{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T04:51:04Z","timestamp":1786164664647,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22104111"],"award-info":[{"award-number":["22104111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021J011039"],"award-info":[{"award-number":["2021J011039"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["G2021020006L"],"award-info":[{"award-number":["G2021020006L"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.talanta.2026.129560","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T08:00:28Z","timestamp":1771315228000},"page":"129560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Harnessing soft DNA nanospheres as a superior alternative to hard nanoparticles for boosting DNAzyme-based colorimetric sensing of lead ions"],"prefix":"10.1016","volume":"304","author":[{"given":"Hengxin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9930-8878","authenticated-orcid":false,"given":"Huo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.talanta.2026.129560_bib1","first-page":"14131","article-title":"Ratiometric fluorescence sensing system for lead ions based on self-assembly of bioprobes triggered by specific Pb2+-Peptide interactions","volume":"15","author":"Mehta","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2026.129560_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173834","article-title":"The stabilization ability of NaA zeolite derived from fly ash for lead and cadmium in soil: mechanisms and evaluation of effectiveness","volume":"942","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.talanta.2026.129560_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136935","article-title":"Early-warning ecological risk assessments of multi-element pollution in the surface soil of karst basins in southwest China based on the delayed geochemical hazard model","volume":"485","author":"Luo","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.talanta.2026.129560_bib4","first-page":"11","article-title":"From urbanization to bioaccumulation: a comparative study of metal pollution and biomarker responses in Donax trunculus along a touristic coastal area in Morocco","volume":"65","author":"Ben-Haddad","year":"2023","journal-title":"Reg. Stud. Mar. Sci."},{"key":"10.1016\/j.talanta.2026.129560_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.enceco.2023.02.001","article-title":"Lead pollution: impact on environment and human health and approach for a sustainable solution","volume":"5","author":"Raj","year":"2023","journal-title":"Environ. Chem. Ecotoxicol."},{"key":"10.1016\/j.talanta.2026.129560_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.122210","article-title":"Telomere length declines with mean blood lead concentration in an urban passerine","volume":"284","author":"Chik","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.talanta.2026.129560_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340714","article-title":"A convenient paper-based fluorescent aptasensor for high-throughput detection of Pb2+ in multiple real samples (water-soil-food)","volume":"1239","author":"Suo","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2026.129560_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.foodchem.2025.145047","article-title":"Streamlining metal analysis in wine: matrix purification for simple lead detection by AAS or portable electrochemical sensor","volume":"491","author":"Sikolenko","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.talanta.2026.129560_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342294","article-title":"Simultaneous preconcentration and quantification of ultra-trace tin and lead species in seawater by online SPE coupled with HPLC-ICP-MS","volume":"1294","author":"Guo","year":"2024","journal-title":"Anal. Chim. Acta"},{"issue":"14","key":"10.1016\/j.talanta.2026.129560_bib10","doi-asserted-by":"crossref","first-page":"41834","DOI":"10.1007\/s11356-023-25242-y","article-title":"Low-pressure ultraviolet-H2O2 photolysis for restoring the anodic stripping voltammetry signal: a new strategy for the detection of heavy metal ions in complex organic matter","volume":"30","author":"Wang","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"9","key":"10.1016\/j.talanta.2026.129560_bib11","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1021\/acs.analchem.7b00383","article-title":"A new electrochemical system based on a flow-field shaped solid electrode and 3D-Printed thin-layer flow cell: detection of Pb2+ ions by continuous flow accumulation square-wave anodic stripping voltammetry","volume":"89","author":"Sun","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.129560_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.saa.2020.118880","article-title":"Eco-friendly and enhanced colorimetric detection of aluminum ions using pectin-rich apple extract-based gold nanoparticles","volume":"245","author":"Park","year":"2021","journal-title":"Spectrochim. Acta, Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2026.129560_bib13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bios.2016.05.038","article-title":"Dual channel sensor for detection and discrimination of heavy metal ions based on colorimetric and fluorescence response of the AuNPs-DNA conjugates","volume":"85","author":"Tan","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.129560_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115282","article-title":"Functional DNA sensors integrated with nucleic acid signal amplification strategies for non-nucleic acid targets detection","volume":"230","author":"Zhu","year":"2023","journal-title":"Biosens. Bioelectron."},{"issue":"Pt 1","key":"10.1016\/j.talanta.2026.129560_bib15","article-title":"Advances of functional nucleic acids based on specific recognition:a review","volume":"304","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.talanta.2026.129560_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.trac.2023.116931","article-title":"Nucleic acid-assisted CRISPR-Cas systems for advanced biosensing and bioimaging","volume":"159","author":"Chen","year":"2023","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"6","key":"10.1016\/j.talanta.2026.129560_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/tcr.202300018","article-title":"Metal-organic frameworks nanocarriers for functional nucleic acid delivery in biomedical applications","volume":"23","author":"He","year":"2023","journal-title":"Chem. Rec."},{"key":"10.1016\/j.talanta.2026.129560_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115549","article-title":"Selective detection of Pb2+ ions based on a graphene field-effect transistor gated by DNAzymes in binding mode","volume":"237","author":"Zhao","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.129560_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137437","article-title":"DNA nanosphere-enhanced DNAzyme system for sensitive and rapid detection of lead contamination in water and living cells","volume":"488","author":"Xu","year":"2025","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.talanta.2026.129560_bib20","first-page":"13","article-title":"Spermine enhances the peroxidase activities of multimeric antiparallel G-quadruplex DNAzymes","volume":"15","author":"Adeoye","year":"2025","journal-title":"Biosensors (Basel)"},{"issue":"5","key":"10.1016\/j.talanta.2026.129560_bib21","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1021\/acs.analchem.9b05343","article-title":"DNAzyme-Triggered visual and ratiometric electrochemiluminescence dual-readout assay for Pb(II) based on an assembled paper device","volume":"92","author":"Zhang","year":"2020","journal-title":"Anal. Chem."},{"issue":"14","key":"10.1016\/j.talanta.2026.129560_bib22","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1007\/s00216-023-04681-z","article-title":"The fluorescence regulation of a tri-functional oligonucleotide probe HEX-OND in detecting Pb(II), cysteine, and K(I) based on two G-quadruplex forms","volume":"415","author":"Zhang","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"issue":"9","key":"10.1016\/j.talanta.2026.129560_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/bios13090856","article-title":"Advances and trends in miRNA analysis using DNAzyme-Based biosensors","volume":"13","author":"Lee","year":"2023","journal-title":"Biosensors"},{"key":"10.1016\/j.talanta.2026.129560_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126187","article-title":"Pt-S bond stabilized DNAzyme nanosensor with thiol-resistance enabling high-fidelity biosensing","volume":"276","author":"Lei","year":"2024","journal-title":"Talanta"},{"issue":"1","key":"10.1016\/j.talanta.2026.129560_bib25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11783-019-1094-7","article-title":"Label-free colorimetric nanosensor with improved sensitivity for Pb2+ in water by using a truncated 8-17 DNAzyme","volume":"13","author":"Memon","year":"2019","journal-title":"Front. Environ. Sci. Eng."},{"issue":"1","key":"10.1016\/j.talanta.2026.129560_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00604-024-06883-3","article-title":"Effective multicolor visual biosensor for ochratoxin A detection enabled by DNAzyme catalysis and gold nanorod etching","volume":"192","author":"Guo","year":"2024","journal-title":"Mikrochim. Acta"},{"key":"10.1016\/j.talanta.2026.129560_bib27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.microc.2025.114039","article-title":"Target-induced DNAzyme recycle amplification strategy for colorimetric detection of cystatin C","volume":"214","author":"Lin","year":"2025","journal-title":"Microchem. J."},{"issue":"27","key":"10.1016\/j.talanta.2026.129560_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/adhm.202301066","article-title":"The creation of DNA origami-based supramolecular nanostructures for cancer therapy","volume":"12","author":"Zhang","year":"2023","journal-title":"Adv. Healthcare Mater."},{"issue":"3","key":"10.1016\/j.talanta.2026.129560_bib29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cclet.2023.108384","article-title":"Applying dynamic light scattering to investigate the self-assembly process of DNA nanostructures","volume":"35","author":"Yuan","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.talanta.2026.129560_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2016.10.005","article-title":"Enzyme spheres as novel tracing tags coupled with target-induced DNAzyme assembly for ultrasensitive electrochemical microRNA assay","volume":"948","author":"Wu","year":"2016","journal-title":"Anal. Chim. Acta"},{"issue":"12","key":"10.1016\/j.talanta.2026.129560_bib31","doi-asserted-by":"crossref","first-page":"8272","DOI":"10.1021\/acs.chemrev.7b00063","article-title":"Metal sensing by DNA","volume":"117","author":"Zhou","year":"2017","journal-title":"Chem. Rev."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026002158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026002158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:17:04Z","timestamp":1777447024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026002158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":31,"alternative-id":["S0039914026002158"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.129560","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing soft DNA nanospheres as a superior alternative to hard nanoparticles for boosting DNAzyme-based colorimetric sensing of lead ions","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.129560","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129560"}}