{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:32:30Z","timestamp":1787725950820,"version":"build-2784847793"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"am","delay-in-days":203,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK126739"],"award-info":[{"award-number":["R01DK126739"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM138843"],"award-info":[{"award-number":["R01GM138843"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R33CA196470"],"award-info":[{"award-number":["R33CA196470"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["201706120141"],"award-info":[{"award-number":["201706120141"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI067773"],"award-info":[{"award-number":["U19AI067773"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.talanta.2022.123697","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T15:15:40Z","timestamp":1655738140000},"page":"123697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Towards detection of biomarkers in the eye using an aptamer-based graphene affinity nanobiosensor"],"prefix":"10.1016","volume":"250","author":[{"given":"Ziran","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-5497","authenticated-orcid":false,"given":"Shifeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjun","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Gustavo","family":"De Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leejee H.","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.talanta.2022.123697_bib1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/elan.201501116","volume":"28","author":"Pankratov","year":"2016","journal-title":"Electroanalysis"},{"key":"10.1016\/j.talanta.2022.123697_bib2","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.snb.2017.08.164","volume":"255","author":"Filipiak","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"issue":"1","key":"10.1016\/j.talanta.2022.123697_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-016-0009-6","volume":"8","author":"Kim","year":"2017","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.talanta.2022.123697_bib4","volume":"3","author":"Wang","year":"2022","journal-title":"Cell Rep. Phys. Sci."},{"issue":"12","key":"10.1016\/j.talanta.2022.123697_bib5","first-page":"3317","volume":"52","author":"Blay","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.talanta.2022.123697_bib6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bios.2019.03.053","volume":"134","author":"Hao","year":"2019","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.talanta.2022.123697_bib7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.advms.2017.03.003","volume":"62","author":"Mrugacz","year":"2017","journal-title":"Adv. Med. Sci."},{"issue":"4","key":"10.1016\/j.talanta.2022.123697_bib8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41587-019-0045-y","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.talanta.2022.123697_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-anchem-061318-114910","volume":"12","author":"Bandodkar","year":"2019","journal-title":"Annu. Rev. Anal. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2022.123697_bib10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/mi11010060","volume":"11","author":"Bai","year":"2020","journal-title":"Micromachines"},{"issue":"10","key":"10.1016\/j.talanta.2022.123697_bib11","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/j.bios.2004.09.002","volume":"20","author":"Ikebukuro","year":"2005","journal-title":"Biosens. Bioelectron."},{"issue":"46","key":"10.1016\/j.talanta.2022.123697_bib12","doi-asserted-by":"crossref","first-page":"11547","DOI":"10.1021\/ja0022223","volume":"122","author":"Stojanovic","year":"2000","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"10.1016\/j.talanta.2022.123697_bib13","volume":"31","author":"Wang","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"23","key":"10.1016\/j.talanta.2022.123697_bib14","volume":"20","author":"Kim","year":"2009","journal-title":"Nanotechnology"},{"issue":"4","key":"10.1016\/j.talanta.2022.123697_bib15","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.bios.2010.07.090","volume":"26","author":"Kara","year":"2010","journal-title":"Biosens. Bioelectron."},{"issue":"44","key":"10.1016\/j.talanta.2022.123697_bib16","volume":"29","author":"Wang","year":"2019","journal-title":"Adv. Funct. Mater."},{"issue":"51","key":"10.1016\/j.talanta.2022.123697_bib17","doi-asserted-by":"crossref","first-page":"18012","DOI":"10.1021\/ja108127r","volume":"132","author":"Ohno","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2022.123697_bib18","volume":"165","author":"Wang","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"18","key":"10.1016\/j.talanta.2022.123697_bib19","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1007\/s00216-018-1076-9","volume":"410","author":"Liu","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"issue":"7","key":"10.1016\/j.talanta.2022.123697_bib20","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrd3141","volume":"9","author":"Keefe","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.talanta.2022.123697_bib21","doi-asserted-by":"crossref","unstructured":"B.J. Kim, H. Jang, S.K. Lee, B.H. Hong, J.H. Ahn, J.H. Cho, Nano Lett.. 10(9) 3464-3466.","DOI":"10.1021\/nl101559n"},{"key":"10.1016\/j.talanta.2022.123697_bib22","first-page":"11","volume":"6","author":"Geim","year":"2009","journal-title":"Nat. Mater."},{"key":"10.1016\/j.talanta.2022.123697_bib23","doi-asserted-by":"crossref","unstructured":"D. Choi, M.-Y. Choi, W.M. Choi, H.-J. Shin, H.-K. Park, J.-S. Seo, J. Park, S.-M. Yoon, S.J. Chae, Y.H. Lee, Adv. Mater. 22(19) 2187-2192.","DOI":"10.1002\/adma.200903815"},{"key":"10.1016\/j.talanta.2022.123697_bib24","doi-asserted-by":"crossref","unstructured":"Y. Shao, J. Wang, H. Wu, J. Liu, I.A. Aksay, Y. Lin, Electroanalysis 22(10) 1027-1036.","DOI":"10.1002\/elan.200900571"},{"key":"10.1016\/j.talanta.2022.123697_bib25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bios.2015.07.002","volume":"76","author":"Song","year":"2015","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.talanta.2022.123697_bib26","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bios.2016.03.068","volume":"89","author":"Bollella","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2022.123697_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bios.2017.10.004","volume":"101","author":"Can","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2022.123697_bib28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bios.2019.04.058","volume":"137","author":"Sempionatto","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2022.123697_bib29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bios.2017.08.051","volume":"100","author":"Afsahi","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"10","key":"10.1016\/j.talanta.2022.123697_bib30","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.bios.2004.09.023","volume":"20","author":"Wee","year":"2005","journal-title":"Biosens. Bioelectron."},{"issue":"12","key":"10.1016\/j.talanta.2022.123697_bib31","doi-asserted-by":"crossref","first-page":"9883","DOI":"10.1021\/nn2035796","volume":"5","author":"Chang","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2022.123697_bib32","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.electacta.2018.08.062","volume":"290","author":"Wang","year":"2018","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.talanta.2022.123697_bib33","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bios.2016.09.012","volume":"93","author":"Shi","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"51","key":"10.1016\/j.talanta.2022.123697_bib34","doi-asserted-by":"crossref","first-page":"14633","DOI":"10.1073\/pnas.1625010114","volume":"113","author":"Gao","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.talanta.2022.123697_bib35","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1021\/ac0486140","volume":"77","author":"Uchida","year":"2005","journal-title":"Anal. Chem."},{"issue":"8","key":"10.1016\/j.talanta.2022.123697_bib36","doi-asserted-by":"crossref","first-page":"18040","DOI":"10.3390\/s150818040","volume":"15","author":"Wang","year":"2015","journal-title":"Sensors"},{"issue":"25","key":"10.1016\/j.talanta.2022.123697_bib37","doi-asserted-by":"crossref","first-page":"10903","DOI":"10.1039\/C5NR01187F","volume":"7","author":"Gao","year":"2015","journal-title":"Nanoscale"},{"issue":"11","key":"10.1016\/j.talanta.2022.123697_bib38","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0198-8859(01)00322-6","volume":"62","author":"Hajeer","year":"2001","journal-title":"Hum. Immunol."},{"issue":"5","key":"10.1016\/j.talanta.2022.123697_bib39","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0952-7915(98)80226-4","volume":"10","author":"Lejeune","year":"1998","journal-title":"Curr. Opin. Immunol."},{"issue":"2","key":"10.1016\/j.talanta.2022.123697_bib40","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0196-9781(91)90015-H","volume":"12","author":"Martin","year":"1991","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.talanta.2022.123697_bib41","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1146\/annurev.bb.23.060194.003415","volume":"23","author":"Williamson","year":"1994","journal-title":"Annu. Rev. Biophys."},{"issue":"1","key":"10.1016\/j.talanta.2022.123697_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-20314-w","volume":"12","author":"Lee","year":"2021","journal-title":"Nat. Commun."},{"issue":"14","key":"10.1016\/j.talanta.2022.123697_bib43","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/adma.200903645","volume":"22","author":"Dong","year":"2010","journal-title":"Adv. Mater."},{"issue":"3","key":"10.1016\/j.talanta.2022.123697_bib44","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1021\/acs.nanolett.5b00133","volume":"15","author":"Gao","year":"2015","journal-title":"Nano Lett."},{"key":"10.1016\/j.talanta.2022.123697_bib45","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.apsusc.2012.12.138","volume":"275","author":"Say","year":"2013","journal-title":"Appl. Surf. Sci."},{"issue":"4","key":"10.1016\/j.talanta.2022.123697_bib46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1109\/TNB.2018.2852261","volume":"17","author":"Ghosh","year":"2018","journal-title":"IEEE Trans. NanoBioscience"},{"issue":"15","key":"10.1016\/j.talanta.2022.123697_bib47","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1039\/c3an00818e","volume":"138","author":"Liu","year":"2013","journal-title":"Analyst"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914022004933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914022004933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T16:47:14Z","timestamp":1736354834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914022004933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":47,"alternative-id":["S0039914022004933"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2022.123697","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Towards detection of biomarkers in the eye using an aptamer-based graphene affinity nanobiosensor","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2022.123697","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123697"}}