{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:28:26Z","timestamp":1773959306240,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82222068"],"award-info":[{"award-number":["82222068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574365"],"award-info":[{"award-number":["82574365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173779"],"award-info":[{"award-number":["82173779"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720250053"],"award-info":[{"award-number":["20720250053"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.talanta.2025.129342","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:56:02Z","timestamp":1767167762000},"page":"129342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["NITCD: A streamlined metabolomics strategy based on bromine isotopes and MS-TDF software"],"prefix":"10.1016","volume":"301","author":[{"given":"Dandan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hairong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caisheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"39","key":"10.1016\/j.talanta.2025.129342_bib1","doi-asserted-by":"crossref","first-page":"15754","DOI":"10.1021\/acs.analchem.4c03719","article-title":"Discovery of hypoxanthine and inosine as robust biomarkers for predicting the preanalytical quality of human plasma and serum for metabolomics","volume":"96","author":"Nagana Gowda","year":"2024","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2025.129342_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-66764-w","article-title":"Detection of pharmacolipidodynamic effects following the intravenous and oral administration of gefitinib to C57Bl\/6JRj mice by rapid UHPLC-MS analysis of plasma","volume":"14","author":"Plumb","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.talanta.2025.129342_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-71423-1","article-title":"New insight into primary hyperparathyroidism using untargeted metabolomics","volume":"14","author":"Wielog\u00f3rska-Partyka","year":"2024","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.talanta.2025.129342_bib4","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.cell.2018.03.055","article-title":"Metabolomics and isotope tracing","volume":"173","author":"Jang","year":"2018","journal-title":"Cell"},{"issue":"37","key":"10.1016\/j.talanta.2025.129342_bib5","doi-asserted-by":"crossref","first-page":"10943","DOI":"10.1021\/acs.jafc.1c03582","article-title":"Metabolic profiling of carbonyl compounds for unveiling protective mechanisms of Pueraria lobata against diabetic nephropathy by UPLC-Q-Orbitrap HRMS\/MS analysis","volume":"69","author":"Zhang","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"7","key":"10.1016\/j.talanta.2025.129342_bib6","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1021\/acs.analchem.1c04719","article-title":"MS-IDF: a software tool for nontargeted identification of endogenous metabolites after chemical isotope labeling based on a narrow mass defect filter","volume":"94","author":"Wang","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2025.129342_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.342119","article-title":"A chemical derivatization-based pseudotargeted liquid chromatography-tandem mass spectrometry method for sensitive and high coverage determination of bile acids in human serum","volume":"1287","author":"Xiong","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2025.129342_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.342117","article-title":"Improved quantification of carbonyl sub-metabolome by liquid chromatography mass spectrometry using a fragment controlled multiplexed isotopic tag","volume":"1287","author":"Tian","year":"2024","journal-title":"Anal. Chim. Acta"},{"issue":"19","key":"10.1016\/j.talanta.2025.129342_bib9","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.1021\/acs.analchem.4c00527","article-title":"Strategy to empower nontargeted metabolomics by triple-dimensional combinatorial derivatization with MS-TDF software","volume":"96","author":"Yuan","year":"2024","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.talanta.2025.129342_bib10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00216-010-3575-1","article-title":"Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA","volume":"397","author":"Eggink","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"issue":"12","key":"10.1016\/j.talanta.2025.129342_bib11","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1002\/jssc.201300083","article-title":"A novel derivatization reagent possessing a bromoquinolinium structure for biological carboxylic acids in HPLC-ESI-MS\/MS","volume":"36","author":"Mochizuki","year":"2013","journal-title":"J. Separ. Sci."},{"issue":"2","key":"10.1016\/j.talanta.2025.129342_bib12","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1021\/acs.analchem.9b03252","article-title":"Sensitive bromine-labeled probe D-BPBr for simultaneous identification and quantification of chiral amino acids and amino-containing metabolites profiling in human biofluid by HPLC\/MS","volume":"92","author":"Shen","year":"2020","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.talanta.2025.129342_bib13","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1021\/acs.analchem.0c05037","article-title":"Boron isotope tag-assisted ultrahigh-performance liquid chromatography coupled with high-resolution mass spectrometry for discovery and annotation of cis-diol-containing metabolites","volume":"93","author":"Xiong","year":"2021","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2025.129342_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27010283","article-title":"A fast and selective approach for profiling vicinal diols using liquid chromatography-post column derivatization-double precursor ion scanning mass spectrometry","volume":"27","author":"Wan","year":"2022","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.talanta.2025.129342_bib15","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41573-024-00953-0","article-title":"Navigating the complexities of drug development for inflammatory bowel disease","volume":"23","author":"Honap","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.talanta.2025.129342_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/phrs.2021.1603990","article-title":"A review of inflammatory bowel disease: a model of microbial, immune and neuropsychological integration","volume":"42","author":"Tavakoli","year":"2021","journal-title":"Public Health Rev."},{"key":"10.1016\/j.talanta.2025.129342_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/ijph.2024.1607440","article-title":"Global burden of inflammatory bowel disease among children and adolescents: a comprehensive analysis (1990\u20132019)","volume":"69","author":"Chen","year":"2024","journal-title":"Int. J. Publ. Health"},{"issue":"1","key":"10.1016\/j.talanta.2025.129342_bib18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1053\/j.gastro.2013.04.007","article-title":"Incidence and phenotype of inflammatory bowel disease based on results from the Asia-Pacific crohn's and colitis epidemiology study","volume":"145","author":"Ng","year":"2013","journal-title":"Gastroenterology"},{"issue":"9853","key":"10.1016\/j.talanta.2025.129342_bib19","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/S0140-6736(12)60026-9","article-title":"Crohn's disease","volume":"380","author":"Baumgart","year":"2012","journal-title":"Lancet"},{"issue":"45","key":"10.1016\/j.talanta.2025.129342_bib20","doi-asserted-by":"crossref","first-page":"50692","DOI":"10.1021\/acsami.2c17827","article-title":"pH\/ROS dual-sensitive natural polysaccharide nanoparticles enhance \u201cOne Stone Four Birds\u201d effect of rhein on ulcerative colitis","volume":"14","author":"Qi","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"23","key":"10.1016\/j.talanta.2025.129342_bib21","doi-asserted-by":"crossref","first-page":"10665","DOI":"10.7150\/thno.43528","article-title":"Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis","volume":"10","author":"Wu","year":"2020","journal-title":"Theranostics"},{"issue":"19","key":"10.1016\/j.talanta.2025.129342_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202304674","article-title":"Red\/NIR-I-Fluorescence carbon dots based on rhein with active oxygen scavenging and colitis targeting for UC therapeutics","volume":"13","author":"Xia","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"49","key":"10.1016\/j.talanta.2025.129342_bib23","doi-asserted-by":"crossref","first-page":"17641","DOI":"10.1002\/anie.201910461","article-title":"15-Hydroperoxy-PGE2: intermediate in Mammalian and algal prostaglandin biosynthesis","volume":"58","author":"Jagusch","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"issue":"13","key":"10.1016\/j.talanta.2025.129342_bib24","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1111\/j.1742-4658.2012.08612.x","article-title":"Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics--a pilot study","volume":"279","author":"Zhang","year":"2012","journal-title":"FEBS J."},{"issue":"7","key":"10.1016\/j.talanta.2025.129342_bib25","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1136\/gutjnl-2022-327337","article-title":"Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases","volume":"72","author":"Michaudel","year":"2023","journal-title":"Gut"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914025018338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914025018338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:00:36Z","timestamp":1773946836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914025018338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":25,"alternative-id":["S0039914025018338"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2025.129342","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NITCD: A streamlined metabolomics strategy based on bromine isotopes and MS-TDF software","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2025.129342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129342"}}