{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:39:34Z","timestamp":1780623574432,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22074026"],"award-info":[{"award-number":["22074026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.talanta.2024.125768","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T22:44:17Z","timestamp":1707345857000},"page":"125768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Determination of amino acid metabolic diseases from dried blood spots with a rapid extraction method coupled with nanoelectrospray ionization mass spectrometry"],"prefix":"10.1016","volume":"272","author":[{"given":"Yali","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxiao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5357-7204","authenticated-orcid":false,"given":"Guangfeng","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-1759","authenticated-orcid":false,"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2024.125768_bib1","first-page":"5","article-title":"Diversity in the incidence and spectrum of organic acidemias, fatty acid oxidation disorders, and amino acid disorders in Asian countries: selective screening vs. expanded newborn screening","volume":"16","author":"Shibata","year":"2018","journal-title":"Mol. Genet. Metab. Rep."},{"key":"10.1016\/j.talanta.2024.125768_bib2","doi-asserted-by":"crossref","first-page":"10113","DOI":"10.1021\/ac302527m","article-title":"Metabonomics of newborn screening dried blood spot samples: a novel approach in the screening and diagnostics of inborn errors of metabolism","volume":"84","author":"Denes","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41436-018-0022-8","article-title":"A proposed nosology of inborn errors of metabolism","volume":"21","author":"Ferreira","year":"2019","journal-title":"Genet. Med."},{"key":"10.1016\/j.talanta.2024.125768_bib4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1373\/clinchem.2015.240903","article-title":"Challenges for worldwide harmonization of newborn screening programs","volume":"62","author":"Martinez-Morillo","year":"2016","journal-title":"Clin. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/gim.2013.98","article-title":"Decision-making process for conditions nominated to the recommended uniform screening panel: statement of the US department of health and human services secretary's advisory committee on heritable disorders in newborns and children","volume":"16","author":"Kemper","year":"2014","journal-title":"Genet. Med."},{"key":"10.1016\/j.talanta.2024.125768_bib6","first-page":"279","article-title":"Inborn errors of metabolism with seizures: defects of glycine and serine metabolism and cofactor-related disorders","volume":"65","author":"Almannai","year":"2018","journal-title":"Pediatr. Clin."},{"key":"10.1016\/j.talanta.2024.125768_bib7","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1021\/ac202695h","article-title":"LC-MS\/MS method for simultaneous determination on a dried blood spot of multiple analytes relevant for treatment monitoring in patients with tyrosinemia type I","volume":"84","author":"la Marca","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib8","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.3390\/ijerph17103601","article-title":"A false-positive case of methylmalonic aciduria by tandem mass spectrometry newborn screening dependent on maternal malnutrition in pregnancy","volume":"17","author":"Rossi","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.talanta.2024.125768_bib9","doi-asserted-by":"crossref","first-page":"7823","DOI":"10.1007\/s00216-022-04316-9","article-title":"A simple method for rapid screening and diagnosis of common organic acidemias: quantitative detection of serum and urine organic acid profiles based on liquid chromatography-tandem mass spectrometry","volume":"414","author":"Jin","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/metabo11010051","article-title":"L-Carnitine and acylcarnitines: mitochondrial biomarkers for precision medicine","volume":"11","author":"McCann","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.talanta.2024.125768_bib11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/s41436-020-01070-0","article-title":"Impact of newborn screening on the reported incidence and clinical outcomes associated with medium- and long-chain fatty acid oxidation disorders","volume":"23","author":"Marsden","year":"2021","journal-title":"Genet. Med."},{"key":"10.1016\/j.talanta.2024.125768_bib12","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/rcm.1054","article-title":"ESI-MS\/MS analysis of underivatised amino acids: a new tool for the diagnosis of inherited disorders of amino acid metabolism. Fragmentation study of 79 molecules of biological interest in positive and negative ionisation mode","volume":"17","author":"Piraud","year":"2003","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.talanta.2024.125768_bib13","doi-asserted-by":"crossref","first-page":"2506S","DOI":"10.1093\/jn\/nxaa134","article-title":"Lessons learned from inherited metabolic disorders of sulfur-containing amino acids metabolism","volume":"150","author":"Kozich","year":"2020","journal-title":"J. Nutr."},{"key":"10.1016\/j.talanta.2024.125768_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmsacl.2022.05.002","article-title":"Quantitation of non-derivatized free amino acids for detecting inborn errors of metabolism by incorporating mixed-mode chromatography with tandem mass spectrometry","volume":"25","author":"DeArmond","year":"2022","journal-title":"J. Mass Spectrom. Adv. Clin. Lab"},{"key":"10.1016\/j.talanta.2024.125768_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23159","article-title":"Expanded newborn screening for inborn errors of metabolism by tandem mass spectrometry in newborns from Xinxiang city in China","volume":"34","author":"Ma","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.talanta.2024.125768_bib16","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1038\/s41436-018-0407-8","article-title":"Phenylalanine and tyrosine measurements across gestation by tandem mass spectrometer on dried blood spot cards from normal pregnant women","volume":"21","author":"McBride","year":"2019","journal-title":"Genet. Med."},{"key":"10.1016\/j.talanta.2024.125768_bib17","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/jimd.12318","article-title":"Additional Individual Contributors of MetabERN, Liver and\/or kidney transplantation in amino and organic acid-related inborn errors of metabolism: an overview on European data","volume":"44","author":"Molema","year":"2021","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.talanta.2024.125768_bib18","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1007\/s00216-013-6713-8","article-title":"Newborn screening of phenylketonuria using direct analysis in real time (DART) mass spectrometry","volume":"405","author":"Wang","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/mnfr.200500186","article-title":"Evaluation of electrospray-tandem mass spectrometry for the detection of phenylketonuria and other rare disorders","volume":"50","author":"Lukacs","year":"2006","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.talanta.2024.125768_bib20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1373\/clinchem.2007.098434","article-title":"Second-tier test for quantification of alloisoleucine and branched-chain amino acids in dried blood spots to improve newborn screening for maple syrup urine disease (MSUD)","volume":"54","author":"Oglesbee","year":"2008","journal-title":"Clin. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib21","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(10)60961-0","article-title":"Phenylketonuria","volume":"376","author":"Blau","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.talanta.2024.125768_bib22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S2213-8587(16)30320-5","article-title":"Key European guidelines for the diagnosis and management of patients with phenylketonuria","volume":"5","author":"van Spronsen","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.talanta.2024.125768_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.631688","article-title":"Tandem mass spectrometry screening for inborn errors of metabolism in newborns and high-risk infants in southern China: disease spectrum and genetic characteristics in a Chinese population","volume":"12","author":"Tan","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.talanta.2024.125768_bib24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1373\/clinchem.2015.248146","article-title":"Effective use of mass spectrometry in the clinical laboratory","volume":"62","author":"Jannetto","year":"2016","journal-title":"Clin. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/jclinpath-2019-206269","article-title":"Emerging role of clinical mass spectrometry in pathology","volume":"73","author":"Fung","year":"2020","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.talanta.2024.125768_bib26","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1021\/acs.analchem.2c03098","article-title":"Development of a universal second-tier newborn screening LC-MS\/MS method for amino acids, lysophosphatidylcholines, and organic acids","volume":"95","author":"Kilgore","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10545-007-0543-9","article-title":"Selective screening for inborn errors of metabolism on clinical patients using tandem mass spectrometry in China: a four-year report","volume":"30","author":"Han","year":"2007","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.talanta.2024.125768_bib28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2020.03.004","article-title":"After another decade: LC-MS\/MS became routine in clinical diagnostics","volume":"82","author":"Seger","year":"2020","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.talanta.2024.125768_bib29","doi-asserted-by":"crossref","first-page":"10702","DOI":"10.1021\/acs.analchem.9b02050","article-title":"Improved dried blood spot-based metabolomics analysis by a postcolumn infused-internal standard assisted liquid chromatography-electrospray ionization mass spectrometry method","volume":"91","author":"Chepyala","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib30","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1039\/C8AN01722K","article-title":"Direct sampling mass spectrometry for clinical analysis","volume":"144","author":"Pu","year":"2019","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2024.125768_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113509","article-title":"Integration of GC-MS and LC-MS for untargeted metabolomics profiling","volume":"190","author":"Zeki","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.talanta.2024.125768_bib32","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1021\/acs.analchem.9b00807","article-title":"Ambient ionization mass spectrometry: recent developments and applications","volume":"91","author":"Feider","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116548","article-title":"Recent advances in on-site mass spectrometry analysis for clinical applications","volume":"149","author":"Zhou","year":"2022","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116896","article-title":"Mass spectrometry-based metabolomics for clinical study: recent progresses and applications","volume":"158","author":"Ding","year":"2023","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.talanta.2024.125768_bib35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cca.2019.12.022","article-title":"Newborn screening and diagnosis of inborn errors of metabolism: a 5-year study in an eastern Chinese population","volume":"502","author":"Yang","year":"2020","journal-title":"Clin. Chim. Acta"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024001474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024001474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:59:44Z","timestamp":1777445984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914024001474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":35,"alternative-id":["S0039914024001474"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2024.125768","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination of amino acid metabolic diseases from dried blood spots with a rapid extraction method coupled with nanoelectrospray ionization mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2024.125768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"125768"}}