{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:31:19Z","timestamp":1792603879174,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173573"],"award-info":[{"award-number":["82173573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.talanta.2024.127348","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T16:45:02Z","timestamp":1733503502000},"page":"127348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["A two-color fluorescence sensing strategy based on functionalized tetrahedral DNAzyme nanotweezers for ochratoxin A detection"],"prefix":"10.1016","volume":"285","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-7077","authenticated-orcid":false,"given":"Yingao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruipeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyue","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"976","key":"10.1016\/j.talanta.2024.127348_bib1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/2051112a0","article-title":"Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh","volume":"205","author":"van der Merwe","year":"1965","journal-title":"Nature"},{"key":"10.1016\/j.talanta.2024.127348_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131978","article-title":"Distribution, toxicity, interactive effects, and detection of ochratoxin and deoxynivalenol in food: a review","volume":"378","author":"Ganesan","year":"2022","journal-title":"Food Chem."},{"issue":"46","key":"10.1016\/j.talanta.2024.127348_bib3","doi-asserted-by":"crossref","first-page":"13974","DOI":"10.1021\/acs.jafc.1c05994","article-title":"Detection, contamination, toxicity, and prevention methods of ochratoxins: an update review","volume":"69","author":"Samuel","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.talanta.2024.127348_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.toxicon.2020.08.031","article-title":"Ochratoxins in food and feed: occurrence and its impact on human health and management strategies","volume":"187","author":"Kumar","year":"2020","journal-title":"Toxicon"},{"key":"10.1016\/j.talanta.2024.127348_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2019.125851","article-title":"Aptamer assisted ultrafiltration cleanup with high performance liquid chromatography-fluorescence detector for the determination of OTA in green coffee","volume":"310","author":"Moez","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.talanta.2024.127348_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.135951","article-title":"Ultra-sensitive determination of Ochratoxin A in coffee and tea samples using a novel semi-automated in-syringe based coagulant-assisted fast mycotoxin extraction (FaMEx) technique coupled with UHPLC-MS\/MS","volume":"417","author":"Prakasham","year":"2023","journal-title":"Food Chem."},{"issue":"20","key":"10.1016\/j.talanta.2024.127348_bib7","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1080\/10408398.2021.1885340","article-title":"Recent progress in determination of ochratoxin a in foods by chromatographic and mass spectrometry methods","volume":"62","author":"Li","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.talanta.2024.127348_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134316","article-title":"A novel method for detection of ochratoxin A in foods-Co-MOFs based dual signal ratiometric electrochemical aptamer sensor coupled with DNA walker","volume":"403","author":"Guan","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.talanta.2024.127348_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.trac.2022.116679","article-title":"DNA sensing technology a useful food scanning tool","volume":"154","author":"Melinte","year":"2022","journal-title":"Trac. Trends Anal. Chem."},{"issue":"22","key":"10.1016\/j.talanta.2024.127348_bib10","doi-asserted-by":"crossref","first-page":"9975","DOI":"10.1021\/jacs.9b13737","article-title":"Ultrafast DNA sensors with DNA framework-bridged hybridization reactions","volume":"142","author":"Li","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2024.127348_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.138312","article-title":"A DNA tetrahedral scaffolds-based electrochemical biosensor for simultaneous detection of AFB1 and OTA","volume":"442","author":"Li","year":"2024","journal-title":"Food Chem."},{"issue":"23","key":"10.1016\/j.talanta.2024.127348_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202207736","article-title":"Closed cyclic DNA machine for sensitive logic operation and APE1 detection","volume":"19","author":"Chai","year":"2023","journal-title":"Small"},{"issue":"31","key":"10.1016\/j.talanta.2024.127348_bib13","doi-asserted-by":"crossref","first-page":"11777","DOI":"10.1021\/acs.analchem.3c02014","article-title":"Three-dimensional CHA-HCR system using DNA nanospheres for sensitive and rapid imaging of miRNA in live cells and tissues","volume":"95","author":"Mo","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2024.127348_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.112982","article-title":"DNA pom-pom nanostructure as a multifunctional platform for pathogenic bacteria determination and inactivation","volume":"177","author":"Zeng","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127348_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114405","article-title":"Janus wireframe DNA cube-based 3D nanomachine for rapid and stable fluorescence detection of exosomal microRNA","volume":"212","author":"Xu","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"4","key":"10.1016\/j.talanta.2024.127348_bib16","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1021\/acsami.0c22062","article-title":"Self-assembled DNA nanoflowers triggered by a DNA walker for highly sensitive electrochemical detection of Staphylococcus aureus","volume":"13","author":"Cai","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"4","key":"10.1016\/j.talanta.2024.127348_bib17","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.copbio.2010.06.001","article-title":"Functional nucleic acid nanostructures and DNA machines","volume":"21","author":"Teller","year":"2010","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.talanta.2024.127348_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115445","article-title":"Application of DNA Nanotweezers in biosensing: nanoarchitectonics and advanced challenges","volume":"237","author":"Zhang","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127348_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.131686","article-title":"Rational engineering the DNA tetrahedrons of dual wavelength ratiometric electrochemiluminescence biosensor for high efficient detection of SARS-CoV-2 RdRp gene by using entropy-driven and bipedal DNA walker amplification strategy","volume":"427","author":"Fan","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"6","key":"10.1016\/j.talanta.2024.127348_bib20","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1021\/acs.analchem.3c05210","article-title":"DNA robots for CRISPR\/Cas12a activity management and universal platforms for biosensing","volume":"96","author":"Xia","year":"2024","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.talanta.2024.127348_bib21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nnano.2009.83","article-title":"A DNA nanomachine that maps spatial and temporal pH changes inside living cells","volume":"4","author":"Modi","year":"2009","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"10.1016\/j.talanta.2024.127348_bib22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1021\/nl104088s","article-title":"DNA machines: bipedal walker and stepper","volume":"11","author":"Wang","year":"2011","journal-title":"Nano Lett."},{"issue":"7","key":"10.1016\/j.talanta.2024.127348_bib23","doi-asserted-by":"crossref","first-page":"9021","DOI":"10.1021\/acsnano.0c04031","article-title":"DNA tetrahedra modules as versatile optical sensing platforms for multiplexed analysis of mirnas, endonucleases, and aptamer-ligand complexes","volume":"14","author":"Zhou","year":"2020","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.talanta.2024.127348_bib24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41557-019-0369-8","article-title":"Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition","volume":"12","author":"Kwon","year":"2020","journal-title":"Nat. Chem."},{"issue":"6070","key":"10.1016\/j.talanta.2024.127348_bib25","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1126\/science.1214081","article-title":"A logic-gated nanorobot for targeted transport of molecular payloads","volume":"335","author":"Douglas","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.talanta.2024.127348_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114423","article-title":"Recent advance of RNA aptamers and DNAzymes for MicroRNA detection","volume":"212","author":"Wang","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127348_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128303","article-title":"A competitive fluorescence assay based on free-complementary DNA for ochratoxin A detection","volume":"342","author":"Hitabatuma","year":"2021","journal-title":"Food Chem."},{"issue":"2","key":"10.1016\/j.talanta.2024.127348_bib28","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1111\/1541-4337.12858","article-title":"Aptasensors for mycotoxins in foods: recent advances and future trends","volume":"21","author":"Hou","year":"2022","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"10","key":"10.1016\/j.talanta.2024.127348_bib29","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1093\/nar\/gkae295","article-title":"Multivalent DNAzyme agents for cleaving folded RNA","volume":"52","author":"Dubovichenko","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"Pt A","key":"10.1016\/j.talanta.2024.127348_bib30","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.ijbiomac.2022.11.084","article-title":"Protein-free, ultrasensitive miRNA analysis based on an entropy-driven catalytic reaction switched on a smart-responsive DNAzyme dual-walker amplification strategy","volume":"223","author":"Fan","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"10.1016\/j.talanta.2024.127348_bib31","doi-asserted-by":"crossref","first-page":"13943","DOI":"10.1021\/acsnano.1c04327","article-title":"DNAzyme-based biosensors: immobilization strategies, applications, and future prospective","volume":"15","author":"Khan","year":"2021","journal-title":"ACS Nano"},{"issue":"16","key":"10.1016\/j.talanta.2024.127348_bib32","doi-asserted-by":"crossref","first-page":"8954","DOI":"10.1039\/D1CS00240F","article-title":"Biosensing with DNAzymes","volume":"50","author":"McConnell","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2024.127348_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134144","article-title":"Robust and facile label-free colorimetric aptasensor for ochratoxin A detection using aptamer-enhanced oxidase-like activity of MnO(2) nanoflowers","volume":"401","author":"Lv","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.talanta.2024.127348_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121758","article-title":"Colorimetric aptasensor for ochratoxin A detection based on enzyme-induced gold nanoparticle aggregation","volume":"388","author":"He","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.talanta.2024.127348_bib35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.foodchem.2022.134007","article-title":"Taking glucose as intermediate bridge-signal-molecule for on-site and convenient detection of ochratoxin A in rice with portable glucose meter","volume":"400","author":"Zhang","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.talanta.2024.127348_bib36","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bios.2020.112654","article-title":"Hairpin DNA assisted dual-ratiometric electrochemical aptasensor with high reliability and anti-interference ability for simultaneous detection of aflatoxin B1 and ochratoxin A","volume":"174","author":"Zhu","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127348_bib37","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jelechem.2021.115269","article-title":"An amplified electrochemical aptasensor for ochratoxin A based on DNAzyme-mediated DNA walker","volume":"891","author":"Wei","year":"2021","journal-title":"J. Electroanal. Chem."},{"issue":"8","key":"10.1016\/j.talanta.2024.127348_bib38","first-page":"15","article-title":"The electrochemical detection of ochratoxin A in apple juice via MnCO3 nanostructures incorporated into carbon fibers containing a molecularly imprinting polymer","volume":"13","author":"Kaya","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2024.127348_bib39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.foodchem.2020.128122","article-title":"Simultaneous detection of aflatoxin B1 and ochratoxin A in food samples by dual DNA tweezers nanomachine","volume":"338","author":"Xiong","year":"2021","journal-title":"Food Chem."},{"issue":"10","key":"10.1016\/j.talanta.2024.127348_bib40","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1039\/C9AN00316A","article-title":"Primer remodeling amplification-activated multisite-catalytic hairpin assembly enabling the concurrent formation of Y-shaped DNA nanotorches for the fluorescence assay of ochratoxin A","volume":"144","author":"Wang","year":"2019","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2024.127348_bib41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.aca.2023.341503","article-title":"A G-triplex and G-quadruplex concatemer-enhanced fluorescence probe coupled with hybridization chain reaction for ultrasensitive aptasensing of ochratoxin A","volume":"1272","author":"Wen","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2024.127348_bib42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.aca.2019.08.057","article-title":"Detachable nanoladders: a new method for signal identification and their application in the detection of ochratoxin A (OTA)","volume":"1087","author":"Shao","year":"2019","journal-title":"Anal. Chim. Acta"},{"issue":"26","key":"10.1016\/j.talanta.2024.127348_bib43","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1007\/s00216-021-03635-7","article-title":"Magnetic beads-assisted fluorescence aptasensing approach based on dual DNA tweezers for detection of ochratoxin A and fumonisin B1 in wine and corn","volume":"413","author":"Qu","year":"2021","journal-title":"Anal. Bioanal. Chem."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024017302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914024017302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T05:38:44Z","timestamp":1737005924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914024017302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":43,"alternative-id":["S0039914024017302"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2024.127348","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A two-color fluorescence sensing strategy based on functionalized tetrahedral DNAzyme nanotweezers for ochratoxin A detection","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2024.127348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"127348"}}