{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T17:45:11Z","timestamp":1776361511658,"version":"3.51.2"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21575148"],"award-info":[{"award-number":["21575148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21575149"],"award-info":[{"award-number":["21575149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.talanta.2021.122548","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T12:00:47Z","timestamp":1621857647000},"page":"122548","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Non-conjugated flexible network for the functional design of silica-based stationary phase for mixed-mode liquid chromatography"],"prefix":"10.1016","volume":"233","author":[{"given":"Fangbin","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.talanta.2021.122548_bib1","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1002\/anie.201909880","article-title":"Porphyrin-based metal-organic frameworks for biomedical applications","volume":"60","author":"Chen","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2021.122548_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/anie.202015790","article-title":"Current trends in metal-organic and covalent organic framework membrane materials","volume":"60","author":"Hosseini Monjezi","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"issue":"22","key":"10.1016\/j.talanta.2021.122548_bib3","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1002\/anie.201902961","article-title":"Pore-surface engineering by decorating metal-oxo nodes with phenylsilane to give versatile super-hydrophobic metal-organic frameworks (MOFs)","volume":"58","author":"Sun","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2021.122548_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2018.02.023","article-title":"Advances in covalent organic frameworks in separation science","volume":"1542","author":"Qian","year":"2018","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.talanta.2021.122548_bib5","article-title":"Phase-enabled metal-organic framework homojunction for highly selective CO2 photoreduction","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.talanta.2021.122548_bib6","first-page":"1960","article-title":"Advances in covalent organic frameworks","volume":"33","author":"Li","year":"2017","journal-title":"Acta Phys. Chim. Sin."},{"issue":"1\u20132","key":"10.1016\/j.talanta.2021.122548_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10847-019-00924-8","article-title":"Research of covalent organic frame materials based on porphyrin units","volume":"95","author":"Liu","year":"2019","journal-title":"J. Incl. Phenom. Macro."},{"issue":"83","key":"10.1016\/j.talanta.2021.122548_bib8","doi-asserted-by":"crossref","first-page":"11469","DOI":"10.1039\/C7CC06244C","article-title":"A versatile covalent organic framework-based platform for sensing biomolecules","volume":"53","author":"Li","year":"2017","journal-title":"Chem. Commun."},{"issue":"6","key":"10.1016\/j.talanta.2021.122548_bib9","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.cclet.2017.03.026","article-title":"Applications of covalent organic frameworks (COFs): from gas storage and separation to drug delivery","volume":"28","author":"Wu","year":"2017","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.talanta.2021.122548_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.chroma.2014.08.077","article-title":"Preparation and evaluation of silica-UIO-66 composite as liquid chromatographic stationary phase for fast and efficient separation","volume":"1366","author":"Yan","year":"2014","journal-title":"J. Chromatogr. A"},{"issue":"18","key":"10.1016\/j.talanta.2021.122548_bib11","doi-asserted-by":"crossref","first-page":"7144","DOI":"10.1021\/ac201517c","article-title":"Metal-organic framework MIL-101(Cr) for high-performance liquid chromatographic separation of substituted aromatics","volume":"83","author":"Yang","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2021.122548_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.chroma.2017.05.031","article-title":"Core-shell silica particles with dendritic pore channels impregnated with zeolite imidazolate framework-8 for high performance liquid chromatography separation","volume":"1505","author":"Qu","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2021.122548_bib13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.chroma.2014.10.036","article-title":"Separations of substituted benzenes and polycyclic aromatic hydrocarbons using normal- and reverse-phase high performance liquid chromatography with UiO-66 as the stationary phase","volume":"1370","author":"Zhao","year":"2014","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.talanta.2021.122548_bib14","article-title":"A solvent-assisted ligand exchange approach enables metal-organic frameworks with diverse and complex architectures","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.talanta.2021.122548_bib15","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1021\/acsaelm.0c00867","article-title":"Tunability of the electronic properties of covalent organic frameworks","volume":"3","author":"Sinha","year":"2021","journal-title":"Acs Appl. Electron. Mater."},{"issue":"3","key":"10.1016\/j.talanta.2021.122548_bib16","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1021\/jacs.7b12110","article-title":"Chiral 3D covalent organic frameworks for high performance liquid chromatographic enantioseparation","volume":"140","author":"Hang","year":"2018","journal-title":"J. Am. Chem. Soc."},{"issue":"24","key":"10.1016\/j.talanta.2021.122548_bib17","doi-asserted-by":"crossref","first-page":"8119","DOI":"10.1002\/anie.201903367","article-title":"Transformation of metal-organic frameworks into stable organic frameworks with inherited skeletons and catalytic properties","volume":"58","author":"Chen","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"issue":"33","key":"10.1016\/j.talanta.2021.122548_bib18","doi-asserted-by":"crossref","first-page":"13722","DOI":"10.1002\/anie.202004796","article-title":"Metal-covalent organic frameworks (MCOFs): a bridge between metal-organic frameworks and covalent organic frameworks","volume":"59","author":"Dong","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2021.122548_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.micromeso.2020.110739","article-title":"Synthesis of nitrogen-containing covalent organic framework with reversible iodine capture capability","volume":"312","author":"Chen","year":"2021","journal-title":"Microporous Mesoporous Mater."},{"issue":"1","key":"10.1016\/j.talanta.2021.122548_bib20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1021\/jacs.9b11401","article-title":"Fabricating organic nanotubes through selective disassembly of two-dimensional covalent organic frameworks","volume":"142","author":"Liang","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"2","key":"10.1016\/j.talanta.2021.122548_bib21","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1021\/acsami.8b19100","article-title":"Reprocessable polyhydroxyurethane network composites: effect of filler surface functionality on cross-link density recovery and stress relaxation","volume":"11","author":"Chen","year":"2019","journal-title":"Acs Appl. Mater. Inter."},{"issue":"4","key":"10.1016\/j.talanta.2021.122548_bib22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/09243046.2017.1407278","article-title":"Analysis of structure characteristics in laminated graphene oxide nanocomposites using molecular dynamics simulation","volume":"27","author":"Oya","year":"2018","journal-title":"Adv. Compos. Mater."},{"issue":"55","key":"10.1016\/j.talanta.2021.122548_bib23","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1039\/D0CC02707C","article-title":"Improved photocatalytic performance of metal-organic frameworks for CO(2)conversion by ligand modification","volume":"56","author":"Cheng","year":"2020","journal-title":"Chem. Commun."},{"issue":"19","key":"10.1016\/j.talanta.2021.122548_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24193480","article-title":"Substituted 1,3,5-triazine hexacarboxylates as potential linkers for MOFs","volume":"24","author":"Klinkebiel","year":"2019","journal-title":"Molecules"},{"issue":"28","key":"10.1016\/j.talanta.2021.122548_bib25","doi-asserted-by":"crossref","first-page":"8438","DOI":"10.1002\/anie.201801128","article-title":"Direct synthesis of a covalent triazine-based framework from aromatic amides","volume":"57","author":"Yu","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"issue":"13","key":"10.1016\/j.talanta.2021.122548_bib26","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1021\/jacs.0c00923","article-title":"Construction of fully conjugated covalent organic frameworks via facile linkage conversion for efficient photoenzymatic catalysis","volume":"142","author":"Wang","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"45","key":"10.1016\/j.talanta.2021.122548_bib27","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.1016\/j.chroma.2011.09.037","article-title":"Characterization of enhanced-fluidity liquid hydrophilic interaction chromatography for the separation of nucleosides and nucleotides","volume":"1218","author":"Philibert","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2021.122548_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461472","article-title":"A facile process for the preparation of organic gel-assisted silica microsphere material for multi-mode liquid chromatography","volume":"1628","author":"Fan","year":"2020","journal-title":"J. Chromatogr. A"},{"issue":"3","key":"10.1016\/j.talanta.2021.122548_bib29","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.cclet.2019.08.030","article-title":"A novel double polymer modified hydrophobic\/hydrophilic stationary phase for liquid chromatography","volume":"31","author":"Fan","year":"2020","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.talanta.2021.122548_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462010","article-title":"Prospects of using hyperbranched stationary phase based on poly(styrene-divinylbenzene) in mixed-mode chromatography","volume":"1642","author":"Popov","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2021.122548_bib31","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.micromeso.2018.01.003","article-title":"MOF@SiO2 core-shell composites as stationary phase in high performance liquid chromatography","volume":"263","author":"Ehrling","year":"2018","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.talanta.2021.122548_bib32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chroma.2016.12.082","article-title":"Silica gel microspheres decorated with covalent triazine-based frameworks as an improved stationary phase for high performance liquid chromatography","volume":"1487","author":"Zhao","year":"2017","journal-title":"J. Chromatogr. A"},{"issue":"83","key":"10.1016\/j.talanta.2021.122548_bib33","doi-asserted-by":"crossref","first-page":"11765","DOI":"10.1039\/C8CC06621C","article-title":"Layer-by-layer preparation of 3D covalent organic framework\/silica composites for chromatographic separation of position isomers","volume":"54","author":"Qian","year":"2018","journal-title":"Chem. Commun."},{"issue":"9","key":"10.1016\/j.talanta.2021.122548_bib34","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/jssc.200800051","article-title":"Stationary phases for hydrophilic interaction chromatography, their characterization and implementation into multidimensional chromatography concepts","volume":"31","author":"Jandera","year":"2008","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.talanta.2021.122548_bib35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.chroma.2018.11.051","article-title":"Investigation and prediction of retention characteristics of imidazoline and serotonin receptor ligands and their related compounds on mixed-mode stationary phase","volume":"1585","author":"Obradovic","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2021.122548_bib36","doi-asserted-by":"crossref","first-page":"460951","DOI":"10.1016\/j.chroma.2020.460951","article-title":"Novel computational approaches to retention modeling in dual hydrophilic interactions\/reversed phase chromatography","volume":"1619","author":"Obradovic","year":"2020","journal-title":"J. Chromatogr. A"},{"issue":"3","key":"10.1016\/j.talanta.2021.122548_bib37","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.talanta.2008.03.042","article-title":"Study on the retention equation in hydrophilic interaction liquid chromatography","volume":"76","author":"Jin","year":"2008","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2021.122548_bib38","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0021-9673(00)81008-0","article-title":"Gradient selection in reversed-phase liquid chromatography","volume":"149","author":"Schoenmakers","year":"1978","journal-title":"J. Chromatogr. A"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914021004690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914021004690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T12:54:20Z","timestamp":1758545660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914021004690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":38,"alternative-id":["S0039914021004690"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2021.122548","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-conjugated flexible network for the functional design of silica-based stationary phase for mixed-mode liquid chromatography","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2021.122548","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122548"}}