{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:16:44Z","timestamp":1783059404942,"version":"3.54.6"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","award":["2025JY034"],"award-info":[{"award-number":["2025JY034"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004030","name":"Jiangsu Normal University","doi-asserted-by":"publisher","award":["16XLR012"],"award-info":[{"award-number":["16XLR012"]}],"id":[{"id":"10.13039\/501100004030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0524203"],"award-info":[{"award-number":["2024ZD0524203"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.talanta.2026.130064","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:51:08Z","timestamp":1780069868000},"page":"130064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["An intramolecular self-catalysis-boosted electrochemiluminescence biosensor for alpha fetoprotein detection in serum samples from liver cancer patients"],"prefix":"10.1016","volume":"309","author":[{"given":"Yongfeng","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouqi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-6811","authenticated-orcid":false,"given":"Qiumei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2026.130064_bib1","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jhep.2022.08.021","article-title":"Global burden of primary liver cancer in 2020 and predictions to 2040","volume":"77","author":"Rumgay","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.talanta.2026.130064_bib2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jhep.2023.02.022","article-title":"International liver cancer association (ILCA) white paper on hepatocellular carcinoma risk stratification and surveillance","volume":"79","author":"Singal","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.talanta.2026.130064_bib3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s43018-023-00671-3","article-title":"Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer","volume":"5","author":"Li","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.talanta.2026.130064_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.125638","article-title":"Electrochemical immuno-biosensors for the detection of the tumor marker alpha-fetoprotein: a review","volume":"271","author":"Shan","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.130064_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jhep.2022.01.027","article-title":"Duration and cost-effectiveness of hepatocellular carcinoma surveillance in hepatitis C patients after viral eradication","volume":"77","author":"Mueller","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.talanta.2026.130064_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.116234","article-title":"Advanced electrochemical impedance immunosensor based on PS-b-PAA film architecture for sensitive alpha-fetoprotein detection","volume":"219","author":"Qin","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.talanta.2026.130064_bib7","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.1021\/acs.analchem.2c00079","article-title":"Hand-operated, paper-based rotational vertical-flow immunosensor for the impedimetric detection of \u03b1-fetoprotein","volume":"94","author":"Yakoh","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130064_bib8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1021\/jacs.5c15881","article-title":"A new method to enhance electrochemiluminescence of Imine-based covalent organic frameworks","volume":"148","author":"Wang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2026.130064_bib9","doi-asserted-by":"crossref","first-page":"35501","DOI":"10.1021\/jacs.5c10211","article-title":"Stimuli-responsive luminophore drives mechanism switch for highly efficient electrochemiluminescence immunosensing","volume":"147","author":"Fracassa","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.talanta.2026.130064_bib10","article-title":"Single cell imaging of electrochemiluminescence-driven photodynamic therapy","volume":"61","author":"Chen","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2026.130064_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116735","article-title":"Electrochemiluminescence metal-organic frameworks biosensing materials for detecting cancer biomarkers","volume":"157","author":"Mohan","year":"2022","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130064_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101874","article-title":"Electrochemiluminescence biosensors for detection of cancer biomarkers in biofluids: principles, opportunities, and challenges","volume":"50","author":"Barhoum","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.talanta.2026.130064_bib13","doi-asserted-by":"crossref","first-page":"20510","DOI":"10.1021\/acs.analchem.4c04766","article-title":"Zinc-organic gel with self-catalysis-enhanced electrochemiluminescence as an emitter for the evaluation of liver cancer markers","volume":"96","author":"Liu","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130064_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.127120","article-title":"Ultrasensitive ECL immunoassay for CA15-3 via self-enhanced L012-loaded ZnNi-MOF as an emitter and CeO2-Pt as a co-reaction accelerator","volume":"283","author":"Cui","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.130064_bib15","doi-asserted-by":"crossref","first-page":"10024","DOI":"10.1021\/acs.analchem.8b02642","article-title":"Ternary electrochemiluminescence nanostructure of Au nanoclusters as a highly efficient signal label for ultrasensitive detection of cancer biomarkers","volume":"90","author":"Zhou","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130064_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.342091","article-title":"Ternary electrochemiluminescence quenching effects of CuFe2O4@PDA-MB towards self-enhanced Ru(dcbpy)32+ functionalized 2D metal-organic layer and application in carcinoembryonic antigen immunosensing","volume":"1287","author":"Ren","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2026.130064_bib17","doi-asserted-by":"crossref","first-page":"11076","DOI":"10.1021\/acs.analchem.7b03125","article-title":"High-sensitive electrochemiluminescence C-peptide biosensor via the double quenching of dopamine to the novel Ru(II)-organic complex with dual intramolecular self-catalysis","volume":"89","author":"Wang","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130064_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2026.345095","article-title":"Ultrasensitive electrochemiluminescence aptasensor for heparin-binding protein based on hybridization chain reaction (HCR) amplification and magnetic enrichment","volume":"1388","author":"Cheng","year":"2026","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2026.130064_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129868","article-title":"Exploring an ultra-sensitive electrochemiluminescence monitoring strategy for SARS-CoV-2 using hairpin-assisted cycling and dumbbell hybridization chain amplification","volume":"440","author":"Wu","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.talanta.2026.130064_bib20","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1016\/j.ijbiomac.2021.06.027","article-title":"Label-free electrochemical homogeneous detection of the depression marker human apolipoprotein A4 based on proximity hybridization triggered rolling circle amplification","volume":"183","author":"Liao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.talanta.2026.130064_bib21","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1039\/D3AN00414G","article-title":"Ultrasensitive detection of CA125 based on a triple signal amplification strategy with a huge number of loaded probes via exonuclease cyclic cleavage, rolling cyclic amplification and strand self-growth","volume":"148","author":"He","year":"2023","journal-title":"Analyst"},{"key":"10.1016\/j.talanta.2026.130064_bib22","doi-asserted-by":"crossref","first-page":"9057","DOI":"10.1021\/acs.analchem.5c01402","article-title":"Efficient Al\u2013H3NTB-MOG ECL emitter with self-enhanced and AIECL performance for ultrasensitive sensing of miRNA-141 combined with a Y-shaped multiregion dual-drive DNA walker","volume":"97","author":"Yang","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130064_bib23","article-title":"A self-serviced-track 3D DNA walker for ultrasensitive detection of tumor exosomes by glycoprotein profiling","volume":"134","author":"Wang","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.talanta.2026.130064_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131268","article-title":"Entropy-driven assisted T7 RNA polymerase amplification-activated CRISPR\/Cas13a activity for SARS-CoV-2 detection in human pharyngeal swabs and environment by an electrochemiluminescence biosensor","volume":"452","author":"Wei","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.talanta.2026.130064_bib25","article-title":"CeO2\/MXene heterojunction-based ultrasensitive electrochemiluminescence biosensing for BCR-ABL fusion gene detection combined with dual-toehold strand displacement reaction for signal amplification","volume":"208","author":"Cheng","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130064_bib26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12951-025-03847-4","article-title":"Entropy-driven signal amplification integrated with machine learning in multiplex lateral flow immunoassay for sensitive point-of-care Colon cancer diagnosis","volume":"23","author":"He","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.talanta.2026.130064_bib27","article-title":"Confined and fluid entropy-driven strand displacement reaction on red blood cell membrane for rapid and efficient detection of MicroRNA","volume":"270","author":"Wang","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130064_bib28","article-title":"A fluorescent aptasensor for enzyme-free and sensitive detection of kanamycin based on entropy-driven strand displacement reaction","volume":"1307","author":"Xie","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2026.130064_bib29","article-title":"Recent advance in nucleic acid amplification-integrated methods for DNA methyltransferase assay","volume":"161","author":"Liu","year":"2023","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130064_bib30","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1021\/acssensors.6c00154","article-title":"Entropy-driven proximity strand displacement amplification strategy for electrochemical sensing of cancer-related miRNA","volume":"11","author":"Xing","year":"2026","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2026.130064_bib31","article-title":"Dual electric field coupling with tunable schottky barrier synergistically regulating electronic configuration in CoP@Ni-CdS heterojunction for efficient photocatalytic H2 evolution","volume":"35","author":"Zhang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.talanta.2026.130064_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.124074","article-title":"A dual-stimuli responsive electrochemiluminescence biosensor for pathogenic bacterial sensing and killing in foods","volume":"253","author":"Wang","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.130064_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.est.2023.109224","article-title":"Interface engineering combined with nitrogen and phosphorus co-doped synergistic optimization strategies for designing hollow\/porous N, P-CoWO4@Co3O4 heterojunction nanocubes for superior-performance supercapacitor and oxygen evolution reaction","volume":"73","author":"Feng","year":"2023","journal-title":"J. Energy Storage"},{"key":"10.1016\/j.talanta.2026.130064_bib34","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s11426-022-1544-x","article-title":"Full reaction mechanism of hydrogen peroxide catalyzed by reductive CoP nanoparticles: the enzyme-like activity","volume":"66","author":"Wan","year":"2023","journal-title":"Sci. China Chem."},{"key":"10.1016\/j.talanta.2026.130064_bib35","doi-asserted-by":"crossref","first-page":"29345","DOI":"10.1021\/jacs.5c10672","article-title":"Interplay between through-space and through-bond electronic coupling in singlet fission","volume":"147","author":"Thiel","year":"2025","journal-title":"J. Am. Chem. Soc."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026007204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026007204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:24:46Z","timestamp":1783056286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026007204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":35,"alternative-id":["S0039914026007204"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130064","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An intramolecular self-catalysis-boosted electrochemiluminescence biosensor for alpha fetoprotein detection in serum samples from liver cancer patients","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130064"}}