{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:08:49Z","timestamp":1778836129009,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008050","name":"University of Shanghai for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["Z-2025-312-023"],"award-info":[{"award-number":["Z-2025-312-023"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.talanta.2026.129771","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:47:15Z","timestamp":1775231235000},"page":"129771","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rational design of Cr(VI) aptamer guided by revealed cation-mediated binding mechanism and construction of a label-free fluorescent aptasensor"],"prefix":"10.1016","volume":"307","author":[{"given":"Xiuxiu","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sicheng","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-6987","authenticated-orcid":false,"given":"Fugang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7745-2855","authenticated-orcid":false,"given":"Fei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.talanta.2026.129771_bib1","doi-asserted-by":"crossref","first-page":"10904","DOI":"10.1021\/acs.est.2c00709","article-title":"Mapping the global anthropogenic chromium cycle: implications for resource efficiency and potential supply risk","volume":"56","author":"Gao","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.talanta.2026.129771_bib2","article-title":"Heavy metal pollution: insights into chromium eco-toxicity and recent advancement in its remediation","volume":"15","author":"Sharma","year":"2021","journal-title":"Environ. Nanotechnol. Monit. Manag."},{"issue":"11","key":"10.1016\/j.talanta.2026.129771_bib3","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.chemosphere.2009.02.044","article-title":"A global assessment of chromium pollution using sperm whales (Physeter macrocephalus) as an indicator species","volume":"75","author":"Wise","year":"2009","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.talanta.2026.129771_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202400111","article-title":"Nucleic acid aptamer\u2010based sensors for bacteria detection: a review","volume":"47","author":"Tang","year":"2025","journal-title":"Bioessays"},{"key":"10.1016\/j.talanta.2026.129771_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132509","article-title":"A stabilized weak measurement sensor for aptamer detection","volume":"371","author":"Xu","year":"2022","journal-title":"Sensor. Actuator. B Chem."},{"issue":"1","key":"10.1016\/j.talanta.2026.129771_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-021-00914-4","article-title":"Advances in aptamer screening and aptasensors' detection of heavy metal ions","volume":"19","author":"Guo","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"D1","key":"10.1016\/j.talanta.2026.129771_bib7","doi-asserted-by":"crossref","first-page":"D351","DOI":"10.1093\/nar\/gkad959","article-title":"UTexas aptamer database: the collection and long-term preservation of aptamer sequence information","volume":"52","author":"Askari","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.talanta.2026.129771_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/open.202400463","article-title":"Progress in aptamer research and future applications","author":"Liu","year":"2025","journal-title":"ChemistryOpen"},{"issue":"7","key":"10.1016\/j.talanta.2026.129771_bib9","doi-asserted-by":"crossref","first-page":"11959","DOI":"10.3390\/molecules200711959","article-title":"A highlight of recent advances in aptamer technology and its application","volume":"20","author":"Sun","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.talanta.2026.129771_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2025.111257","article-title":"Electrochemical RNA-Based aptasensor for neomycin detection in milk samples","volume":"175","author":"Jackowska","year":"2025","journal-title":"Food Control"},{"key":"10.1016\/j.talanta.2026.129771_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2022.109361","article-title":"Portable chemiluminescence optical fiber aptamer-based biosensors for analysis of multiple mycotoxins","volume":"144","author":"Jia","year":"2023","journal-title":"Food Control"},{"key":"10.1016\/j.talanta.2026.129771_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2023.110105","article-title":"Label-free and low-background fluorescent structure-switching aptasensor for sensitive detection of staphylococcal enterotoxin A based on graphene oxide-assisted separation of ssDNA","volume":"155","author":"Ma","year":"2024","journal-title":"Food Control"},{"issue":"6","key":"10.1016\/j.talanta.2026.129771_bib13","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.biotechadv.2015.02.008","article-title":"Current approaches in SELEX: an update to aptamer selection technology","volume":"33","author":"Darmostuk","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.talanta.2026.129771_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2025.115890","article-title":"A beginners guide to SELEX and DNA aptamers","volume":"703","author":"Stephens","year":"2025","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.talanta.2026.129771_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ymeth.2016.04.020","article-title":"Aptamers: the \u201cevolution\u201d of SELEX","volume":"106","author":"Wu","year":"2016","journal-title":"Methods"},{"key":"10.1016\/j.talanta.2026.129771_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121750","article-title":"Screening aptamers for serine \u03b2-lactamase-expressing bacteria with Precision-SELEX","volume":"224","author":"Yu","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.129771_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117446","article-title":"Screening broad-spectrum aptamers for cephalosporin antibiotics using real samples and development of a DNA walker-driven dual-mode aptasensor","volume":"280","author":"Sun","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"10","key":"10.1016\/j.talanta.2026.129771_bib18","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/bios12100848","article-title":"Aptamer against aflatoxin B1 obtained by SELEX and applied in detection","volume":"12","author":"Yang","year":"2022","journal-title":"Biosensors"},{"key":"10.1016\/j.talanta.2026.129771_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135427","article-title":"Ratiometric fluorescent sensor based on a truncated specific aptamer by MGO-SELEX screening for streptomycin detection","volume":"406","author":"Zhang","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2026.129771_bib20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.snb.2017.07.068","article-title":"Selection of DNA aptamers for the development of light-up biosensor to detect Pb(II)","volume":"254","author":"Chen","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"issue":"10","key":"10.1016\/j.talanta.2026.129771_bib21","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3390\/bios15100637","article-title":"Designing the future of biosensing: advances in aptamer discovery, computational modeling, and diagnostic applications","volume":"15","author":"Jesky","year":"2025","journal-title":"Biosensors"},{"key":"10.1016\/j.talanta.2026.129771_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.164540","article-title":"In silico-guided engineering of broad-spectrum aptamer for the highly sensitive detection of organophosphate pesticides","volume":"517","author":"Mo","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"5","key":"10.1016\/j.talanta.2026.129771_bib23","article-title":"Aptamers meet structural bioinformatics, computational chemistry, and artificial intelligence","volume":"15","author":"Rosa","year":"2025","journal-title":"Wiley Interdiscip. Rev. Comput. Mol. Sci."},{"issue":"7","key":"10.1016\/j.talanta.2026.129771_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s00604-023-05836-6","article-title":"Improving aptamer performance: key factors and strategies","volume":"190","author":"Yu","year":"2023","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.talanta.2026.129771_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135452","article-title":"Assembly of a multivalent aptamer for efficient inhibition of thermostable direct hemolysin toxicity induced by Vibrio parahaemolyticus","volume":"478","author":"Chen","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.talanta.2026.129771_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132427","article-title":"Comprehensive analysis of bisphenol analogues in complex water using a group-targeting aptamer engineered by base mutation","volume":"460","author":"Wu","year":"2023","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.talanta.2026.129771_bib27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev-biochem-030222-120000","article-title":"The art and science of molecular docking","volume":"93","author":"Paggi","year":"2024","journal-title":"Annu. Rev. Biochem."},{"issue":"39","key":"10.1016\/j.talanta.2026.129771_bib28","doi-asserted-by":"crossref","first-page":"15567","DOI":"10.1021\/jacs.9b06256","article-title":"Redox-switchable binding properties of the ATP\u2013aptamer","volume":"141","author":"Biniuri","year":"2019","journal-title":"J. Am. Chem. Soc."},{"issue":"6","key":"10.1016\/j.talanta.2026.129771_bib29","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.neuron.2018.08.011","article-title":"Molecular dynamics simulation for all","volume":"99","author":"Hollingsworth","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.talanta.2026.129771_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.132171","article-title":"Aptamer truncation strategy assisted by molecular docking and sensitive detection of T-2 toxin using SYBR green I as a signal amplifier","volume":"381","author":"Ma","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.talanta.2026.129771_bib31","series-title":"Hexavalent chromium aptamer, aptamer derivative and application thereof","author":"Xie","year":"2021"},{"issue":"13","key":"10.1016\/j.talanta.2026.129771_bib32","doi-asserted-by":"crossref","first-page":"8008","DOI":"10.1002\/jsfa.13631","article-title":"Tag-free fluorometric aptasensor for detection of chromium(VI) in foods via SYBR green I signal amplification and aptamer structure transition","volume":"104","author":"Zhu","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.talanta.2026.129771_bib33","author":"Schr\u00f6dinger"},{"key":"10.1016\/j.talanta.2026.129771_bib34","series-title":"Gaussian 09 (Version A.02)","author":"Frisch","year":"2016"},{"issue":"5","key":"10.1016\/j.talanta.2026.129771_bib35","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcc.22885","article-title":"Multiwfn: a multifunctional wavefunction analyzer","volume":"33","author":"Lu","year":"2011","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.talanta.2026.129771_bib47","unstructured":"Tian Lu (n.d.). Sobtop (Version 1.0(dev3.1)) [computer software]. Retrieved March 14, 2026, from http:\/\/sobereva.com\/soft\/Sobtop."},{"key":"10.1016\/j.talanta.2026.129771_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"issue":"2","key":"10.1016\/j.talanta.2026.129771_bib37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/comjnl\/6.2.163","article-title":"A rapidly convergent descent method for minimization","volume":"6","author":"Fletcher","year":"1963","journal-title":"Comput. J."},{"issue":"8","key":"10.1016\/j.talanta.2026.129771_bib38","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/jcc.540130805","article-title":"Settle: an analytical version of the SHAKE and RATTLE algorithm for rigid water models","volume":"13","author":"Miyamoto","year":"1992","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2026.129771_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"issue":"6","key":"10.1016\/j.talanta.2026.129771_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202401572","article-title":"Dissociation constant (Kd) measurement for small-molecule binding aptamers: homogeneous assay methods and critical evaluations","volume":"9","author":"Stangherlin","year":"2025","journal-title":"Small Methods"},{"issue":"2","key":"10.1016\/j.talanta.2026.129771_bib41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bios.2006.01.007","article-title":"Cr(VI) quantification using an amperometric enzyme-based sensor: interference and physical and chemical factors controlling the biosensor response in ground waters","volume":"22","author":"Michel","year":"2006","journal-title":"Biosens. Bioelectron."},{"issue":"66","key":"10.1016\/j.talanta.2026.129771_bib42","doi-asserted-by":"crossref","first-page":"61966","DOI":"10.1039\/C6RA12819J","article-title":"Selective picomolar level fluorometric sensing of the Cr(VI)-oxoanion in a water medium by a novel metal\u2013organic complex","volume":"6","author":"Mondal","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.talanta.2026.129771_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.diamond.2022.109138","article-title":"Fluorescent carbon quantum dots as a novel solution and paper strip-based dual sensor for the selective detection of Cr(VI) ions","volume":"126","author":"John","year":"2022","journal-title":"Diam. Relat. Mater."},{"key":"10.1016\/j.talanta.2026.129771_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2022.107627","article-title":"Non-toxic carbon dots fluorescence sensor based on chitosan for sensitive and selective detection of Cr (VI) in water","volume":"180","author":"Feng","year":"2022","journal-title":"Microchem. J."},{"key":"10.1016\/j.talanta.2026.129771_bib45","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.talanta.2016.09.032","article-title":"Colorimetric detection of Cr (VI) based on the leaching of gold nanoparticles using a paper-based sensor","volume":"161","author":"Guo","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.129771_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.129219","article-title":"A blood compatible, high-efficient sensor for detection of Cr(VI) in whole blood","volume":"329","author":"Fang","year":"2021","journal-title":"Sensor. Actuator. B Chem."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026004273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026004273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:20:51Z","timestamp":1778833251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026004273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"alternative-id":["S0039914026004273"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.129771","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rational design of Cr(VI) aptamer guided by revealed cation-mediated binding mechanism and construction of a label-free fluorescent aptasensor","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.129771","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129771"}}