{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:03:04Z","timestamp":1791831784660,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016809","name":"Bureau of Science and Technology Nanchong City","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.talanta.2023.125097","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T03:43:29Z","timestamp":1692416609000},"page":"125097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"P2","title":["A dual signal amplification system with specific signal identification for rapid and sensitive detection of miRNA"],"prefix":"10.1016","volume":"266","author":[{"given":"Yan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixi","family":"Shiyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruonan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-9981","authenticated-orcid":false,"given":"Hongfei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2023.125097_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101092","article-title":"Point-of-care diagnostics for infectious diseases: from methods to devices","volume":"37","author":"Wang","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.talanta.2023.125097_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114109","article-title":"Advances in nucleic acid amplification techniques (NAATs): COVID-19 point-of-care diagnostics as an example","volume":"206","author":"Kang","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125097_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112349","article-title":"Diagnostic methods and potential portable biosensors for coronavirus disease 2019","volume":"165","author":"Cui","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125097_bib4","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.2999980","article-title":"Enzymatic amplification of \u03b2-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia","volume":"230","author":"Saiki","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.talanta.2023.125097_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1473-3099(04)01044-8","article-title":"PCR-based diagnostics for infectious diseases: uses, limitations, and future applications in acute-care settings","volume":"4","author":"Yang","year":"2004","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.talanta.2023.125097_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.130708","article-title":"Recent advances and challenges of biosensing in point-of-care molecular diagnosis","volume":"348","author":"Chu","year":"2021","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2023.125097_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.124244","article-title":"Signal amplification strategies in biosensing of extracellular vesicles (EVs)","volume":"256","author":"Khaksari","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2023.125097_bib8","doi-asserted-by":"crossref","first-page":"11251","DOI":"10.1039\/C9CC05583E","article-title":"Sensitive and sustained imaging of intracellular microRNA in living cells by a high biocompatible liposomal vehicle introduced isothermal symmetric exponential amplification reaction","volume":"55","author":"Yin","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2023.125097_bib10","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1093\/nar\/26.22.5073","article-title":"Signal amplification of padlock probes by rolling circle replication","volume":"26","author":"Ban\u00e9r","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.talanta.2023.125097_bib11","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1093\/nar\/gkn1024","article-title":"Sensitive fluorescence detection of nucleic acids based on isothermal circular strand-displacement polymerization reaction","volume":"37","author":"Guo","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.talanta.2023.125097_bib12","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1073\/pnas.0730811100","article-title":"Isothermal reactions for the amplification of oligonucleotides","volume":"100","author":"Van Ness","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.talanta.2023.125097_bib9","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1093\/nar\/28.12.e63","article-title":"Loop-mediated isothermal amplification of DNA","volume":"28","author":"Notomi","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.talanta.2023.125097_bib13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4155\/bio.10.172","article-title":"Isothermal DNA amplification in bioanalysis: strategies and applications","volume":"3","author":"Kim","year":"2011","journal-title":"Bioanalysis"},{"key":"10.1016\/j.talanta.2023.125097_bib14","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1039\/c2lc40100b","article-title":"Isothermal nucleic acid amplification technologies for point-of-care diagnostics: a critical review","volume":"12","author":"Craw","year":"2012","journal-title":"Lab Chip"},{"key":"10.1016\/j.talanta.2023.125097_bib15","doi-asserted-by":"crossref","first-page":"7400","DOI":"10.1038\/s41598-019-43817-z","article-title":"Reduced false positives and improved reporting of loop-mediated isothermal amplification using quenched fluorescent primers","volume":"9","author":"Hardinge","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.talanta.2023.125097_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2144\/000113072","article-title":"Colorimetric detection of loop-mediated isothermal amplification reaction by using hydroxy naphthol blue","volume":"46","author":"Goto","year":"2009","journal-title":"Biotechniques"},{"key":"10.1016\/j.talanta.2023.125097_bib17","doi-asserted-by":"crossref","first-page":"12187","DOI":"10.1039\/C6CC05679B","article-title":"A capillary-based multiplexed isothermal nucleic acid-based test for sexually transmitted diseases in patients","volume":"52","author":"Xu","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2023.125097_bib18","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1021\/acs.analchem.9b04752","article-title":"Signal amplification in living cells: a review of microRNA detection and imaging","volume":"92","author":"Peng","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125097_bib19","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1021\/acssensors.0c01453","article-title":"The recent development of hybridization chain reaction strategies in biosensors","volume":"5","author":"Zhang","year":"2020","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2023.125097_bib20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.aca.2019.06.048","article-title":"A signal-flexible gene diagnostic strategy coupling loop-mediated isothermal amplification with hybridization chain reaction","volume":"1079","author":"Dong","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2023.125097_bib21","doi-asserted-by":"crossref","first-page":"10611","DOI":"10.1021\/acs.analchem.1c01812","article-title":"Signal extraction, transformation, and magnification for ultrasensitive and specific detection of nucleic acids","volume":"93","author":"He","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125097_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.123978","article-title":"Nucleic acid amplification with specific signal filtration and magnification for ultrasensitive colorimetric detection","volume":"253","author":"He","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2023.125097_bib23","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1021\/acs.chemrev.0c01140","article-title":"Aptamer-based detection of circulating targets for precision medicine","volume":"121","author":"Wu","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.talanta.2023.125097_bib24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature10888","article-title":"The microcosmos of cancer","volume":"482","author":"Lujambio","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.talanta.2023.125097_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111528","article-title":"MicroRNA: a signature for cancer progression","volume":"138","author":"Hussen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.talanta.2023.125097_bib26","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1021\/am506933r","article-title":"In situ DNA-templated synthesis of silver nanoclusters for ultrasensitive and label-free electrochemical detection of microRNA","volume":"7","author":"Yang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2023.125097_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.121579","article-title":"Fluorescence biosensing of the leukemia gene by combining target-programmed controllable signal inspiring engineering","volume":"281","author":"Li","year":"2022","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2023.125097_bib28","doi-asserted-by":"crossref","first-page":"17173","DOI":"10.1073\/pnas.1316493110","article-title":"Watching DNA breath one molecule at a time","volume":"110","author":"Fei","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.talanta.2023.125097_bib29","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1093\/nar\/gkaa016","article-title":"Elucidation of leak-resistance DNA hybridization chain reaction with universality and extensibility","volume":"48","author":"Li","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.talanta.2023.125097_bib30","doi-asserted-by":"crossref","first-page":"15275","DOI":"10.1073\/pnas.0407024101","article-title":"Triggered amplification by hybridization chain reaction","volume":"101","author":"Dirks","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914023008482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914023008482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:13:30Z","timestamp":1758546810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914023008482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":30,"alternative-id":["S0039914023008482"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2023.125097","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dual signal amplification system with specific signal identification for rapid and sensitive detection of miRNA","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2023.125097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"125097"}}