{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:43:50Z","timestamp":1784346230258,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21677019"],"award-info":[{"award-number":["21677019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005024","name":"Beijing Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006739","name":"Capital Foundation of Medical Development","doi-asserted-by":"publisher","award":["2018-1-302"],"award-info":[{"award-number":["2018-1-302"]}],"id":[{"id":"10.13039\/501100006739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.talanta.2021.122919","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T19:55:27Z","timestamp":1633377327000},"page":"122919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Distribution visualization of the chlorinated disinfection byproduct of diazepam in zebrafish with desorption electrospray ionization mass spectrometry imaging"],"prefix":"10.1016","volume":"237","author":[{"given":"Xiaole","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2021.122919_bib1","doi-asserted-by":"crossref","first-page":"17024","DOI":"10.1038\/nrdp.2017.24","article-title":"Anxiety disorders","volume":"3","author":"Craske","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.talanta.2021.122919_bib2","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.talanta.2021.122919_bib3","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.watres.2017.04.063","article-title":"Reaction of diazepam and related benzodiazepines with chlorine. Kinetics, transformation products and in-silico toxicological assessment","volume":"120","author":"Carpinteiro","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.talanta.2021.122919_bib4","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1038\/s41386-018-0123-8","article-title":"Diazepam reverses increased anxiety-like behavior, social behavior deficit, and dopamine dysregulation following withdrawal from acute amphetamine","volume":"43","author":"Rincon-Cortes","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.talanta.2021.122919_bib5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1126\/science.aax5719","article-title":"Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions","volume":"366","author":"Han","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.talanta.2021.122919_bib6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41586-018-0832-5","article-title":"GABAA receptor signalling mechanisms revealed by structural pharmacology","volume":"565","author":"Masiulis","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.talanta.2021.122919_bib7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.watres.2011.10.056","article-title":"Environmental occurrence, fate and transformation of benzodiazepines in water treatment","volume":"46","author":"Kosjek","year":"2012","journal-title":"Water Res."},{"key":"10.1016\/j.talanta.2021.122919_bib8","doi-asserted-by":"crossref","first-page":"16999","DOI":"10.1038\/s41598-017-15462-x","article-title":"Bioaccumulation of pharmaceuticals and personal care product chemicals in fish exposed to wastewater effluent in an urban wetland","volume":"7","author":"Muir","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.talanta.2021.122919_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.chemosphere.2018.11.076","article-title":"Determination of emerging chlorinated byproducts of diazepam in drinking water","volume":"218","author":"Zhang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.talanta.2021.122919_bib10","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1021\/es203529z","article-title":"Aqueous phototransformation of diazepam and related human metabolites under simulated sunlight","volume":"46","author":"West","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.talanta.2021.122919_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat9931","article-title":"Separating host and microbiome contributions to drug pharmacokinetics and toxicity","volume":"363","author":"Zimmermann","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.talanta.2021.122919_bib12","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1021\/acs.accounts.8b00641","article-title":"formation of iodinated disinfection byproducts (I-DBPs) in drinking water: emerging concerns and current issues","volume":"52","author":"Dong","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.talanta.2021.122919_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/mas.21607","article-title":"Strategies and challenges in method development and validation for the absolute quantification of endogenous biomarker metabolites using liquid chromatography\u2010tandem mass spectrometry","author":"Khamis","year":"2021","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.talanta.2021.122919_bib14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1126\/science.1104404","article-title":"Mass spectrometry sampling under ambient conditions with desorption electrospray ionization","volume":"306","author":"Tak\u00e1ts","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.talanta.2021.122919_bib15","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1126\/science.1119426","article-title":"Ambient mass spectrometry","volume":"311","author":"Cooks","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.talanta.2021.122919_bib16","doi-asserted-by":"crossref","first-page":"18120","DOI":"10.1073\/pnas.0801066105","article-title":"Desorption electrospray ionization mass spectrometry: imaging drugs and metabolites in tissues","volume":"105","author":"Wiseman","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.talanta.2021.122919_bib17","doi-asserted-by":"crossref","first-page":"8473","DOI":"10.1021\/ac502217r","article-title":"Mass spectrometry imaging of cassette-dosed drugs for higher throughput pharmacokinetic and biodistribution analysis","volume":"86","author":"Swales","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2021.122919_bib18","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1021\/acs.analchem.9b00711","article-title":"In situ detection and imaging of PFOS in mouse kidney by matrix-assisted laser desorption\/ionization imaging mass spectrometry","volume":"91","author":"Yang","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2021.122919_bib19","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1021\/cr3004295","article-title":"Analysis of tissue specimens by matrix-assisted laser desorption\/ionization imaging mass spectrometry in biological and clinical research","volume":"113","author":"Norris","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.talanta.2021.122919_bib20","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1021\/pr8005777","article-title":"MALDI imaging combined with hierarchical clustering as a new tool for the interpretation of complex human cancers","volume":"7","author":"Deininger","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.talanta.2021.122919_bib21","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.apsb.2019.12.004","article-title":"In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging","volume":"10","author":"Wang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.talanta.2021.122919_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8815349","article-title":"Diazepam and its disinfection byproduct promote the early development of nervous system in zebrafish embryos","volume":"2020","author":"Zhao","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.talanta.2021.122919_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.chroma.2013.04.001","article-title":"Effect of mobile phase additives on qualitative and quantitative analysis of ginsenosides by liquid chromatography hybrid quadrupole-time of flight mass spectrometry","volume":"1297","author":"Liang","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2021.122919_bib24","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.watres.2008.11.050","article-title":"Effect of ozone exposure on the oxidation of trace organic contaminants in wastewater","volume":"43","author":"Wert","year":"2009","journal-title":"Water Res."},{"key":"10.1016\/j.talanta.2021.122919_bib25","doi-asserted-by":"crossref","first-page":"14398","DOI":"10.1021\/acs.est.9b05327","article-title":"Experimental study of OH-initiated heterogeneous oxidation of organophosphate flame retardants: kinetics, mechanism, and toxicity","volume":"53","author":"Liu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.talanta.2021.122919_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.watres.2016.10.048","article-title":"Chlorination of bisphenol F and the estrogenic and peroxisome proliferator-activated receptor gamma effects of its disinfection byproducts","volume":"107","author":"Zheng","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.talanta.2021.122919_bib27","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1126\/science.1226850","article-title":"Dilute concentrations of a psychiatric drug alter behavior of fish from natural populations","volume":"339","author":"Brodin","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.talanta.2021.122919_bib28","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1289\/ehp.1408989","article-title":"A systematic review and comparison of the hormonal activity of bisphenol A substitutes","volume":"123","author":"Rochester","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.talanta.2021.122919_bib29","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1073\/pnas.1417731112","article-title":"Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish","volume":"112","author":"Kinch","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.talanta.2021.122919_bib30","doi-asserted-by":"crossref","first-page":"114969","DOI":"10.1016\/j.watres.2019.114969","article-title":"Sonolytic degradation of bisphenol S: effect of dissolved oxygen and peroxydisulfate, oxidation products and acute toxicity","volume":"165","author":"Lu","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.talanta.2021.122919_bib31","doi-asserted-by":"crossref","first-page":"8089","DOI":"10.1038\/ncomms9089","article-title":"Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds","volume":"6","author":"Delfosse","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.talanta.2021.122919_bib32","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/hep.22345","article-title":"Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo","volume":"48","author":"Gorg","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.talanta.2021.122919_bib33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ecoenv.2017.10.054","article-title":"Mixtures of diflubenzuron and p-chloroaniline changes the activities of enzymes biomarkers on tilapia fish (Oreochromis niloticus) in the presence and absence of soil","volume":"148","author":"Dantzger","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.talanta.2021.122919_bib34","doi-asserted-by":"crossref","first-page":"12494","DOI":"10.1038\/ncomms12494","article-title":"Amine synthesis via iron-catalysed reductive coupling of nitroarenes with alkyl halides","volume":"7","author":"Cheung","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.talanta.2021.122919_bib35","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1038\/ncomms6998","article-title":"Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids","volume":"6","author":"Kurczy","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.talanta.2021.122919_bib36","doi-asserted-by":"crossref","first-page":"8386362","DOI":"10.1155\/2016\/8386362","article-title":"Chlorinated phospholipids and fatty acids: (Patho)physiological relevance, potential toxicity, and analysis of lipid chlorohydrins","volume":"2016","author":"Schroter","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.talanta.2021.122919_bib37","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41582-019-0217-x","article-title":"Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy","volume":"15","author":"Vezzani","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.talanta.2021.122919_bib38","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1038\/s41467-019-10462-z","article-title":"XX sex chromosome complement promotes atherosclerosis in mice","volume":"10","author":"AlSiraj","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.talanta.2021.122919_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctrv.2017.10.013","article-title":"Cancer chemoprevention revisited: cytochrome P450 family 1B1 as a target in the tumor and the microenvironment","volume":"63","author":"D'Uva","year":"2018","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.talanta.2021.122919_bib40","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1001\/jamainternmed.2016.5766","article-title":"Endocrine-disrupting chemicals","volume":"176","author":"Gore","year":"2016","journal-title":"JAMA Int. Med."},{"key":"10.1016\/j.talanta.2021.122919_bib41","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1124\/pr.117.014407","article-title":"Interindividual differences in caffeine metabolism and factors driving caffeine consumption","volume":"70","author":"Nehlig","year":"2018","journal-title":"Pharmacol. Rev."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914021008419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914021008419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T12:55:37Z","timestamp":1758545737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914021008419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":41,"alternative-id":["S0039914021008419"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2021.122919","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distribution visualization of the chlorinated disinfection byproduct of diazepam in zebrafish with desorption electrospray ionization mass spectrometry imaging","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2021.122919","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122919"}}