{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:48:11Z","timestamp":1790477291016,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014440","name":"Spain Ministry of Science and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.talanta.2024.126566","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T10:15:51Z","timestamp":1720952151000},"page":"126566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Portable point-of-care surface enhanced Raman scattering spectroscopy for the quantification of glutathione in whole blood microsamples"],"prefix":"10.1016","volume":"279","author":[{"given":"Abel","family":"Albiach-Delgado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Moreno-Casillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Ettabaa-Bahji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4883-7948","authenticated-orcid":false,"given":"Isabel","family":"Ten-Dom\u00e9nech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari Merce","family":"Cascant-Vilaplana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-4742","authenticated-orcid":false,"given":"M\u00e1ximo","family":"Vento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4240-9846","authenticated-orcid":false,"given":"Guillermo","family":"Quint\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-2235","authenticated-orcid":false,"given":"Julia","family":"Kuligowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2024.126566_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.talanta.2024.126566_bib2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s12013-011-9320-3","article-title":"Quantitative redox biology: an approach to understand the role of reactive species in defining the cellular redox environment","volume":"67","author":"Buettner","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.talanta.2024.126566_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.talanta.2024.126566_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.siny.2010.04.001","article-title":"Maturation of the antioxidant system and the effects on preterm birth","volume":"15","author":"Davis","year":"2010","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.talanta.2024.126566_bib5","article-title":"Oxygen supplementation to stabilize preterm infants in the fetal to neonatal transition: No satisfactory answer","volume":"4","author":"Vento","year":"2016","journal-title":"Frontiers in Pediatrics"},{"key":"10.1016\/j.talanta.2024.126566_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212504","article-title":"Oxidative stress and respiratory diseases in preterm newborns","volume":"22","author":"Cannav\u00f2","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.talanta.2024.126566_bib7","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-1165","article-title":"Persistent pulmonary hypertension of the newborn in late preterm and term infants in California","volume":"139","author":"Steurer","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.talanta.2024.126566_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.siny.2022.101347","article-title":"Pulmonary hypertension and oxidative stress: where is the link?","volume":"27","author":"Rawat","year":"2022","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.talanta.2024.126566_bib9","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.freeradbiomed.2017.08.008","article-title":"Assessment of glutathione\/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells","volume":"112","author":"Giustarini","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.talanta.2024.126566_bib10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jpba.2016.02.007","article-title":"Development of a reliable method based on ultra-performance liquid chromatography coupled to tandem mass spectrometry to measure thiol-associated oxidative stress in whole blood samples","volume":"123","author":"Escobar","year":"2016","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.talanta.2024.126566_bib11","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3390\/antiox11061165","article-title":"Direct derivatization in dried blood spots for oxidized and reduced glutathione quantification in newborns","volume":"11","author":"Ten-Dom\u00e9nech","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.talanta.2024.126566_bib12","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1039\/C5AN01865J","article-title":"Surface enhanced Raman spectroscopic direct determination of low molecular weight biothiols in umbilical cord whole blood","volume":"141","author":"Kuligowski","year":"2016","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2024.126566_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchromb.2016.02.015","article-title":"Pitfalls in the analysis of the physiological antioxidant glutathione (GSH) and its disulfide (GSSG) in biological samples: an elephant in the room","volume":"1019","author":"Giustarini","year":"2016","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.talanta.2024.126566_bib14","series-title":"Metabolic Reprogramming: Methods and Protocols","first-page":"133","article-title":"Quantitation of glutathione and oxidized glutathione ratios from biological matrices using LC-MS\/MS","author":"Mathews","year":"2023"},{"key":"10.1016\/j.talanta.2024.126566_bib15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpba.2012.08.013","article-title":"Direct glutathione quantification in human blood by LC\u2013MS\/MS: comparison with HPLC with electrochemical detection","volume":"71","author":"Squellerio","year":"2012","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.talanta.2024.126566_bib16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bios.2015.09.033","article-title":"Sensitive and selective determination of GSH based on the ECL quenching of Ru(II) 1,10-phenanthroline-5,6-dione complex","volume":"77","author":"Xu","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.126566_bib17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.bbrc.2021.04.016","article-title":"Determination of glutathione-binding to proteins by fluorescence spectroscopy","volume":"557","author":"Duysak","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.talanta.2024.126566_bib18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/elsc.201100056","article-title":"Bioanalytical application of surface- and tip-enhanced Raman spectroscopy: bioanalytical application of SERS and TERS","volume":"12","author":"Pahlow","year":"2012","journal-title":"Eng. Life Sci."},{"key":"10.1016\/j.talanta.2024.126566_bib19","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1080\/10408347.2022.2036941","article-title":"Raman, infrared and brillouin spectroscopies of biofluids for medical diagnostics and for detection of biomarkers","volume":"53","author":"Aitekenov","year":"2023","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126566_bib20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jpba.2016.12.020","article-title":"Quantitative determinations using portable Raman spectroscopy","volume":"136","author":"Navin","year":"2017","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.talanta.2024.126566_bib21","doi-asserted-by":"crossref","first-page":"14554","DOI":"10.3390\/ijms160714554","article-title":"Advances in the in vivo Raman spectroscopy of malignant skin tumors using portable instrumentation","volume":"16","author":"Kourkoumelis","year":"2015","journal-title":"IJMS"},{"key":"10.1016\/j.talanta.2024.126566_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/acsnano.9b04224","article-title":"Present and future of surface-enhanced Raman scattering","volume":"14","author":"Langer","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2024.126566_bib23","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.7150\/thno.66859","article-title":"SERS tags for biomedical detection and bioimaging","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.talanta.2024.126566_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.112064","article-title":"SERS liquid biopsy: an emerging tool for medical diagnosis","volume":"208","author":"Moisoiu","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.talanta.2024.126566_bib25","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/jrs.1304","article-title":"Analysis of glutathione and immunoglobulin G inside chromatographic beads using surface-enhanced Raman scattering spectroscopy","volume":"36","author":"Larsson","year":"2005","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.talanta.2024.126566_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsusc.2020.148381","article-title":"Highly reproducible SERS sensor based on self-assembled Au nanocubic monolayer film for sensitive and quantitative detection of glutathione","volume":"540","author":"Li","year":"2021","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.talanta.2024.126566_bib27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/jrs.6522","article-title":"Development of an electrochemical surface-enhanced Raman spectroscopic biosensor for the direct detection of glutathione","volume":"54","author":"Chotoye","year":"2023","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.talanta.2024.126566_bib28","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1021\/acs.analchem.8b01492","article-title":"On-capillary surface-enhanced Raman spectroscopy: determination of glutathione in whole blood microsamples","volume":"90","author":"S\u00e1nchez-Illana","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.126566_bib29","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1021\/jp027460u","article-title":"A new method for fast preparation of highly surface-enhanced Raman scattering (SERS) active silver colloids at room temperature by reduction of silver nitrate with hydroxylamine hydrochloride","volume":"107","author":"Leopold","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.talanta.2024.126566_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121552","article-title":"Identification of polystyrene nanoplastics using surface enhanced Raman spectroscopy","volume":"221","author":"Zhou","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2024.126566_bib31","doi-asserted-by":"crossref","first-page":"11382","DOI":"10.1364\/OE.18.011382","article-title":"Optimal algorithm for fluorescence suppression of modulated Raman spectroscopy","volume":"18","author":"Mazilu","year":"2010","journal-title":"Opt Express"},{"key":"10.1016\/j.talanta.2024.126566_bib32","first-page":"1134","article-title":"Vibrational spectral studies of solutions at elevated temperatures and pressures","volume":"62","author":"Ratcliffe","year":"1984","journal-title":"VI. Raman studies of perchloric acid, Can. J. Chem."},{"key":"10.1016\/j.talanta.2024.126566_bib33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.molstruc.2012.07.002","article-title":"Investigation of 3D silvernanodendrite@glass as surface-enhanced Raman scattering substrate for the detection of Sildenafil and GSH","volume":"1029","author":"Lv","year":"2012","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.talanta.2024.126566_bib34","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1366\/000370210792973523","article-title":"A study of glutathione molecules adsorbed on silver surfaces under different chemical environments by surface-enhanced Raman scattering in combination with the heat-induced sensing method","volume":"64","author":"Huang","year":"2010","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.talanta.2024.126566_bib35","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00726-022-03144-6","article-title":"Crystalline structures of l-cysteine and l-cystine: a combined theoretical and experimental characterization","volume":"54","author":"Su","year":"2022","journal-title":"Amino Acids"},{"key":"10.1016\/j.talanta.2024.126566_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56517-5","article-title":"Nanostructured silver dendrites for photon-induced Cysteine dimerization","volume":"9","author":"Chang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.talanta.2024.126566_bib37","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.saa.2004.09.012","article-title":"l-Cysteine: neutron spectroscopy, Raman, IR and ab initio study","volume":"61","author":"Pawlukoj\u0107","year":"2005","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2024.126566_bib38","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s11302-017-9578-z","article-title":"Blood purine measurements as a rapid real-time indicator of reversible brain ischaemia","volume":"13","author":"Tian","year":"2017","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.talanta.2024.126566_bib39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.11613\/BM.2011.010","article-title":"Comparison of methods: passing and bablok regression","volume":"21","author":"Bili\u0107-Zulle","year":"2011","journal-title":"Biochem. Med."},{"key":"10.1016\/j.talanta.2024.126566_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.11613\/BM.2015.015","article-title":"Understanding Bland altman analysis","volume":"25","author":"Giavarina","year":"2015","journal-title":"Biochem. Med."},{"key":"10.1016\/j.talanta.2024.126566_bib41","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.freeradbiomed.2013.08.002","article-title":"The concentration of glutathione in human erythrocytes is a heritable trait","volume":"65","author":"van \u2018t Erve","year":"2013","journal-title":"Free Radic. Biol. Med."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024009457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024009457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T22:10:33Z","timestamp":1728511833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914024009457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":41,"alternative-id":["S0039914024009457"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2024.126566","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Portable point-of-care surface enhanced Raman scattering spectroscopy for the quantification of glutathione in whole blood microsamples","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2024.126566","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126566"}}