{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:01:07Z","timestamp":1781254867438,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018554","name":"Science and Technology Program of Gansu Province","doi-asserted-by":"publisher","award":["24JRRA049"],"award-info":[{"award-number":["24JRRA049"]}],"id":[{"id":"10.13039\/501100018554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018531","name":"Major Science and Technology Projects in Yunnan Province","doi-asserted-by":"publisher","award":["202302AE090007"],"award-info":[{"award-number":["202302AE090007"]}],"id":[{"id":"10.13039\/501100018531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018531","name":"Major Science and Technology Projects in Yunnan Province","doi-asserted-by":"publisher","award":["202402AA310034"],"award-info":[{"award-number":["202402AA310034"]}],"id":[{"id":"10.13039\/501100018531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003999","name":"Science Fund for Creative Research Groups","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003999","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.talanta.2025.129222","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:08:28Z","timestamp":1764979708000},"page":"129222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["ZIF-8 gated dual miRNA-sensing nanoplatform for enzyme-free amplification and precision diagnosis of metabolic dysfunction-associated steatohepatitis"],"prefix":"10.1016","volume":"300","author":[{"given":"Jing","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duolong","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-3800","authenticated-orcid":false,"given":"Dong","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2025.129222_bib1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S2468-1253(23)00066-3","article-title":"Non-invasive diagnosis and monitoring of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis","volume":"8","author":"Tincopa","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.talanta.2025.129222_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2023.101238","article-title":"Lipidomics in pathogenesis, progression and treatment of nonalcoholic steatohepatitis (NASH): recent advances","volume":"91","author":"Musso","year":"2023","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.talanta.2025.129222_bib3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1053\/j.gastro.2025.03.010","article-title":"Regulation of hepatic stellate cell phenotypes in metabolic dysfunction\u2013associated steatohepatitis","volume":"169","author":"Kisseleva","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.talanta.2025.129222_bib4","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000488","article-title":"Estimating the economic impact of comorbidities in patients with MASH and defining high-cost burden in patients with noncirrhotic MASH","volume":"8","author":"Younossi","year":"2024","journal-title":"Hepatology Communications"},{"key":"10.1016\/j.talanta.2025.129222_bib5","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/s41401-021-00822-1","article-title":"Current status and challenges in the drug treatment for fibrotic nonalcoholic steatohepatitis","volume":"43","author":"Shi","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.talanta.2025.129222_bib6","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.eprac.2022.03.010","volume":"28","author":"Cusi","year":"2022","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.talanta.2025.129222_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/HEP.0000000000000542","article-title":"Serum identification of at-risk MASH: the metabolomics-advanced steatohepatitis fibrosis score (MASEF)","volume":"79","author":"Noureddin","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.talanta.2025.129222_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/apt.17762","article-title":"Liver biopsy for assessment of suspected drug-induced liver injury in metabolic dysfunction-associated steatohepatitis clinical trials: expert consensus from the liver Forum","volume":"59","author":"Palmer","year":"2024","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.talanta.2025.129222_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jhep.2024.03.023","article-title":"Prospective head-to-head comparison of non-invasive scores for diagnosis of fibrotic MASH in patients with type 2 diabetes","volume":"81","author":"Castera","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.talanta.2025.129222_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/liv.16127","article-title":"Accuracy of non-invasive imaging techniques for the diagnosis of MASH in patients with MASLD: a systematic review","volume":"45","author":"Cathcart","year":"2025","journal-title":"Liver Int."},{"key":"10.1016\/j.talanta.2025.129222_bib11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/liv.15766","article-title":"Development and validation of an image biomarker to identify metabolic dysfunction associated steatohepatitis: MR\u2013MASH score","volume":"44","author":"Marti-Aguado","year":"2024","journal-title":"Liver Int."},{"key":"10.1016\/j.talanta.2025.129222_bib12","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1021\/acssensors.1c02748","article-title":"Single-molecule sensor for high-confidence detection of miRNA","volume":"7","author":"Wijesinghe","year":"2022","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2025.129222_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tcb.2020.10.005","article-title":"Global miRNA to miRNA interactions: impacts for miR-21","volume":"31","author":"Hill","year":"2021","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.talanta.2025.129222_bib14","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.copbio.2021.12.007","article-title":"Advances in quantifying circulatory microRNA for early disease detection","volume":"74","author":"Cheong","year":"2022","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.talanta.2025.129222_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107083","article-title":"Metabolic disorders affecting the liver and heart: therapeutic efficacy of miRNA-based therapies?","volume":"201","author":"La Sala","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.talanta.2025.129222_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130459","article-title":"Integrated miRNA-mRNA analysis reveals the dysregulation of lipid metabolism in mouse liver induced by developmental arsenic exposure","volume":"445","author":"Chen","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.talanta.2025.129222_bib17","doi-asserted-by":"crossref","first-page":"14284","DOI":"10.1021\/acs.jafc.2c03049","article-title":"Multiomics analysis revealed the molecular mechanism of miRNAs in fluoride-induced hepatic glucose and lipid metabolism disorders","volume":"70","author":"Zhao","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.talanta.2025.129222_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202305227","article-title":"An extracellular miRNA-Responsive artificial receptor via dynamic DNA nano-assembly for biomarker-driven therapy","volume":"62","author":"He","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2025.129222_bib19","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1111\/liv.15740","article-title":"miR-21p-5p coordinates biological pathways to promote MASLD progression","volume":"43","author":"Aspichueta","year":"2023","journal-title":"Liver Int."},{"key":"10.1016\/j.talanta.2025.129222_bib20","doi-asserted-by":"crossref","first-page":"24860","DOI":"10.1021\/acsnano.4c05081","article-title":"Multiplex profiling of miR-122 for preclinical and clinical evaluation of drug-induced liver injury by a full-scale platform","volume":"18","author":"Dong","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2025.129222_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s10020-019-0085-2","article-title":"miR-122 promotes hepatic lipogenesis via inhibiting the LKB1\/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease","volume":"25","author":"Long","year":"2019","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.talanta.2025.129222_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126108","article-title":"Ultrasensitive upconverting nanoprobes for in situ imaging of drug-induced liver injury using miR-122 as the biomarker","volume":"274","author":"Wang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2025.129222_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/S0168-8278(20)30973-9","article-title":"THU189 - Administration of lactobacillus alleviates experimental NASH by reducing miR-21 in the liver","volume":"73","author":"Santos","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.talanta.2025.129222_bib24","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1021\/acssensors.3c02024","article-title":"Novel SERS signal amplification strategy for ultrasensitive and specific detection of spinal cord injury-related miRNA","volume":"9","author":"Wang","year":"2024","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2025.129222_bib25","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1021\/acssensors.6b00105","article-title":"Simple isothermal strategy for multiplexed, rapid, sensitive, and accurate miRNA detection","volume":"1","author":"Wee","year":"2016","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2025.129222_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342743","article-title":"Target-driven cascade amplified assembly of covalent organic frameworks on tetrahedral DNA nanostructure with multiplex recognition domains for ultrasensitive detection of microRNA","volume":"1311","author":"Yang","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2025.129222_bib27","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1021\/acssensors.3c02183","article-title":"Flexible-arranged biomimetic array integrated with parallel entropy-driven circuits for ultrasensitive, multiple, and reliable detection of cancer-related MicroRNAs","volume":"9","author":"Tian","year":"2024","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2025.129222_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124820","article-title":"An intelligent DNA nanomachine for amplified MicroRNA imaging and MicroRNA-Guided efficient gene silencing","volume":"265","author":"Zhang","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2025.129222_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.127033","article-title":"Enhanced-electrochemiluminescence biosensor for detecting miRNA-21 based on a CuO-mediated click reaction and catalytic hairpin self-assembly","volume":"282","author":"Liu","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2025.129222_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137542","article-title":"Construction of a light-up multicolor fluorescent aptasensor for simultaneous measurement of multiple miRNAs in breast cancer tissues","volume":"433","author":"Jiao","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2025.129222_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.127590","article-title":"DNA logic nanomachine for the accurate identification of multiple microRNAs in tumor cells","volume":"287","author":"Dong","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2025.129222_bib32","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1039\/D0SC00580K","article-title":"Simultaneous and ultrasensitive detection of multiple microRNAs by single-molecule fluorescence imaging","volume":"11","author":"Zhang","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.talanta.2025.129222_bib33","first-page":"19470","article-title":"Nanoparticle\u2013patch system for localized, effective, and sustained miRNA administration into infarcted myocardium to alleviate myocardial ischemia\u2013reperfusion injury","volume":"18","author":"Chen","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2025.129222_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.132867","article-title":"Delivery of therapeutic miRNAs using nanoscale zeolitic imidazolate framework for accelerating vascularized bone regeneration","volume":"430","author":"Feng","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2025.129222_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.133812","article-title":"A ZIF-8@DNAzyme-based DNA walker nanosystem for microRNAs sensing in living cells with high accuracy","volume":"387","author":"Liu","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2025.129222_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado9311","article-title":"Compromised macrophages contribute to progression of MASH to hepatocellular carcinoma in FGF21KO mice","volume":"10","author":"Shi","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.talanta.2025.129222_bib37","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1021\/acs.analchem.0c05473","article-title":"Fluorescent assay of FEN1 activity with nicking enzyme-assisted signal amplification based on ZIF-8 for imaging in living cells","volume":"93","author":"Tang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2025.129222_bib38","doi-asserted-by":"crossref","first-page":"12351","DOI":"10.1021\/acs.analchem.7b03369","article-title":"Nanoscale zeolitic imidazolate Framework-8 for ratiometric fluorescence imaging of MicroRNA in living cells","volume":"89","author":"Yi","year":"2017","journal-title":"Anal.Chem."},{"key":"10.1016\/j.talanta.2025.129222_bib39","doi-asserted-by":"crossref","first-page":"7555","DOI":"10.1021\/acs.analchem.5c01163","article-title":"Target-triggered cascaded self-feedback DNAzyme circuit loaded in ZIF-8 for highly sensitive miRNA imaging in living cells","volume":"97","author":"Huang","year":"2025","journal-title":"Anal.Chem."},{"key":"10.1016\/j.talanta.2025.129222_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70145","article-title":"Carabrone attenuates metabolic dysfunction\u2013associated steatohepatitis by targeting STAT3 in mice","volume":"6","author":"Pan","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.talanta.2025.129222_bib41","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.jhep.2024.06.034","article-title":"Should the new EASL\u2013EASD\u2013EASO Clinical Practice guidelines on MASLD recommend pioglitazone as a MASH-targeted pharmacotherapy?","volume":"82","author":"Silva J\u00fanior","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.talanta.2025.129222_bib42","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/apt.14674","article-title":"Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease","volume":"47","author":"Chalasani","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.talanta.2025.129222_bib43","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1093\/nar\/gkx1254","article-title":"Nuclear miR-122 directly regulates the biogenesis of cell survival oncomiR miR-21 at the posttranscriptional level","volume":"46","author":"Wang","year":"2018","journal-title":"Nucleic Acids Res."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914025017138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914025017138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:50:38Z","timestamp":1781254238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914025017138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":43,"alternative-id":["S0039914025017138"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2025.129222","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ZIF-8 gated dual miRNA-sensing nanoplatform for enzyme-free amplification and precision diagnosis of metabolic dysfunction-associated steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2025.129222","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129222"}}