{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:05:45Z","timestamp":1789592745717,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014472","name":"Scientific Research Foundation of Hunan Provincial Education Department","doi-asserted-by":"publisher","award":["22A0345"],"award-info":[{"award-number":["22A0345"]}],"id":[{"id":"10.13039\/100014472","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.talanta.2024.127173","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T21:39:59Z","timestamp":1730842799000},"page":"127173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Tunable multi-enzyme activities of platinum nanoclusters for enhanced specificity and sensitivity in biosensing"],"prefix":"10.1016","volume":"283","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruishu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2024.127173_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s40820-021-00717-0","article-title":"Nanozymes in point-of-care diagnosis: an emerging futuristic approach for biosensing","volume":"13","author":"Das","year":"2021","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.talanta.2024.127173_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.102025","article-title":"Bimodal single-atom iron nanozyme biosensor for volatile amine and food freshness detection","volume":"53","author":"Song","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.talanta.2024.127173_bib3","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2116\/analsci.19P004","article-title":"Enhanced mimetic enzyme activity of phosphorylated porphyrin nanocomposite induced by localized surface plasmon resonance for colorimetric assay","volume":"35","author":"Yang","year":"2019","journal-title":"Anal. Sci."},{"key":"10.1016\/j.talanta.2024.127173_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.152656","article-title":"MnO2 nanosheets based catechol oxidase mimics for robust electrochemical sensor: synthesis, mechanism and its application for ultrasensitive and selective detection of dopamine","volume":"493","author":"Zhang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2024.127173_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.148775","article-title":"Mechanism of ferrous ions reversibly inhibiting of oxidase-Like activity of Co3O4 nanowires and its application in horticultural fertilizer analysis","volume":"482","author":"Lin","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2024.127173_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.153606","article-title":"A twin S-scheme CoFe2O4\/VCNDA\/BiVO4 nanozyme for photo-auto-enzyme-coupled catalytic degradation of carbamazepine","volume":"495","author":"Feng","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2024.127173_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101429","article-title":"Piezoelectric enhanced peroxidase-like activity of metal-free sulfur doped graphdiyne nanosheets for efficient water pollutant degradation and bacterial disinfection","volume":"43","author":"Zhang","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.talanta.2024.127173_bib8","article-title":"Bioinspired hierarchical self-assembled nanozyme for efficient antibacterial treatment","volume":"36","author":"Song","year":"2024","journal-title":"Adv. Mater. (Weinheim, Ger.)"},{"key":"10.1016\/j.talanta.2024.127173_bib9","doi-asserted-by":"crossref","first-page":"40241","DOI":"10.1021\/acsami.3c07625","article-title":"Multifunctional gold\u2013silver\u2013carbon quantum dots nano-hybrid composite: advancing antibacterial wound healing and cell proliferation","volume":"15","author":"Wang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2024.127173_bib10","article-title":"Light-controlled regulation of dual-enzyme properties in YbGd-carbon quantum dots nano-hybrid for advanced biosensing","author":"Li","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127173_bib11","doi-asserted-by":"crossref","first-page":"10844","DOI":"10.1021\/acs.analchem.3c01005","article-title":"Research progress in iron-based nanozymes: catalytic mechanisms, classification, and biomedical applications","volume":"95","author":"Fu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127173_bib12","article-title":"Smart nanozymes for cancer therapy: the next frontier in oncology, adv. Health","volume":"12","author":"N","year":"2023","journal-title":"Materials"},{"key":"10.1016\/j.talanta.2024.127173_bib13","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1039\/D4SC01147C","article-title":"A dynamic cascade DNA nanocomplex to synergistically disrupt the pyroptosis checkpoint and relieve tumor hypoxia for efficient pyroptosis cancer therapy","volume":"15","author":"Wang","year":"2024","journal-title":"Chem. Sci."},{"key":"10.1016\/j.talanta.2024.127173_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202211041","article-title":"Nanozymes: definition, activity, and mechanisms","volume":"36","author":"Zandieh","year":"2024","journal-title":"Adv. Mater. (Weinheim, Ger.)"},{"key":"10.1016\/j.talanta.2024.127173_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.216166","article-title":"Oxidase mimicking nanozyme: classification, catalytic mechanisms and sensing applications","volume":"520","author":"Lin","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.talanta.2024.127173_bib16","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1021\/acs.analchem.2c00058","article-title":"Biomimic nanozymes with tunable peroxidase-like activity based on the confinement effect of metal\u2013organic frameworks (MOFs) for biosensing","volume":"94","author":"Zhu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127173_bib17","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1021\/acssuschemeng.1c07907","article-title":"Laser-induced N- and B-codoped graphene nanozymes with intrinsic peroxidase-like activities for bactericidal application","volume":"10","author":"Chen","year":"2022","journal-title":"ACS Sustainable Chem. Eng."},{"key":"10.1016\/j.talanta.2024.127173_bib18","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1007\/s12274-023-5915-4","article-title":"Rapid and sensitive detection of Epstein-Barr virus antibodies in nasopharyngeal carcinoma by chemiluminescence strips based on iron-porphyrin single atom nanozyme","volume":"17","author":"Wang","year":"2024","journal-title":"Nano Res."},{"key":"10.1016\/j.talanta.2024.127173_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126003","article-title":"Iron-driven self-assembly of dopamine into dumbbell-shaped nanozyme for visual and rapid detection of norfloxacin on a smartphone-assisted platform","volume":"274","author":"Ye","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2024.127173_bib20","article-title":"Rapid modification of hemoglobin heme to form enhanced peroxidase-like activity for colorimetric assay","volume":"4","author":"Hua","year":"2020","journal-title":"Biosens. Bioelectron. X"},{"key":"10.1016\/j.talanta.2024.127173_bib21","doi-asserted-by":"crossref","first-page":"18099","DOI":"10.1021\/acs.analchem.2c04767","article-title":"Morphology and enzyme-mimicking activity of copper nanoassemblies regulated by peptide: mechanism, ultrasensitive assaying of trypsin, and screening of trypsin inhibitors","volume":"94","author":"Cai","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127173_bib22","article-title":"Vanadium nitride@carbon nanofiber composite: synthesis, cascade enzyme mimics and its sensitive and selective colorimetric sensing of superoxide anion","volume":"210","author":"Liu","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127173_bib23","article-title":"Atomic-level regulation of cobalt single-atom nanozymes: engineering high-efficiency catalase mimics","volume":"62","author":"Chen","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2024.127173_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303078","article-title":"Transition metal high-entropy nanozyme: multi-site orbital coupling modulated high-efficiency peroxidase mimics","volume":"10","author":"Feng","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.talanta.2024.127173_bib25","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1021\/acs.analchem.5b04089","article-title":"Strategy to fabricate naked-eye readout ultrasensitive plasmonic nanosensor based on enzyme mimetic gold nanoclusters","volume":"88","author":"Zhao","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127173_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114841","article-title":"CeO2@NC nanozyme with robust dephosphorylation ability of phosphotriester: a simple colorimetric assay for rapid and selective detection of paraoxon","volume":"220","author":"Gai","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127173_bib27","doi-asserted-by":"crossref","first-page":"23098","DOI":"10.1021\/acs.jpcc.1c04878","article-title":"Density functional theory mechanistic insight into the peroxidase- and oxidase-like activities of nanoceria","volume":"125","author":"Wang","year":"2021","journal-title":"J. Phys. Chem. C"},{"key":"10.1016\/j.talanta.2024.127173_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126320","article-title":"Mn-based Prussian blue analogues: multifunctional nanozymes for hydrogen peroxide detection and photothermal therapy of tumors","volume":"277","author":"Liu","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2024.127173_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2022.214784","article-title":"Multi-enzyme activity nanozymes for biosensing and disease treatment","volume":"473","author":"Su","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.talanta.2024.127173_bib30","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1021\/jacs.2c13689","article-title":"Multi-enzyme Co-expressed dual-atom nanozymes induce cascade immunogenic ferroptosis via activating interferon-\u03b3 and targeting arachidonic acid metabolism","volume":"145","author":"Liu","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2024.127173_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.128053","article-title":"Hierarchical porous MoS2 particles: excellent multi-enzyme-like activities, mechanism and its sensitive phenol sensing based on inhibition of sulfite oxidase mimics","volume":"425","author":"Cai","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.talanta.2024.127173_bib32","article-title":"Copper sulfide nanoclusters with multi-enzyme-like activities and its application in acid phosphatase sensing based on enzymatic cascade reaction","volume":"233","author":"Zhang","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2024.127173_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112342","article-title":"Facile synthesis of magnetic hierarchical flower-like Co3O4 spheres: mechanism, excellent tetra-enzyme mimics and their colorimetric biosensing applications","volume":"165","author":"Liu","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127173_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.133116","article-title":"Green synthesis of kudzu vine biochar decorated graphene-like MoSe2 with the oxidase-like activity as intelligent nanozyme sensing platform for hesperetin","volume":"289","author":"Rao","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.talanta.2024.127173_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301375","article-title":"pH switchable nanozyme platform for healing skin tumor wound infected with drug-resistant bacteria","volume":"12","author":"Yan","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.talanta.2024.127173_bib36","doi-asserted-by":"crossref","first-page":"10636","DOI":"10.1021\/acs.analchem.2c00804","article-title":"A dopamine-enabled universal assay for catalase and catalase-like nanozymes","volume":"94","author":"Lin","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127173_bib37","article-title":"Photothermal-switched single-atom nanozyme specificity for pretreatment and sensing","volume":"19","author":"Wu","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.talanta.2024.127173_bib38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1021\/acs.nanolett.2c04235","article-title":"High-indexed intermetallic Pt3Sn nanozymes with high activity and specificity for sensitive immunoassay","volume":"23","author":"Tang","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.talanta.2024.127173_bib39","article-title":"Specific and magnetic covalent organic framework confined Os nanoclusterzyme for interference-free and ultrasensitive biosensing","author":"Zhou","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"4","key":"10.1016\/j.talanta.2024.127173_bib43","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1021\/bc00028a006","article-title":"Platinum (II)-adenosine phosphothiorate complexes: kinetics of formation and phosphorus-31 NMR characterization studies","volume":"5","author":"Slavin","year":"1994","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.talanta.2024.127173_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccr.2016.09.017","article-title":"Platinum complexes containing adenine-based ligands: an overview of selected structural features","volume":"332","author":"Pavel","year":"2017","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.talanta.2024.127173_bib45","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1111\/1541-4337.13170","article-title":"Antioxidant potential and factors influencing the content of antioxidant compounds of pepper: a review with current knowledge","volume":"22","author":"Sanatombi","year":"2023","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.talanta.2024.127173_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303817","article-title":"Antioxidant hydrogels: antioxidant mechanisms, design strategies, and applications in the treatment of oxidative stress-related diseases","volume":"13","author":"Hu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.talanta.2024.127173_bib47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jacc.2020.10.048","article-title":"Diet-derived circulating antioxidants and risk of coronary heart disease: a mendelian randomization study","volume":"77","author":"Luo","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.talanta.2024.127173_bib48","doi-asserted-by":"crossref","first-page":"22527","DOI":"10.1021\/acsnano.3c06105","article-title":"Vanadium carbide nanosheets with broad-spectrum antioxidant activity for pulmonary fibrosis therapy","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2024.127173_bib49","article-title":"A self-sustaining antioxidant strategy for effective treatment of myocardial infarction","volume":"10","author":"Sun","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.talanta.2024.127173_bib50","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1111\/1541-4337.12792","article-title":"A comprehensive review on polarity, partitioning, and interactions of phenolic antioxidants at oil\u2013water interface of food emulsions","volume":"20","author":"Farooq","year":"2021","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.talanta.2024.127173_bib51","article-title":"Advancements in metal organic framework-based materials for the detection of antioxidants in food and biological fluids","volume":"17","author":"Kumar","year":"2024","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127173_bib52","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.cclet.2020.12.041","article-title":"Self-assembled all-inclusive organic-inorganic nanoparticles enable cascade reaction for the detection of glucose","volume":"32","author":"Sun","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.talanta.2024.127173_bib53","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1039\/D3AY02121A","article-title":"A platinum glutamate acid complex as a peroxidase mimic: high activity, controllable chemical modification, and application in biosensors","volume":"16","author":"Zhang","year":"2024","journal-title":"Anal. Methods"},{"key":"10.1016\/j.talanta.2024.127173_bib54","article-title":"Single iron site nanozyme for ultrasensitive glucose detection","volume":"16","author":"Chen","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.talanta.2024.127173_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114386","article-title":"Bimetallic nanozyme mediated urine glucose monitoring through discriminant analysis of colorimetric signal","volume":"212","author":"Naveen Prasad","year":"2022","journal-title":"Biosens. Bioelectron."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024015522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024015522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T04:30:18Z","timestamp":1733286618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914024015522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":52,"alternative-id":["S0039914024015522"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2024.127173","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tunable multi-enzyme activities of platinum nanoclusters for enhanced specificity and sensitivity in biosensing","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2024.127173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"127173"}}