{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:49:36Z","timestamp":1785890976122,"version":"3.56.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["A-0009502-01-00"],"award-info":[{"award-number":["A-0009502-01-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["A-8001143-00-00"],"award-info":[{"award-number":["A-8001143-00-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["R397-000-356-133"],"award-info":[{"award-number":["R397-000-356-133"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.talanta.2023.124561","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T04:21:47Z","timestamp":1681446107000},"page":"124561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Real-time in vivo cancer staging of nasopharyngeal carcinoma patients with rapid fiberoptic Raman endoscopy"],"prefix":"10.1016","volume":"259","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-5627","authenticated-orcid":false,"given":"Chi","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-8174","authenticated-orcid":false,"given":"Kan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chwee Ming","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-9135","authenticated-orcid":false,"given":"Zhiwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2023.124561_bib1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.talanta.2023.124561_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40880-016-0174-3","article-title":"Associations of lifestyle and diet with the risk of nasopharyngeal carcinoma in Singapore: a case\u2013control study","volume":"36","author":"Yong","year":"2017","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.talanta.2023.124561_bib3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1186\/s12885-018-4419-1","article-title":"Comparison of the seventh and eighth editions of the UICC\/AJCC staging system for nasopharyngeal carcinoma: analysis of 1317 patients treated with intensity-modulated radiotherapy at two centers","volume":"18","author":"Yang","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.talanta.2023.124561_bib4","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/cncr.29795","article-title":"Proposal for the 8th edition of the AJCC\/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy","volume":"122","author":"Pan","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.talanta.2023.124561_bib5","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.7150\/jca.19197","article-title":"Evaluation of 7th edition of AJCC staging system for nasopharyngeal carcinoma","volume":"8","author":"Ren","year":"2017","journal-title":"J. Cancer"},{"key":"10.1016\/j.talanta.2023.124561_bib6","article-title":"Patterns and prognostic value of lymph node metastasis on distant metastasis and survival in nasopharyngeal carcinoma: a surveillance, epidemiology, and end results study","volume":"2019","author":"Xu","year":"2019","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.talanta.2023.124561_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.703995","article-title":"Prognostic factors for overall survival in nasopharyngeal cancer and implication for TNM staging by UICC: a systematic Review of the literature","volume":"11","author":"Chiang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.talanta.2023.124561_bib8","article-title":"Advances in real-time fiber-optic Raman spectroscopy for early cancer diagnosis: pushing the frontier into clinical endoscopic applications, Transl","volume":"3","author":"Heng","year":"2021","journal-title":"Biophotonics"},{"key":"10.1016\/j.talanta.2023.124561_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa2384","article-title":"Intraoperative brain cancer detection with Raman spectroscopy in humans","volume":"7","author":"Jermyn","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.talanta.2023.124561_bib10","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1364\/BOE.7.003705","article-title":"Real-time in vivo diagnosis of laryngeal carcinoma with rapid fiber-optic Raman spectroscopy","volume":"7","author":"Lin","year":"2016","journal-title":"Biomed. Opt Express"},{"key":"10.1016\/j.talanta.2023.124561_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1053\/j.gastro.2013.11.002","article-title":"Fiberoptic confocal Raman spectroscopy for real-time in vivo diagnosis of dysplasia in barrett's esophagus","volume":"146","author":"Bergholt","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.talanta.2023.124561_bib12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1039\/C5FD00151J","article-title":"Fiber-optic Raman spectroscopy for in vivo diagnosis of gastric dysplasia","volume":"187","author":"Wang","year":"2016","journal-title":"Faraday Discuss"},{"key":"10.1016\/j.talanta.2023.124561_bib13","doi-asserted-by":"crossref","first-page":"8908","DOI":"10.1021\/ac9015159","article-title":"High wavenumber Raman spectroscopy for in vivo detection of cervical dysplasia","volume":"81","author":"Mo","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.124561_bib14","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.7150\/thno.16359","article-title":"Real-time in vivo diagnosis of nasopharyngeal carcinoma using rapid fiber-optic Raman spectroscopy","volume":"7","author":"Lin","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.talanta.2023.124561_bib15","doi-asserted-by":"crossref","first-page":"10898","DOI":"10.1021\/acs.analchem.1c01559","article-title":"Deep learning-guided fiberoptic Raman spectroscopy enables real-time in vivo diagnosis and assessment of nasopharyngeal carcinoma and post-treatment efficacy during endoscopy","volume":"93","author":"Shu","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.124561_bib16","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1021\/acs.analchem.0c03778","article-title":"Label-free follow-up surveying of post-treatment efficacy and recurrence in nasopharyngeal carcinoma patients with fiberoptic Raman endoscopy","volume":"93","author":"Shu","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.124561_bib17","doi-asserted-by":"crossref","first-page":"8101","DOI":"10.1021\/acs.analchem.9b00173","article-title":"Fiber-Optic Raman spectroscopy with nature-inspired genetic algorithms enhances real-time in vivo detection and diagnosis of nasopharyngeal carcinoma","volume":"91","author":"\u017duvela","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.124561_bib18","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.3892\/ol.2016.4239","article-title":"Label-free discrimination of different stage nasopharyngeal carcinoma tissue based on Raman spectroscopy","volume":"11","author":"Qiu","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.talanta.2023.124561_bib19","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1364\/OL.26.001782","article-title":"Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements","volume":"26","author":"Huang","year":"2001","journal-title":"Opt. Lett."},{"key":"10.1016\/j.talanta.2023.124561_bib20","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1364\/OL.34.000758","article-title":"Integrated Raman spectroscopy and trimodal wide-field imaging techniques for real-time in vivo tissue Raman measurements at endoscopy","volume":"34","author":"Huang","year":"2009","journal-title":"Opt. Lett."},{"key":"10.1016\/j.talanta.2023.124561_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1364\/BOE.1.000017","article-title":"Fiber-optic Raman probe couples ball lens for depth-selected Raman measurements of epithelial tissue","volume":"1","author":"Mo","year":"2010","journal-title":"Biomed. Opt Express"},{"key":"10.1016\/j.talanta.2023.124561_bib22","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1364\/OL.38.002321","article-title":"Development of a beveled fiber-optic confocal Raman probe for enhancing in vivo epithelial tissue Raman measurements at endoscopy","volume":"38","author":"Wang","year":"2013","journal-title":"Opt. Lett."},{"key":"10.1016\/j.talanta.2023.124561_bib23","doi-asserted-by":"crossref","first-page":"8303","DOI":"10.1007\/s00216-015-8727-x","article-title":"Comparative study of the endoscope-based bevelled and volume fiber-optic Raman probes for optical diagnosis of gastric dysplasia in vivo at endoscopy","volume":"407","author":"Wang","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2023.124561_bib24","series-title":"The Laser Institute of America","article-title":"American National Standard for Safe Use of Lasers: Approved March 16, 2007","year":"2007"},{"key":"10.1016\/j.talanta.2023.124561_bib25","series-title":"Relative Intensity Correction of Raman Spectrometers: NIST SRMs 2241 through 2243 for 785 Nm, 532 Nm, and 488 nm\/514.5 Nm Excitation","author":"Choquette","year":"2007"},{"key":"10.1016\/j.talanta.2023.124561_bib26","article-title":"Metabolic reprogramming and immune evasion in nasopharyngeal carcinoma","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.talanta.2023.124561_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-4598-6-1","article-title":"Nasopharyngeal carcinoma: molecular biomarker discovery and progress","volume":"6","author":"Cho","year":"2007","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.talanta.2023.124561_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01911","article-title":"Chondroitin sulfate proteoglycan 4 and its potential as an antibody immunotherapy target across different tumor types","volume":"8","author":"Ilieva","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.talanta.2023.124561_bib29","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820945804","article-title":"Suppressed \u201cwarburg effect\u201d in nasopharyngeal carcinoma via the inhibition of pyruvate kinase type M2-mediated energy generation pathway","volume":"19","author":"Zhao","year":"2020","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.talanta.2023.124561_bib30","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1007\/s13277-015-4042-6","article-title":"Pretreatment anemia and survival in nasopharyngeal carcinoma","volume":"37","author":"Zhang","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.talanta.2023.124561_bib31","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s13277-012-0605-y","article-title":"Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma","volume":"34","author":"Kao","year":"2013","journal-title":"Tumor Biol."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914023003120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914023003120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:11:20Z","timestamp":1758546680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914023003120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":31,"alternative-id":["S0039914023003120"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2023.124561","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Real-time in vivo cancer staging of nasopharyngeal carcinoma patients with rapid fiberoptic Raman endoscopy","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2023.124561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"124561"}}