{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:10:11Z","timestamp":1777659011600,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2023MB001"],"award-info":[{"award-number":["ZR2023MB001"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2017LB016"],"award-info":[{"award-number":["ZR2017LB016"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202211231"],"award-info":[{"award-number":["tsqn202211231"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21705120"],"award-info":[{"award-number":["21705120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.talanta.2026.129534","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:37:13Z","timestamp":1770741433000},"page":"129534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A sensitive pH fluorescent probe with large Stokes shift and narrow transition for lysosome imaging during cell cycle"],"prefix":"10.1016","volume":"304","author":[{"given":"Bochao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-3408","authenticated-orcid":false,"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2026.129534_bib1","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1039\/C6CS00719H","article-title":"Fluorescent bioimaging of pH: from design to applications","volume":"46","author":"Hou","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2026.129534_bib2","doi-asserted-by":"crossref","first-page":"14256","DOI":"10.1021\/acs.analchem.5c00894","article-title":"Lipid droplet-targeted BODIPY\u2013hemicyanine hybrid fluorescent probes for real-time monitoring of pH and viscosity","volume":"97","author":"Zuo","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib3","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1021\/acs.analchem.6b01010","article-title":"Ratiometric fluorescence nanoprobes for subcellular pH imaging with a single-wavelength excitation in living cells","volume":"88","author":"Pan","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib4","article-title":"De novo construction of pKa-tunable xanthene molecules for pH sensitive fluorescence navigation","volume":"35","author":"Zhang","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.talanta.2026.129534_bib5","doi-asserted-by":"crossref","first-page":"11409","DOI":"10.1021\/acs.analchem.9b02782","article-title":"Mitochondria-immobilized near-infrared ratiometric fluorescent pH probe to evaluate cellular mitophagy","volume":"91","author":"Li","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib6","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1021\/acssensors.3c00340","article-title":"Constant conversion rate of endolysosomes revealed by a pH-sensitive fluorescent probe","volume":"8","author":"Chen","year":"2023","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2026.129534_bib7","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41586-024-07249-8","article-title":"The HEAT repeat protein HPO-27 is a lysosome fission factor","volume":"628","author":"Li","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.talanta.2026.129534_bib8","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1021\/acs.analchem.3c00314","article-title":"Migration from lysosome to nucleus: monitoring lysosomal alkalization-related biological processes with an aminofluorene-based probe","volume":"95","author":"Liu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib9","doi-asserted-by":"crossref","first-page":"16639","DOI":"10.1021\/acs.analchem.4c02723","article-title":"Tetrahedral DNA-based ternary recognition ratiometric fluorescent probes for real-time in situ resolving lysosome subpopulations in living cells via Cl\u2013, Ca2+, and pH","volume":"96","author":"Zou","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0092-8674(85)90237-5","article-title":"Cytoplasmic pH and the regulation of the dictyostelium cell cycle","volume":"43","author":"Aerts","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.talanta.2026.129534_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13068","article-title":"Roles of pH in control of cell proliferation","volume":"223","author":"Flinck","year":"2018","journal-title":"Acta Physiol."},{"key":"10.1016\/j.talanta.2026.129534_bib12","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/s42255-023-00872-1","article-title":"Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth","volume":"5","author":"Okreglak","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.talanta.2026.129534_bib13","doi-asserted-by":"crossref","first-page":"15165","DOI":"10.1021\/acs.jmedchem.5c01403","article-title":"Lipid droplet-targeted NIR polarity probe for the imaging of acute asthma in vivo","volume":"68","author":"Li","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib14","doi-asserted-by":"crossref","first-page":"16528","DOI":"10.1021\/acs.jmedchem.5c01354","article-title":"Polarity-tuned lipid droplet-specific probe for heart failure imaging","volume":"68","author":"Xu","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib15","doi-asserted-by":"crossref","first-page":"7827","DOI":"10.1021\/acs.jmedchem.5c00588","article-title":"PaAP-activatable NIR probe for diagnosing, imaging, and discovering small-molecule therapeutics against implant-associated biofilm infections","volume":"68","author":"Liu","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib16","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1021\/acs.chemrev.3c00776","article-title":"Fluorescent probes for disease diagnosis","volume":"124","author":"Wang","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.talanta.2026.129534_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137645","article-title":"Coumarin-based fluorescent probe for hypochlorite detection and imaging of acute kidney injury","volume":"435","author":"Kong","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137275","article-title":"Cancer-targeted and biomarker-activated fluorescent probe for diagnosis imaging and therapy","volume":"429","author":"Liu","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.138305","article-title":"Intraoperative pathological diagnosis for breast cancer with a polarity fluorescent probe targeting lipid droplets","author":"Meng","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib20","article-title":"Fabricating a mitochondrial viscosity-activated fluorescent probe for highly sensitive imaging of kidney injury in vivo","author":"Zheng","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.138556","article-title":"Inflammation-responsive near-infrared fluorescence probe for real-time imaging of NO and its antiarthritis evaluation of protopine","author":"Wang","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.127843","article-title":"Hydroxyl and phenyl co-modified carbon nitride-based ratiometric fluorescent nanoprobe for monitoring mitochondrial pH in live cells and differentiating cell death","volume":"291","author":"Chen","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.129534_bib23","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.snb.2018.03.133","article-title":"A rhodamine-based fluorescent probe for the detection of lysosomal pH changes in living cells","volume":"266","author":"Lee","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2019.107620","article-title":"An off-on fluorescent probe for real-time sensing the fluctuations of intracellular pH values in biological processes","volume":"170","author":"Zhang","year":"2019","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.talanta.2026.129534_bib25","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.tcb.2022.03.010","article-title":"Mechanical regulation of cell-cycle progression and division","volume":"32","author":"Gupta","year":"2022","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.talanta.2026.129534_bib26","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41580-021-00404-3","article-title":"Cell cycle control in cancer","volume":"23","author":"Matthews","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.talanta.2026.129534_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwaa306","article-title":"Role of cell cycle progression on analyzing telomerase in cancer cells based on aggregation-induced emission luminogens","volume":"8","author":"Wu","year":"2021","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.talanta.2026.129534_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/adom.202300850","article-title":"Peptide-modified AIEgen probe for selective imaging and killing of drug-resistant cancer cells based on cell-cycle-dependent uptake","volume":"11","author":"Wu","year":"2023","journal-title":"Adv. Opt. Mater."},{"key":"10.1016\/j.talanta.2026.129534_bib29","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1021\/acs.analchem.2c00583","article-title":"Precisely detecting the telomerase activities by an AIEgen probe with dual signal outputs after cell-cycle synchronization","volume":"94","author":"Liu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.129534_bib30","doi-asserted-by":"crossref","first-page":"8383","DOI":"10.1021\/acs.analchem.9b01191","article-title":"Cell-penetrating peptide conjugated SERS nanosensor for in situ intracellular pH imaging of single living cells during cell cycle","volume":"91","author":"Zheng","year":"2019","journal-title":"Anal. Chem."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003991402600189X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003991402600189X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:17:49Z","timestamp":1777447069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003991402600189X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":30,"alternative-id":["S003991402600189X"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.129534","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A sensitive pH fluorescent probe with large Stokes shift and narrow transition for lysosome imaging during cell cycle","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.129534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129534"}}