{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:08:31Z","timestamp":1773810511824,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011290","name":"State Key Laboratory of Precision Measurement Technology and Instruments","doi-asserted-by":"publisher","award":["PILAB2407"],"award-info":[{"award-number":["PILAB2407"]}],"id":[{"id":"10.13039\/501100011290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004517","name":"Tianjin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004517","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFB3203700"],"award-info":[{"award-number":["2022YFB3203700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.talanta.2025.129122","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T20:11:45Z","timestamp":1763669505000},"page":"129122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A highly sensitive and regenerable electrochemical immunosensor chip for blood adiponectin detection"],"prefix":"10.1016","volume":"299","author":[{"given":"Chunjie","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiale","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengtao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3297-6182","authenticated-orcid":false,"given":"Haixia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dachao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10267","key":"10.1016\/j.talanta.2025.129122_bib1","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(20)32374-6","article-title":"The lancet commission on diabetes: using data to transform diabetes care and patient lives","volume":"396","author":"Chan","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.talanta.2025.129122_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"6","key":"10.1016\/j.talanta.2025.129122_bib3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s11606-019-04832-y","article-title":"The role of health literacy in diabetes knowledge, self-care, and glycemic control: a meta-analysis","volume":"34","author":"Marciano","year":"2019","journal-title":"J. Gen. Intern. Med."},{"issue":"1","key":"10.1016\/j.talanta.2025.129122_bib4","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2015-000093","article-title":"Clinical characteristics, complications, comorbidities and treatment patterns among patients with type 2 diabetes mellitus in a large integrated health system","volume":"3","author":"Pantalone","year":"2015","journal-title":"BMJ Open Diabete Res. Care"},{"issue":"2","key":"10.1016\/j.talanta.2025.129122_bib5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.talanta.2025.129122_bib6","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2337\/dc18-1970","article-title":"Long-term effects of metformin on diabetes prevention: identification of subgroups that benefited most in the diabetes prevention program and diabetes prevention program outcomes study","volume":"42","year":"2019","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.talanta.2025.129122_bib7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S2213-8587(19)30093-2","article-title":"Morbidity and mortality after lifestyle intervention for people with impaired glucose tolerance: 30-year results of the Da Qing Diabetes Prevention Outcome Study","volume":"7","author":"Gong","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"2","key":"10.1016\/j.talanta.2025.129122_bib8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s00125-012-2752-5","article-title":"Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish diabetes prevention study (DPS)","volume":"56","author":"Lindstr\u00f6m","year":"2013","journal-title":"Diabetologia"},{"issue":"12","key":"10.1016\/j.talanta.2025.129122_bib9","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.2337\/diacare.26.12.3230","article-title":"The Finnish diabetes prevention study (DPS): Lifestyle intervention and 3-year results on diet and physical activity","volume":"26","author":"Lindstrom","year":"2003","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.talanta.2025.129122_bib10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S2213-8587(18)30234-1","article-title":"Successful treatment of prediabetes in clinical practice using physiological assessment (STOP DIABETES)","volume":"6","author":"Armato","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.talanta.2025.129122_bib11","first-page":"1031","article-title":"Adiponectin regulation and function[M]","author":"Fang","year":"2018","journal-title":"Compr. Physiol."},{"issue":"3","key":"10.1016\/j.talanta.2025.129122_bib12","first-page":"170","article-title":"Variation of adiponectin levels in normal and obese subjects: possible correlation with lipid profiles","volume":"7","author":"Mamaghani","year":"2009","journal-title":"Int. J. Endocrinol. Metabol."},{"issue":"9326","key":"10.1016\/j.talanta.2025.129122_bib13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0140-6736(02)09335-2","article-title":"Adiponectin and development of type 2 diabetes in the pima Indian population","volume":"360","author":"Lindsay","year":"2002","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.talanta.2025.129122_bib14","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1055\/s-0029-1216359","article-title":"Low serum adiponectin predicts 10-year risk of type 2 diabetes and HbA1c independently of obesity, lipids, and inflammation: whitehall II study","volume":"41","author":"Tab\u00e1k","year":"2009","journal-title":"Horm. Metab. Res."},{"issue":"9","key":"10.1016\/j.talanta.2025.129122_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jid.2013.287","article-title":"Enzyme immunoassay and enzyme-linked immunosorbent assay","volume":"133","author":"Gan","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"12","key":"10.1016\/j.talanta.2025.129122_bib16","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.4088\/JCP.14m09587","article-title":"Association of obesity and inflammatory marker levels on treatment outcome: results from a double-blind, randomized study of adjunctive L-methylfolate calcium in patients with MDD who are inadequate responders to SSRIs","volume":"76","author":"Shelton","year":"2015","journal-title":"J. Clin. Psychiatr."},{"issue":"2","key":"10.1016\/j.talanta.2025.129122_bib17","article-title":"Dietary quality score is positively associated with serum adiponectin level in Indonesian preschool-age children living in the urban area of Jakarta","volume":"16","author":"Hayuningtyas","year":"2021","journal-title":"Public Library Sci. ONE"},{"issue":"13","key":"10.1016\/j.talanta.2025.129122_bib18","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1021\/acs.analchem.6b01063","article-title":"Ultrasensitive detection of low-abundance protein biomarkers by mass spectrometry signal amplification assay","volume":"88","author":"Du","year":"2016","journal-title":"Anal. Chem."},{"issue":"14","key":"10.1016\/j.talanta.2025.129122_bib19","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1039\/C9AN00112C","article-title":"Insulin: a review of analytical methods","volume":"144","author":"Shen","year":"2019","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2025.129122_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2021.462000","article-title":"Preparation and characterization of cyclic citrullinated peptide-immobilized latex beads for measurement of anti-citrillinated protein antibody through latex particle-enhanced turbidimetric immunoassay","volume":"1642","author":"Deng","year":"2021","journal-title":"J. Chromatogr. A"},{"issue":"6","key":"10.1016\/j.talanta.2025.129122_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5358","article-title":"Development, validation and application of a UHPLC MS\/MS method for quantification of the Adiponectin-derived active peptide ADP355 in rat plasma","volume":"36","author":"Li","year":"2022","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.talanta.2025.129122_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131356","article-title":"Sensitive analytical detection of nitrite using an electrochemical sensor with STAB-functionalized Nb2C@MWCNTs for signal amplification","volume":"372","author":"Chen","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.talanta.2025.129122_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2021.107133","article-title":"A facile electrochemical chiral sensor for tryptophan enantiomers based on multiwalled carbon nanotube\/hydroxypropyl-\u03b2-cyclodextrin functionalized carboxymethyl cellulose","volume":"175","author":"Ji","year":"2022","journal-title":"Microchem. J."},{"issue":"19","key":"10.1016\/j.talanta.2025.129122_bib24","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.1039\/D3AN01221B","article-title":"A bimetallic metal-organic framework with high enzyme-mimicking activity for an integrated electrochemical immunoassay of carcinoembryonic antigen","volume":"148","author":"Shu","year":"2023","journal-title":"Analyst"},{"issue":"15","key":"10.1016\/j.talanta.2025.129122_bib25","article-title":"Paper-based electrochemical immunosensor device via Ni-Co MOF nanosheet as a peroxidase mimic for the label-free detection of alpha-fetoprotein","volume":"373","author":"Shu","year":"2022","journal-title":"Sensor. Actuator. B Chem."},{"issue":"1","key":"10.1016\/j.talanta.2025.129122_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1452-3981(23)13316-5","article-title":"Voltammetry of adiponectin and its interactions with collagen on a carbon paste electrode at femtogram level","volume":"7","author":"Sobrova","year":"2012","journal-title":"Int. J. Electrochem. Sci."},{"key":"10.1016\/j.talanta.2025.129122_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.129051","article-title":"A high sensitive and cost-effective disposable biosensor for adiponectin determination in real human serum samples","volume":"328","author":"\u0130nce","year":"2021","journal-title":"Sensor. Actuator. B Chem."},{"issue":"8","key":"10.1016\/j.talanta.2025.129122_bib28","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1021\/acsbiomaterials.1c00094","article-title":"Highly sensitive and single-use biosensing system based on a GP electrode for analysis of adiponectin, an obesity biomarker","volume":"7","author":"\u00d6zcan","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"12","key":"10.1016\/j.talanta.2025.129122_bib29","doi-asserted-by":"crossref","first-page":"20922","DOI":"10.1021\/acsnano.2c08511","article-title":"A wireless, regeneratable cocaine sensing scheme enabled by allosteric regulation of pH sensitive aptamers","volume":"16","author":"Chen","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2025.129122_bib30","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.snb.2013.09.040","article-title":"A regenerable screen-printed DNA biosensor based on acrylic microsphere-gold nanoparticle composite for genetically modified soybean determination","volume":"190","author":"Ulianas","year":"2014","journal-title":"Sensor. Actuator. B Chem."},{"issue":"11","key":"10.1016\/j.talanta.2025.129122_bib31","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41551-022-00916-z","article-title":"A wearable electrochemical biosensor for the monitoring of metabolites and nutrients","volume":"6","author":"Wang","year":"2022","journal-title":"Nat. Biomed. Eng."},{"issue":"8","key":"10.1016\/j.talanta.2025.129122_bib32","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1021\/acs.analchem.7b05442","article-title":"Photoinduced regeneration of an aptamer-based electrochemical sensor for sensitively detecting adenosine triphosphate","volume":"90","author":"Zhang","year":"2018","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2025.129122_bib33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.snb.2010.05.047","article-title":"A reusable DNA biosensor for the detection of genetically modified organism using magnetic bead-based electrochemiluminescence","volume":"149","author":"Zhu","year":"2010","journal-title":"Sensor. Actuator. B Chem."},{"issue":"11","key":"10.1016\/j.talanta.2025.129122_bib34","article-title":"Electrochemical immunosensor based on gold nanoparticles for the detection of creatine kinase as a cardiac marker","volume":"19","author":"Zhang","year":"2024","journal-title":"Int. J. Electrochem. Sci."},{"key":"10.1016\/j.talanta.2025.129122_bib35","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1039\/D3RA08586D","article-title":"Sensitive electrochemical gold nanoparticle-based immunosensor for norovirus detection in food samples","volume":"14","author":"Janicka","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.talanta.2025.129122_bib36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bios.2014.12.032","article-title":"A regenerating ultrasensitive electrochemical impedance immunosensor for the detection of adenovirus","volume":"68","author":"Lin","year":"2015","journal-title":"Biosens. Bioelectron."},{"issue":"4","key":"10.1016\/j.talanta.2025.129122_bib37","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.bios.2004.03.027","article-title":"Regeneration of ethyl parathion antibodies for repeated use in immunosensor: a study on dissociation of antigens from antibodies","volume":"20","author":"Kandimalla","year":"2004","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2025.129122_bib38","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1039\/D3NR05456J","article-title":"Recent progress in biosensor regeneration techniques","volume":"16","author":"Jia","year":"2024","journal-title":"Nanoscale"},{"issue":"12","key":"10.1016\/j.talanta.2025.129122_bib39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0956-5663(03)00173-8","article-title":"Antibody immobilisation on fibre optic TIRF sensors","volume":"19","author":"Tedeschi","year":"2003","journal-title":"Biosens. Bioelectron."},{"issue":"12","key":"10.1016\/j.talanta.2025.129122_bib40","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1373\/clinchem.2007.090670","article-title":"Analytical validation and biological evaluation of a high molecular-weight adiponectin ELISA","volume":"53","author":"Sinha","year":"2007","journal-title":"Clin. Chem."},{"key":"10.1016\/j.talanta.2025.129122_bib41","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.snb.2015.09.055","article-title":"An electrochemical immunosensor for adiponectin using reduced graphene oxide-carboxymethylcellulose hybrid as electrode scaffold","volume":"223","author":"Arenas","year":"2016","journal-title":"Sensor. Actuator. B Chem."},{"issue":"6","key":"10.1016\/j.talanta.2025.129122_bib42","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/celc.201600099","article-title":"Transmembrane protein-based electrochemical biosensor for adiponectin hormone quantification","volume":"3","author":"Brazaca","year":"2016","journal-title":"Chemelectrochem"},{"key":"10.1016\/j.talanta.2025.129122_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2019.120643","article-title":"Platform with biomimetic electrochemical sensors for adiponectin and leptin detection in human serum","volume":"210","author":"Mihailescu","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2025.129122_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fmats.2020.583739","article-title":"Materials and methods of biosensor interfaces with stability","volume":"7","author":"Song","year":"2021","journal-title":"Front. Mater."},{"key":"10.1016\/j.talanta.2025.129122_bib45","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10008-021-05081-y","article-title":"Label-free PSA electrochemical determination by seed-mediated electrochemically-deposited gold nanoparticles on an FTO electrode","volume":"26","author":"Sajadpour","year":"2022","journal-title":"J. Solid State Electrochem."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914025016133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914025016133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:10:47Z","timestamp":1773807047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914025016133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":45,"alternative-id":["S0039914025016133"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2025.129122","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A highly sensitive and regenerable electrochemical immunosensor chip for blood adiponectin detection","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2025.129122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129122"}}