{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:13:20Z","timestamp":1789827200991,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21976052"],"award-info":[{"award-number":["21976052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277021"],"award-info":[{"award-number":["22277021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.talanta.2024.125734","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T04:31:41Z","timestamp":1706589101000},"page":"125734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["An asymmetrical flavylium based probe with large Stokes shift and near infrared emission for highly sensitive detecting and visualizing cellular drug induced H2S fluctuations"],"prefix":"10.1016","volume":"271","author":[{"given":"Qian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2212Jun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2024.125734_bib1","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1039\/D1CS01097B","article-title":"Photoinduced electron transfer (PeT) based fluorescent probes for cellular imaging and disease therapy","volume":"52","author":"Niu","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2024.125734_bib2","doi-asserted-by":"crossref","first-page":"5607","DOI":"10.1039\/D2CS00799A","article-title":"Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects","volume":"52","author":"Zeng","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2024.125734_bib3","doi-asserted-by":"crossref","first-page":"9391","DOI":"10.1039\/D0CS01183E","article-title":"Small-molecule fluorescence-based probes for interrogating major organ diseases","volume":"50","author":"Han","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2024.125734_bib4","doi-asserted-by":"crossref","first-page":"11718","DOI":"10.1021\/acs.chemrev.9b00379","article-title":"Small molecule as fluorescent probes for monitoring intracellular enzymatic transformations","volume":"119","author":"Singh","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.talanta.2024.125734_bib5","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1039\/D1CS00388G","article-title":"Fluorescent probe strategy for live cell distinction","volume":"51","author":"Liu","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2024.125734_bib6","doi-asserted-by":"crossref","first-page":"10403","DOI":"10.1021\/acs.chemrev.9b00145","article-title":"Coumarin-based small-molecule fluorescent chemosensors","volume":"119","author":"Cao","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.talanta.2024.125734_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2020.213713","article-title":"1,8-Naphthalimide based fluorescent sensors for enzymes","volume":"437","author":"Geraghty","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.talanta.2024.125734_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.trac.2017.08.013","article-title":"Fluorescein applications as fluorescent probes for the detection of analytes","volume":"97","author":"Yan","year":"2017","journal-title":"TrAC-Trend. Anal. Chem."},{"key":"10.1016\/j.talanta.2024.125734_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2023.215193","article-title":"Emerging near infrared fluorophore: dicyanoisophorone-based small-molecule fluorescent probes with large Stokes shifts for bioimaging","volume":"489","author":"Dai","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.talanta.2024.125734_bib10","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1039\/D1CS00307K","article-title":"Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook","volume":"51","author":"Li","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2024.125734_bib11","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1021\/acs.chemrev.1c00399","article-title":"Natural and synthetic flavylium-based dyes: the chemistry behind the color","volume":"122","author":"Cruz","year":"2022","journal-title":"Chem. Rev."},{"key":"10.1016\/j.talanta.2024.125734_bib12","doi-asserted-by":"crossref","first-page":"12960","DOI":"10.1021\/ja204781t","article-title":"\u03b2-Galactosidase fluorescence probe with improved cellular accumulation based on a spirocyclized rhodol scaffold","volume":"133","author":"Kamiya","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2024.125734_bib13","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1021\/acssensors.0c01555","article-title":"Visualizing peroxynitrite in microvessels of the brain with stroke using an engineered highly specific fluorescent probe","volume":"5","author":"Xiong","year":"2020","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2024.125734_bib14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.saa.2018.01.033","article-title":"A chromogenic and fluorogenic rhodol-based chemosensor for hydrazine detection and its application in live cell bioimaging","volume":"195","author":"Tiensomjitr","year":"2018","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2024.125734_bib15","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.3390\/s20174768","article-title":"A red emissive fluorescent turn-on sensor for the rapid detection of selenocysteine and its application in living cells imaging","volume":"20","author":"Wang","year":"2020","journal-title":"Sensors"},{"key":"10.1016\/j.talanta.2024.125734_bib16","doi-asserted-by":"crossref","first-page":"15974","DOI":"10.1021\/acs.analchem.9b04564","article-title":"Evolving a unique red-emitting fluorophore with an optically tunable hydroxy group for imaging nitroreductase in cells, in tissues, and in vivo","volume":"91","author":"Peng","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.125734_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132285","article-title":"Imaging the dynamic processes of hydrogen sulfide using a rapid \u201cturn-on\u201d mitochondria-targeting fluorescent probe","volume":"369","author":"Wang","year":"2022","journal-title":"Sens. Actuat. B-Chem."},{"key":"10.1016\/j.talanta.2024.125734_bib18","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1039\/C5SC04014K","article-title":"A unique approach toward near-infrared fluorescent probes for bioimaging with remarkably enhanced contrast","volume":"7","author":"Gong","year":"2016","journal-title":"Chem. Sci."},{"key":"10.1016\/j.talanta.2024.125734_bib19","doi-asserted-by":"crossref","first-page":"11633","DOI":"10.1021\/acs.analchem.2c02177","article-title":"PET- and ICT-based ratiometric probe: an unusual phenomenon of morpholine-conjugated fluorophore for mitochondrial pH mapping during mitophagy","volume":"94","author":"Munan","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.125734_bib20","doi-asserted-by":"crossref","first-page":"22562","DOI":"10.1021\/jacs.2c08602","article-title":"Cardiolipin-targeted NIR-II fluorophore causes \"avalanche effects\" for Re-engaging cancer apoptosis and inhibiting metastasis","volume":"144","author":"Bian","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2024.125734_bib21","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1039\/D2TB00181K","article-title":"Rational engineering of biomimetic flavylium fluorophores for regulating the lysosomal and mitochondrial localization behavior by pH-induced structure switch and application to fluorescence imaging","volume":"10","author":"Wang","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.talanta.2024.125734_bib22","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1177\/1091581810384882","article-title":"Hydrogen sulfide: advances in understanding human toxicity","volume":"29","author":"Guidotti","year":"2010","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.talanta.2024.125734_bib23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/cbf.1618","article-title":"Regulation of cardiovascular cell function by hydrogen sulfide (H(2)S)","volume":"28","author":"Elsey","year":"2010","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.talanta.2024.125734_bib24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3390\/antiox9070621","article-title":"Hydrogen sulfide: from a toxic molecule to a key molecule of cell life","volume":"9","author":"Aroca","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.talanta.2024.125734_bib25","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/ars.2013.5309","article-title":"Production and physiological effects of hydrogen sulfide","volume":"20","author":"Kimura","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.talanta.2024.125734_bib26","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1089\/ars.2013.5339","article-title":"Enzymology of H2S biogenesis, decay and signaling","volume":"20","author":"Kabil","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.talanta.2024.125734_bib27","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.bbapap.2011.02.004","article-title":"PLP-dependent H(2)S biogenesis","volume":"1814","author":"Singh","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.talanta.2024.125734_bib28","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signaling"},{"key":"10.1016\/j.talanta.2024.125734_bib29","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.talanta.2024.125734_bib30","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine \u03b3-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.talanta.2024.125734_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3285074","article-title":"Implications of hydrogen sulfide in glucose regulation: how H2S can alter glucose homeostasis through metabolic hormones","volume":"2016","author":"Pichette","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.talanta.2024.125734_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/MN:26:1:013","article-title":"Hydrogen sulfide as a neuromodulator","volume":"26","author":"Kimura","year":"2002","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.talanta.2024.125734_bib33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bbrc.2004.12.028","article-title":"Hydrogen sulfide may improve the hippocampal damage induced by recurrent febrile seizures in rats","volume":"327","author":"Han","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.talanta.2024.125734_bib34","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/90507","article-title":"Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation","volume":"4","author":"Parri","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.talanta.2024.125734_bib35","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1073\/pnas.1306241110","article-title":"Tumor-derived hydrogen sulfide, produced by cystathionine-\u03b2-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer","volume":"110","author":"Szabo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024001139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024001139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:57:30Z","timestamp":1778659050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914024001139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":35,"alternative-id":["S0039914024001139"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2024.125734","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An asymmetrical flavylium based probe with large Stokes shift and near infrared emission for highly sensitive detecting and visualizing cellular drug induced H2S fluctuations","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2024.125734","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"125734"}}