{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:47:43Z","timestamp":1787161663545,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.talanta.2024.127087","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T12:23:52Z","timestamp":1729513432000},"page":"127087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Endogenous enzyme-activated AND-gate DNA nanomachines for intracellular miRNA detection and cell-selective imaging"],"prefix":"10.1016","volume":"283","author":[{"given":"Jin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoquan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-8368","authenticated-orcid":false,"given":"Fenglei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2024.127087_bib1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev-pathol-012513-104715","article-title":"MicroRNAs in cancer","volume":"9","author":"Di Leva","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.talanta.2024.127087_bib2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"Chen","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.talanta.2024.127087_bib3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ncb0309-228","article-title":"Many roads to maturity: microRNA biogenesis pathways and their regulation","volume":"11","author":"Winter","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.talanta.2024.127087_bib4","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1002\/anie.201911712","article-title":"A smart, autocatalytic, DNAzyme biocircuit for in vivo, amplified, MicroRNA imaging","volume":"59","author":"Wei","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2024.127087_bib5","doi-asserted-by":"crossref","first-page":"9869","DOI":"10.1021\/acs.analchem.1c01856","article-title":"Stimuli-responsive autonomous-motion molecular machine for sensitive simultaneous fluorescence imaging of intracellular MicroRNAs","volume":"93","author":"Xue","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib6","doi-asserted-by":"crossref","first-page":"11777","DOI":"10.1021\/acs.analchem.3c02014","article-title":"Three-dimensional CHA-HCR system using DNA nanospheres for sensitive and rapid imaging of miRNA in live cells and tissues","volume":"95","author":"Mo","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib7","doi-asserted-by":"crossref","first-page":"15025","DOI":"10.1021\/acs.analchem.3c03012","article-title":"Endogenous enzyme-powered DNA nanomotor operating in living cells for microRNA imaging","volume":"95","author":"Li","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib8","doi-asserted-by":"crossref","first-page":"14438","DOI":"10.1002\/anie.202017039","article-title":"Poly-adenine-based spherical nucleic acids for efficient live-cell MicroRNA capture","volume":"60","author":"Jiao","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2024.127087_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/35003155","article-title":"DNA computing on surfaces","volume":"403","author":"Liu","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.talanta.2024.127087_bib10","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1126\/science.7973651","article-title":"Molecular computation of solutions to combinatorial problems","volume":"266","author":"Adleman","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.talanta.2024.127087_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202203341","article-title":"Multiply guaranteed and successively amplified activation of a catalytic DNA machine for highly efficient intracellular imaging of MicroRNA","volume":"18","author":"Yu","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.talanta.2024.127087_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112554","article-title":"Electrochemical biosensor for ultrasensitive exosomal miRNA analysis by cascade primer exchange reaction and MOF@Pt@MOF nanozyme","volume":"168","author":"Li","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127087_bib13","doi-asserted-by":"crossref","first-page":"44054","DOI":"10.1021\/acsami.2c10355","article-title":"Sensitive imaging of cellular RNA via cascaded proximity-induced fluorogenic reactions","volume":"14","author":"Chen","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2024.127087_bib14","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1021\/acs.analchem.0c04483","article-title":"Hierarchical hybridization chain reaction for amplified signal output and cascade DNA logic circuits","volume":"93","author":"Lv","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201901795","article-title":"Active self-assembly of train-shaped DNA nanostructures via catalytic hairpin assembly reactions","volume":"15","author":"Xing","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.talanta.2024.127087_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113783","article-title":"Catalytic hairpin assembled polymeric tetrahedral DNA frameworks for MicroRNA imaging in live cells","volume":"197","author":"Wang","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127087_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202306587","article-title":"Nucleic acid-to-small molecule converter through amplified hairpin DNA circuits","volume":"62","author":"Morihiro","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2024.127087_bib18","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1021\/acs.analchem.0c05444","article-title":"A homogeneous multicomponent nucleic acid enzyme assay for universal nucleic acid detection by single-particle inductively coupled plasma mass spectrometry","volume":"93","author":"Yin","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib19","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1021\/acs.analchem.0c04092","article-title":"Encoding DNA frameworks for amplified multiplexed imaging of intracellular microRNAs","volume":"93","author":"Zhu","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.112976","article-title":"DNAzyme cascade circuits in highly integrated DNA nanomachines for sensitive microRNAs imaging in living cells","volume":"177","author":"Duan","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127087_bib21","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1021\/acs.analchem.8b05920","article-title":"Metastable dumbbell probe-based hybridization chain reaction for sensitive and accurate imaging of intracellular-specific MicroRNAs in situ in living cells","volume":"91","author":"Chen","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib22","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.3390\/cells10071655","article-title":"CRISPR\/Cas13-Based approaches for ultrasensitive and specific detection of microRNAs","volume":"10","author":"Granados-Riveron","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.talanta.2024.127087_bib23","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1021\/acs.analchem.0c05060","article-title":"Rational design of a dual-layered metal-organic framework nanostructure for enhancing the cell imaging of molecular beacons","volume":"93","author":"Gao","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib24","doi-asserted-by":"crossref","first-page":"9458","DOI":"10.1021\/ja047628k","article-title":"DNA logic gates","volume":"126","author":"Okamoto","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2024.127087_bib25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1039\/D0NH00587H","article-title":"Boolean logic gate based on DNA strand displacement for biosensing: current and emerging strategies","volume":"6","author":"Zhao","year":"2021","journal-title":"Nanoscale Horizons"},{"key":"10.1016\/j.talanta.2024.127087_bib26","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1021\/acs.analchem.1c04347","article-title":"Membrane protein and extracellular acid heterogeneity-driven amplified DNA logic gate enables accurate and sensitive identification of cancer cells","volume":"94","author":"Chen","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib27","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.1021\/acs.analchem.3c01080","article-title":"Polymerase-driven logic signal amplification for the detection of small extracellular vesicle surface proteins and the identification of breast cancer","volume":"95","author":"Hu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib28","doi-asserted-by":"crossref","first-page":"8216","DOI":"10.1021\/acs.nanolett.2c02934","article-title":"Size-controllable and self-assembled DNA nanosphere for amplified MicroRNA imaging through ATP-fueled cyclic dissociation","volume":"22","author":"Wang","year":"2022","journal-title":"Nano Lett."},{"key":"10.1016\/j.talanta.2024.127087_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202205191","article-title":"Simulation-assisted localized DNA logical circuits for cancer biomarkers detection and imaging","volume":"18","author":"Kou","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.talanta.2024.127087_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101553","article-title":"Construction of an endogenously activated catalytic DNA circuit for highly robust in vivo microRNA imaging","volume":"45","author":"Shang","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.talanta.2024.127087_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114724","article-title":"A simple and smart AND-gate DNA nanoprobe for correlated enzymes tracking and cell-selective imaging","volume":"217","author":"Zeng","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127087_bib32","doi-asserted-by":"crossref","first-page":"9388","DOI":"10.1021\/acs.analchem.3c01963","article-title":"Enzymatically activated autonomous-motion DNAzyme signal amplification strategy for tumor cell-specific molecular imaging with improved spatial specificity","volume":"95","author":"Wang","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib33","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1021\/jacs.1c11543","article-title":"Noninvasive and spatiotemporal control of DNAzyme-based imaging of metal ions in vivo using high-intensity focused ultrasound","volume":"144","author":"Wang","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2024.127087_bib34","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/hep.22160","article-title":"Identification of metastasis-related microRNAs in hepatocellular carcinoma","volume":"47","author":"Budhu","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.talanta.2024.127087_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143732","article-title":"An \"On-Off\" self-powered biosensor via GOD activated signal transduction for ultrasensitive detection of multiple biomarkers","volume":"468","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2024.127087_bib36","doi-asserted-by":"crossref","first-page":"12059","DOI":"10.1021\/acs.analchem.8b02847","article-title":"DNA octahedron-based fluorescence nanoprobe for dual tumor-related mRNAs detection and imaging","volume":"90","author":"Zhong","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127087_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101130","article-title":"DNA logic circuits for multiple tumor cells identification using intracellular MicroRNA molecular bispecific recognition","volume":"10","author":"Yang","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.talanta.2024.127087_bib38","doi-asserted-by":"crossref","first-page":"12059","DOI":"10.1021\/acsami.1c23227","article-title":"Simultaneous imaging of dual microRNAs in cancer cells through catalytic hairpin assembly on a DNA tetrahedron","volume":"14","author":"Li","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2024.127087_bib39","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41419-020-02952-6","article-title":"A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1\u03b1 and p53 activity in triple-negative breast cancer","volume":"11","author":"Du","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.talanta.2024.127087_bib40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12943-017-0688-6","article-title":"Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-\u03baB signaling pathway","volume":"16","author":"Ren","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.talanta.2024.127087_bib41","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.talanta.2018.02.088","article-title":"Recent biomedical applications of gold nanoparticles: a review","volume":"184","author":"Elahi","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2024.127087_bib42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jconrel.2009.12.006","article-title":"The forthcoming applications of gold nanoparticles in drug and gene delivery systems","volume":"149","author":"Pissuwan","year":"2011","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.talanta.2024.127087_bib43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ctrv.2009.12.006","article-title":"Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer","volume":"36","author":"Abbotts","year":"2010","journal-title":"Cancer Treat Rev."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024014668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024014668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T04:27:27Z","timestamp":1733286447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914024014668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":43,"alternative-id":["S0039914024014668"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2024.127087","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endogenous enzyme-activated AND-gate DNA nanomachines for intracellular miRNA detection and cell-selective imaging","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2024.127087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127087"}}