{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:53:54Z","timestamp":1788494034468,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.talanta.2022.123858","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T09:33:25Z","timestamp":1661074405000},"page":"123858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Rapid and low-cost liquid biopsy with ATR-FTIR spectroscopy to discriminate the molecular subtypes of breast cancer"],"prefix":"10.1016","volume":"254","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-5187","authenticated-orcid":false,"given":"Nikolas Mateus","family":"Pereira de Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Hunter","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licerio Vicente","family":"Padoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2818-0173","authenticated-orcid":false,"given":"Daniel","family":"Pr\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Poisl","family":"Fay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8052-5354","authenticated-orcid":false,"given":"Valeriano Antonio","family":"Corbellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7523-7211","authenticated-orcid":false,"given":"Alexandre","family":"Rieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2022.123858_bib1","first-page":"209","volume":"vol. 71","author":"Sung","year":"2021"},{"key":"10.1016\/j.talanta.2022.123858_bib2","first-page":"26","volume":"vol. 24","author":"Prat","year":"2015"},{"key":"10.1016\/j.talanta.2022.123858_bib3","first-page":"465","volume":"5","author":"Unger-salda\u00f1a","year":"2014"},{"key":"10.1016\/j.talanta.2022.123858_bib4","first-page":"1783","article-title":"Eighth edition of the AJCC cancer staging manual","volume":"25","author":"Giuliano","year":"2018","journal-title":"Breast Cancer"},{"key":"10.1016\/j.talanta.2022.123858_bib5","series-title":"Comparison of Treatment Costs for Breast Cancer , by Tumor Stage and Type of Service","first-page":"23","author":"Blumen","year":"2016"},{"key":"10.1016\/j.talanta.2022.123858_bib6","series-title":"The Costs of Breast Cancer Prior to and Following Diagnosis","first-page":"311","author":"Broekx","year":"2011"},{"key":"10.1016\/j.talanta.2022.123858_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.breast.2011.07.008","article-title":"Characteristics and outcomes according to molecular subtypes of breast cancer as classified by a panel of four biomarkers using immunohistochemistry","volume":"21","author":"Park","year":"2012","journal-title":"Breast"},{"key":"10.1016\/j.talanta.2022.123858_bib8","series-title":"Current and Emerging Biomarkers in Breast Cancer : Prognosis and Prediction","first-page":"245","author":"Weigel","year":"2010"},{"key":"10.1016\/j.talanta.2022.123858_bib9","series-title":"Defining Breast Cancer Prognosis Based on Molecular Phenotypes : Results from a Large Cohort Study","first-page":"185","author":"Dawood","year":"2011"},{"key":"10.1016\/j.talanta.2022.123858_bib10","first-page":"151","article-title":"Epidemiological characteristics of and risk factors for breast cancer in the world","volume":"11","author":"Momenimovahed","year":"2019","journal-title":"Breast Cancer"},{"key":"10.1016\/j.talanta.2022.123858_bib11","series-title":"Breast Cancer Survival by Molecular Subtype: a Population- Based Analysis of Cancer Registry Data","author":"Mph","year":"2017"},{"key":"10.1016\/j.talanta.2022.123858_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1148\/radiol.2251011667","article-title":"Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations","volume":"225","author":"Kolb","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.talanta.2022.123858_bib13","first-page":"17","article-title":"Early diagnosis of breast cancer","author":"Wang","year":"2017","journal-title":"Sensors"},{"key":"10.1016\/j.talanta.2022.123858_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.path.2017.09.001","article-title":"Core needle biopsy of the breast: an evaluation of contemporary data","volume":"11","author":"Calhoun","year":"2018","journal-title":"Surg. Pathol. Clin."},{"key":"10.1016\/j.talanta.2022.123858_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/05704928.2020.1738453","article-title":"ATR-FTIR spectroscopy as the future of diagnostics: a systematic review of the approach using bio-fluids","volume":"56","author":"Naseer","year":"2021","journal-title":"Appl. Spectrosc. Rev."},{"key":"10.1016\/j.talanta.2022.123858_bib16","series-title":"Introduc\u00e3o \u00e0 Espectroscopia \u2013 Traduc\u00e3o da 4a Edi\u00e7\u00e3o Norte-Americana","author":"Pavia","year":"2010"},{"key":"10.1016\/j.talanta.2022.123858_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.saa.2018.05.022","article-title":"Quantitative analysis of glycated albumin in serum based on ATR-FTIR spectrum combined with SiPLS and SVM","volume":"201","author":"Li","year":"2018","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2022.123858_bib18","doi-asserted-by":"crossref","unstructured":"C. Dna, Liquid Biopsy of Methylation Biomarkers in, Trends Mol. Med. 27 (n.d.) 482\u2013500. https:\/\/doi.org\/10.1016\/j.molmed.2020.12.011.","DOI":"10.1016\/j.molmed.2020.12.011"},{"key":"10.1016\/j.talanta.2022.123858_bib19","doi-asserted-by":"crossref","unstructured":"K. Pantel, C. Alix-panabi, Liquid biopsy and minimal residual disease \u2014 latest advances and implications for cure, (n.d.). https:\/\/doi.org\/10.1038\/s41571-019-0187-3.","DOI":"10.1038\/s41571-019-0187-3"},{"key":"10.1016\/j.talanta.2022.123858_bib20","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41574-021-00487-0","article-title":"Metabolic pathways in obesity-related breast cancer","volume":"17","author":"Brown","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.talanta.2022.123858_bib21","series-title":"Critical Reviews in Analytical Chemistry Applications of FT-IR Spectrophotometry in Cancer Diagnostics Applications of FT-IR Spectrophotometry in Cancer Diagnostics","first-page":"8347","author":"Bunaciu","year":"2015"},{"key":"10.1016\/j.talanta.2022.123858_bib22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.vibspec.2010.01.013","article-title":"Diagnosis of breast cancer with infrared spectroscopy from serum samples","volume":"52","author":"Backhaus","year":"2010","journal-title":"Vib. Spectrosc."},{"key":"10.1016\/j.talanta.2022.123858_bib23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.saa.2017.06.021","article-title":"Spectrochimica acta Part A : molecular and biomolecular spectroscopy application of FT-IR spectroscopy on breast cancer serum analysis","volume":"187","author":"Elmi","year":"2017","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2022.123858_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.120857","article-title":"Breast cancer detection by ATR-FTIR spectroscopy of blood serum and multivariate data-analysis","volume":"214","author":"Sitnikova","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2022.123858_bib25","article-title":"Attenuated total reflection-fourier transform infrared (ATR-FTIR) spectroscopy analysis of saliva for breast cancer diagnosis","volume":"2020","author":"Ferreira","year":"2020","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.talanta.2022.123858_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.117210","article-title":"Raman spectroscopy of blood plasma samples from breast cancer patients at different stages","volume":"222","author":"Nargis","year":"2019","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2022.123858_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.chemolab.2017.02.008","article-title":"A contemporary review on Data Preprocessing (DP) practice strategy in ATR-FTIR spectrum","volume":"163","author":"Lee","year":"2017","journal-title":"Chemometr. Intell. Lab. Syst."},{"key":"10.1016\/j.talanta.2022.123858_bib28","series-title":"Quimiometria: conceitos, m\u00e9todos e aplica\u00e7\u00f5es","isbn-type":"print","doi-asserted-by":"crossref","first-page":"493","DOI":"10.7476\/9788526814714","author":"Ferreira","year":"2015","ISBN":"https:\/\/id.crossref.org\/isbn\/9788526814714"},{"key":"10.1016\/j.talanta.2022.123858_bib29","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1039\/C8AN00599K","article-title":"Partial least squares-discriminant analysis (PLS-DA) for classification of high-dimensional (HD) data: a review of contemporary practice strategies and knowledge gaps","volume":"143","author":"Lee","year":"2018","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2022.123858_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.forc.2016.06.003","article-title":"Forensic body fluid identification and differentiation by Raman spectroscopy","volume":"1","author":"Muro","year":"2016","journal-title":"Forensic Chem."},{"key":"10.1016\/j.talanta.2022.123858_bib31","series-title":"Standard Practices for Infrared Multivariate Quantitative Analysis","author":"E1655-17","year":"2017"},{"key":"10.1016\/j.talanta.2022.123858_bib32","doi-asserted-by":"crossref","first-page":"9925","DOI":"10.18632\/oncotarget.7155","article-title":"Human plasma metabolomics for identifying differential metabolites and predicting molecular subtypes of breast cancer","volume":"7","author":"Fan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.talanta.2022.123858_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers13010147","article-title":"Human plasma metabolomics for biomarker discovery: targeting the molecular subtypes in breast cancer","volume":"13","author":"D\u00edaz-Beltr\u00e1n","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.talanta.2022.123858_bib34","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/bip.10165","article-title":"Surface enhanced IR absorption of nucleic acids from tumor cells: FTIR reflectance study","volume":"67","author":"Dovbeshko","year":"2002","journal-title":"Biopolym. - Biospectroscopy Sect."},{"key":"10.1016\/j.talanta.2022.123858_bib35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0039-9140(00)00462-8","article-title":"FTIR spectroscopy studies of nucleic acid damage","volume":"53","author":"Dovbeshko","year":"2000","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2022.123858_bib36","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cdp.2003.11.004","article-title":"Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy","volume":"28","author":"Fujioka","year":"2004","journal-title":"Cancer Detect. Prev."},{"key":"10.1016\/j.talanta.2022.123858_bib37","first-page":"37","article-title":"MANTSCH\u2019+ HEINZ FABIAN,\u2019* MICHAEL JACKSON,\u2019 LEIGH MURPHY,* PETER H. WATSON, breast tumors and breast tumor cell xenografts","volume":"1","year":"1995","journal-title":"Breast"},{"key":"10.1016\/j.talanta.2022.123858_bib38","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/05704920701829043","article-title":"Fourier transform infrared (FTIR) spectroscopy of biological tissues","volume":"43","author":"Movasaghi","year":"2008","journal-title":"Appl. Spectrosc. Rev."},{"key":"10.1016\/j.talanta.2022.123858_bib39","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.steroids.2011.02.025","article-title":"Association between breast cancer subtypes and response to neoadjuvant anastrozole","volume":"76","author":"Dunbier","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.talanta.2022.123858_bib40","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/modpathol.2013.60","article-title":"Intrinsic breast cancer subtypes defined by estrogen receptor signalling - prognostic relevance of progesterone receptor loss","volume":"26","author":"Braun","year":"2013","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.talanta.2022.123858_bib41","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1200\/JCO.2008.19.7939","article-title":"Disease-free survival according to degree of HER2 amplification for patients treated with adjuvant chemotherapy with or without 1 year of trastuzumab: the HERA trial","volume":"27","author":"Dowsett","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.talanta.2022.123858_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-019-0069-2","article-title":"Targeted therapeutic options and future perspectives for her2-positive breast cancer","volume":"4","author":"Wang","year":"2019","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.talanta.2022.123858_bib43","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/annonc\/mdz235","article-title":"Estimating the benefits of therapy for early-stage breast cancer: the St. Gallen International Consensus Guidelines for the primary therapy of early breast cancer 2019","volume":"30","author":"Burstein","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.talanta.2022.123858_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.120857","article-title":"Breast cancer detection by ATR-FTIR spectroscopy of blood serum and multivariate data-analysis","volume":"214","author":"Sitnikova","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2022.123858_bib45","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/1097-0142(19950115)75:2<503::AID-CNCR2820750213>3.0.CO;2-0","article-title":"The etiology and prediction of breast cancer. Fourier transform-infrared spectroscopy reveals progressive alterations in breast DNA leading to a cancer-like phenotype in a high proportion of normal women","volume":"75","author":"Malins","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.talanta.2022.123858_bib46","doi-asserted-by":"crossref","DOI":"10.1364\/OE.19.013565","article-title":"Colorectal cancer detection by gold nanoparticle based surface-enhanced Raman spectroscopy of blood serum and statistical analysis","volume":"19","author":"Lin","year":"2011","journal-title":"Opt Express"},{"key":"10.1016\/j.talanta.2022.123858_bib47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.saa.2013.11.049","article-title":"FTIR spectroscopic comparison of serum from lung cancer patients and healthy persons","volume":"122","author":"Wang","year":"2014","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2022.123858_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-015-1414-7","article-title":"Early detection of breast cancer using total biochemical analysis of peripheral blood components: a preliminary study","volume":"15","author":"Zelig","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.talanta.2022.123858_bib49","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10549-019-05512-5","article-title":"Clinical significance of gene mutation in ctDNA analysis for hormone receptor-positive metastatic breast cancer","volume":"180","author":"Shibayama","year":"2020","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.talanta.2022.123858_bib50","doi-asserted-by":"crossref","first-page":"11517","DOI":"10.2147\/OTT.S227156","article-title":"Circulating cell-free DNA or circulating tumor dna in the management of ovarian and endometrial cancer","volume":"12","author":"Chen","year":"2019","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.talanta.2022.123858_bib51","first-page":"898","article-title":"Cell-free DNA (cfDNA): clinical signi fi cance and utility in cancer shaped by","volume":"14","author":"Volik","year":"2016","journal-title":"Emerg. Technol."},{"key":"10.1016\/j.talanta.2022.123858_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-019-1235-8","article-title":"Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer","volume":"21","author":"Fernandez-Garcia","year":"2019","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.talanta.2022.123858_bib53","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/10408363.2019.1670615","article-title":"The potential of ctDNA analysis in breast cancer","volume":"57","author":"Tzanikou","year":"2020","journal-title":"Crit. Rev. Clin. Lab Sci."},{"key":"10.1016\/j.talanta.2022.123858_bib54","first-page":"79","article-title":"Principle component analysis and partial least squares : two dimension reduction techniques for reegression","author":"Saikat","year":"2008","journal-title":"Casualty Actuar. Soc."},{"key":"10.1016\/j.talanta.2022.123858_bib55","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature14539","article-title":"Deep learning","volume":"521","author":"Lecun","year":"2015","journal-title":"Nature"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914022006543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914022006543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:06:24Z","timestamp":1758546384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914022006543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":55,"alternative-id":["S0039914022006543"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2022.123858","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid and low-cost liquid biopsy with ATR-FTIR spectroscopy to discriminate the molecular subtypes of breast cancer","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2022.123858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123858"}}