{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:53:30Z","timestamp":1793843610385,"version":"4.6.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.talanta.2024.127148","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T17:09:06Z","timestamp":1730567346000},"page":"127148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Combining array-assisted SERS microfluidic chips and machine learning algorithms for clinical leukemia phenotyping"],"prefix":"10.1016","volume":"283","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-1951","authenticated-orcid":false,"given":"Kuo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-6009","authenticated-orcid":false,"given":"Zhuyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2024.127148_bib1","article-title":"Association between leukemia incidence and mortality and residential petrochemical exposure: a systematic review and meta-analysis","volume":"145","author":"Boonhat","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.talanta.2024.127148_bib2","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2021-151937","article-title":"CHOP Plus sequential mogamulizumab as first-line therapy for untreated adult T-cell leukemia-lymphoma","volume":"138","author":"Tanimoto","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.talanta.2024.127148_bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1182\/blood.2021012411","article-title":"How I treat high-risk acute myeloid leukemia using preemptive adoptive cellular immunotherapy","volume":"141","author":"Biederst\u00e4dt","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.talanta.2024.127148_bib4","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2020-143281","article-title":"Clinical utility of flow cytometry immunophenotyping in acute lymphoblastic leukemia","volume":"136","author":"Silva","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.talanta.2024.127148_bib5","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.3324\/haematol.2022.281493","article-title":"Measurable residual disease in chronic myeloid leukemia","volume":"107","author":"Branford","year":"2022","journal-title":"Haematologica"},{"key":"10.1016\/j.talanta.2024.127148_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/ajh.27089","article-title":"Reappraisal of mast cell leukemia based on a single institution review of 16 cases: mast cell morphology determines clinical outcome","volume":"99","author":"Pardanani","year":"2024","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.talanta.2024.127148_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3390\/bios12030169","article-title":"Ultra-sensitive, rapid and on-site sensing harmful ingredients used in aquaculture with magnetic fluid SERS","volume":"12","author":"Zhang","year":"2022","journal-title":"Biosensors"},{"key":"10.1016\/j.talanta.2024.127148_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137455","article-title":"A bifunctional core\u2013shell gold@Prussian blue nanozyme enabling dual-readout microfluidic immunoassay of food allergic protein","volume":"434","author":"Zhang","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.talanta.2024.127148_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114167","article-title":"SERS-based CRISPR\/Cas assay on microfluidic paper analytical devices for supersensitive detection of pathogenic bacteria in foods","volume":"207","author":"Zhuang","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127148_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135298","article-title":"In-situ SERS monitoring of membrane receptor PTK7 for assessing cancer cell migration at single-cell level on a microfluidic chip","volume":"404","author":"Liu","year":"2024","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.talanta.2024.127148_bib11","article-title":"Combining multiplex SERS nanovectors and multivariate analysis for in situ profiling of circulating tumor cell phenotype using a microfluidic chip","volume":"14","author":"Zhang","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.talanta.2024.127148_bib12","doi-asserted-by":"crossref","first-page":"14754","DOI":"10.1021\/acs.analchem.0c03375","article-title":"Hierarchical particle-in-quasicavity architecture for ultratrace in situ Raman sensing and its application in real-time monitoring of toxic pollutants","volume":"92","author":"Yu","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127148_bib13","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1039\/D3LC00136A","article-title":"On-chip monitoring of toxic gases: capture and label-free SERS detection with plasmonic mesoporous sorbents","volume":"23","author":"Lafuente","year":"2023","journal-title":"Lab Chip"},{"key":"10.1016\/j.talanta.2024.127148_bib14","doi-asserted-by":"crossref","first-page":"19335","DOI":"10.1021\/acsnano.2c08906","article-title":"A programmable plasmonic gas microsystem for detecting arbitrarily combinated volatile organic compounds (VOCs) with ultrahigh resolution","volume":"16","author":"Yang","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2024.127148_bib15","doi-asserted-by":"crossref","first-page":"59037","DOI":"10.1021\/acsami.3c14176","article-title":"Encapsulation of Caenorhabditis elegans in water-in-water microdroplets to study the worm viability: alternative avenue to manipulate microdroplet environment","volume":"15","author":"Jegatheeswaran","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2024.127148_bib16","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1021\/acs.analchem.1c04827","article-title":"Artificial intelligence-controlled microfluidic device for fluid automation and bubble removal of immunoassay operated by a smartphone","volume":"94","author":"Bhuiyan","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127148_bib17","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1021\/acssensors.2c02808","article-title":"Plasmonic coupling of Au nanoclusters on a flexible MXene\/graphene oxide fiber for ultrasensitive SERS sensing","volume":"8","author":"Liu","year":"2023","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2024.127148_bib18","article-title":"Periodic folded gold nanostructures with a sub-10 nm nanogap for surface-enhanced Raman spectroscopy","author":"Ye","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2024.127148_bib19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s00216-017-0609-y","article-title":"A droplet-based microfluidic chip as a platform for leukemia cell lysate identification using surface-enhanced Raman scattering","volume":"410","author":"Hassoun","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2024.127148_bib20","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1080\/01932691.2015.1052880","article-title":"Transportation and settling distribution of microparticles in low-Reynolds-number Poiseuille flow in microchannel","volume":"37","author":"Razaghi","year":"2016","journal-title":"J. Dispersion Sci. Technol."},{"key":"10.1016\/j.talanta.2024.127148_bib21","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1021\/acsami.9b19358","article-title":"Array-assisted SERS microfluidic chips for highly sensitive and multiplex gas sensing","volume":"12","author":"Yang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2024.127148_bib22","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1021\/acs.analchem.3c04717","article-title":"Aptamer-based multiparameter analysis for molecular profiling of hematological malignancies","volume":"96","author":"Liu","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127148_bib23","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1021\/acs.nanolett.3c05060","article-title":"Accurate cancer screening and prediction of PD-L1-guided immunotherapy efficacy using quantum dot nanosphere self-assembly and machine learning","volume":"24","author":"Zhang","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.talanta.2024.127148_bib24","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1038\/s41467-023-42878-z","article-title":"NIPMAP: niche-phenotype mapping of multiplex histology data by community ecology","volume":"14","author":"El Marrahi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.talanta.2024.127148_bib25","doi-asserted-by":"crossref","first-page":"34706","DOI":"10.1021\/acsami.7b11107","article-title":"Highly efficient capture and electrochemical release of circulating tumor cells by using aptamers modified gold nanowire arrays","volume":"9","author":"Zhai","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2024.127148_bib26","article-title":"Combining multiplex SERS nanovectors and multivariate analysis for in situ profiling of circulating tumor cell phenotype using a microfluidic chip","volume":"14","author":"Zhang","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.talanta.2024.127148_bib27","doi-asserted-by":"crossref","first-page":"11838","DOI":"10.1073\/pnas.0602615103","article-title":"Aptamers evolved from live cells as effective molecular probes for cancer study","volume":"103","author":"Shangguan","year":"2006","journal-title":"Proceedings of The National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.talanta.2024.127148_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/leu.2008.335","article-title":"Molecular recognition of acute myeloid leukemia using aptamers","volume":"23","author":"Sefah","year":"2009","journal-title":"Leukemia"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024015273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024015273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T09:29:27Z","timestamp":1733304567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914024015273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":28,"alternative-id":["S0039914024015273"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2024.127148","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combining array-assisted SERS microfluidic chips and machine learning algorithms for clinical leukemia phenotyping","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2024.127148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127148"}}