{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:02:16Z","timestamp":1791000136760,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.talanta.2022.123265","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T19:12:23Z","timestamp":1643483543000},"page":"123265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Development and validation of a UHPLC-HRMS-QTOF method for the detection of 132 New Psychoactive Substances and synthetic opioids, including fentanyl, in Dried Blood Spots"],"prefix":"10.1016","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-6512","authenticated-orcid":false,"given":"Marta","family":"Massano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5323-5415","authenticated-orcid":false,"given":"Carola","family":"Incardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-4276","authenticated-orcid":false,"given":"Enrico","family":"Gerace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7041-9806","authenticated-orcid":false,"given":"Pierre","family":"Negri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Alladio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-4799","authenticated-orcid":false,"given":"Alberto","family":"Salomone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-7194","authenticated-orcid":false,"given":"Marco","family":"Vincenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2022.123265_bib1","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/S0140-6736(19)32231-7","article-title":"New psychoactive substances: challenges for drug surveillance, control, and public health responses","volume":"394","author":"Peacock","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.talanta.2022.123265_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/2045125314559539","article-title":"Legal highs: staying on top of the flood of novel psychoactive substances","volume":"5","author":"Baumeister","year":"2015","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"10.1016\/j.talanta.2022.123265_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/7854_2016_54","article-title":"Predicting the abuse liability of entactogen-class, new and emerging psychoactive substances via preclinical models of drug self-administration","volume":"32","author":"Aarde","year":"2017","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.talanta.2022.123265_bib4","doi-asserted-by":"crossref","DOI":"10.1177\/2045125320967197","article-title":"New psychoactive substances: a review and updates","volume":"10","author":"Shafi","year":"2020","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"10.1016\/j.talanta.2022.123265_bib5","series-title":"European Drug Report: Trends and Developments","year":"2021"},{"key":"10.1016\/j.talanta.2022.123265_bib6","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1007\/s00216-015-9247-4","article-title":"Determination of cathinones and other stimulant, psychedelic, and dissociative designer drugs in real hair samples","volume":"408","author":"Salomone","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2022.123265_bib7","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/dta.310","article-title":"Social, policy, and public health perspectives on new psychoactive substances","volume":"3","author":"Sumnall","year":"2011","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.talanta.2022.123265_bib8","first-page":"318","article-title":"A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants, by Robert Guthrie and Ada Susi","volume":"32","author":"Scriver","year":"1963","journal-title":"Pediatrics"},{"key":"10.1016\/j.talanta.2022.123265_bib9","first-page":"E248","article-title":"Dried blood spot in laboratory: directions and prospects","volume":"10","author":"Malsagova","year":"2020","journal-title":"Diagn. Basel Switz."},{"key":"10.1016\/j.talanta.2022.123265_bib10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3109\/10408444.2011.650790","article-title":"Dried blood spots in toxicology: from the cradle to the grave?","volume":"42","author":"Stove","year":"2012","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.talanta.2022.123265_bib11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11419-020-00567-2","article-title":"A comparison between two different dried blood substrates in determination of psychoactive substances in postmortem samples","volume":"39","author":"Moretti","year":"2021","journal-title":"Forensic Toxicol."},{"key":"10.1016\/j.talanta.2022.123265_bib12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/dta.3011","article-title":"Do dried blood spots have the potential to support result management processes in routine sports drug testing? - Part 2: proactive sampling for follow-up investigations concerning atypical or adverse analytical findings","volume":"13","author":"Thevis","year":"2021","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.talanta.2022.123265_bib13","first-page":"90","article-title":"Dry blood spot technique: a review","volume":"15","author":"Deep","year":"2012","journal-title":"Int. J. Pharmaceut. Sci. Rev. Res."},{"key":"10.1016\/j.talanta.2022.123265_bib14","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.4155\/bio.14.156","article-title":"Spot them in the spot: analysis of abused substances using dried blood spots","volume":"6","author":"Sadones","year":"2014","journal-title":"Bioanalysis"},{"key":"10.1016\/j.talanta.2022.123265_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461731","article-title":"A review of recent advances in microsampling techniques of biological fluids for therapeutic drug monitoring","volume":"1635","author":"Tey","year":"2021","journal-title":"J. Chromatogr., A"},{"key":"10.1016\/j.talanta.2022.123265_bib16","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1021\/ac403672u","article-title":"Fully-automated approach for online dried blood spot extraction and bioanalysis by two-dimensional-liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry","volume":"86","author":"Oliveira","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2022.123265_bib17","series-title":"Dried Blood Spots","first-page":"1","article-title":"Overview of the history and applications of dried blood samples","author":"Harry Hannon","year":"2014"},{"key":"10.1016\/j.talanta.2022.123265_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.120867","article-title":"Effective validation of chromatographic analytical methods: the illustrative case of androgenic steroids","volume":"215","author":"Alladio","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2022.123265_bib19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jat\/bkx002","article-title":"Procedure for the selection and validation of a calibration model i-description and application","volume":"41","author":"Desharnais","year":"2017","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.talanta.2022.123265_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2020.100919","article-title":"Experimental and statistical protocol for the effective validation of chromatographic analytical methods","volume":"7","author":"Alladio","year":"2020","journal-title":"MethodsX"},{"key":"10.1016\/j.talanta.2022.123265_bib21","doi-asserted-by":"crossref","first-page":"8959","DOI":"10.1021\/ac5018265","volume":"86","author":"Gu","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2022.123265_bib22","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/ac60290a013","article-title":"Decision and detection limits for calibration curves","volume":"42","author":"Hubaux","year":"1970","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2022.123265_bib23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0003-2670(99)00105-1","article-title":"Detection and quantification limits: origins and historical overview","volume":"391","author":"Currie","year":"1999","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2022.123265_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/jat\/bkx002","article-title":"Procedure for the selection and validation of a calibration model II-Theoretical basis","volume":"41","author":"Desharnais","year":"2017","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.talanta.2022.123265_bib25","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/jat\/bkt054","article-title":"Scientific working group for forensic toxicology, scientific working group for forensic toxicology (SWGTOX) standard practices for method validation in forensic toxicology","volume":"37","year":"2013","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.talanta.2022.123265_bib26","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/FTD.0000000000000643","article-title":"Official international association for therapeutic drug monitoring and clinical toxicology guideline: development and validation of dried blood spot\u2013based methods for therapeutic drug monitoring","volume":"41","author":"Capiau","year":"2019","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.talanta.2022.123265_bib27","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00216-012-6403-y","article-title":"Fast screening of 88 pharmaceutical drugs and metabolites in whole blood by ultrahigh-performance liquid chromatography\u2013tandem mass spectrometry","volume":"405","author":"Vincenti","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2022.123265_bib28","article-title":"Screening of synthetic cathinones and metabolites in dried blood spots by UPLC\u2013MS-MS","volume":"45","author":"Wang","year":"2020","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.talanta.2022.123265_bib29","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jpba.2017.02.046","article-title":"Dried blood spots combined to an UPLC-MS\/MS method for the simultaneous determination of drugs of abuse in forensic toxicology","volume":"147","author":"Sadler Sim\u00f5es","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.talanta.2022.123265_bib30","doi-asserted-by":"crossref","first-page":"9437","DOI":"10.1007\/s00216-013-7386-z","article-title":"Simultaneous quantification of 28 synthetic cathinones and metabolites in urine by liquid chromatography-high resolution mass spectrometry","volume":"405","author":"Concheiro","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2022.123265_bib31","doi-asserted-by":"crossref","first-page":"e1174","DOI":"10.1002\/wfs2.1174","article-title":"Relevance of published blood concentrations of new psychoactive substance for rational case interpretation","volume":"1","author":"Welter-Luedeke","year":"2019","journal-title":"WIREs Forensic Sci."},{"key":"10.1016\/j.talanta.2022.123265_bib32","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/1556-4029.13583","article-title":"Experimental study on the postmortem redistribution of the substituted phenethylamine, 25B-NBOMe","volume":"63","author":"Shintani-Ishida","year":"2018","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.talanta.2022.123265_bib33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.forsciint.2017.12.003","article-title":"MDPV in forensic routine cases: psychotic and aggressive behavior in relation to plasma concentrations","volume":"283","author":"Diestelmann","year":"2018","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.talanta.2022.123265_bib34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.17145\/jab.15.007","article-title":"Dried blood spot analysis; facing new challenges","volume":"1","author":"Koster","year":"2015","journal-title":"J. Appl. Bioanal."},{"key":"10.1016\/j.talanta.2022.123265_bib35","unstructured":"The EU Early Warning System on new psychoactive substances (NPS) | www.emcdda.europa.eu. https:\/\/www.emcdda.europa.eu\/publications\/topic-overviews\/eu-early-warning-system."},{"key":"10.1016\/j.talanta.2022.123265_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.forsciint.2021.110904","article-title":"Seizures of new psychoactive substances on the Italian territory during the COVID-19 pandemic","volume":"326","author":"Vincenti","year":"2021","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.talanta.2022.123265_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.semperi.2019.01.001","article-title":"The United States opioid epidemic","volume":"43","author":"Lyden","year":"2019","journal-title":"Semin. Perinatol."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914022000613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914022000613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:02:17Z","timestamp":1758546137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914022000613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":37,"alternative-id":["S0039914022000613"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2022.123265","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a UHPLC-HRMS-QTOF method for the detection of 132 New Psychoactive Substances and synthetic opioids, including fentanyl, in Dried Blood Spots","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2022.123265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123265"}}