{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:30:10Z","timestamp":1792549810173,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019627","name":"Yibin University Key Lab of Process Analysis and Control of Sichuan Universities of China","doi-asserted-by":"publisher","award":["GCFX2023005"],"award-info":[{"award-number":["GCFX2023005"]}],"id":[{"id":"10.13039\/501100019627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.talanta.2026.130013","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:52:56Z","timestamp":1779295976000},"page":"130013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Machine learning integrated MIL-88B@ZIF-67 built-in electric field heterojunction nanozyme for enhanced colorimetric detection of ascorbic acid and alkaline phosphatase"],"prefix":"10.1016","volume":"309","author":[{"given":"Jianlong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanke","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5407-4350","authenticated-orcid":false,"given":"Xiaoli","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.talanta.2026.130013_bib1","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3390\/antiox11101993","article-title":"Antioxidative and anti-inflammatory activity of ascorbic acid","volume":"11","author":"G\u0119gotek","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.talanta.2026.130013_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.765906","article-title":"Vitamin C, from supplement to treatment: a re-emerging adjunct for cancer immunotherapy?","volume":"12","author":"Kouakanou","year":"2021","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.talanta.2026.130013_bib3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3390\/antiox14050506","article-title":"Vitamin C in cardiovascular disease: from molecular mechanisms to clinical evidence and therapeutic applications","volume":"14","author":"Xu","year":"2025","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.talanta.2026.130013_bib4","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.mayocp.2024.11.019","article-title":"Diagnostic approach to abnormal alkaline phosphatase value","volume":"100","author":"Minisola","year":"2025","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.talanta.2026.130013_bib5","article-title":"Association between vitamin D serum levels and thyroid cancer: a meta-analysis","volume":"16","author":"Yang","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"9","key":"10.1016\/j.talanta.2026.130013_bib6","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00216-024-05679-x","article-title":"A review of a colorimetric biosensor based on Fe3O4 nanozymes for food safety detection","volume":"417","author":"Guo","year":"2025","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2026.130013_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.150612","article-title":"Research progress of nanozymes in colorimetric biosensing: classification, activity and application","volume":"487","author":"Yang","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"6","key":"10.1016\/j.talanta.2026.130013_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202414837","article-title":"A novel Ce-Mn heterojunction\u2010based multi\u2010enzymatic nanozyme with cancer\u2010specific enzymatic activity and photothermal capacity for efficient tumor combination therapy","volume":"35","author":"Qiao","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.talanta.2026.130013_bib9","doi-asserted-by":"crossref","first-page":"22885","DOI":"10.1039\/D5TA02242H","article-title":"Engineering electron distribution of Cu2O\/FeOx@CNFs P\u2013N heterojunction nanozyme: boosting the fenton reaction efficiency","volume":"13","author":"Zhao","year":"2025","journal-title":"J. Mater. Chem. A"},{"issue":"16","key":"10.1016\/j.talanta.2026.130013_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202500441","article-title":"Enhanced interfacial electric field of an S\u2010scheme heterojunction by an ultrasonication\u2010triggered piezoelectric effect for sonocatalytic therapy of bacterial infections","volume":"64","author":"Wei","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"issue":"9","key":"10.1016\/j.talanta.2026.130013_bib11","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1039\/D4NR04496G","article-title":"Built-in electric field in the Mn\/C60 heterojunction promotes electrocatalytic nitrogen reduction to ammonia","volume":"17","author":"Xue","year":"2025","journal-title":"Nanoscale"},{"issue":"2","key":"10.1016\/j.talanta.2026.130013_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202407281","article-title":"Interface\u2010engineered CuxO@ Bi2MoO6 heterojunctions to inhibit piezoelectric screening effect and promote double\u2010nanozyme catalysis for antibacterial treatment","volume":"21","author":"Zhang","year":"2025","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.talanta.2026.130013_bib13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s40820-021-00674-8","article-title":"A review on metal-and metal oxide-based nanozymes: properties, mechanisms, and applications","volume":"13","author":"Liu","year":"2021","journal-title":"Nano-Micro Lett."},{"issue":"5","key":"10.1016\/j.talanta.2026.130013_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2025.119128","article-title":"The interfacial optimization and pn heterojunction construction in nanozyme for improved laccase-mimic and antibiofouling activities","volume":"13","author":"Qi","year":"2025","journal-title":"J. Environ. Chem. Eng."},{"issue":"7","key":"10.1016\/j.talanta.2026.130013_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/ange.202420200","article-title":"Tailored metal\u2013organic framework\u2010based nanozymes for enhanced enzyme\u2010like catalysis","volume":"137","author":"Yu","year":"2025","journal-title":"Angew. Chem."},{"issue":"6","key":"10.1016\/j.talanta.2026.130013_bib16","article-title":"A novel \u201cThree\u2010in\u2010One\u201d copper\u2010based metal\u2010organic framework nanozyme eradicates colorectal cancer and overcomes chemoresistance for tumor therapy","volume":"12","author":"Dong","year":"2025","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.talanta.2026.130013_bib17","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12951-024-02508-2","article-title":"Iron (II)-Based metal-organic framework nanozyme for boosting tumor ferroptosis through inhibiting DNA damage repair and system Xc","volume":"22","author":"Xue","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.talanta.2026.130013_bib18","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1039\/D2CE01272C","article-title":"MOF-on-MOF heterostructures with core\u2013shell and core\u2013satellite structures via controllable nucleation of guest MOFs","volume":"25","author":"Li","year":"2023","journal-title":"CrystEngComm"},{"issue":"8","key":"10.1016\/j.talanta.2026.130013_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202306910","article-title":"Heterostructured bimetallic MOF\u2010on\u2010MOF architectures for efficient oxygen evolution reaction","volume":"36","author":"Jiang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.talanta.2026.130013_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.teac.2025.e00280","article-title":"Artificial intelligence and machine learning for colorimetric detections: techniques, applications, and future prospects","volume":"48","author":"Parakh","year":"2025","journal-title":"Trends Environ. Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130013_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.216850","article-title":"Nanozyme-based biosensors with different combinations of sensing modes for clinical biomarker detection: biosensing strategies, practical applications, and future perspectives","volume":"542","author":"Yu","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.talanta.2026.130013_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.217067","article-title":"Recent advancements for defect engineering in nanozymes","volume":"546","author":"Han","year":"2026","journal-title":"Coord. Chem. Rev."},{"issue":"50","key":"10.1016\/j.talanta.2026.130013_bib23","doi-asserted-by":"crossref","first-page":"27674","DOI":"10.1021\/acs.analchem.5c04463","article-title":"Surface-enhanced raman spectroscopy\u2013machine learning for multiplex naphthenic acid profiling in water","volume":"97","author":"Rashidi","year":"2025","journal-title":"Anal. Chem."},{"issue":"22","key":"10.1016\/j.talanta.2026.130013_bib24","doi-asserted-by":"crossref","first-page":"12305","DOI":"10.1021\/jacs.3c02835","article-title":"Near-infrared spectroscopy and machine learning for accurate dating of historical books","volume":"145","author":"Coppola","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"12","key":"10.1016\/j.talanta.2026.130013_bib25","doi-asserted-by":"crossref","first-page":"12660","DOI":"10.1021\/nn505582e","article-title":"Carbonized nanoscale metal\u2013organic frameworks as high performance electrocatalyst for oxygen reduction reaction","volume":"8","author":"Zhao","year":"2014","journal-title":"ACS Nano"},{"issue":"9","key":"10.1016\/j.talanta.2026.130013_bib26","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1038\/nprot.2013.095","article-title":"Analysis of GSH and GSSG after derivatization with N-ethylmaleimide","volume":"8","author":"Giustarini","year":"2013","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.talanta.2026.130013_bib27","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1039\/C6TA07860E","article-title":"Characterization and properties of Zn\/Co zeolitic imidazolate frameworks vs. ZIF-8 and ZIF-67","volume":"5","author":"Zhou","year":"2017","journal-title":"J. Mater. Chem. A"},{"key":"10.1016\/j.talanta.2026.130013_bib28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jechem.2020.04.057","article-title":"ZIF-67@ cellulose nanofiber hybrid membrane with controlled porosity for use as Li-ion battery separator","volume":"52","author":"Sun","year":"2021","journal-title":"J. Energy Chem."},{"issue":"17","key":"10.1016\/j.talanta.2026.130013_bib29","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1021\/ic800538r","article-title":"High-throughput assisted rationalization of the formation of metal organic frameworks in the iron (III) aminoterephthalate solvothermal system","volume":"47","author":"Bauer","year":"2008","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.talanta.2026.130013_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jallcom.2025.179011","article-title":"A novel NH2-MIL-88B@ ZIF-67 heterostructure based on MOF-on-MOF strategy for efficient oxygen evolution reaction","volume":"1017","author":"Ou","year":"2025","journal-title":"J. Alloys Compd."},{"issue":"1","key":"10.1016\/j.talanta.2026.130013_bib31","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41467-025-56215-z","article-title":"Atomically resolved imaging of radiation-sensitive metal-organic frameworks via electron ptychography","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.talanta.2026.130013_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s42004-020-00361-6","article-title":"Bulk and local structures of metal\u2013organic frameworks unravelled by high-resolution electron microscopy","volume":"3","author":"Liu","year":"2020","journal-title":"Commun. Chem."},{"issue":"20","key":"10.1016\/j.talanta.2026.130013_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202214627","article-title":"AS\u2010scheme MOF\u2010on\u2010MOF heterostructure","volume":"33","author":"Yuan","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"41","key":"10.1016\/j.talanta.2026.130013_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202409799","article-title":"MOF\u2010on\u2010MOF heterostructured electrocatalysts for efficient nitrate reduction to ammonia","volume":"63","author":"Zou","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"issue":"20","key":"10.1016\/j.talanta.2026.130013_bib35","doi-asserted-by":"crossref","first-page":"7170","DOI":"10.1016\/j.ijhydene.2022.11.080","article-title":"Construction of ZIF-67\/MIL-88 (fe, ni) catalysts as a novel platform for efficient overall water splitting","volume":"48","author":"Chen","year":"2023","journal-title":"Int. J. Hydrogen Energy"},{"issue":"16","key":"10.1016\/j.talanta.2026.130013_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201604103","article-title":"Boosting bifunctional oxygen electrolysis for n\u2010doped carbon via bimetal addition","volume":"13","author":"Wang","year":"2017","journal-title":"Small"},{"key":"10.1016\/j.talanta.2026.130013_bib37","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jcat.2020.09.014","article-title":"Synergetic catalytic behavior of dual metal-organic framework coated hematite photoanode for photoelectrochemical water splitting performance","volume":"391","author":"Reddy","year":"2020","journal-title":"J. Catal."},{"key":"10.1016\/j.talanta.2026.130013_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsusc.2019.144616","article-title":"Carbon nanodots anchored onto the metal-organic framework NH2-MIL-88B (fe) as a novel visible light-driven photocatalyst: photocatalytic performance and mechanism investigation","volume":"505","author":"Shao","year":"2020","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.talanta.2026.130013_bib39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.apsusc.2017.07.050","article-title":"Metal organic framework g-C3N4\/MIL-53 (fe) heterojunctions with enhanced photocatalytic activity for Cr (VI) reduction under visible light","volume":"425","author":"Huang","year":"2017","journal-title":"Appl. Surf. Sci."},{"issue":"1","key":"10.1016\/j.talanta.2026.130013_bib40","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1038\/s41598-017-03526-x","article-title":"Effective adsorption and removal of phosphate from aqueous solutions and eutrophic water by Fe-based MOFs of MIL-101","volume":"7","author":"Xie","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.talanta.2026.130013_bib41","doi-asserted-by":"crossref","first-page":"16186","DOI":"10.1021\/acssuschemeng.8b02968","article-title":"TiO2 nanoparticles anchored onto the metal\u2013organic framework NH2-MIL-88B (Fe) as an adsorptive photocatalyst with enhanced fenton-like degradation of organic pollutants under visible light irradiation","volume":"6","author":"Li","year":"2018","journal-title":"ACS Sustainable Chem. Eng."},{"issue":"6","key":"10.1016\/j.talanta.2026.130013_bib42","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1021\/acs.inorgchem.1c00097","article-title":"Electrospun Fe-incorporated ZIF-67 nanofibers for effective electrocatalytic water splitting","volume":"60","author":"Sankar","year":"2021","journal-title":"Inorg. Chem."},{"issue":"10","key":"10.1016\/j.talanta.2026.130013_bib43","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.1021\/acscatal.2c01113","article-title":"Atomically dispersed Co\u2013S\u2013N active sites anchored on hierarchically porous carbon for efficient catalytic hydrogenation of nitro compounds","volume":"12","author":"Zhang","year":"2022","journal-title":"ACS Catal."},{"issue":"1","key":"10.1016\/j.talanta.2026.130013_bib44","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1038\/s41467-025-57560-9","article-title":"Surface-hydroxylated single-atom catalyst with an isolated Co-O-Zn configuration achieves high selectivity in regulating active species","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.talanta.2026.130013_bib45","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ijhydene.2023.06.238","article-title":"Development of SnCo2O4 spinel supported on the rGO nanosheet with the improved electrochemical performance of OER activity","volume":"51","author":"Donya","year":"2024","journal-title":"Int. J. Hydrogen Energy"},{"issue":"1","key":"10.1016\/j.talanta.2026.130013_bib46","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.1038\/s41467-024-51022-4","article-title":"Atom-pair engineering of single-atom nanozyme for boosting peroxidase-like activity","volume":"15","author":"Wei","year":"2024","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.talanta.2026.130013_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202002631","article-title":"Interface engineering of Co\u2010LDH@ MOF heterojunction in highly stable and efficient oxygen evolution reaction","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.talanta.2026.130013_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.112969","article-title":"Smartphone-assisted colorimetric sensing platform based on Cu (BDC) nanosheets derived CuS nanoparticles embedded in porous carbon with peroxidase-like activity for gallic acid detection","volume":"210","author":"Yuan","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.talanta.2026.130013_bib49","article-title":"Rational design of CuCo-ZIF@ HHTP heterojunction nanozyme via MOF-on-MOF strategy for efficient colorimetric sensing of quercetin","volume":"220","author":"Li","year":"2026","journal-title":"Microchem. J."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026006697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026006697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:48:06Z","timestamp":1783136886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026006697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":49,"alternative-id":["S0039914026006697"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130013","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Machine learning integrated MIL-88B@ZIF-67 built-in electric field heterojunction nanozyme for enhanced colorimetric detection of ascorbic acid and alkaline phosphatase","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130013"}}