{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:07:34Z","timestamp":1790795254250,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017607","name":"Shenzhen Municipal Fundamental Research Program","doi-asserted-by":"publisher","award":["JCYJ20200109115601720"],"award-info":[{"award-number":["JCYJ20200109115601720"]}],"id":[{"id":"10.13039\/501100017607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2016321"],"award-info":[{"award-number":["2016321"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["C7018-20G"],"award-info":[{"award-number":["C7018-20G"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["202010160046"],"award-info":[{"award-number":["202010160046"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["17209320"],"award-info":[{"award-number":["17209320"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["AoE\/P-701\/20"],"award-info":[{"award-number":["AoE\/P-701\/20"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["202011159235"],"award-info":[{"award-number":["202011159235"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["17207419"],"award-info":[{"award-number":["17207419"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515220156"],"award-info":[{"award-number":["2021A1515220156"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62275260"],"award-info":[{"award-number":["62275260"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003803","name":"University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021172","name":"Chinese Academy of Sciences Key Laboratory of Health Informatics","doi-asserted-by":"publisher","award":["2011DP173015"],"award-info":[{"award-number":["2011DP173015"]}],"id":[{"id":"10.13039\/501100021172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.talanta.2024.126533","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T05:06:16Z","timestamp":1720933576000},"page":"126533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Gradient nanoplasmonic imaging metasurface for rapid and label-free detection of SARS-CoV-2 sequences"],"prefix":"10.1016","volume":"278","author":[{"given":"Hongtao","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuofei","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Di","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-3400","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2024.126533_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112455","article-title":"Detection of COVID-19: A review of the current literature and future perspectives","volume":"166","author":"Ji","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.126533_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112752","article-title":"COVID-19 diagnosis -A review of current methods","volume":"172","author":"Yuce","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.126533_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.113974","article-title":"All-solid-state SARS-CoV-2 protein biosensor employing colloidal quantum dots-modified electrode","volume":"202","author":"Zhao","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.126533_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114331","article-title":"Electronic field effect detection of SARS-CoV-2 N-protein before the onset of symptoms","volume":"210","author":"Novodchuk","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.126533_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112479","article-title":"DNA nanoscaffold-based SARS-CoV-2 detection for COVID-19 diagnosis","volume":"167","author":"Jiao","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.126533_bib6","doi-asserted-by":"crossref","DOI":"10.1088\/0034-4885\/79\/7\/076401","article-title":"A review of metasurfaces: physics and applications","volume":"79","author":"Chen","year":"2016","journal-title":"Rep. Prog. Phys."},{"key":"10.1016\/j.talanta.2024.126533_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3390\/s22010133","article-title":"Plasmonic metasurfaces for medical diagnosis applications: a review","volume":"22","author":"Wang","year":"2022","journal-title":"Sensors"},{"key":"10.1016\/j.talanta.2024.126533_bib8","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nbt.2886","article-title":"Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor","volume":"32","author":"Im","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.talanta.2024.126533_bib9","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1039\/C7LC00277G","article-title":"Plasmonic nanohole array biosensor for label-free and real-time analysis of live cell secretion","volume":"17","author":"Li","year":"2017","journal-title":"Lab Chip"},{"key":"10.1016\/j.talanta.2024.126533_bib10","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1126\/science.aas9768","article-title":"Imaging-based molecular barcoding with pixelated dielectric metasurfaces","volume":"360","author":"Tittl","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.talanta.2024.126533_bib11","doi-asserted-by":"crossref","first-page":"12471","DOI":"10.1039\/C9NR00455F","article-title":"Patterned plasmonic gradient for high-precision biosensing using a smartphone reader","volume":"11","author":"Bian","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.talanta.2024.126533_bib12","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41566-019-0394-6","article-title":"Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces","volume":"13","author":"Yesilkoy","year":"2019","journal-title":"Nat. Photonics"},{"key":"10.1016\/j.talanta.2024.126533_bib13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41378-020-00215-0","article-title":"Gradient wettability induced by deterministically patterned nanostructures","volume":"6","author":"Min","year":"2020","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.talanta.2024.126533_bib14","doi-asserted-by":"crossref","first-page":"8194","DOI":"10.1364\/OE.26.008194","article-title":"Wafer-scale nanopatterning using fast-reconfigurable and actively-stabilized two-beam fiber-optic interference lithography","volume":"26","author":"Liang","year":"2018","journal-title":"Opt Express"},{"key":"10.1016\/j.talanta.2024.126533_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202100270","article-title":"Ultrasensitive molecular detection by imaging of centimeter-scale metasurfaces with a deterministic gradient geometry","volume":"33","author":"Min","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.talanta.2024.126533_bib16","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00216-008-2555-1","article-title":"Label-free detection of DNA mutations by SPR: application to the early detection of inherited breast cancer","volume":"393","author":"Carrascosa","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2024.126533_bib17","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.bios.2004.08.040","article-title":"Detection of TP53 mutation using a portable surface plasmon resonance DNA-based biosensor","volume":"20","author":"Jiang","year":"2005","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.126533_bib18","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1007\/s00604-017-2276-2","article-title":"Gold nanoparticle enhanced surface plasmon resonance imaging of microRNA-155 using a functional nucleic acid-based amplification machine","volume":"184","author":"Zeng","year":"2017","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.talanta.2024.126533_bib19","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1021\/ja001215b","article-title":"Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization","volume":"122","author":"He","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2024.126533_bib20","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s00216-011-5318-3","article-title":"Functionalized gold nanoparticles for ultrasensitive DNA detection","volume":"402","author":"Zanoli","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2024.126533_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112599","article-title":"Recent advances in surface plasmon resonance biosensors for microRNAs detection","volume":"169","author":"Jebelli","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.126533_bib22","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.snb.2015.09.152","article-title":"Surface plasmon resonance biosensor for enzyme-free amplified microRNA detection based on gold nanoparticles and DNA supersandwich","volume":"223","author":"Wang","year":"2016","journal-title":"Sensor Actuat B-Chem"},{"key":"10.1016\/j.talanta.2024.126533_bib23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bios.2016.08.090","article-title":"Surface plasmon resonance biosensor for sensitive detection of microRNA and cancer cell using multiple signal amplification strategy","volume":"87","author":"Liu","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.126533_bib24","doi-asserted-by":"crossref","first-page":"9630","DOI":"10.1021\/ac8009559","article-title":"Effect of linker structure on surface density of aptamer monolayers and their corresponding protein binding efficiency","volume":"80","author":"Balamurugan","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126533_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1039\/df9511100055","article-title":"A study of the nucleation and growth processes in the synthesis of colloidal gold","volume":"11","author":"Turkevich","year":"1951","journal-title":"Discuss. Faraday Soc."},{"key":"10.1016\/j.talanta.2024.126533_bib26","doi-asserted-by":"crossref","first-page":"8916","DOI":"10.1021\/ja9719586","article-title":"Characterization of DNA probes immobilized on gold surfaces","volume":"119","author":"Herne","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2024.126533_bib27","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1021\/acsnano.0c02439","article-title":"Dual-Functional plasmonic photothermal biosensors for highly accurate severe acute respiratory syndrome coronavirus 2 detection","volume":"14","author":"Qiu","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2024.126533_bib28","first-page":"885","article-title":"The preparation of gold nanoparticles and evaluation of their immunological function effects on rats","volume":"24","author":"Wang","year":"2014","journal-title":"Bio Med. Mater. Eng."},{"key":"10.1016\/j.talanta.2024.126533_bib29","doi-asserted-by":"crossref","first-page":"7536","DOI":"10.1021\/acsnano.1c00957","article-title":"Thermoplasmonic-assisted cyclic cleavage amplification for self-validating plasmonic detection of SARS-CoV-2","volume":"15","author":"Qiu","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2024.126533_bib30","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.bios.2008.02.004","article-title":"Femtomol SPR detection of DNA\u2013PNA hybridization with the assistance of DNA-guided polyaniline deposition","volume":"23","author":"Su","year":"2008","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.126533_bib31","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1021\/ac3036316","article-title":"Approach for plasmonic based DNA sensing: amplification of the wavelength shift and simultaneous detection of the plasmon modes of gold nanostructures","volume":"85","author":"Spadavecchia","year":"2013","journal-title":"Anal. Chem."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024009123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024009123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:12:09Z","timestamp":1728432729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914024009123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":31,"alternative-id":["S0039914024009123"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2024.126533","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gradient nanoplasmonic imaging metasurface for rapid and label-free detection of SARS-CoV-2 sequences","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2024.126533","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126533"}}