{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:26:32Z","timestamp":1792812392296,"version":"4.5.0"},"reference-count":191,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.talanta.2023.125198","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T08:39:24Z","timestamp":1694767164000},"page":"125198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["SERS-based methods for the detection of genomic biomarkers of cancer"],"prefix":"10.1016","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-9354","authenticated-orcid":false,"given":"Aizhan","family":"Issatayeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Farnesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Cialla-May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6670-2588","authenticated-orcid":false,"given":"Federica Maria Angel","family":"Rizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Milanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Selleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Cucinotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2023.125198_bib1","doi-asserted-by":"crossref","first-page":"209\u2014","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"Cancer J. Clin."},{"key":"10.1016\/j.talanta.2023.125198_bib2","doi-asserted-by":"crossref","first-page":"1\u2014","DOI":"10.3390\/ijms19102877","article-title":"Blood-based cancer biomarkers in liquid biopsy: a promising non-invasive alternative to tissue biopsy","volume":"19","author":"Marrugo-Ramirez","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.talanta.2023.125198_bib3","doi-asserted-by":"crossref","first-page":"847\u2014","DOI":"10.1016\/j.bbagen.2007.01.017","article-title":"Biomarkers for early detection of breast cancer: what, when, and where?","volume":"1770","author":"Levenson","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.talanta.2023.125198_bib4","doi-asserted-by":"crossref","first-page":"172\u2014","DOI":"10.7150\/jca.5834","article-title":"Evidence-based guidelines for precision risk stratification-based screening (prsbs) for colorectal cancer: lessons learned from the us armed forces: consensus and future directions","volume":"4","author":"Avital","year":"2013","journal-title":"J. Cancer"},{"key":"10.1016\/j.talanta.2023.125198_bib5","doi-asserted-by":"crossref","first-page":"1\u2014","DOI":"10.1002\/adom.202001171","article-title":"Multiplexing liquid biopsy with surface-enhanced Raman scattering spectroscopy","volume":"9","author":"Abalde-Cela","year":"2021","journal-title":"Adv. Opt. Mater."},{"key":"10.1016\/j.talanta.2023.125198_bib6","doi-asserted-by":"crossref","first-page":"394\u2014","DOI":"10.2174\/138920208785699580","article-title":"Cause and consequences of genetic and epigenetic alterations in human cancer","volume":"9","author":"Sadikovic","year":"2008","journal-title":"Curr. Genom."},{"key":"10.1016\/j.talanta.2023.125198_bib7","first-page":"149","article-title":"Genetic tests and genomic biomarkers: regulation, qualification and validation","volume":"5","author":"Novelli","year":"2008","journal-title":"Clinical Cases Miner. Bone Metabol."},{"key":"10.1016\/j.talanta.2023.125198_bib8","first-page":"332\u2014","article-title":"Circulating biomarkers for early diagnosis of pancreatic cancer: facts and hopes","volume":"8","author":"Zhang","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.talanta.2023.125198_bib9","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1021\/acs.analchem.0c04896","article-title":"Attomolar-level ultrasensitive and multiplex microrna detection enabled by a nanomaterial locally assembled microfluidic biochip for cancer diagnosis","volume":"93","author":"Chu","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib10","doi-asserted-by":"crossref","first-page":"1476\u2014","DOI":"10.1039\/C9RA09029K","article-title":"A centrifugation-assisted visual detection of snp in circulating tumor dna using gold nanoparticles coupled with isothermal amplification","volume":"10","author":"Wang","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.talanta.2023.125198_bib11","doi-asserted-by":"crossref","first-page":"17862\u2014","DOI":"10.1038\/s41598-020-74494-y","article-title":"Mlh1 single-nucleotide variant in circulating tumor dna predicts overall survival of patients with hepatocellular carcinoma","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.talanta.2023.125198_bib12","doi-asserted-by":"crossref","first-page":"724\u2014","DOI":"10.1038\/s41416-018-0233-4","article-title":"A review of the most promising biomarkers for early diagnosis and prognosis prediction of tongue squamous cell carcinoma","volume":"119","author":"Hussein","year":"2018","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.talanta.2023.125198_bib13","doi-asserted-by":"crossref","first-page":"189\u2014","DOI":"10.1089\/thy.2016.0339","article-title":"Single point mutations in pediatric differentiated thyroid cancer","volume":"27","author":"Alzahrani","year":"2017","journal-title":"Thyroid"},{"key":"10.1016\/j.talanta.2023.125198_bib14","doi-asserted-by":"crossref","first-page":"1\u2014","DOI":"10.1038\/s41598-019-43520-z","article-title":"Non-invasive detection of dna methylation states in carcinoma and pluripotent stem cells using Raman microspectroscopy and imaging","volume":"9","author":"Daum","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.talanta.2023.125198_bib15","doi-asserted-by":"crossref","first-page":"1\u2014","DOI":"10.3389\/fgene.2019.01150","article-title":"Dna methylation cancer biomarkers: translation to the clinic","volume":"10","author":"Locke","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.talanta.2023.125198_bib16","doi-asserted-by":"crossref","first-page":"821\u2014","DOI":"10.3390\/genes5030821","article-title":"Dna methylation biomarkers: cancer and beyond","volume":"5","author":"Mikeska","year":"2014","journal-title":"Genes"},{"key":"10.1016\/j.talanta.2023.125198_bib17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jpha.2019.05.004","article-title":"Research advances in the detection of mirna","volume":"9","author":"Ye","year":"2019","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.talanta.2023.125198_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-1-4939-2963-4_19","article-title":"Analysis of dna methylation by pyrosequencing","volume":"1343","author":"Delaney","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.talanta.2023.125198_bib19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1021\/acsphotonics.1c01934","article-title":"Prospects of surface-enhanced Raman spectroscopy for biomarker monitoring toward precision medicine","volume":"9","author":"Plou","year":"2022","journal-title":"ACS Photonics"},{"key":"10.1016\/j.talanta.2023.125198_bib20","doi-asserted-by":"crossref","first-page":"28\u2014","DOI":"10.1021\/acsnano.9b04224","article-title":"Present and future of surface-enhanced Raman scattering","volume":"14","author":"Langer","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2023.125198_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sbsr.2021.100406","article-title":"Fast, highly sensitive and label free detection of small genetic sequence difference of dna using novel surface-enhanced Raman spectroscopy nanostructured sensor","volume":"32","author":"Gaidi","year":"2021","journal-title":"Sensing and Bio-Sensing Res."},{"key":"10.1016\/j.talanta.2023.125198_bib22","doi-asserted-by":"crossref","first-page":"1\u2014","DOI":"10.1002\/advs.201900730","article-title":"Engineering state-of-the-art plasmonic nanomaterials for sers-based clinical liquid biopsy applications","volume":"6","author":"Wang","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.talanta.2023.125198_bib23","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1039\/D0SC00809E","article-title":"Surface-enhanced Raman spectroscopy: benefits, trade-offs and future developments","volume":"11","author":"Perez-Jimenez","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.talanta.2023.125198_bib24","doi-asserted-by":"crossref","first-page":"691\u2014","DOI":"10.1007\/s10555-018-9770-9","article-title":"Applications of Raman spectroscopy in cancer diagnosis","volume":"37","author":"Auner","year":"2018","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.talanta.2023.125198_bib25","doi-asserted-by":"crossref","first-page":"338\u2014","DOI":"10.1021\/ac053456d","article-title":"New substrates and single-molecule detection are just two of the advances that are fueling interest in sers","author":"Haynes","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib26","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1039\/C5AN02057C","article-title":"Plasmonic nanostructures for surface enhanced spectroscopic methods","volume":"141","author":"Jahn","year":"2012","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2023.125198_bib27","series-title":"Principles of Surface-Enhanced Raman Spectroscopy: and Related Plasmonic Effects","author":"Ru","year":"2008"},{"key":"10.1016\/j.talanta.2023.125198_bib28","doi-asserted-by":"crossref","first-page":"1\u2014","DOI":"10.1016\/j.trac.2021.116401","article-title":"Surface-enhanced Raman scattering inspired by programmable nucleic acid isothermal amplification technology","volume":"143","author":"Yuan","year":"2021","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib29","doi-asserted-by":"crossref","first-page":"1\u2014","DOI":"10.3390\/nano7060142","article-title":"Review of sers substrates for chemical sensing","volume":"7","author":"Mosier-Boss","year":"2017","journal-title":"Nanomaterials"},{"key":"10.1016\/j.talanta.2023.125198_bib30","doi-asserted-by":"crossref","first-page":"3379\u2014","DOI":"10.1021\/ac00092a014","article-title":"Surface-enhanced Raman gene probes","volume":"66","author":"Vo-Dinh","year":"1994","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib31","doi-asserted-by":"crossref","first-page":"383\u2014","DOI":"10.1515\/nanoph-2013-0024","article-title":"Sers-based detection of biomolecules","volume":"3","author":"Cialla","year":"2014","journal-title":"Nanophotonics"},{"key":"10.1016\/j.talanta.2023.125198_bib32","doi-asserted-by":"crossref","first-page":"15580\u2014","DOI":"10.1021\/ja066263w","article-title":"Surface-enhanced Raman spectroscopy (sers) for sub-micromolar detection of dna\/rna mononucleotides","volume":"128","author":"Bell","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2023.125198_bib33","first-page":"6281\u2014","article-title":"Detection and identification of a single dna base molecule using surface-enhanced Raman scattering (sers)","volume":"57","author":"Kneipp","year":"1998","journal-title":"Phys. Rev."},{"key":"10.1016\/j.talanta.2023.125198_bib34","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.1039\/c1cc11925g","article-title":"Quantitative label-free rna detection using surface-enhanced Raman spectroscopy","volume":"47","author":"Prado","year":"2011","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2023.125198_bib35","doi-asserted-by":"crossref","first-page":"13730","DOI":"10.1021\/jp103304r","article-title":"Sers and computational studies on microrna chains adsorbed on silver surfaces","volume":"114","author":"Muniz-Miranda","year":"2010","journal-title":"J. Phys. Chem. C"},{"key":"10.1016\/j.talanta.2023.125198_bib36","doi-asserted-by":"crossref","first-page":"12769","DOI":"10.1021\/acs.analchem.0c03335","article-title":"Label-free detection of mirna using surface-enhanced Raman spectroscopy","volume":"92","author":"Li","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib37","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.bios.2008.07.060","article-title":"Rapid microrna (mirna) detection and classification via surface-enhanced Raman spectroscopy (sers)","volume":"24","author":"Driskell","year":"2008","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/3659423","article-title":"Rapid detection and identification of mirnas by surface-enhanced Raman spectroscopy using hollow au nanoflowers substrates","author":"Cao","year":"2017","journal-title":"J. Nanomater."},{"key":"10.1016\/j.talanta.2023.125198_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.saa.2021.120015","article-title":"Three-dimensional nanorod array for label-free surface-enhanced Raman spectroscopy analysis of microrna pneumoconiosis biomarkers","volume":"261","author":"Cui","year":"2021","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2023.125198_bib40","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1021\/acsnano.5b07966","article-title":"Fast optical chemical and structural classification of rna","volume":"10","author":"Morla-Folch","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2023.125198_bib41","doi-asserted-by":"crossref","first-page":"9058","DOI":"10.1002\/anie.201102776","article-title":"Label-free detection of single-base mismatches in dna by surface-enhanced Raman spectroscopy","volume":"50","author":"Papadopoulou","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2023.125198_bib42","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1021\/jacs.5b01426","article-title":"Label-free surface-enhanced Raman spectroscopy detection of dna with single-base sensitivity","volume":"137","author":"Xu","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2023.125198_bib43","doi-asserted-by":"crossref","first-page":"7980","DOI":"10.1021\/acs.analchem.9b01887","article-title":"Direct approach toward label-free dna detection by surface-enhanced Raman spectroscopy: discrimination of a single-base mutation in 50 base-paired double helixes","volume":"91","author":"Li","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib44","doi-asserted-by":"crossref","first-page":"121746","DOI":"10.1016\/j.talanta.2020.121746","article-title":"A new method towards the detection of dna mutation by surface-enhanced Raman spectroscopy","volume":"223","author":"Zeng","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2023.125198_bib45","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/acs.analchem.0c04052","article-title":"Label-free detection of ct mutations by surface-enhanced Raman spectroscopy using thiosulfate-modified nanoparticles","volume":"93","author":"Zeng","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib46","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1002\/ange.201611243","article-title":"Conformational sers classification of k-ras point mutations for cancer diagnostics","volume":"129","author":"Morla-Folch","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2023.125198_bib47","doi-asserted-by":"crossref","first-page":"102100","DOI":"10.1016\/j.nano.2019.102100","article-title":"Label-free liquid biopsy based on blood circulating dna detection using sers-based nanotechnology for nasopharyngeal cancer screening","volume":"22","author":"Lin","year":"2019","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.talanta.2023.125198_bib48","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1021\/acs.jpclett.6b01424","article-title":"Direct quantification of dna base composition by surface enhanced Raman scattering spectroscopy","volume":"7","author":"Morla-Folch","year":"2016","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.talanta.2023.125198_bib49","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jrs.3029","article-title":"Sers study of methylated and nonmethylated ribonucleosides and the effect of aggregating agents","volume":"43","author":"Hobro","year":"2012","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.talanta.2023.125198_bib50","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1021\/jz201423b","article-title":"Detecting chemically modified dna bases using surface-enhanced Raman spectroscopy","volume":"2","author":"Barhoumi","year":"2011","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.talanta.2023.125198_bib51","first-page":"1","article-title":"Direct surface-enhanced Raman scattering analysis of dna duplexes","volume":"53","author":"Guerrini","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2023.125198_bib52","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41467-020-14774-3","article-title":"Quantum scale organic semiconductors for sers detection of dna methylation and gene expression","volume":"11","author":"Ganesh","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.talanta.2023.125198_bib53","first-page":"698","article-title":"Detecting dna methylation using surface-enhanced Raman spectroscopy","volume":"123","author":"Hasan","year":"2019","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib54","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1021\/acs.analchem.9b01004","article-title":"Label-free Raman observation of tet1 protein-mediated epigenetic alterations in dna","volume":"91","author":"Luo","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib55","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1021\/acssensors.9b00008","article-title":"Plasmonic gold nanohole array for surface-enhanced Raman scattering detection of dna methylation","volume":"4","author":"Luo","year":"2019","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2023.125198_bib56","doi-asserted-by":"crossref","first-page":"703268","DOI":"10.3389\/fbioe.2021.703268","article-title":"Sers-based evaluation of the dna methylation pattern associated with progression in clonal leukemogenesis of down syndrome","volume":"9","author":"Moisoiu","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.talanta.2023.125198_bib57","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jbio.201000085","article-title":"Characterisation of dna methylation status using spectroscopy (mid-ir versus Raman) with multivariate analysis","volume":"4","author":"Kelly","year":"2011","journal-title":"J. Biophot."},{"key":"10.1016\/j.talanta.2023.125198_bib58","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1007\/s00216-019-02213-2","article-title":"Sers assessment of the cancer-specific methylation pattern of genomic dna: towards the detection of acute myeloid leukemia in patients undergoing hematopoietic stem cell transplantation","volume":"411","author":"Moisoiu","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib59","doi-asserted-by":"crossref","first-page":"120216","DOI":"10.1016\/j.saa.2021.120216","article-title":"Sers-based dna methylation profiling allows the differential diagnosis of malignant lymphadenopathy","volume":"264","author":"Stefancu","year":"2022","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2023.125198_bib60","doi-asserted-by":"crossref","first-page":"898","DOI":"10.7150\/thno.30204","article-title":"Polymerase chain reaction \u2013 surface-enhanced Raman spectroscopy (pcr-sers) method for gene methylation level detection in plasma","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.talanta.2023.125198_bib61","doi-asserted-by":"crossref","first-page":"9554","DOI":"10.1021\/acs.analchem.6b02186","article-title":"Immobilization of oligonucleotides on metal-dielectric nanostructures for mirna detection","volume":"88","author":"Chiado","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib62","doi-asserted-by":"crossref","first-page":"12889","DOI":"10.1021\/ja3043432","article-title":"Label-free detection of micro-rna hybridization using surface enhanced Raman spectroscopy and least-squares analysis","volume":"134","author":"Abell","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2023.125198_bib63","doi-asserted-by":"crossref","first-page":"8362","DOI":"10.1021\/acsnano.8b03698","article-title":"Design and clinical verification of surface-enhanced Raman spectroscopy diagnostic technology for individual cancer risk prediction","volume":"12","author":"Koo","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2023.125198_bib64","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1039\/C6NR09928A","article-title":"A nanoplasmonic label-free surface-enhanced Raman scattering strategy for non-invasive cancer genetic subtyping in patient samples","volume":"9","author":"Wang","year":"2017","journal-title":"Nanoscale"},{"key":"10.1016\/j.talanta.2023.125198_bib65","first-page":"972","article-title":"Detection of dna mutations using novel sers (surface-enhanced Raman spectroscopy) diagnostic platform","volume":"7","author":"Kami\u0144ska","year":"2013","journal-title":"J. Chem. Chem. Eng."},{"key":"10.1016\/j.talanta.2023.125198_bib66","doi-asserted-by":"crossref","first-page":"144","DOI":"10.21608\/ejs.2021.101958.1027","article-title":"Sers detection of dna cancer with single-base mutation for kras-gene","volume":"43","author":"Abdallah","year":"2021","journal-title":"Egypt. J. Solid."},{"key":"10.1016\/j.talanta.2023.125198_bib67","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/celc.201701220","article-title":"Monitoring potential-induced dna dehybridization kinetics for single nucleotide polymorphism detection by using in situ surface enhanced Raman scattering","volume":"5","author":"Kayran","year":"2018","journal-title":"Chemelectrochem"},{"key":"10.1016\/j.talanta.2023.125198_bib68","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.7150\/thno.22502","article-title":"Surface enhanced Raman spectroscopy (sers) for the multiplex detection of braf, kras, and pik3ca mutations in plasma of colorectal cancer patients","volume":"8","author":"Li","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.talanta.2023.125198_bib69","doi-asserted-by":"crossref","first-page":"15589","DOI":"10.1021\/ja805517q","article-title":"Sers-melting: a new method for discriminating mutations in dna sequences","volume":"130","author":"Mahajan","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2023.125198_bib70","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1002\/elan.200904681","article-title":"The use of an electroactive marker as a sers label in an e-melting mutation discrimination assay","volume":"21","author":"Mahajan","year":"2009","journal-title":"Electroanalysis"},{"key":"10.1016\/j.talanta.2023.125198_bib71","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.4103\/0366-6999.211874","article-title":"Label-free detection for a dna methylation assay using Raman spectroscopy","volume":"130","author":"Kim","year":"2017","journal-title":"Chinese Med J"},{"key":"10.1016\/j.talanta.2023.125198_bib72","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bios.2011.11.014","article-title":"Single base extension reaction-based surface enhanced Raman spectroscopy for dna methylation assay","volume":"31","author":"Hu","year":"2012","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib73","doi-asserted-by":"crossref","first-page":"10144","DOI":"10.1021\/acs.analchem.8b01798","article-title":"Frequency shift Raman-based sensing of serum micrornas for early diagnosis and discrimination of primary liver cancers","volume":"90","author":"Zhu","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib74","doi-asserted-by":"crossref","first-page":"34869","DOI":"10.1021\/acsami.8b10252","article-title":"Ultrasensitive detection of serum microrna using branched dna-based sers platform combining simultaneous detection of alpha-fetoprotein for early diagnosis of liver cancer","volume":"10","author":"Cheng","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2023.125198_bib75","doi-asserted-by":"crossref","first-page":"18145","DOI":"10.1021\/acsami.9b02953","article-title":"Ultrasensitive detection of circulating tumor dna of lung cancer via an enzymatically amplified sers-based frequency shift assay","volume":"11","author":"Zhang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2023.125198_bib76","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1039\/c002059a","article-title":"Label-free sers detection of microrna based on affinity for an unmodified silver nanorod array substrate","volume":"46","author":"Driskell","year":"2010","journal-title":"Chem. Commun. J."},{"key":"10.1016\/j.talanta.2023.125198_bib77","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1039\/C8CC09586H","article-title":"Nanodendritic gold\/graphene-based biosensor for tri-mode mirna sensing","volume":"55","author":"Song","year":"2019","journal-title":"Chem. Commun. J."},{"key":"10.1016\/j.talanta.2023.125198_bib78","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.1039\/C5CC01003A","article-title":"Dna-templated in situ growth of agnps on swnts: a new approach for highly sensitive sers assay of microrna","volume":"51","author":"Zheng","year":"2015","journal-title":"Chem. Commun. J."},{"key":"10.1016\/j.talanta.2023.125198_bib79","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.colsurfb.2011.12.026","article-title":"Aggregation effects of gold nanoparticles for single-base mismatch detection in influenza a (h1n1) dna sequences using fluorescence and Raman measurements","volume":"93","author":"Ganbold","year":"2012","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.talanta.2023.125198_bib80","first-page":"1","article-title":"Sers platform based on bimetallic au-ag nanowires-decorated filter paper for rapid detection of mir-196a in lung cancer patients serum","volume":"2020","author":"Xia","year":"2020","journal-title":"J. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib81","first-page":"1","article-title":"Ultrasensitive sers sensor for simultaneous detection of multiple cancer-related mirnas","author":"Song","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.talanta.2023.125198_bib82","first-page":"1","article-title":"Microfluidic chip based micro rna detection through the combination of fluorescence and surface enhanced Raman scattering techniques","volume":"28","author":"Wang","year":"2017","journal-title":"Nanotechnology"},{"key":"10.1016\/j.talanta.2023.125198_bib83","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1021\/acs.analchem.0c04561","article-title":"Controlled self-assembly of a close-packed gold octahedra array for sers sensing exosomal micrornas","volume":"93","author":"Kang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib84","doi-asserted-by":"crossref","first-page":"2001214","DOI":"10.1002\/adom.202001214","article-title":"Ultrasensitive sers detection of cancer-related mirna-182 by mxene\/mos2@aunps with controllable morphology and optimized self-internal standards","volume":"8","author":"Liu","year":"2020","journal-title":"Adv. Opt. Mater."},{"key":"10.1016\/j.talanta.2023.125198_bib85","doi-asserted-by":"crossref","first-page":"113470","DOI":"10.1016\/j.bios.2021.113470","article-title":"Surface-enhanced Raman scattering holography chip for rapid, sensitive and multiplexed detection of human breast cancer-associated micrornas in clinical samples","volume":"190","author":"Meng","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib86","first-page":"11619","article-title":"Ratiometric sers biosensor for sensitive and reproducible detection of microrna based on mismatched catalytic hairpin assembly","volume":"144","author":"Chen","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib87","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1364\/OME.439069","article-title":"Easy-to-make-and-use gold nanotrench arrays for surface-enhanced Raman scattering","volume":"11","author":"Wi","year":"2021","journal-title":"Opt. Mater. Express"},{"key":"10.1016\/j.talanta.2023.125198_bib88","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1039\/D0TC05737A","article-title":"Rapid and sensitive detection of dual lung cancer-associated mirna biomarkers by a novel sers-lfa strip coupling with catalytic hairpin assembly signal amplification","volume":"9","author":"Cao","year":"2021","journal-title":"J. Mater. Chem. C"},{"key":"10.1016\/j.talanta.2023.125198_bib89","doi-asserted-by":"crossref","first-page":"338800","DOI":"10.1016\/j.aca.2021.338800","article-title":"Ultra-sensitive and high efficiency detection of multiple non-small cell lung cancer-related mirnas on a single test line in catalytic hairpin assembly-based sers-lfa strip","volume":"1178","author":"Mao","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2023.125198_bib90","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1039\/C8AY02423E","article-title":"Magnetic-capture-based sers detection of multiple serum microrna biomarkers for cancer diagnosis","volume":"11","author":"Zhang","year":"2019","journal-title":"Anal. Methods"},{"key":"10.1016\/j.talanta.2023.125198_bib91","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00216-010-3992-1","article-title":"Plasmonics nanoprobes: detection of single-nucleotide polymorphisms in the breast cancer brca1 gene","volume":"398","author":"Wabuyele","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib92","doi-asserted-by":"crossref","first-page":"7781","DOI":"10.1039\/C9NR00501C","article-title":"Amplification-free sers analysis of dna mutation in cancer cells with single-base sensitivity","volume":"11","author":"Wu","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.talanta.2023.125198_bib93","series-title":"IEEE Proceeding","first-page":"1","article-title":"Inkjet-printed paper surface enhanced Raman spectroscopy (sers) sensors","author":"Restaino","year":"2016"},{"key":"10.1016\/j.talanta.2023.125198_bib94","first-page":"1005502","article-title":"Surface enhanced Raman spectroscopy (sers) methods for endpoint and real-time quantification of mirna assays","volume":"III 10055","author":"Restaino","year":"2017","journal-title":"Optics and Biophotonics in Low-Resource Settings"},{"key":"10.1016\/j.talanta.2023.125198_bib95","doi-asserted-by":"crossref","first-page":"19656","DOI":"10.1021\/acsomega.1c02306","article-title":"Highly sensitive and reliable microrna detection with a recyclable microfluidic device and an easily assembled sers substrate","volume":"6","author":"Lee","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.talanta.2023.125198_bib96","first-page":"1","article-title":"Highly robust, uniform and ultra-sensitive surface-enhanced Raman scattering substrates for microrna detection fabricated by using silver nanostructures grown in gold nanobowls","author":"Lee","year":"2013","journal-title":"Nanoscale"},{"key":"10.1016\/j.talanta.2023.125198_bib97","doi-asserted-by":"crossref","first-page":"114143","DOI":"10.1016\/j.bios.2022.114143","article-title":"Simultaneous dual-targeted monitoring of breast cancer circulating mirna via surface-enhanced Raman spectroscopy","volume":"207","author":"Kim","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib98","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1021\/acs.analchem.0c05221","article-title":"Dual-mode sers and electrochemical detection of mirna based on popcorn-like gold nanofilms and toehold-mediated strand displacement amplification reaction","volume":"93","author":"Zhou","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib99","doi-asserted-by":"crossref","first-page":"1902477","DOI":"10.1002\/advs.201902477","article-title":"Single functionalized prna\/gold nanoparticle for ultrasensitive microrna detection using electrochemical surface-enhanced Raman spectroscopy","volume":"7","author":"Lee","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.talanta.2023.125198_bib100","doi-asserted-by":"crossref","first-page":"11288","DOI":"10.1021\/acs.analchem.6b03320","article-title":"Sensitive surface enhanced Raman scattering-based detection of a bigh3 point mutation associated with avellino corneal dystrophy","volume":"88","author":"Kim","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib101","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1002\/smll.201400164","article-title":"Ultra-specifi c zeptomole microrna detection by plasmonic nanowire interstice sensor with bi-temperature hybridization","volume":"10","author":"Kang","year":"2014","journal-title":"Small Bomarkers"},{"key":"10.1016\/j.talanta.2023.125198_bib102","first-page":"271","article-title":"Sers-active metal-dielectric nanostructures integrated in microfluidic devices for label-free quantitative detection of mirna","volume":"205","author":"Novara","year":"2017","journal-title":"The Royal Soc. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib103","doi-asserted-by":"crossref","first-page":"148456","DOI":"10.1016\/j.apsusc.2020.148456","article-title":"Large-area surface-enhanced Raman spectroscopy substrate by hybrid porous gan with au\/ag for breast cancer mirna detection","volume":"541","author":"Han","year":"2021","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.talanta.2023.125198_bib104","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1039\/C9AN01748H","article-title":"Detection of cardiovascular disease associated mir-29a using paper-based microfluidics and surface enhanced Raman scattering","volume":"145","author":"Mabbott","year":"2020","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2023.125198_bib105","doi-asserted-by":"crossref","first-page":"11883","DOI":"10.1039\/C4CC05598E","article-title":"Surface-enhanced Raman spectroscopy for simultaneous sensitive detection of multiple micrornas in lung cancer cells","volume":"50","author":"Ye","year":"2014","journal-title":"Chem. Commun. J."},{"key":"10.1016\/j.talanta.2023.125198_bib106","doi-asserted-by":"crossref","first-page":"20990","DOI":"10.1039\/C8NR07348A","article-title":"Superwettable nanodendritic gold substrates for direct mirna sers detection","volume":"10","author":"Song","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.talanta.2023.125198_bib107","first-page":"1008008","article-title":"Sers-based inverse molecular sentinel (ims) nanoprobes for multiplexed detection of microrna cancer biomarkers in biological samples","volume":"10080","author":"Crawford","year":"2018","journal-title":"Plasmonics Biol. Med. XIV"},{"key":"10.1016\/j.talanta.2023.125198_bib108","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1039\/D0AN00193G","article-title":"Plasmonic nanobiosensors for detection of microrna cancer biomarkers in clinical samples","volume":"145","author":"Crawford","year":"2020","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2023.125198_bib109","first-page":"21047","article-title":"Multiplexed detection of microrna biomarkers using sers-based inverse molecular sentinel (ims) nanoprobes","volume":"120","author":"Wang","year":"2016","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib110","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1021\/acs.analchem.6b04082","article-title":"off\u201d to \u201con\u201d surface-enhanced Raman spectroscopy platform with padlock probe-based exponential rolling circle amplification for ultrasensitive detection of microrna 155","volume":"89","author":"He","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib111","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.snb.2018.08.057","article-title":"A novel recyclable surface-enhanced Raman spectroscopy platform with duplex-specific nuclease signal amplification for ultrasensitive analysis of microrna 155","volume":"275","author":"Wu","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib112","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1039\/c3an01600e","article-title":"Sers-based direct and sandwich assay methods for mir-21 detection","volume":"139","author":"Guven","year":"2014","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2023.125198_bib113","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1021\/acs.analchem.6b04729","article-title":"Multicolor gold-silver nano-mushrooms as ready-to-use sers probes for ultrasensitive and multiplex dna\/mirna detection","volume":"89","author":"Su","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib114","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1039\/C9AY00573K","article-title":"Sers-based sandwich bioassay protocol of mirna-21 using au@ag core\u2013shell nanoparticles and a ag\/tio2 nanowires substrate","volume":"11","author":"Peng","year":"2019","journal-title":"Anal. Methods"},{"key":"10.1016\/j.talanta.2023.125198_bib115","doi-asserted-by":"crossref","first-page":"9850","DOI":"10.1021\/acs.analchem.7b01861","article-title":"Dna-encoded Raman-active anisotropic nanoparticles for microrna detection","volume":"89","author":"Qi","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib116","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1021\/acs.analchem.7b00902","article-title":"Simultaneous surface-enhanced Raman spectroscopy detection of multiplexed microrna biomarkers","volume":"89","author":"Zhou","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib117","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1039\/C8AN01745J","article-title":"A label-free, ultra-highly sensitive and multiplexed sers nanoplasmonic biosensor for mirna detection using a head-flocked gold nanopillar","volume":"144","author":"Kim","year":"2019","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2023.125198_bib118","doi-asserted-by":"crossref","first-page":"114116","DOI":"10.1016\/j.bios.2022.114116","article-title":"Three-dimensional hierarchical plasmonic nano-architecture based label-free surface-enhanced Raman spectroscopy detection of urinary exosomal mirna for clinical diagnosis of prostate cancer","volume":"205","author":"Kim","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib119","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1039\/C8AN02259C","article-title":"Sers-based cascade amplification bioassay protocol of mirna-21 by using sandwich structure with biotin\u2013streptavidin system","volume":"144","author":"Liang","year":"2019","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2023.125198_bib120","doi-asserted-by":"crossref","first-page":"1804968","DOI":"10.1002\/smll.201804968","article-title":"Quantitative and specific detection of exosomal mirnas for accurate diagnosis of breast cancer using a surface-enhanced Raman scattering sensor based on plasmonic head-flocked gold nanopillars","volume":"15","author":"Lee","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.talanta.2023.125198_bib121","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1016\/j.cclet.2021.08.047","article-title":"A microfluidic surface-enhanced Raman scattering (sers) sensor for microrna in extracellular vesicles with nucleic acid-tyramine cascade amplification","volume":"33","author":"Zhao","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.talanta.2023.125198_bib122","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1021\/ac802247y","article-title":"Statistically significant Raman detection of midsequence single nucleotide polymorphisms","volume":"81","author":"Moody","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib123","doi-asserted-by":"crossref","DOI":"10.1117\/1.3400702","article-title":"Using surface-enhanced Raman spectroscopy to probe for genetic markers on single-stranded dna","volume":"15","author":"Moody","year":"2010","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.talanta.2023.125198_bib124","doi-asserted-by":"crossref","first-page":"10953\u2014","DOI":"10.1039\/C5CC03921E","article-title":"Highly sensitive dna methylation analysis at cpg resolution by surface-enhanced Raman scattering via ligase chain reaction","volume":"51","author":"Wang","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2023.125198_bib125","doi-asserted-by":"crossref","first-page":"10544","DOI":"10.1002\/anie.201805640","article-title":"Microrna-directed intracellular self-assembly of chiral nanorod dimers","volume":"57","author":"Xu","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2023.125198_bib126","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.23.1.017002","article-title":"Development of a mirna surface-enhanced Raman scattering assay using benchtop and handheld Raman systems","volume":"23","author":"Schechinger","year":"2018","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.talanta.2023.125198_bib127","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1039\/C9AN00653B","article-title":"A sers approach for rapid detection of microrna-17 in the picomolar range","volume":"144","author":"Schechinger","year":"2019","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2023.125198_bib128","first-page":"33","article-title":"Dna\u2013gold nanoparticle conjugates for intracellular mirna detection using surface-enhanced Raman spectroscopy","volume":"16","author":"Lee","year":"2022","journal-title":"BiChip Journal"},{"key":"10.1016\/j.talanta.2023.125198_bib129","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chroma.2018.04.057","article-title":"Feasibility study for combination of field-flow fractionation (fff)-based separation of size-coded particle probes with amplified surface enhanced Raman scattering (sers) tagging for simultaneous detection of multiple mirnas","volume":"1556","author":"Shin","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.talanta.2023.125198_bib130","doi-asserted-by":"crossref","first-page":"1900017","DOI":"10.1002\/smtd.201900017","article-title":"Oriented assembly of gold nanoparticles with freezing-driven surface dna manipulation and its application in sers-based microrna assay","volume":"3","author":"He","year":"2019","journal-title":"Small Methods"},{"key":"10.1016\/j.talanta.2023.125198_bib131","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1021\/acssensors.0c01900","article-title":"In situ exosomal microrna determination by target-triggered sers and fe3o4@tio2-based exosome accumulation","volume":"6","author":"Jiang","year":"2021","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2023.125198_bib132","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1002\/smll.201101380","article-title":"Plasmonic coupling interference (pci) nanoprobes for nucleic acid detection","volume":"7","author":"Wang","year":"2011","journal-title":"Small Biosensors"},{"key":"10.1016\/j.talanta.2023.125198_bib133","doi-asserted-by":"crossref","first-page":"821405","DOI":"10.1117\/12.917630","article-title":"Plasmonic coupling interference: a new approach for cancer diagnostics using sers detection","volume":"8214","author":"Wang","year":"2012","journal-title":"Adv. Biomed. Clin. Diagnostic Syst. X"},{"key":"10.1016\/j.talanta.2023.125198_bib134","doi-asserted-by":"crossref","first-page":"10245","DOI":"10.1021\/acs.jpcb.9b06804","article-title":"Direct and label-free detection of microrna cancer biomarkers using sers-based plasmonic coupling interference (pci) nanoprobes","volume":"123","author":"Wang","year":"2019","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib135","article-title":"Simultaneous and multiplex detection of exosomal micrornas based on the asymmetric au@au@ag probes with enhanced Raman signal","volume":"21","author":"Hou","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.talanta.2023.125198_bib136","doi-asserted-by":"crossref","first-page":"8386","DOI":"10.1021\/acsabm.1c00845","article-title":"Highly sensitive detection of elevated exosomal mir-122 levels in radiation injury and hepatic inflammation using an aptamer-functionalized sers-sandwich assay","volume":"4","author":"Muhammad","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.talanta.2023.125198_bib137","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s40843-017-9022-1","article-title":"Synthesis of magnetic core-branched au shell nanostructures and their application in cancer-related mirna detection via sers","volume":"60","author":"Yang","year":"2017","journal-title":"Sci. China Mater."},{"key":"10.1016\/j.talanta.2023.125198_bib138","first-page":"52782","article-title":"Sers detection of microrna biomarkers for cancer diagnosis using gold-coated paramagnetic nanoparticles to capture sers-active gold nanoparticles","volume":"7","author":"Zhang","year":"2017","journal-title":"RCS Andances"},{"key":"10.1016\/j.talanta.2023.125198_bib139","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1039\/C7AY02727C","article-title":"Magnetic-based sers approach for highly sensitive and reproducible detection of cancer-related serum micrornas","volume":"10","author":"Zhang","year":"2018","journal-title":"Anal. Methods"},{"key":"10.1016\/j.talanta.2023.125198_bib140","doi-asserted-by":"crossref","first-page":"8799","DOI":"10.1021\/acs.analchem.1c00478","article-title":"Ultrasensitive and simultaneous sers detection of multiplex microrna using fractal gold nanotags for early diagnosis and prognosis of hepatocellular carcinoma","volume":"93","author":"Wu","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib141","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bios.2016.01.073","article-title":"Sensitive dna detection and snp discrimination using ultrabright sers nanorattles and magnetic beads for malaria diagnostics","volume":"81","author":"Ngo","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib142","article-title":"Dna detection and single nucleotide mutation identification using sers for molecular diagnostics and global health","volume":"10054","author":"Ngo","year":"2017","journal-title":"Proc. SPIE"},{"key":"10.1016\/j.talanta.2023.125198_bib143","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1039\/D1AN01108A","article-title":"Highly specific detection of kras single nucleotide polymorphism by asymmetric pcr\/sers assay","volume":"146","author":"Lyu","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2023.125198_bib144","doi-asserted-by":"crossref","first-page":"13431","DOI":"10.1039\/C8CC08231F","article-title":"Ultrasensitive sers detection of highly homologous mirnas by generating 3d organic-nanoclusters and a functionalized chip with locked nucleic acid probes","volume":"54","author":"Zhu","year":"2018","journal-title":"Chem. Commun. J."},{"key":"10.1016\/j.talanta.2023.125198_bib145","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ab.2018.10.004","article-title":"Dual cycle amplification and dual signal enhancement assisted sensitive sers assay of microrna","volume":"564","author":"Wu","year":"2019","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.talanta.2023.125198_bib146","doi-asserted-by":"crossref","first-page":"7786","DOI":"10.1039\/C8CC02910E","article-title":"A dna\u2013linker\u2013dna bifunctional probe for simultaneous sers detection of mirnas via symmetric signal amplification","volume":"54","author":"Ye","year":"2018","journal-title":"Chem. Commun. J."},{"key":"10.1016\/j.talanta.2023.125198_bib147","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1021\/acsanm.0c03208","article-title":"Ag nanocubes coupled with heating-enhanced dsn-assisted cycling amplification for surface-enhanced Raman spectroscopy detection of microrna-21","volume":"4","author":"Du","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.talanta.2023.125198_bib148","doi-asserted-by":"crossref","first-page":"16836","DOI":"10.1039\/C5CC06225J","article-title":"Sensitive sers detection of mirna using a label-free multifunctional probe","volume":"51","author":"Zhang","year":"2015","journal-title":"Chem. Commun. J."},{"key":"10.1016\/j.talanta.2023.125198_bib149","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1021\/acs.analchem.7b00697","article-title":"Fluorescence and sers imaging for the simultaneous absolute quantification of multiple mirnas in living cells","volume":"89","author":"Ye","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib150","doi-asserted-by":"crossref","first-page":"11614","DOI":"10.1021\/acs.analchem.8b03067","article-title":"Composition-tunable hollow au\/ag sers nanoprobes coupled with target-catalyzed hairpin assembly for triple-amplification detection of mirna","volume":"90","author":"Sun","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib151","doi-asserted-by":"crossref","first-page":"10591","DOI":"10.1021\/acs.analchem.8b02819","article-title":"Target-triggered catalytic hairpin assembly-induced core-satellite nanostructures for high-sensitive \u201coff-to-on\u201d sers detection of intracellular microrna","volume":"90","author":"Liu","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib152","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1021\/acssensors.0c01876","article-title":"Catalytic hairpin self-assembly-based sers sensor array for the simultaneous measurement of multiple cancer-associated mirnas","volume":"5","author":"Si","year":"2020","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2023.125198_bib153","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1021\/acs.analchem.8b05172","article-title":"Triggerable mutually amplified signal probe based sers-microfluidics platform for the efficient enrichment and quantitative detection of mirna","volume":"91","author":"Wang","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib154","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1002\/anie.201902776","article-title":"Functionalized h-bn nanosheets as a theranostic platform for sers real-time monitoring of microrna and photodynamic therapy","volume":"58","author":"Liu","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2023.125198_bib155","doi-asserted-by":"crossref","first-page":"7250","DOI":"10.1039\/C9AN01579E","article-title":"Quantitative and specific detection of cancer-related micrornas in living cells using surface-enhanced Raman scattering imaging based on hairpin dna-functionalized gold nanocages","volume":"144","author":"Wang","year":"2019","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2023.125198_bib156","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1021\/acs.analchem.0c03491","article-title":"Fluorescent-Raman binary star ratio probe for microrna detection and imaging in living cells","volume":"93","author":"Zhang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib157","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1039\/C9NR07791J","article-title":"Gold nanocage-based surface-enhanced Raman scattering probes for long-term monitoring of intracellular microrna during bone marrow stem cell differentiation","volume":"12","author":"Cao","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.talanta.2023.125198_bib158","doi-asserted-by":"crossref","first-page":"111616","DOI":"10.1016\/j.bios.2019.111616","article-title":"A multiple signal amplification sandwich-type sers biosensor for femtomolar detection of mirna","volume":"143","author":"Shao","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib159","doi-asserted-by":"crossref","first-page":"13755","DOI":"10.1021\/acs.analchem.1c01338","article-title":"Target-triggered nanomaterial self-assembly induced electromagnetic hot-spot generation for sers-fluorescence dual-mode in situ monitoring mirna-guided phototherapy","volume":"93","author":"Wang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib160","doi-asserted-by":"crossref","first-page":"8242","DOI":"10.1021\/acs.analchem.5b01186","article-title":"Asymmetric signal amplification for simultaneous sers detection of multiple cancer markers with significantly different levels","volume":"87","author":"Ye","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib161","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1039\/C6CC04391G","article-title":"Sensitive sers detection of mirna via enzyme-free dna machine signal amplification","volume":"52","author":"Li","year":"2016","journal-title":"Chem. Commun. J."},{"key":"10.1016\/j.talanta.2023.125198_bib162","doi-asserted-by":"crossref","first-page":"16271","DOI":"10.1039\/C5CC06549F","article-title":"A new enzyme-free quadratic sers signal amplification approach for circulating microrna detection in human serum","volume":"51","author":"Zheng","year":"2015","journal-title":"Chem. Commun. J."},{"key":"10.1016\/j.talanta.2023.125198_bib163","doi-asserted-by":"crossref","first-page":"18301","DOI":"10.1021\/acsami.1c01834","article-title":"Boosting long-range surface-enhanced Raman scattering on plasmonic nanohole arrays for ultrasensitive detection of mirna","volume":"13","author":"Luo","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2023.125198_bib164","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1021\/acssensors.1c00063","article-title":"Sers-microfluidic approach for the quantitative detection of mirna using dnazyme-mediated reciprocal signal amplification","volume":"6","author":"Ma","year":"2021","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2023.125198_bib165","doi-asserted-by":"crossref","first-page":"15573","DOI":"10.1021\/acs.analchem.0c03633","article-title":"Liquid phase interfacial surface-enhanced Raman scattering platform for ratiometric detection of microrna 155","volume":"92","author":"Luo","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib166","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bios.2015.12.052","article-title":"Fe3o4@ag magnetic nanoparticles for microrna capture and duplex-specific nuclease signal amplification based sers detection in cancer cells","volume":"79","author":"Pang","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib167","doi-asserted-by":"crossref","first-page":"12298","DOI":"10.1021\/acs.analchem.9b02476","article-title":"Plasmon coupling-enhanced Raman sensing platform integrated with exonuclease-assisted target recycling amplification for ultrasensitive and selective detection of microrna-21","volume":"91","author":"Wen","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib168","doi-asserted-by":"crossref","first-page":"122240","DOI":"10.1016\/j.talanta.2021.122240","article-title":"A novel sers substrate with high reusability for sensitive detection of mirna 21","volume":"228","author":"Hu","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2023.125198_bib169","doi-asserted-by":"crossref","first-page":"10907","DOI":"10.1039\/D1NJ00173F","article-title":"A target-activated plasmon coupling surface-enhanced Raman scattering platform for the highly sensitive and reproducible detection of mirna-21","volume":"45","author":"Cui","year":"2021","journal-title":"New J. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib170","doi-asserted-by":"crossref","first-page":"8657","DOI":"10.1002\/chem.201003372","article-title":"Detection of single nucleotide polymorphisms by a gold nanowire-on-film sers sensor coupled with s1 nuclease treatment","volume":"17","author":"Yoo","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib171","doi-asserted-by":"crossref","first-page":"676065","DOI":"10.3389\/fmolb.2021.676065","article-title":"Integrating cycled enzymatic dna amplification and surface-enhanced Raman scattering for sensitive detection of circulating tumor dna","volume":"8","author":"Miao","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.talanta.2023.125198_bib172","doi-asserted-by":"crossref","first-page":"132109","DOI":"10.1016\/j.cej.2021.132109","article-title":"Crispr-cas12a mediated sers lateral flow assay for amplification-free detection of double-stranded dna and single-base mutation","volume":"429","author":"Pang","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2023.125198_bib173","doi-asserted-by":"crossref","first-page":"122728","DOI":"10.1016\/j.talanta.2021.122728","article-title":"Iodide-modified ag nanoparticles coupled with dsn-assisted cycling amplification for label-free and ultrasensitive sers detection of microrna-21","volume":"235","author":"Yao","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2023.125198_bib174","doi-asserted-by":"crossref","first-page":"122432","DOI":"10.1016\/j.talanta.2021.122432","article-title":"Simultaneous detection of tumor-related mrna and mirna in cancer cells with magnetic sers nanotags","volume":"232","author":"Li","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2023.125198_bib175","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00604-020-04330-7","article-title":"Au@ag core-shell nanoparticles for microrna-21 determination based on duplex-specific nuclease signal amplification and surface-enhanced Raman scattering","volume":"187","author":"Xu","year":"2020","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.talanta.2023.125198_bib176","doi-asserted-by":"crossref","first-page":"167\u2014","DOI":"10.1016\/j.bios.2017.08.062","article-title":"Quantitative detection of exosomal microrna extracted from human blood based on surface-enhanced Raman scattering","volume":"101","author":"Ma","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib177","doi-asserted-by":"crossref","first-page":"8538","DOI":"10.1021\/acs.analchem.7b02321","article-title":"Switchable target-responsive 3d dna hydrogels as a signal amplification strategy combining with sers technique for ultrasensitive detection of mirna 155","volume":"89","author":"He","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib178","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1039\/C8TB02894J","article-title":"A novel ratiometric sers biosensor with one Raman probe for ultrasensitive microrna detection based on dna hydrogel amplification","volume":"7","author":"He","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.talanta.2023.125198_bib179","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1021\/acs.analchem.9b04606","article-title":"Target microrna-responsive dna hydrogel-based surface-enhanced Raman scattering sensor arrays for microrna-marked cancer screening","volume":"92","author":"Si","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib180","doi-asserted-by":"crossref","first-page":"12491","DOI":"10.1021\/acsami.8b01974","article-title":"Stimuli-responsive dna microcapsules for sers sensing of trace microrna","volume":"10","author":"Yang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2023.125198_bib181","first-page":"281\u2014","article-title":"Optofluidic surface enhanced Raman scattering based detection of single nucleotide polymorphism","volume":"13","author":"Huh","year":"2009"},{"key":"10.1016\/j.talanta.2023.125198_bib182","doi-asserted-by":"crossref","first-page":"2208\u2014","DOI":"10.1021\/ja807526v","article-title":"Surface-enhanced Raman scattering based ligase detection reaction","volume":"131","author":"Huh","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2023.125198_bib183","doi-asserted-by":"crossref","first-page":"5810\u2014","DOI":"10.1021\/ac100921b","article-title":"Multiplex single nucleotide polymorphism genotyping utilizing ligase detection reaction coupled surface enhanced Raman spectroscopy","volume":"82","author":"Lowe","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib184","doi-asserted-by":"crossref","first-page":"2734\u2014","DOI":"10.1021\/ac504000p","article-title":"Ultrasensitive detection of single nucleotide polymorphism in human mitochondrial dna utilizing ion-mediated cascade surface-enhanced Raman spectroscopy amplification","volume":"87","author":"Shi","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2023.125198_bib185","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/bkcs.12298","article-title":"Integration of surface-enhanced Raman spectroscopy with pcr for monitoring single copy of kras g12d mutation","volume":"42","author":"Barea","year":"2021","journal-title":"Bull. Kor. Chem. Soc."},{"key":"10.1016\/j.talanta.2023.125198_bib186","doi-asserted-by":"crossref","first-page":"224","DOI":"10.7150\/ntno.48905","article-title":"Multiplex detection of ctdna mutations in plasma of colorectal cancer patients by pcr\/sers assay","volume":"4","author":"Lyu","year":"2020","journal-title":"Nanotheranostics"},{"key":"10.1016\/j.talanta.2023.125198_bib187","doi-asserted-by":"crossref","first-page":"191\u2014","DOI":"10.1016\/j.bios.2014.10.035","article-title":"Sensitive detection of point mutation using exponential strand displacement amplification-based surface enhanced Raman spectroscopy","volume":"65","author":"Huang","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib188","doi-asserted-by":"crossref","first-page":"755\u2014","DOI":"10.1016\/j.bios.2016.09.072","article-title":"A reusable laser wrapped graphene-ag array based sers sensor for trace detection of genomic dna methylation","volume":"92","author":"Ouyang","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2023.125198_bib189","doi-asserted-by":"crossref","first-page":"114022\u2014","DOI":"10.1088\/2040-8978\/17\/11\/114022","article-title":"Plasmonic coupling-dependent sers of gold nanoparticles anchored on methylated dna and detection of global dna methylation in sers-based platforms","volume":"17","author":"Nguyen","year":"2015","journal-title":"J. Opt."},{"key":"10.1016\/j.talanta.2023.125198_bib190","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1039\/C6CC00547K","article-title":"Accurate and sensitive total genomic dna methylation analysis from sub-nanogram input with embedded sers nanotags","volume":"52","author":"Wang","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2023.125198_bib191","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1039\/C9AN00374F","article-title":"Lateral flow assay ruler for quantitative and rapid point-of-care testing","volume":"144","author":"Li","year":"2019","journal-title":"Analyst"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914023009499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914023009499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T06:32:55Z","timestamp":1729319575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914023009499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":191,"alternative-id":["S0039914023009499"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2023.125198","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SERS-based methods for the detection of genomic biomarkers of cancer","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2023.125198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"125198"}}