{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:00:23Z","timestamp":1789095623978,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21775133"],"award-info":[{"award-number":["21775133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22174122"],"award-info":[{"award-number":["22174122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009555","name":"Henan Normal University","doi-asserted-by":"publisher","award":["2020YB01"],"award-info":[{"award-number":["2020YB01"]}],"id":[{"id":"10.13039\/100009555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ30654"],"award-info":[{"award-number":["2021JJ30654"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014472","name":"Scientific Research Foundation of Hunan Provincial Education Department","doi-asserted-by":"publisher","award":["19A479"],"award-info":[{"award-number":["19A479"]}],"id":[{"id":"10.13039\/100014472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010083","name":"Hunan Provincial Innovation Foundation for Postgraduate","doi-asserted-by":"publisher","award":["CX20220593"],"award-info":[{"award-number":["CX20220593"]}],"id":[{"id":"10.13039\/501100010083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.talanta.2024.126227","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T01:00:36Z","timestamp":1715389236000},"page":"126227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Near-infrared fluorescent probe for the imaging of viscosity in fatty liver mice and valuation of drug efficacy"],"prefix":"10.1016","volume":"276","author":[{"given":"Jing-Jing","family":"Chao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin-Ting","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3411-2852","authenticated-orcid":false,"given":"Zhen-Zhen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Jiang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2024.126227_bib1","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1038\/d41586-017-06927-0","article-title":"Fatty liver disease","volume":"551","author":"Brody","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.talanta.2024.126227_bib2","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.talanta.2024.126227_bib3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/cld.710","article-title":"The epidemiology of nonalcoholic steatohepatitis","volume":"11","author":"Younossi","year":"2018","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.talanta.2024.126227_bib4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease \u2013 a global public health perspective","volume":"70","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.talanta.2024.126227_bib5","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.talanta.2024.126227_bib6","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jacc.2018.11.050","article-title":"Nonalcoholic fatty liver disease and the heart","volume":"73","author":"Stahl","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.talanta.2024.126227_bib7","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1016\/j.cgh.2021.09.021","article-title":"A meta-analysis on the global prevalence, risk factors and screening of coronary heart disease in nonalcoholic fatty liver disease","volume":"20","author":"Toh","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.talanta.2024.126227_bib8","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.1021\/ja403851p","article-title":"A self-calibrating bipartite viscosity sensor for mitochondria","volume":"135","author":"Yang","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2024.126227_bib9","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1039\/C4CS00051J","article-title":"Macro-\/micro-environment-sensitive chemosensing and biological imaging","volume":"43","author":"Yang","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2024.126227_bib10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-0028-1091979","article-title":"Abnormalities of lipid metabolism in nonalcoholic fatty liver disease","volume":"28","author":"Cheung","year":"2008","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.talanta.2024.126227_bib11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-230X-12-20","article-title":"Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease","volume":"12","author":"Chavez Tapia","year":"2012","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.talanta.2024.126227_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.numecd.2008.12.015","article-title":"Hepatic lipid metabolism and non-alcoholic fatty liver disease","volume":"19","author":"Tessari","year":"2009","journal-title":"Nutr. Metabol. Cardiovasc. Dis."},{"key":"10.1016\/j.talanta.2024.126227_bib13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41586-019-0984-y","article-title":"An integrative systems genetic analysis of mammalian lipid metabolism","volume":"567","author":"Parker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.talanta.2024.126227_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1534\/genetics.112.143362","article-title":"Lipid droplets and peroxisomes: key players in cellular lipid homeostasis or a matter of fat\u2014store \u2019em up or burn \u2019em down","volume":"193","author":"Kohlwein","year":"2013","journal-title":"Genetics"},{"key":"10.1016\/j.talanta.2024.126227_bib15","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/152214a0","article-title":"Measurement of anomalous viscosity by the capillary tube method","volume":"152","author":"Merrington","year":"1943","journal-title":"Nature"},{"key":"10.1016\/j.talanta.2024.126227_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0956-5663(01)00314-1","article-title":"Measurement of blood viscosity using mass-detecting sensor","volume":"17","author":"Shin","year":"2002","journal-title":"Biosens.Bioelectn."},{"key":"10.1016\/j.talanta.2024.126227_bib17","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1021\/acs.analchem.2c05568","article-title":"Mitochondrial membrane potential independent near-infrared mitochondrial viscosity probes for real-time tracking mitophagy","volume":"95","author":"Hong","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib18","doi-asserted-by":"crossref","first-page":"7254","DOI":"10.1021\/acs.analchem.3c00220","article-title":"Selective visualization of tumor cell membranes and tumors with a viscosity-sensitive plasma membrane probe","volume":"95","author":"Li","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib19","article-title":"Multi-organelle-targeting pH-dependent NIR fluorescent probe for lysosomal viscosity","volume":"34","author":"Wang","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.talanta.2024.126227_bib20","doi-asserted-by":"crossref","first-page":"13510","DOI":"10.1021\/ja305802v","article-title":"A unique approach to development of near-infrared fluorescent sensors for in vivo imaging","volume":"134","author":"Yuan","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2024.126227_bib21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1039\/C3CS60271K","article-title":"Recent progress in the development of near-infrared fluorescent probes for bioimaging applications","volume":"43","author":"Guo","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2024.126227_bib22","doi-asserted-by":"crossref","first-page":"9746","DOI":"10.1021\/acs.analchem.6b02646","article-title":"Near-infrared fluorescent probe with high quantum yield and its application in the selective detection of glutathione in living cells and tissues","volume":"88","author":"Xie","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib23","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1021\/acs.analchem.3c00142","article-title":"Multifunctional fluorescent probe for simultaneous detection of ONOO\u2013, viscosity, and polarity and its application in ferroptosis and cancer models","volume":"95","author":"Fan","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132648","article-title":"Development of novel near-infrared GFP chromophore-based fluorescent probes for imaging of amyloid-\u03b2 plaque and viscosity","volume":"372","author":"Guo","year":"2022","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2021.109466","article-title":"Research progress of multi-functional fluorescent probes for Alzheimer's disease monitoring","volume":"193","author":"Yang","year":"2021","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.talanta.2024.126227_bib26","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1039\/C9CC08267K","article-title":"Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift","volume":"56","author":"Li","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2024.126227_bib27","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1039\/D0CC02943B","article-title":"Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization","volume":"56","author":"Yu","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.talanta.2024.126227_bib28","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1021\/acs.analchem.0c03803","article-title":"Noninvasive cancer diagnosis in vivo based on a viscosity-activated near-infrared fluorescent probe","volume":"93","author":"Yin","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib29","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/cjoc.202000725","article-title":"A Mitochondria\u2010specific orange\/near\u2010infrared\u2010emissive fluorescent probe for dual\u2010imaging of viscosity and H2O2 in inflammation and tumor models","volume":"39","author":"Fan","year":"2021","journal-title":"Chin. J. Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.122719","article-title":"A dual lock-and-key two photon fluorescence probe in response to hydrogen peroxide and viscosity: application in cellular imaging and inflammation therapy","volume":"235","author":"Liang","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2024.126227_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340192","article-title":"A HPQ-based far-red fluorescent probe for monitoring viscosity in mice model of acute inflammation","volume":"1226","author":"Fu","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2024.126227_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.340967","article-title":"Mitochondria-targeting fluorescent sensor with high photostability and permeability for visualizing viscosity in mitochondrial malfunction, inflammation, and AD models","volume":"1250","author":"Li","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2024.126227_bib33","doi-asserted-by":"crossref","first-page":"8067","DOI":"10.1039\/D1TB01150B","article-title":"A coumarin-based TICT fluorescent probe for real-time fluorescence lifetime imaging of mitochondrial viscosity and systemic inflammation in vivo","volume":"9","author":"Liang","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.talanta.2024.126227_bib34","doi-asserted-by":"crossref","first-page":"17439","DOI":"10.1021\/acs.analchem.2c03419","article-title":"Dual-channel fluorescent probe for detecting viscosity and ONOO\u2013 without signal crosstalk in nonalcoholic fatty liver","volume":"94","author":"Liu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib35","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1021\/acs.analchem.1c05288","article-title":"Mitochondrial-targeting near-infrared fluorescent probe for visualizing viscosity in drug-induced cells and a fatty liver mouse model","volume":"94","author":"Wu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib36","doi-asserted-by":"crossref","first-page":"8415","DOI":"10.1021\/acs.analchem.9b01293","article-title":"Visualization of mitochondrial viscosity in inflammation, fatty liver, and cancer living mice by a robust fluorescent probe","volume":"91","author":"Yin","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.136448","article-title":"Viscosity activated NIR fluorescent probe for visualizing mitochondrial viscosity dynamic and fatty liver mice","volume":"445","author":"Song","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2024.126227_bib38","doi-asserted-by":"crossref","first-page":"12149","DOI":"10.1039\/D0SC02922J","article-title":"In situvisualization of peroxisomal viscosity in the liver of mice with non-alcoholic fatty liver disease by near-infrared fluorescence and photoacoustic imaging","volume":"11","author":"Zhou","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.talanta.2024.126227_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.123647","article-title":"A new NIR emission mitochondrial targetable fluorescent probe and its application in detecting viscosity changes in mouse liver and kidney injury","volume":"249","author":"Tang","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2024.126227_bib40","doi-asserted-by":"crossref","first-page":"9244","DOI":"10.1021\/acs.analchem.1c01511","article-title":"A mitochondrial-targeting near-infrared fluorescent probe for revealing the effects of hydrogen peroxide and heavy metal Ions on viscosity","volume":"93","author":"Zheng","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126227_bib41","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.3390\/nu11102283","article-title":"Role of oleic acid in the gut-liver axis: from diet to the regulation of its synthesis via stearoyl-CoA desaturase 1 (SCD1)","volume":"11","author":"Piccinin","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.talanta.2024.126227_bib42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/1753465812437563","article-title":"N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease","volume":"6","author":"Sadowska","year":"2012","journal-title":"Ther. Adv. Respir. Dis."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024006064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024006064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:09:59Z","timestamp":1777457399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914024006064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":42,"alternative-id":["S0039914024006064"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2024.126227","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Near-infrared fluorescent probe for the imaging of viscosity in fatty liver mice and valuation of drug efficacy","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2024.126227","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126227"}}