imidazole","volume":"128","author":"Li","year":"2014","journal-title":"Spectroc. Acta Pt. A-Molec. Biomolec. Spectr."},{"issue":"10","key":"10.1016\/j.talanta.2020.120732_bib36","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00432-011-1039-4","article-title":"The CDK inhibitors in cancer research and therapy","volume":"137","author":"Cicenas","year":"2011","journal-title":"J. Cancer Res. Clin. Oncol."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914020300230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914020300230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T12:34:22Z","timestamp":1758544462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914020300230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":36,"alternative-id":["S0039914020300230"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2020.120732","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the accumulation of disulfiram and its copper complex in A549\u00a0cells using mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2020.120732","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120732"}}