{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:33:57Z","timestamp":1786480437755,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M761885"],"award-info":[{"award-number":["2024M761885"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404820"],"award-info":[{"award-number":["82404820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.talanta.2025.128948","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T03:00:04Z","timestamp":1759460404000},"page":"128948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Competitive ultrafiltration: A ligand-displacement strategy for rapid discovery of high-quality neuraminidase inhibitors from natural product mixtures"],"prefix":"10.1016","volume":"298","author":[{"given":"Menghan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.talanta.2025.128948_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.talanta.2025.128948_bib2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"10152","key":"10.1016\/j.talanta.2025.128948_bib3","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0140-6736(18)31924-X","article-title":"Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial","volume":"392","author":"Gaziano","year":"2018","journal-title":"Lancet"},{"issue":"35","key":"10.1016\/j.talanta.2025.128948_bib4","doi-asserted-by":"crossref","first-page":"10210","DOI":"10.1002\/anie.201601967","article-title":"Artemisinin-A gift from traditional Chinese medicine to the world (Nobel lecture)","volume":"55","author":"Tu","year":"2016","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.talanta.2025.128948_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104770","article-title":"Bioactivity-guided isolation of anti-inflammatory constituents from the bark of Streblus zeylanicus","volume":"147","author":"Zhou","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.talanta.2025.128948_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114079","article-title":"Bioactivity-guided isolation of immunomodulatory compounds from the fruits of Ligustrum lucidum","volume":"274","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.talanta.2025.128948_bib7","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1039\/D1FO04095B","article-title":"Bioactivity-guided isolation of the major anthocyanin from Lycium ruthenicum Murr. fruit and its antioxidant activity and neuroprotective effects in vitro and in vivo","volume":"13","author":"Chen","year":"2022","journal-title":"Food Funct."},{"issue":"12","key":"10.1016\/j.talanta.2025.128948_bib8","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1039\/D2NP00035K","article-title":"Artificial intelligence in microbial natural product drug discovery: current and emerging role","volume":"39","author":"Sahayasheela","year":"2022","journal-title":"Nat. Prod. Rep."},{"issue":"11","key":"10.1016\/j.talanta.2025.128948_bib9","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41573-023-00774-7","article-title":"Artificial intelligence for natural product drug discovery","volume":"22","author":"Mullowney","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.talanta.2025.128948_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463338","article-title":"An affinity interaction guided two-dimensional separation system for the screening of neuraminidase inhibitors from Reynoutria japonica Houtt. roots","volume":"1678","author":"Chen","year":"2022","journal-title":"J. Chromatogr. A"},{"issue":"10","key":"10.1016\/j.talanta.2025.128948_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202200937","article-title":"Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking","volume":"46","author":"Wang","year":"2023","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.talanta.2025.128948_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126750","article-title":"Pancreatic lipase immobilization on cellulose filter paper for inhibitors screening and network pharmacology study of anti-obesity mechanism","volume":"280","author":"Chen","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2025.128948_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125583","article-title":"A magnetic beads-based ligand fishing method coupled with UHPLC-QTOF MS for screening and identification of alpha-glucosidase inhibitors from Houttuynia cordata Thunb","volume":"270","author":"Zhu","year":"2024","journal-title":"Talanta"},{"issue":"2","key":"10.1016\/j.talanta.2025.128948_bib14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"16","key":"10.1016\/j.talanta.2025.128948_bib15","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.talanta.2025.128948_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1","author":"Abraham M J","year":"2015","journal-title":"SoftwareX"},{"issue":"1","key":"10.1016\/j.talanta.2025.128948_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1039\/C1NP00053E","article-title":"Influenza neuraminidase: a druggable target for natural products","volume":"29","author":"Grienke","year":"2012","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.talanta.2025.128948_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2025.106764","article-title":"Lonicera japonica Thunb. in acute lung injury: a systematic review of bioactive components and multi-target mechanisms","volume":"185","author":"Cao","year":"2025","journal-title":"Fitoterapia"},{"issue":"Pt B","key":"10.1016\/j.talanta.2025.128948_bib19","article-title":"Bio-affinity ultra-filtration combined with HPLC-ESI-qTOF-MS\/MS for screening potential alpha-glucosidase inhibitors from Cerasus humilis (Bge.) Sok. Leaf-tea and in silico analysis","volume":"373","author":"Li","year":"2022","journal-title":"Food Chem."},{"issue":"2","key":"10.1016\/j.talanta.2025.128948_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13020186","article-title":"Metabolomics analysis of different tissues of Lonicera japonica thunb. Based on liquid chromatography with mass spectrometry","volume":"13","author":"Wang","year":"2023","journal-title":"Metabolites"},{"issue":"3","key":"10.1016\/j.talanta.2025.128948_bib21","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1021\/bi0205449","article-title":"Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series","volume":"42","author":"Stoll","year":"2003","journal-title":"Biochemistry"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914025014390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914025014390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:20:18Z","timestamp":1786479618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914025014390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":21,"alternative-id":["S0039914025014390"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2025.128948","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Competitive ultrafiltration: A ligand-displacement strategy for rapid discovery of high-quality neuraminidase inhibitors from natural product mixtures","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2025.128948","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"128948"}}