{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:05:05Z","timestamp":1788357905730,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"am","delay-in-days":280,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006180","name":"the Science and Technology Development Fund, Macau SAR","doi-asserted-by":"publisher","award":["FDCT 0044\/2018\/AFJ and 0002\/2019\/APD"],"award-info":[{"award-number":["FDCT 0044\/2018\/AFJ and 0002\/2019\/APD"]}],"id":[{"id":"10.13039\/100006180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.talanta.2020.122056","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T02:09:32Z","timestamp":1609207772000},"page":"122056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Stand out from matrix: Ultra-sensitive LC\u2212MS\/MS method for determination of histamine in complex biological samples using derivatization and solid phase extraction"],"prefix":"10.1016","volume":"225","author":[{"given":"Xiaolan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqing","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Yi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Lin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-6431","authenticated-orcid":false,"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.talanta.2020.122056_bib1","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1111\/j.1582-4934.2012.01566.x","article-title":"Histamine: an undercover agent in multiple rare diseases?","volume":"16","author":"Pino-Angeles","year":"2012","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.talanta.2020.122056_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1067\/mai.2003.1585","article-title":"Histamine in the immune regulation of allergic inflammation","volume":"112","author":"Akdis","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.talanta.2020.122056_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1471-4906(02)02215-9","article-title":"Trends in histamine research: new functions during immune responses and hematopoiesis","volume":"23","author":"Schneider","year":"2002","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.talanta.2020.122056_bib4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1021\/cn200126p","article-title":"Role of histamine and its receptors in cerebral ischemia","volume":"3","author":"Hu","year":"2012","journal-title":"ACS Chem. Neurosci."},{"issue":"22","key":"10.1016\/j.talanta.2020.122056_bib5","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1056\/NEJM199306033282204","article-title":"Autoantibodies againest the high-affinity IgE receptor as a cause of histamine release in chronic urticaria","volume":"328","author":"Hide","year":"1993","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.talanta.2020.122056_bib6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nm.2278","article-title":"Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells","volume":"17","author":"Yang","year":"2011","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.talanta.2020.122056_bib7","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1084\/jem.189.10.1573","article-title":"Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG","volume":"189","author":"Ujike","year":"1999","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.talanta.2020.122056_bib8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/bmc.264","article-title":"A sensitive and selective determination method of histamine by HPLC with intramolecular excimer-forming derivatization and \ufb02uorescence detection","volume":"17","author":"Yoshitake","year":"2003","journal-title":"Biomed. Chromatogr."},{"issue":"4","key":"10.1016\/j.talanta.2020.122056_bib9","first-page":"236","article-title":"Histamine levels in health and disease","volume":"13","author":"Jackson JA","year":"1998","journal-title":"J. Orthomol. Med."},{"issue":"1 Pt 1","key":"10.1016\/j.talanta.2020.122056_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1067\/mai.2000.107600","article-title":"Histamine and tryptase levels in patients with acute allergic reactions: an emergency department-based study","volume":"106","author":"Lin","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"issue":"7","key":"10.1016\/j.talanta.2020.122056_bib11","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1021\/ac103245b","article-title":"Highly sensitive GC\/MS\/MS method for quantitation of amino and nonamino organic acids","volume":"83","author":"Kvitvang","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2020.122056_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2020.108760","article-title":"LC-MS\/MS analysis of twelve neurotransmitters and amino acids in mouse cerebrospinal fluid","volume":"341","author":"Blanco","year":"2020","journal-title":"J. Neurosci. Methods"},{"issue":"2\u20133","key":"10.1016\/j.talanta.2020.122056_bib13","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00216-012-6269-z","article-title":"Simultaneous determination of sixteen underivatized biogenic amines in human urine by HPLC-MS\/MS","volume":"405","author":"Gosetti","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2020.122056_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jchromb.2014.08.043","article-title":"Development of a UHPLC-MS\/MS method for the determination of plasma histamine in various mammalian species","volume":"971","author":"Liu","year":"2014","journal-title":"J. Chromatogr. B"},{"issue":"2","key":"10.1016\/j.talanta.2020.122056_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/15376516.2019.1672122","article-title":"Cerebrospinal fluid neurotransmitter levels and central nervous system depression in a rat drug overdose model","volume":"30","author":"Tsutsumi","year":"2020","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.talanta.2020.122056_bib16","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jpba.2014.10.016","article-title":"2nd, Development and validation of a liquid-chromatography tandem mass spectrometry method to determine in vitro and in vivo histamine release","volume":"102","author":"Chimalakonda","year":"2015","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"4","key":"10.1016\/j.talanta.2020.122056_bib17","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s00216-011-5200-3","article-title":"Simultaneous determination of histamine and prostaglandin D2 using an LC-ESI-MS\/MS method with positive\/negative ion-switching ionization modes: application to the study of anti-allergic flavonoids on the degranulation of KU812 cells","volume":"401","author":"Koyama","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2020.122056_bib18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1021\/ac202794q","article-title":"In vivo neurochemical monitoring using benzoyl chloride derivatization and liquid chromatography-mass spectrometry","volume":"84","author":"Song","year":"2012","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.talanta.2020.122056_bib19","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/ajcn\/85.5.1185","article-title":"Histamine and histamine intolerance","volume":"85","author":"Maintz N","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.talanta.2020.122056_bib20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00216-011-5224-8","article-title":"Simultaneous quantitation of histamine and its major metabolite 1-methylhistamine in brain dialysates by using precolumn derivatization prior to HILIC-MS\/MS analysis","volume":"402","author":"Bourgogne","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2020.122056_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jpba.2019.04.025","article-title":"Development and validation of a highly sensitive LC-MS\/MS method for in vitro measurement of histamine concentration","volume":"172","author":"Kim","year":"2019","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.talanta.2020.122056_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ab.2010.09.045","article-title":"Histamine and tele-methylhistamine quantification in cerebrospinal fluid from narcoleptic subjects by liquid chromatography tandem mass spectrometry with precolumn derivatization","volume":"409","author":"Croyal","year":"2011","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.talanta.2020.122056_bib23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/rcm.1356","article-title":"Sensitivity improvement of amino acids by N-terminal diisopropyloxyphosphorylation in electrospray ionization mass spectrometry","volume":"18","author":"Chen","year":"2004","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.talanta.2020.122056_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aca.2014.05.053","article-title":"A novel quantification method for analysis of twenty natural amino acids in human serum based on N-phosphorylation labeling using reversed-phase liquid chromatography-tandem mass spectrometry","volume":"836","author":"Chen","year":"2014","journal-title":"Anal. Chim. Acta"},{"issue":"9","key":"10.1016\/j.talanta.2020.122056_bib25","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1039\/c3an00036b","article-title":"N-phosphorylation labeling for analysis of twenty natural amino acids and small peptides by using matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry","volume":"138","author":"Gao","year":"2013","journal-title":"Analyst"},{"issue":"1","key":"10.1016\/j.talanta.2020.122056_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10456-005-2892-z","article-title":"The anti-angiogenic effect of sinomenine","volume":"8","author":"Kok","year":"2005","journal-title":"Angiogenesis"},{"key":"10.1016\/j.talanta.2020.122056_bib27","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.phrs.2016.05.033","article-title":"A rapid and sensitive assay based on particle analysis for cell degranulation detection in basophils and mast cells","volume":"111","author":"Huang","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.talanta.2020.122056_bib28","doi-asserted-by":"crossref","unstructured":"P.J. Dunford, S.T. Holgate, The Role of Histamine in Asthma, Histamine in Inflammation, Springer2010, pp. 53-66.","DOI":"10.1007\/978-1-4419-8056-4_6"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914020313473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914020313473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T19:28:42Z","timestamp":1770924522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914020313473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":28,"alternative-id":["S0039914020313473"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2020.122056","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stand out from matrix: Ultra-sensitive LC\u2212MS\/MS method for determination of histamine in complex biological samples using derivatization and solid phase extraction","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2020.122056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122056"}}