{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:33:41Z","timestamp":1792794821173,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772290"],"award-info":[{"award-number":["81772290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012334","name":"Graduate Scientific Research and Innovation Foundation of Chongqing, China","doi-asserted-by":"publisher","award":["CYB20070"],"award-info":[{"award-number":["CYB20070"]}],"id":[{"id":"10.13039\/501100012334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012334","name":"Graduate Scientific Research and Innovation Foundation of Chongqing, China","doi-asserted-by":"publisher","award":["2020CDCGJ014"],"award-info":[{"award-number":["2020CDCGJ014"]}],"id":[{"id":"10.13039\/501100012334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing science and technology commission","doi-asserted-by":"publisher","award":["CSTC2018jcyjAX0062"],"award-info":[{"award-number":["CSTC2018jcyjAX0062"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2019CDYGZD007"],"award-info":[{"award-number":["2019CDYGZD007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002369","name":"Chongqing University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002369","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.talanta.2020.121816","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T23:19:44Z","timestamp":1604445584000},"page":"121816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Au doped poly-thionine and poly-m-Cresol purple: Synthesis and their application in simultaneously electrochemical detection of two lung cancer markers CEA and CYFRA21-1"],"prefix":"10.1016","volume":"224","author":[{"given":"Huisi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqun","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickey","family":"Samalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2020.121816_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"Ca-Cancer J. Clin."},{"key":"10.1016\/j.talanta.2020.121816_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrc.2016.108","article-title":"Cancer nanomedicine: progress, challenges and opportunities","volume":"17","author":"Shi","year":"2017","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.talanta.2020.121816_bib3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"Ca-Cancer J. Clin."},{"key":"10.1016\/j.talanta.2020.121816_bib4","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","article-title":"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer","volume":"366","author":"Topalian","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.talanta.2020.121816_bib5","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1200\/JCO.2009.24.9342","article-title":"Serum MicroRNA signatures identified in a genome-wide serum MicroRNA expression profiling predict survival of non-small-cell lung cancer","volume":"28","author":"Hu","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.talanta.2020.121816_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.electacta.2012.06.033","article-title":"A review of experimental aspects of electrochemical immunosensors","volume":"84","author":"Ricci","year":"2012","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.talanta.2020.121816_bib7","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1039\/C1CS15134G","article-title":"Cancer detection using nanoparticle-based sensors","volume":"41","author":"Perfezou","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2020.121816_bib8","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1586\/14737159.2015.1052798","article-title":"Design of immunoprobes for electrochemical multiplexed tumor marker detection","volume":"15","author":"Ma","year":"2015","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.talanta.2020.121816_bib9","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1007\/s00604-016-1941-1","article-title":"Simultaneous detection of five biomarkers of lung cancer by electrochemical immunoassay","volume":"183","author":"Shan","year":"2016","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.talanta.2020.121816_bib10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.aca.2013.08.039","article-title":"Simultaneous detection of four biomarkers with one sensing surface based on redox probe tagging strategy","volume":"800","author":"Zhu","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2020.121816_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ab.2015.04.018","article-title":"Simultaneous electrochemical detection of multiple biomarkers using gold nanoparticles decorated multiwall carbon nanotubes as signal enhancers","volume":"482","author":"Feng","year":"2015","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.talanta.2020.121816_bib12","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1039\/C4CS00370E","article-title":"Cancer biomarker detection: recent achievements and challenges","volume":"44","author":"Wu","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2020.121816_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc1566","article-title":"Cancer nanotechnology: opportunities and challenges","volume":"5","author":"Ferrari","year":"2005","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.talanta.2020.121816_bib14","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1021\/acs.analchem.9b05317","article-title":"Simultaneous detection of multiple tumor markers in blood by functional liquid crystal sensors assisted with target-induced dissociation of aptamer","volume":"92","author":"Qi","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2020.121816_bib15","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1039\/c0an00204f","article-title":"Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer","volume":"135","author":"Rusling","year":"2010","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2020.121816_bib16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bios.2014.12.023","article-title":"Ultrasensitive simultaneous detection of four biomarkers based on hybridization chain reaction and biotin-streptavidin signal amplification strategy","volume":"68","author":"Zhu","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2020.121816_bib17","doi-asserted-by":"crossref","first-page":"9263","DOI":"10.1007\/s13277-016-4809-4","article-title":"Correlation of Cyfra 21-1 levels in saliva and serum with CK19 mRNA expression in oral squamous cell carcinoma","volume":"37","author":"Malhotra","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.talanta.2020.121816_bib18","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1007\/s13277-015-3352-z","article-title":"Diagnostic accuracy of cytokeratin-19 fragment (CYFRA 21-1) for bladder cancer: a systematic review and meta-analysis","volume":"36","author":"Huang","year":"2015","journal-title":"Tumor Biol."},{"key":"10.1016\/j.talanta.2020.121816_bib19","first-page":"30","article-title":"Serum cytokeratin-19 fragment (Cyfra 21-1) is a prognostic indicator for epithelial ovarian cancer, Taiwan","volume":"53","author":"Wu","year":"2014","journal-title":"J. Obstet. Gyne."},{"key":"10.1016\/j.talanta.2020.121816_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.lungcan.2006.11.004","article-title":"Compensation of type I and type II cytokeratin pools in lung cancer","volume":"55","author":"Kanaji","year":"2007","journal-title":"Lung Canc."},{"key":"10.1016\/j.talanta.2020.121816_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-017-3070-6","article-title":"The important role of circulating CYFRA21-1 in metastasis diagnosis and prognostic value compared with carcinoembryonic antigen and neuron-specific enolase in lung cancer patients","volume":"17","author":"Zhang","year":"2017","journal-title":"BMC Canc."},{"key":"10.1016\/j.talanta.2020.121816_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bios.2017.10.021","article-title":"A graphene quantum dots based electrochemiluminescence immunosensor for carcinoembryonic antigen detection using poly(5-formylindole)\/reduced graphene oxide nanocomposite","volume":"101","author":"Nie","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2020.121816_bib23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0092-8674(89)90970-7","article-title":"Carcinoembryonic antigen, a human-tumor marker, functions as an intercellular-adhesion molecule","volume":"57","author":"Benchimol","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.talanta.2020.121816_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/scbi.1998.0119","article-title":"The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues","volume":"9","author":"Hammarstrom","year":"1999","journal-title":"Semin. Canc. Biol."},{"key":"10.1016\/j.talanta.2020.121816_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.snb.2017.10.115","article-title":"Simultaneous detection of multiple tumor markers by label-free electrochemical immunoassay using chip-like glass carbon electrodes","volume":"256","author":"Wang","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2020.121816_bib26","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1007\/s00604-016-1941-1","article-title":"Simultaneous detection of five biomarkers of lung cancer by electrochemical immunoassay","volume":"183","author":"Shan","year":"2016","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.talanta.2020.121816_bib27","doi-asserted-by":"crossref","first-page":"7657","DOI":"10.1039\/C5CC00684H","article-title":"3,4,9,10-Perylenetetracarboxylic acid\/o-phenylenediamine nanomaterials as novel redox probes for electrochemical aptasensor systems based on an Fe3O4 magnetic bead as a nonenzymatic catalyst","volume":"51","author":"Chang","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2020.121816_bib28","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1021\/ac503406p","article-title":"New type of redox nanoprobe: C60 -based nanomaterial and its application in electrochemical immunoassay for doping detection","volume":"87","author":"Han","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2020.121816_bib29","article-title":"Signal amplification for highly sensitive immunosensing","volume":"1","author":"Ju","year":"2017","journal-title":"J. Anal. Testing"},{"key":"10.1016\/j.talanta.2020.121816_bib30","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bios.2015.03.062","article-title":"Graphene, carbon nanotubes, zinc oxide and gold as elite nanomaterials for fabrication of biosensors for healthcare","volume":"70","author":"Kumar","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2020.121816_bib31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bios.2015.07.002","article-title":"Recent advances in electrochemical biosensors based on graphene two-dimensional nanomaterials","volume":"76","author":"Song","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2020.121816_bib32","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.talanta.2014.07.019","article-title":"Synthesis and utilisation of graphene for fabrication of electrochemical sensors","volume":"131","author":"Lawal","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2020.121816_bib33","doi-asserted-by":"crossref","first-page":"8490","DOI":"10.1039\/C4TB01439A","article-title":"An electrochemical sensor for detecting triglyceride based on biomimetic polydopamine and gold nanocomposite","volume":"2","author":"Zhang","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.talanta.2020.121816_bib34","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bios.2011.07.018","article-title":"Direct electrochemical reduction of graphene oxide on ionic liquid doped screen-printed electrode and its electrochemical biosensing application","volume":"28","author":"Ping","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2020.121816_bib35","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1007\/s00604-016-1941-1","article-title":"Simultaneous detection of five biomarkers of lung cancer by electrochemical immunoassay","volume":"183","author":"Shan","year":"2016","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.talanta.2020.121816_bib36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bios.2013.01.003","article-title":"A one-pot \u2018green\u2019 synthesis of Pd-decorated PEDOT nanospheres for nonenzymatic hydrogen peroxide sensing","volume":"44","author":"Jiang","year":"2013","journal-title":"Biosens. Bioelectron."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914020311073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914020311073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T12:50:54Z","timestamp":1758545454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914020311073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":36,"alternative-id":["S0039914020311073"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2020.121816","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Au doped poly-thionine and poly-m-Cresol purple: Synthesis and their application in simultaneously electrochemical detection of two lung cancer markers CEA and CYFRA21-1","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2020.121816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121816"}}