{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:08:00Z","timestamp":1788829680828,"version":"build-2803163510"},"reference-count":210,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173885"],"award-info":[{"award-number":["82173885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872933"],"award-info":[{"award-number":["81872933"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.talanta.2026.130217","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T06:47:17Z","timestamp":1782542837000},"page":"130217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mapping alkaloids with mass spectrometry imaging: Application of spatial distribution in medicinal plants and animal tissues"],"prefix":"10.1016","volume":"311","author":[{"given":"Mireyi","family":"Bahatijiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huida","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-4856","authenticated-orcid":false,"given":"Changhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/s12906-019-2739-6","article-title":"Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling","volume":"19","author":"Wan","year":"2019","journal-title":"BMC Compl. Alternative Med."},{"issue":"21","key":"10.1016\/j.talanta.2026.130217_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25214901","article-title":"Biosynthesis and biological activities of newly discovered Amaryllidaceae alkaloids","volume":"25","author":"Ka","year":"2020","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.talanta.2026.130217_bib3","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1039\/D3NP00044C","article-title":"Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential - a review","volume":"41","author":"Jayawardena","year":"2024","journal-title":"Nat. Prod. Rep."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib4","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/s41467-020-15040-2","article-title":"Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.talanta.2026.130217_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04141","article-title":"Antioxidant and anti-inflammatory properties of Erythroxylum cuneatum alkaloid leaf extract","volume":"6","author":"Li","year":"2020","journal-title":"Heliyon"},{"issue":"5","key":"10.1016\/j.talanta.2026.130217_bib6","first-page":"69","article-title":"Progress on the method of classification and identifying of alkaloids","volume":"26","author":"Zhang","year":"2010","journal-title":"Journal of West Anhui University"},{"issue":"14","key":"10.1016\/j.talanta.2026.130217_bib7","doi-asserted-by":"crossref","first-page":"11622","DOI":"10.1021\/acs.jmedchem.4c01122","article-title":"An update on the nitrogen heterocycle compositions and properties of U.S. FDA-approved pharmaceuticals (2013\u20132023)","volume":"67","author":"Marshall","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2015.10.037","article-title":"Effects of harmine, an acetylcholinesterase inhibitor, on spatial learning and memory of APP\/PS1 transgenic mice and scopolamine-induced memory impairment mice","volume":"768","author":"He","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.schres.2014.08.006","article-title":"Harmine for catatonic schizophrenia. A forgotten experiment","volume":"159","author":"Hostiuc","year":"2014","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.talanta.2026.130217_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108131","article-title":"Endogenous opioid peptides in the descending pain modulatory circuit","volume":"173","author":"Bagley","year":"2020","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.talanta.2026.130217_bib11","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1002\/ptr.6649","article-title":"p-Synephrine, ephedrine, p-octopamine and m-synephrine: comparative mechanistic, physiological and pharmacological properties","volume":"34","author":"Stohs","year":"2020","journal-title":"Phytother Res."},{"issue":"2","key":"10.1016\/j.talanta.2026.130217_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tcm.2024.07.003","article-title":"Quinidine for ventricular arrhythmias: a comprehensive review","volume":"35","author":"Rakza","year":"2025","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.talanta.2026.130217_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116143","article-title":"An insight into the medicinal attributes of berberine derivatives: a review","volume":"38","author":"Gaba","year":"2021","journal-title":"Bioorg. Med. Chem."},{"issue":"8","key":"10.1016\/j.talanta.2026.130217_bib14","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1002\/ptr.7539","article-title":"The therapeutic effects of berberine against different diseases: a review on the involvement of the endoplasmic reticulum stress","volume":"36","author":"Yarmohammadi","year":"2022","journal-title":"Phytother Res."},{"key":"10.1016\/j.talanta.2026.130217_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115270","article-title":"Aconitine: a review of its pharmacokinetics, pharmacology, toxicology and detoxification","volume":"293","author":"Gao","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"45","key":"10.1016\/j.talanta.2026.130217_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202212301","article-title":"Biosynthesis of the plant-produced toxin strychnine elucidated","volume":"61","author":"Kandy","year":"2022","journal-title":"Angew. Chem., Int. Ed. Engl."},{"issue":"7","key":"10.1016\/j.talanta.2026.130217_bib17","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/pca.3401","article-title":"Determination of Veratrum alkaloid contents in three Veratrum species by HPLC-MS\/MS","volume":"35","author":"Siegle","year":"2024","journal-title":"Phytochem. Anal."},{"issue":"6","key":"10.1016\/j.talanta.2026.130217_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26061738","article-title":"Determination of cytotoxic activity of Sanguinaria canadensis extracts against human melanoma cells and comparison of their cytotoxicity with cytotoxicity of some anticancer drugs","volume":"26","author":"Tuzimski","year":"2021","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.talanta.2026.130217_bib19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1360\/SSC-2024-0226","article-title":"Research and application of mass spectrometry imaging technology in traditional Chinese medicine analysis","volume":"55","author":"Shen","year":"2025","journal-title":"Sci. Sin. Chim."},{"key":"10.1016\/j.talanta.2026.130217_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104755","article-title":"A review of pharmacological and pharmacokinetic properties of stachydrine","volume":"155","author":"Cheng","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.talanta.2026.130217_bib39","first-page":"1876","article-title":"Determination of stachydrine hydrochloride and leonurine hydrochloride in Yimucao preparations by HPLC-MS","volume":"41","author":"Zhou","year":"2016","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.talanta.2026.130217_bib40","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jpba.2012.12.029","article-title":"Simultaneous determination and pharmacokinetic study of stachydrine and leonurine in rat plasma after oral administration of Herba Leonuri extract by LC-MS\/MS","volume":"76","author":"Li","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"6","key":"10.1016\/j.talanta.2026.130217_bib41","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1002\/fsn3.2822","article-title":"Qualitative and quantitative analyses of chemical components of Citri Sarcodactylis Fructus from different origins based on UPLC-Q-Exactive Orbitrap-MS and GC-MS","volume":"10","author":"Ning","year":"2022","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.talanta.2026.130217_bib42","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.plantsci.2019.03.013","article-title":"Alkaloid chemodiversity in Mandragora spp. is associated with loss-of-functionality of MoH6H, a hyoscyamine 6\u03b2-hydroxylase gene","volume":"283","author":"Schlesinger","year":"2019","journal-title":"Plant Sci."},{"issue":"12","key":"10.1016\/j.talanta.2026.130217_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5485","article-title":"A validated liquid chromatography-tandem mass spectrometry method for the determination of l-hyoscyamine in human plasma: application in a clinical study","volume":"36","author":"Duan","year":"2022","journal-title":"Biomed. Chromatogr."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-36625-4","article-title":"Tropane alkaloids GC\/MS analysis and low dose elicitors' effects on hyoscyamine biosynthetic pathway in hairy roots of Algerian Datura species","volume":"8","author":"Harfi","year":"2018","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.talanta.2026.130217_bib45","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1080\/14786419.2021.2000982","article-title":"A pair of new oxindole alkaloids isolated from Uncaria macrophylla","volume":"37","author":"Liang","year":"2023","journal-title":"Nat. Prod. Res."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib46","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/np1004938","article-title":"Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla","volume":"74","author":"Wang","year":"2011","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2025.101340","article-title":"Unraveling pyrrolizidine alkaloid-induced liver damage with an integrative spatial lipidomics framework","volume":"16","author":"Chen","year":"2026","journal-title":"J. Pharm. Anal."},{"issue":"11","key":"10.1016\/j.talanta.2026.130217_bib48","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.3109\/13880209.2016.1160251","article-title":"The pharmacology, toxicology and potential applications of arecoline: a review","volume":"54","author":"Liu","year":"2016","journal-title":"Pharm. Biol."},{"issue":"22","key":"10.1016\/j.talanta.2026.130217_bib49","first-page":"6066","article-title":"Component profile analysis of Sanhan Huashi Formula based on UHPLC-LTQ-Orbitrap-MS, GC-MS, and UHPLC-QQQ-MS\/MS","volume":"48","author":"Wang","year":"2023","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.talanta.2026.130217_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116158","article-title":"Simultaneous determination of five constituents of areca nut extract in rat plasma using UPLC-MS\/MS and its application in a pharmacokinetic study","volume":"245","author":"Pan","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.talanta.2026.130217_bib51","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2147\/DDDT.S349678","article-title":"Matrine exerts pharmacological effects through multiple signaling pathways: a comprehensive review","volume":"16","author":"Lin","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.talanta.2026.130217_bib52","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jpba.2013.05.003","article-title":"Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS\/MS method","volume":"83","author":"Tang","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.talanta.2026.130217_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1627864","article-title":"Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations","volume":"16","author":"Xu","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.talanta.2026.130217_bib54","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1096\/fj.09-148999","article-title":"Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells","volume":"24","author":"Rana","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.talanta.2026.130217_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8302636","article-title":"Anti-Inflammatory and neuroprotective role of natural product securinine in activated glial cells: implications for Parkinson's Disease","volume":"2017","author":"Leonoudakis","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.talanta.2026.130217_bib56","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jchromb.2014.04.011","article-title":"Development and validation of LC-MS\/MS method for quantitative determination of (-)-securinine in mouse plasma","volume":"960","author":"Wabuyele","year":"2014","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phymed.2014.09.008","article-title":"Cytotoxic effects of stem bark extracts and pure compounds from Margaritaria discoidea on human ovarian cancer cell lines","volume":"22","author":"Johnson-Ajinwo","year":"2015","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.talanta.2026.130217_bib58","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1002\/cbdv.200890160","article-title":"Alkaloids from the roots of Zanthoxylum nitidum and their antiviral and antifungal effects","volume":"5","author":"Yang","year":"2008","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.talanta.2026.130217_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110051","article-title":"Antitumor activity of dictamnine against colorectal cancer through induction of ferroptosis and inhibition of M2 macrophage polarization via the MAPK signaling","volume":"758","author":"Zuo","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.talanta.2026.130217_bib60","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jchromb.2013.03.018","article-title":"Simultaneous determination of limonin, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS\/MS and its application to a pharmacokinetic study after oral administration of Cortex Dictamni extract","volume":"928","author":"Wang","year":"2013","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.talanta.2026.130217_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113232","article-title":"Rapid identification and pharmacokinetic studies of multiple active alkaloids in rat plasma through UPLC-Q-TOF-MS and UPLC-MS\/MS after the oral administration of Zanthoxylum nitidum extract","volume":"186","author":"Lin","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.talanta.2026.130217_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116153","article-title":"Ephedrae herba: a comprehensive review of its traditional uses, phytochemistry, pharmacology, and toxicology","volume":"307","author":"Zheng","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.talanta.2026.130217_bib63","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jpba.2015.04.035","article-title":"GC-MS based metabolomics study of stems and roots of Ephedra sinica","volume":"114","author":"Lv","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"22","key":"10.1016\/j.talanta.2026.130217_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26226991","article-title":"A pharmacokinetic Study of ephedrine and pseudoephedrine after oral administration of Ojeok-San by validated LC-MS\/MS method in human plasma","volume":"26","author":"Lee","year":"2021","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.talanta.2026.130217_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28073149","article-title":"Papaverine: a miraculous alkaloid from opium and its multimedicinal application","volume":"28","author":"Ashrafi","year":"2023","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.talanta.2026.130217_bib66","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/dta.2581","article-title":"UHPLC-MS\/MS quantitation of porphyroxine in opium and application of porphyroxine-acetylated products as signature markers for heroin","volume":"11","author":"Li","year":"2019","journal-title":"Drug Test. Anal."},{"issue":"23","key":"10.1016\/j.talanta.2026.130217_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ma18235316","article-title":"GC-MS\/MS and LC-MS\/MS identification of opium and tropane alkaloids in pottery from funnel beaker culture sites in South-Eastern Poland","volume":"18","author":"Osak","year":"2025","journal-title":"Materials"},{"issue":"6","key":"10.1016\/j.talanta.2026.130217_bib68","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1021\/jasms.1c00337","article-title":"Increasing DESI-MS ion signal by plasma treatment","volume":"33","author":"Baghernia","year":"2022","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.talanta.2026.130217_bib69","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.phytochem.2016.02.005","article-title":"Tetrandrine--A molecule of wide bioactivity","volume":"125","author":"Bhagya","year":"2016","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib70","doi-asserted-by":"crossref","first-page":"932","DOI":"10.7150\/thno.30408","article-title":"Quantitative MALDI imaging of spatial distributions and dynamic changes of tetrandrine in multiple organs of rats","volume":"9","author":"Tang","year":"2019","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.talanta.2026.130217_bib71","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/chromsci\/bmab116","article-title":"UHPLC-MS\/MS method for quantifying fangchinoline, tetrandrine and Calycosin-7-O-\u03b2-D-Glucoside of fangji huangqi decoction in rat plasma and its application to a pharmacokinetic Study","volume":"60","author":"Guan","year":"2022","journal-title":"J. Chromatogr. Sci."},{"issue":"23","key":"10.1016\/j.talanta.2026.130217_bib72","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70256","article-title":"Stephanine protects against osteoporosis by suppressing osteoclastogenesis via inhibition of the RANKL-RANK interaction","volume":"28","author":"Liu","year":"2024","journal-title":"J. Cell Mol. Med."},{"issue":"9","key":"10.1016\/j.talanta.2026.130217_bib73","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/ptr.5861","article-title":"Stephanine from Stephania venosa (Blume) Spreng showed effective antiplasmodial and anticancer activities, the latter by inducing apoptosis through the reverse of mitotic exit","volume":"31","author":"Le","year":"2017","journal-title":"Phytother Res."},{"issue":"3","key":"10.1016\/j.talanta.2026.130217_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24030585","article-title":"Profiling and pharmacokinetic studies of alkaloids in rats after oral administration of Zanthoxylum nitidum decoction by UPLC-Q-TOF-MS\/MS and HPLC-MS\/MS","volume":"24","author":"Huang","year":"2019","journal-title":"Molecules"},{"issue":"Suppl 2","key":"10.1016\/j.talanta.2026.130217_bib75","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/2047-783X-15-S2-184","article-title":"Central antitussive effect of codeine in the anesthetized rabbit","volume":"15","author":"Simera","year":"2010","journal-title":"Eur. J. Med. Res."},{"issue":"5","key":"10.1016\/j.talanta.2026.130217_bib76","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/jvp.13126","article-title":"Pharmacokinetics and effects of codeine in combination with acetaminophen on thermal nociception in horses","volume":"46","author":"Tueshaus","year":"2023","journal-title":"J. Vet. Pharmacol. Therapeut."},{"key":"10.1016\/j.talanta.2026.130217_bib77","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ejps.2018.11.011","article-title":"Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery","volume":"127","author":"Handler","year":"2019","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.talanta.2026.130217_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115623","article-title":"Pharmacokinetics and transplacental transfer of codeine and codeine metabolites from Papaver somniferum L","volume":"298","author":"Chen","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.talanta.2026.130217_bib79","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28124649","article-title":"Detection of three opioids (Morphine, codeine and methadone) and their metabolites (6-Monoacetylmorphine and 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) in Larvae of Lucilia sericata species by UHPLC-TF-MS and validation","volume":"28","author":"Buratti","year":"2023","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.talanta.2026.130217_bib80","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/03602532.2017.1306544","article-title":"The metabolism of berberine and its contribution to the pharmacological effects","volume":"49","author":"Wang","year":"2017","journal-title":"Drug Metab. Rev."},{"issue":"29","key":"10.1016\/j.talanta.2026.130217_bib81","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.1007\/s00216-024-05584-3","article-title":"Visualizing the transdermal delivery of berberine loaded within chitosan microneedles using mass spectrometry imaging","volume":"416","author":"Cui","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119627","article-title":"Exploring the tissue distribution propensity of active alkaloids in normal and stomach heat syndrome rats following oral administration of Zuojin Pill based on pharmacokinetics and mass spectrometry imaging","volume":"346","author":"Xiang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.talanta.2026.130217_bib83","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2165\/00003495-200060050-00008","article-title":"Galantamine: a review of its use in Alzheimer's disease","volume":"60","author":"Scott","year":"2000","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26041710","article-title":"Enhancing galantamine distribution in Rat Brain using microplasma-assisted nose-to-brain drug delivery","volume":"26","author":"Sadiq","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"20","key":"10.1016\/j.talanta.2026.130217_bib85","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1007\/s00216-021-03487-1","article-title":"LC-MS bioanalysis of targeted nasal galantamine bound chitosan nanoparticles in rats' brain homogenate and plasma","volume":"413","author":"Agami","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"issue":"5","key":"10.1016\/j.talanta.2026.130217_bib86","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1078\/09447110260571661","article-title":"Studies on the antinociceptive, anti-inflammatory and anti pyretic effects of Isatis indigotica root","volume":"9","author":"Ho","year":"2002","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib87","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jep.2009.02.028","article-title":"The cytotoxicity to leukemia cells and antiviral effects of Isatis indigotica extracts on pseudorabies virus","volume":"123","author":"Hsuan","year":"2009","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.talanta.2026.130217_bib88","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/rcm.2954","article-title":"Determination of indican, isatin, indirubin and indigotin in Isatis indigotica by liquid chromatography\/electrospray ionization tandem mass spectrometry","volume":"21","author":"Zou","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.talanta.2026.130217_bib89","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.2147\/IJN.S459510","article-title":"Evodiamine: a extremely potential drug development candidate of alkaloids from Evodia rutaecarpa","volume":"19","author":"Lin","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"23","key":"10.1016\/j.talanta.2026.130217_bib90","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1007\/s00216-021-03568-1","volume":"413","author":"Li","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2021.122772","article-title":"UPLC-Q-Exactive-MS analysis for hepatotoxicity components of Evodiae Fructus based on spectrum-toxicity relationship","volume":"1176","author":"Zhang","year":"2021","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"issue":"12","key":"10.1016\/j.talanta.2026.130217_bib92","article-title":"Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis","volume":"12","author":"Gallos","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.talanta.2026.130217_bib93","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s00216-016-0047-2","article-title":"Localization of ergot alkaloids in sclerotia of Claviceps purpurea by matrix-assisted laser desorption\/ionization mass spectrometry imaging","volume":"409","author":"Dopstadt","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"issue":"29","key":"10.1016\/j.talanta.2026.130217_bib94","doi-asserted-by":"crossref","first-page":"18412","DOI":"10.1021\/acs.jafc.5c03345","article-title":"Semisynthesis of stable isotope-labeled ergot alkaloids for HPLC-MS\/MS analysis","volume":"73","author":"Herter","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"8","key":"10.1016\/j.talanta.2026.130217_bib95","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007253","article-title":"Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response","volume":"11","author":"Wang","year":"2023","journal-title":"J. Immunother. Cancer"},{"issue":"22","key":"10.1016\/j.talanta.2026.130217_bib96","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1021\/ac8015467","article-title":"Matrix-assisted laser desorption\/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections","volume":"80","author":"Trim","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114772","article-title":"A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS\/MS","volume":"215","author":"van der Heijden","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib98","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1248\/bpb.28.750","article-title":"Effects of gentianine on the production of pro-inflammatory cytokines in male Sprague-Dawley rats treated with lipopolysaccharide (LPS)","volume":"28","author":"Kwak","year":"2005","journal-title":"Biol. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib99","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/ptr.4763","article-title":"Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-\u03b3 gene expression in 3T3-L1 cells","volume":"27","author":"Vaidya","year":"2013","journal-title":"Phytother Res."},{"key":"10.1016\/j.talanta.2026.130217_bib100","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jchromb.2015.01.007","article-title":"Determination of the metabolic profile of gentianine after oral administration to rats by high performance liquid chromatography\/electrospray ionization-trap mass spectrometry","volume":"989","author":"Wu","year":"2015","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.talanta.2026.130217_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154993","article-title":"Dendrobine rescues cognitive dysfunction in diabetic encephalopathy by inhibiting ferroptosis via activating Nrf2\/GPX4 axis","volume":"119","author":"Shi","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.talanta.2026.130217_bib102","article-title":"Metabolic profiling, in-situ spatial distribution, and biosynthetic pathway of functional metabolites in Dendrobium nobile stem revealed by combining UPLC-QTOF-MS with MALDI-TOF-MSI","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.talanta.2026.130217_bib103","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fmicb.2020.00337","article-title":"New insights into detection of a dendrobine compound from a novel endophytic Trichoderma longibrachiatum strain and its toxicity against phytopathogenic bacteria","volume":"11","author":"Sarsaiya","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.talanta.2026.130217_bib104","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1104473","article-title":"Rapid visual characterization of alkaloid changes in traditional processing of Tibetan medicine Aconitum pendulum by high-performance thin-layer chromatography coupled with desorption electrospray ionization mass spectrometry imaging","volume":"14","author":"Tan","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.talanta.2026.130217_bib105","article-title":"Unveiling the processing mechanism of Hezi-decoction-processed Tiebangchui: a synthesis approach using UPLC-Q-TOF-MS-based metabolomics and DESI-MSI","volume":"16","author":"Zhou","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.talanta.2026.130217_bib106","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jep.2011.09.005","article-title":"Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine","volume":"141","author":"Fan","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.talanta.2026.130217_bib107","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jms.1191","article-title":"Detection and validated quantification of toxic alkaloids in human blood plasma--comparison of LC-APCI-MS with LC-ESI-MS\/MS","volume":"42","author":"Beyer","year":"2007","journal-title":"J. Mass Spectrom."},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib20","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1074\/mcp.R500006-MCP200","article-title":"Tissue profiling by mass spectrometry: a review of methodology and applications","volume":"4","author":"Caldwell","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"issue":"5\u20136","key":"10.1016\/j.talanta.2026.130217_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/prca.201400182","article-title":"State-of-the-art nanoplatform-integrated MALDI-MS impacting resolutions in urinary proteomics, Proteomics","volume":"9","author":"Gopal","year":"2015","journal-title":"Clin. Appl."},{"issue":"10","key":"10.1016\/j.talanta.2026.130217_bib22","first-page":"1382","article-title":"Application of mass spectrometry imaging in metabolism of traditional Chinese medicine","volume":"39","author":"Xie","year":"2022","journal-title":"Chin. J. Mod. Appl. Pharm."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev-anchem-061318-115516","article-title":"Metabolic imaging at the single-cell scale: recent advances in mass spectrometry imaging","volume":"12","author":"Gilmore","year":"2019","journal-title":"Annu. Rev. Anal. Chem."},{"issue":"5","key":"10.1016\/j.talanta.2026.130217_bib24","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00418-010-0753-3","article-title":"Molecular mass spectrometry imaging in biomedical and life science research","volume":"134","author":"P\u00f3l","year":"2010","journal-title":"Histochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tips.2023.11.003","article-title":"Spatial pharmacology using mass spectrometry imaging","volume":"45","author":"Rajbhandari","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"issue":"11","key":"10.1016\/j.talanta.2026.130217_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70031","article-title":"Spatially resolved metabolomics: from metabolite mapping to function visualising","volume":"14","author":"Min","year":"2024","journal-title":"Clin. Transl. Med."},{"issue":"12","key":"10.1016\/j.talanta.2026.130217_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/jms.5104","article-title":"Mass spectrometry imaging for spatial toxicology research","volume":"59","author":"Qiu","year":"2024","journal-title":"J. Mass Spectrom."},{"issue":"29","key":"10.1016\/j.talanta.2026.130217_bib28","doi-asserted-by":"crossref","first-page":"15517","DOI":"10.1021\/acs.analchem.4c05249","article-title":"Mass spectrometry imaging","volume":"97","author":"K\u00f6rber","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2026.466719","article-title":"Advances in desorption electrospray ionization mass spectrometry imaging: research progress and applications","volume":"1769","author":"Zhang","year":"2026","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/nph.70834","article-title":"Mass spectrometry imaging: principles and applications in plant research","volume":"250","author":"Liu","year":"2026","journal-title":"New Phytol."},{"issue":"11","key":"10.1016\/j.talanta.2026.130217_bib31","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1021\/acs.jproteome.3c00167","article-title":"A guide to MALDI imaging mass spectrometry for tissues","volume":"22","author":"Moore","year":"2023","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tplants.2024.08.002","article-title":"Exploring natural product biosynthesis in plants with mass spectrometry imaging","volume":"30","author":"Zou","year":"2025","journal-title":"Trends Plant Sci."},{"issue":"7","key":"10.1016\/j.talanta.2026.130217_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5494","article-title":"Mass spectrometry imaging technology in metabolomics: a systematic review","volume":"37","author":"Gao","year":"2023","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.talanta.2026.130217_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117878","article-title":"State-of-the-art application of mass spectrometry imaging covering the medicinal and edible plants","volume":"179","author":"Jing","year":"2024","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2022.1051756","article-title":"A mass spectrometry imaging approach on spatiotemporal distribution of multiple alkaloids in Gelsemium elegans","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Plant Sci."},{"issue":"2","key":"10.1016\/j.talanta.2026.130217_bib36","doi-asserted-by":"crossref","first-page":"838","DOI":"10.3390\/cimb45020055","article-title":"MALDI imaging mass spectrometry of high-grade gliomas: a review of recent progress and future perspective","volume":"45","author":"Ron\u010devi\u0107","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"issue":"8","key":"10.1016\/j.talanta.2026.130217_bib37","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1039\/C9NP00073A","article-title":"Total synthesis of alkaloids using both chemical and biochemical methods","volume":"37","author":"Tanifuji","year":"2020","journal-title":"Nat. Prod. Rep."},{"issue":"12","key":"10.1016\/j.talanta.2026.130217_bib108","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/j.jprot.2011.03.032","article-title":"Mass spectrometry imaging for drugs and metabolites","volume":"74","author":"Greer","year":"2011","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.talanta.2026.130217_bib109","doi-asserted-by":"crossref","DOI":"10.1002\/ansa.70082","article-title":"Dry deposition strategies for MALDI-MS imaging: principles, advances and emerging applications","volume":"7","author":"Mahamdi","year":"2026","journal-title":"Anal. Sci. Adv"},{"key":"10.1016\/j.talanta.2026.130217_bib110","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fpls.2016.00060","article-title":"Sample preparation for mass spectrometry imaging of plant tissues: a review","volume":"7","author":"Dong","year":"2016","journal-title":"Front. Plant Sci."},{"issue":"6","key":"10.1016\/j.talanta.2026.130217_bib111","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1039\/C3NP70100J","article-title":"Mass spectrometry imaging of plant metabolites-principles and possibilities","volume":"31","author":"Bjarnholt","year":"2014","journal-title":"Nat. Prod. Rep."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib112","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00216-012-6077-5","article-title":"MALDI-mass spectrometry imaging of desalted rat brain sections reveals ischemia-mediated changes of lipids","volume":"404","author":"Wang","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2023.102362","article-title":"Spatial metabolomics principles and application to cancer research","volume":"76","author":"Planque","year":"2023","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.talanta.2026.130217_bib114","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cbpa.2016.12.018","article-title":"From single cells to our planet-recent advances in using mass spectrometry for spatially resolved metabolomics","volume":"36","author":"Petras","year":"2017","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"18","key":"10.1016\/j.talanta.2026.130217_bib115","doi-asserted-by":"crossref","first-page":"9985","DOI":"10.1021\/acs.analchem.5c00843","article-title":"Delineation of subcellular molecular heterogeneity in single cells via ultralow-flow-rate desorption electrospray ionization Mass spectrometry imaging","volume":"97","author":"Zhang","year":"2025","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib116","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1021\/acs.analchem.7b04733","article-title":"Mass spectrometry imaging: a review of emerging advancements and future insights","volume":"90","author":"Buchberger","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2023.113620","article-title":"Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging","volume":"209","author":"Lorensen","year":"2023","journal-title":"Phytochemistry"},{"key":"10.1016\/j.talanta.2026.130217_bib118","article-title":"Dissecting specialized metabolism in space: a MALDI-MSI atlas of Amaryllidaceae alkaloids in Hippeastrum papilio (Ravenna) Van Scheepen","author":"Liyanage","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.talanta.2026.130217_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2025.117544","article-title":"Spatial distribution of alkaloids in Fritillaria Bulbus using UPLC-Q-Exactive Orbitrap MS\/MS and desorption electrospray MS imaging","volume":"218","author":"Guo","year":"2025","journal-title":"LWT"},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib120","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00216-025-06223-1","article-title":"Elucidating spatiotemporal distribution of chemical constituents from Corydalis Decumbentis Rhizoma in rat brain via integrated UPLC-MS\/MS quantification and DESI-MSI visualization","volume":"418","author":"Li","year":"2026","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib121","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/mas.20275","article-title":"Developments in molecular SIMS depth profiling and 3D imaging of biological systems using polyatomic primary ions","volume":"30","author":"Fletcher","year":"2011","journal-title":"Mass Spectrom. Rev."},{"issue":"9","key":"10.1016\/j.talanta.2026.130217_bib122","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1021\/acs.analchem.7b05180","article-title":"Quantitative SIMS imaging of agar-based microbial communities","volume":"90","author":"Dunham","year":"2018","journal-title":"Anal. Chem."},{"issue":"19","key":"10.1016\/j.talanta.2026.130217_bib123","doi-asserted-by":"crossref","first-page":"13281","DOI":"10.1021\/acs.analchem.0c02519","article-title":"Cell-Type-Specific metabolic profiling achieved by combining desorption electrospray ionization Mass spectrometry imaging and immunofluorescence staining","volume":"92","author":"Yan","year":"2020","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.talanta.2026.130217_bib125","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/rcm.8375","article-title":"Sulfur isotope analysis of microcrystalline iron sulfides using secondary ion mass spectrometry imaging: extracting local paleo-environmental information from modern and ancient sediments","volume":"33","author":"Bryant","year":"2019","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"24","key":"10.1016\/j.talanta.2026.130217_bib151","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1039\/D1AN01768C","article-title":"Imaging mass spectrometry of fingermarks on brass bullet casings using sample rotation","volume":"146","author":"Lee","year":"2021","journal-title":"Analyst"},{"issue":"10","key":"10.1016\/j.talanta.2026.130217_bib152","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nmeth1094","article-title":"MALDI imaging mass spectrometry: molecular snapshots of biochemical systems","volume":"4","author":"Cornett","year":"2007","journal-title":"Nat. Methods"},{"issue":"23","key":"10.1016\/j.talanta.2026.130217_bib153","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1021\/ac970888i","article-title":"Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS","volume":"69","author":"Caprioli","year":"1997","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.talanta.2026.130217_bib154","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1021\/ac701703f","article-title":"Atmospheric pressure infrared MALDI imaging mass spectrometry for plant metabolomics","volume":"80","author":"Li","year":"2008","journal-title":"Anal. Chem."},{"issue":"5695","key":"10.1016\/j.talanta.2026.130217_bib155","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1126\/science.1104404","article-title":"Mass spectrometry sampling under ambient conditions with desorption electrospray ionization","volume":"306","author":"Tak\u00e1ts","year":"2004","journal-title":"Science."},{"issue":"43","key":"10.1016\/j.talanta.2026.130217_bib156","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1002\/anie.200602449","article-title":"Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry","volume":"45","author":"Wiseman","year":"2006","journal-title":"Angew. Chem., Int. Ed. Engl."},{"issue":"25","key":"10.1016\/j.talanta.2026.130217_bib124","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1016\/j.chroma.2010.01.033","article-title":"A concise review of mass spectrometry imaging","volume":"1217","author":"Amstalden van Hove","year":"2010","journal-title":"J. Chromatogr., A"},{"issue":"2","key":"10.1016\/j.talanta.2026.130217_bib126","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1021\/ac201179t","article-title":"Identifying individual cell types in heterogeneous cultures using secondary ion mass spectrometry imaging with C60 etching and multivariate analysis","volume":"84","author":"Barnes","year":"2012","journal-title":"Anal. Chem."},{"issue":"17","key":"10.1016\/j.talanta.2026.130217_bib127","doi-asserted-by":"crossref","first-page":"12079","DOI":"10.1021\/acs.analchem.0c02815","article-title":"Multimodal imaging mass spectrometry to identify markers of pulmonary arterial hypertension in human lung tissue using MALDI-ToF, ToF-SIMS, and hybrid SIMS","volume":"92","author":"Van Nuffel","year":"2020","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.talanta.2026.130217_bib128","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1255\/ejms.798","article-title":"Derivatization in mass spectrometry--8. Soft ionization mass spectrometry of small molecules","volume":"12","author":"Zaikin","year":"2006","journal-title":"Eur. J. Mass Spectrom."},{"issue":"26","key":"10.1016\/j.talanta.2026.130217_bib129","doi-asserted-by":"crossref","first-page":"9083","DOI":"10.1021\/acs.analchem.1c00498","article-title":"Hydralazine as a versatile and universal matrix for high-molecular coverage and dual-polarity matrix-assisted laser Desorption\/Ionization mass spectrometry imaging","volume":"93","author":"Tang","year":"2021","journal-title":"Anal. Chem."},{"issue":"12","key":"10.1016\/j.talanta.2026.130217_bib130","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/j.jasms.2005.08.014","article-title":"In situ structural characterization of phosphatidylcholines in brain tissue using MALDI-MS\/MS","volume":"16","author":"Jackson","year":"2005","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib131","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nmeth1145","article-title":"Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction","volume":"5","author":"Andersson","year":"2008","journal-title":"Nat. Methods"},{"issue":"6","key":"10.1016\/j.talanta.2026.130217_bib132","doi-asserted-by":"crossref","first-page":"11277","DOI":"10.3390\/ijms140611277","article-title":"Current status and future perspectives of mass spectrometry imaging","volume":"14","author":"Nimesh","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.talanta.2026.130217_bib133","first-page":"1885","article-title":"An alternative paper based tissue washing method for mass spectrometry imaging: localized washing and fragile tissue analysis","volume":"22","author":"van Hove","year":"2011","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"10","key":"10.1016\/j.talanta.2026.130217_bib134","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1007\/s00216-020-03128-z","article-title":"Removal of optimal cutting temperature (O.C.T.) compound from embedded tissue for MALDI imaging of lipids","volume":"413","author":"Truong","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib135","article-title":"Electrospray deposition device used to precisely control the matrix crystal to improve the performance of MALDI MSI","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"issue":"17","key":"10.1016\/j.talanta.2026.130217_bib136","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1021\/ac070958d","article-title":"Automated MALDI matrix deposition method with inkjet printing for imaging mass spectrometry","volume":"79","author":"Baluya","year":"2007","journal-title":"Anal. Chem."},{"issue":"3","key":"10.1016\/j.talanta.2026.130217_bib137","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1021\/ac051534r","article-title":"Automated acoustic matrix deposition for MALDI sample preparation","volume":"78","author":"Aerni","year":"2006","journal-title":"Anal. Chem."},{"issue":"9","key":"10.1016\/j.talanta.2026.130217_bib138","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.jasms.2007.06.010","article-title":"Sublimation as a method of matrix application for mass spectrometric imaging","volume":"18","author":"Hankin","year":"2007","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib139","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1039\/C4SC01850H","article-title":"Matrix coating assisted by an electric field (MCAEF) for enhanced tissue imaging by MALDI-MS","volume":"6","author":"Wang","year":"2015","journal-title":"Chem. Sci."},{"key":"10.1016\/j.talanta.2026.130217_bib140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijms.2018.09.014","article-title":"The metabolism and distribution of imidazole alkaloids from Lepidium meyenii (Maca) in mouse by matrix-assisted laser desorption\/ionization mass spectrometry imaging","volume":"434","author":"Yang","year":"2018","journal-title":"Int. J. Mass Spectrom."},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib141","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1021\/acs.analchem.9b04768","article-title":"Ultra-High mass resolving power, mass accuracy, and dynamic range MALDI mass spectrometry imaging by 21-T FT-ICR MS","volume":"92","author":"Bowman","year":"2020","journal-title":"Anal. Chem."},{"issue":"10","key":"10.1016\/j.talanta.2026.130217_bib142","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.cmi.2020.03.014","article-title":"Machine learning for microbial identification and antimicrobial susceptibility testing on MALDI-TOF mass spectra: a systematic review","volume":"26","author":"Weis","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"issue":"2","key":"10.1016\/j.talanta.2026.130217_bib143","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1021\/ac302960j","article-title":"Quantitative MALDI Tandem Mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard","volume":"85","author":"Pirman","year":"2013","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib144","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.dmpk.2019.04.006","article-title":"Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development","volume":"34","author":"Nishidate","year":"2019","journal-title":"Drug Metabol. Pharmacokinet."},{"key":"10.1016\/j.talanta.2026.130217_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120967","article-title":"DESI-MS imaging to visualize spatial distribution of xenobiotics and endogenous lipids in the skin","volume":"607","author":"Quartier","year":"2021","journal-title":"Int. J. Pharm."},{"issue":"47","key":"10.1016\/j.talanta.2026.130217_bib146","doi-asserted-by":"crossref","first-page":"26088","DOI":"10.1021\/acs.analchem.5c04730","article-title":"Spatial mapping of stereoisomeric and isobaric alkaloids in Mitragyna speciosa tissues by high-resolution DESI-cIM-MS","volume":"97","author":"Wisanpitayakorn","year":"2025","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.talanta.2026.130217_bib147","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/jms.3604","article-title":"One drop chemical derivatization--DESI-MS analysis for metabolite structure identification","volume":"50","author":"Lubin","year":"2015","journal-title":"J. Mass Spectrom."},{"issue":"11\u201312","key":"10.1016\/j.talanta.2026.130217_bib148","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/pmic.201500422","article-title":"Cryo-sectioning of mice for whole-body imaging of drugs and metabolites with desorption electrospray ionization mass spectrometry imaging-a simplified approach","volume":"16","author":"Okutan","year":"2016","journal-title":"Proteomics"},{"issue":"23","key":"10.1016\/j.talanta.2026.130217_bib149","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1007\/s00216-015-8887-8","article-title":"Personalized monitoring of therapeutic salicylic acid in dried blood spots using a three-layer setup and desorption electrospray ionization mass spectrometry","volume":"407","author":"Siebenhaar","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib150","article-title":"Identification of proteomic markers in head and neck cancer using MALDI-MS Imaging, LC-MS\/MS, and immunohistochemistry","volume":"13","author":"Hoffmann","year":"2019","journal-title":"Proteonomics Clin. Appl."},{"key":"10.1016\/j.talanta.2026.130217_bib157","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/bs.ctdb.2018.11.011","article-title":"The role of plant root systems in evolutionary adaptation","volume":"131","author":"Shekhar","year":"2019","journal-title":"Curr. Top. Dev. Biol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib158","doi-asserted-by":"crossref","DOI":"10.1002\/jms.4674","article-title":"Identification of Sassafras albidum alkaloids by high-performance thin-layer chromatography tandem mass spectrometry and mapping by desorption electrospray ionization mass spectrometry imaging","volume":"56","author":"Concei\u00e7\u00e3o","year":"2021","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.talanta.2026.130217_bib159","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2023.105785","article-title":"The visualization of the spatial distribution of Cocculus orbiculatus based on air flow-assisted desorption electrospray ionization mass spectrometry imaging","volume":"173","author":"Zhang","year":"2024","journal-title":"Fitoterapia"},{"issue":"17","key":"10.1016\/j.talanta.2026.130217_bib169","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29174251","article-title":"Spatial metabolomic profiling of pinelliae rhizoma from different leaf types using matrix-assisted laser Desorption\/Ionization mass spectrometry imaging","volume":"29","author":"Wang","year":"2024","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.talanta.2026.130217_bib176","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1021\/acs.jnatprod.4c00445","article-title":"Mass spectrometry imaging of coniine and other hemlock alkaloids after On-Tissue derivatization reveals distinct alkaloid distributions in the plant","volume":"87","author":"Barrera-Adame","year":"2024","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib172","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/pca.2715","article-title":"The spatial distribution of alkaloids in Psychotria prunifolia (Kunth) steyerm and Palicourea coriacea (Cham.) K. Schum leaves analysed by desorption electrospray ionisation Mass spectrometry imaging","volume":"29","author":"Kato","year":"2018","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.talanta.2026.130217_bib160","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2022.897528","article-title":"Desorption electrospray ionization Mass spectrometry imaging illustrates the quality characters of Isatidis Radix","volume":"13","author":"Nie","year":"2022","journal-title":"Front. Plant Sci."},{"issue":"3","key":"10.1016\/j.talanta.2026.130217_bib161","first-page":"596","article-title":"Application of MALDI-mass spectrometry imaging in spatial distribution of secondary metabolites in medicinal plants-a case study of Lepdium meyenii root","volume":"45","author":"Mi","year":"2020","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.talanta.2026.130217_bib162","article-title":"Metabolic profiling, in-situ spatial distribution, and biosynthetic pathway of functional metabolites in Dendrobium nobile stem revealed by combining UPLC-QTOF-MS with MALDI-TOF-MSI","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.talanta.2026.130217_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2023.113620","article-title":"Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging","volume":"209","author":"Lorensen","year":"2023","journal-title":"Phytochemistry"},{"issue":"49","key":"10.1016\/j.talanta.2026.130217_bib164","doi-asserted-by":"crossref","first-page":"13470","DOI":"10.1021\/acs.jafc.9b01155","article-title":"Mass spectrometry imaging of the spatial and temporal localization of alkaloids in nightshades","volume":"67","author":"Bednarz","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib165","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2023.1203768","article-title":"Microscopic distribution of alkaloids in freeze-fixed stems of Phellodendron amurense","volume":"14","author":"Gong","year":"2023","journal-title":"Front. Plant Sci."},{"issue":"3","key":"10.1016\/j.talanta.2026.130217_bib166","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26030580","article-title":"Localization of major ephedra alkaloids in whole aerial parts of Ephedrae Herba using direct analysis in real time-time of flight-mass spectrometry","volume":"26","author":"Yun","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib167","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1021\/acs.jnatprod.1c00980","article-title":"Spatial distribution and stability of cholinesterase inhibitory protoberberine alkaloids from Papaver setiferum","volume":"85","author":"Safa","year":"2022","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.talanta.2026.130217_bib168","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2022.1092643","article-title":"The localization of the alkaloids in Coptis chinensis rhizome by time-of-flight secondary ion mass spectrometry","volume":"13","author":"He","year":"2022","journal-title":"Front. Plant Sci."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib170","doi-asserted-by":"crossref","DOI":"10.1111\/ppl.70049","article-title":"The spatiotemporal changes of metabolites in Pinellia ternata at different development stages by MALDI-MSI","volume":"177","author":"Pei","year":"2025","journal-title":"Physiol. Plantarum"},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib171","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/jasms.0c00449","article-title":"Analysis of Erythroxylum coca leaves by imaging Mass spectrometry (MALDI-FT-ICR IMS)","volume":"32","author":"Dos Santos","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib173","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1104\/pp.114.248187","article-title":"The last step in cocaine biosynthesis is catalyzed by a BAHD acyltransferase","volume":"167","author":"Schmidt","year":"2015","journal-title":"Plant Physiol."},{"key":"10.1016\/j.talanta.2026.130217_bib174","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.phytochem.2016.02.002","article-title":"Developmental patterning and segregation of alkaloids in areca nut (seed of Areca catechu) revealed by magnetic resonance and mass spectrometry imaging","volume":"125","author":"Srimany","year":"2016","journal-title":"Phytochemistry"},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib175","article-title":"Spatial distribution of metabolites in processing Ziziphi Spinosae Semen as revealed by matrix-assisted laser desorption\/ionization mass spectrometry imaging","volume":"14","author":"Ma","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.talanta.2026.130217_bib177","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2021.112930","article-title":"Visualizing the spatial distribution of metabolites in Clausena lansium (Lour.) skeels using matrix-assisted laser desorption\/ionization mass spectrometry imaging","volume":"192","author":"Tang","year":"2021","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib178","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/tpj.15092","article-title":"Visualizing vinca alkaloids in the petal of Catharanthus roseus using functionalized titanium oxide nanowire substrate for surface-assisted laser desorption\/ionization imaging mass spectrometry","volume":"105","author":"Dutkiewicz","year":"2021","journal-title":"Plant J."},{"key":"10.1016\/j.talanta.2026.130217_bib179","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-1-0716-2349-7_3","article-title":"Surface-Assisted Laser Desorption\/Ionization imaging Mass spectrometry (SALDI-IMS)-Based detection of Vinca alkaloids distribution in the petal of Madagascar Periwinkle","volume":"2505","author":"Su","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib180","first-page":"86","article-title":"Analysis on tissue distribution of metabolites in Lotus seed by MALDI Mass spectrometry imaging technique","volume":"40","author":"Sun","year":"2021","journal-title":"J. Instrum. Anal."},{"issue":"6","key":"10.1016\/j.talanta.2026.130217_bib181","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27061810","article-title":"In Situ visual distribution of Gelsemine, koumine, and gelsenicine by MSI in gelsemiumelegans at different growth stages","volume":"27","author":"Wu","year":"2022","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.talanta.2026.130217_bib182","first-page":"1009","article-title":"Profiling the chemical differences of diterpenoid alkaloids in different processed products of Aconiti Lateralis Radix Praeparata by UHPLC-LTQ-Orbitrap mass spectrometry combined with untargeted metabolomics and mass spectrometry imaging","volume":"23","author":"Yu","year":"2025","journal-title":"Chin. J. Nat. Med."},{"issue":"7","key":"10.1016\/j.talanta.2026.130217_bib183","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1039\/D2AN02051C","article-title":"Spatial distribution and comparative analysis of Aconitum alkaloids in Fuzi using DESI-MSI and UHPLC-QTOF-MS","volume":"148","author":"Ren","year":"2023","journal-title":"Analyst"},{"issue":"19","key":"10.1016\/j.talanta.2026.130217_bib184","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194837","article-title":"Anti-Myocardial infarction effects of Radix Aconiti lateralis preparata extracts and their influence on small molecules in the heart using matrix-assisted laser Desorption\/Ionization-Mass spectrometry imaging","volume":"20","author":"Wu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.talanta.2026.130217_bib185","article-title":"Unveiling dynamic changes of chemical constituents in raw and processed Fuzi with different steaming time points using desorption electrospray ionization Mass spectrometry imaging combined with metabolomics","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"29","key":"10.1016\/j.talanta.2026.130217_bib186","doi-asserted-by":"crossref","first-page":"11869","DOI":"10.1021\/acs.analchem.4c01553","article-title":"Multimodal Image Fusion Workflow Incorporating MALDI imaging Mass spectrometry and microscopy for the Study of small pharmaceutical compounds","volume":"96","author":"Liang","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130217_bib187","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155184","article-title":"Investigation of the active ingredients of Shuangshen Ningxin Fomula and the mechanism underlying their protective effects against myocardial ischemia-reperfusion injury by mass spectrometric imaging","volume":"123","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.talanta.2026.130217_bib188","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119627","article-title":"Exploring the tissue distribution propensity of active alkaloids in normal and stomach heat syndrome rats following oral administration of Zuojin Pill based on pharmacokinetics and mass spectrometry imaging","volume":"346","author":"Xiang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.talanta.2026.130217_bib189","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210076","article-title":"Optimization of mass spectrometry imaging for drug metabolism and distribution studies in the zebrafish larvae model: a case Study with the opioid antagonist naloxone","volume":"24","author":"Park","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0211376","article-title":"MALDI imaging mass spectrometry revealed atropine distribution in the ocular tissues and its transit from anterior to posterior regions in the whole-eye of rabbit after topical administration","volume":"14","author":"Mori","year":"2019","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.talanta.2026.130217_bib191","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.1111\/aos.13889","article-title":"The penetration and distribution of topical atropine in animal ocular tissues","volume":"97","author":"Wang","year":"2019","journal-title":"Acta Ophthalmol."},{"issue":"23","key":"10.1016\/j.talanta.2026.130217_bib192","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1007\/s00216-023-04861-x","article-title":"Application of infrared matrix-assisted laser desorption electrospray ionization mass spectrometry for morphine imaging in brain tissue","volume":"415","author":"Desyaterik","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"issue":"8","key":"10.1016\/j.talanta.2026.130217_bib195","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1007\/s00216-014-8237-2","article-title":"Distribution and quantification of irinotecan and its active metabolite SN-38 in colon cancer murine model systems using MALDI MSI","volume":"407","author":"Buck","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"issue":"17","key":"10.1016\/j.talanta.2026.130217_bib196","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1007\/s00216-022-04130-3","article-title":"Quantitative imaging of natural products in fine brain regions using desorption electrospray ionization mass spectrometry imaging (DESI-MSI): uncaria alkaloids as a case study","volume":"414","author":"Gao","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib197","doi-asserted-by":"crossref","first-page":"7293","DOI":"10.1038\/s41598-020-63474-x","article-title":"Brain distribution of geissoschizine methyl ether in rats using mass spectrometry imaging analysis","volume":"10","author":"Matsumoto","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib198","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10735-017-9726-3","article-title":"Post heroin dose tissue distribution of 6-monoacetylmorphine (6-MAM) with MALDI imaging","volume":"48","author":"Teklezgi","year":"2017","journal-title":"J. Mol. Histol."},{"issue":"3","key":"10.1016\/j.talanta.2026.130217_bib193","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s13361-017-1851-4","article-title":"MALDI Mass spectrometry imaging for evaluation of therapeutics in colorectal tumor organoids","volume":"29","author":"Liu","year":"2018","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib194","first-page":"361","article-title":"A rapid ex vivo tissue model for optimising drug detection and ionisation in MALDI imaging studies, Histochem","volume":"142","author":"Huber","year":"2014","journal-title":"Cell Biol."},{"key":"10.1016\/j.talanta.2026.130217_bib199","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.138748","article-title":"Mass spectrometric analysis strategies for pyrrolizidine alkaloids","volume":"445","author":"Chen","year":"2024","journal-title":"Food Chem."},{"issue":"7","key":"10.1016\/j.talanta.2026.130217_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.01.012","article-title":"Dual mass spectrometry imaging and spatial metabolomics to investigate the metabolism and nephrotoxicity of nitidine chloride","volume":"14","author":"Yang","year":"2024","journal-title":"J. Pharm. Anal."},{"issue":"40","key":"10.1016\/j.talanta.2026.130217_bib201","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1039\/D2AY01257J","article-title":"A review on quantitation-related factors and quantitation strategies in mass spectrometry imaging of small biomolecules","volume":"14","author":"Wu","year":"2022","journal-title":"Anal. Methods"},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib202","doi-asserted-by":"crossref","DOI":"10.1002\/jms.70007","article-title":"Advanced tissue imprinting with pneumatic press for mass spectrometry imaging of plant tissues","volume":"61","author":"Hapuarachchige","year":"2026","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.talanta.2026.130217_bib203","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2026.123058","article-title":"Integrative analysis of alkaloid biosynthesis and distribution in Polygonatum cyrtonema Hua: using advanced imaging and molecular techniques","volume":"243","author":"Khan","year":"2026","journal-title":"Ind. Crop. Prod."},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib204","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/acsagscitech.2c00254","article-title":"Mapping molecular signatures in plant leaves, flowers, and fruits by a TiO2 Nanotube-Based plasmonic chip for imprint Mass spectrometry imaging","volume":"3","author":"Chen","year":"2023","journal-title":"ACS Agricultural Science & Technology"},{"issue":"4","key":"10.1016\/j.talanta.2026.130217_bib205","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/tpj.15092","article-title":"Visualizing vinca alkaloids in the petal of Catharanthus roseus using functionalized titanium oxide nanowire substrate for surface-assisted laser desorption\/ionization imaging mass spectrometry","volume":"105","author":"Dutkiewicz","year":"2021","journal-title":"Plant J."},{"key":"10.1016\/j.talanta.2026.130217_bib206","article-title":"Noble metal nanoparticle assisted mass spectrometry for metabolite-based In Vitro diagnostics","author":"Liu","year":"2024","journal-title":"Small"},{"issue":"10","key":"10.1016\/j.talanta.2026.130217_bib207","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1007\/s00604-019-3770-5","article-title":"Nanoparticle-based surface assisted laser desorption ionization mass spectrometry: a review","volume":"186","author":"Abdelhamid","year":"2019","journal-title":"Mikrochim. Acta"},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib208","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/pca.2715","article-title":"The spatial distribution of alkaloids in Psychotria prunifolia (Kunth) steyerm and Palicourea coriacea (Cham.) K. Schum leaves analysed by desorption electrospray ionisation Mass spectrometry imaging","volume":"29","author":"Kato","year":"2018","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.talanta.2026.130217_bib209","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.344825","article-title":"Single-cell mass spectrometry imaging: emerging advancements and future insights","volume":"1382","author":"Zhang","year":"2026","journal-title":"Anal. Chim. Acta"},{"issue":"1","key":"10.1016\/j.talanta.2026.130217_bib210","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/10408347.2023.2266838","article-title":"Unlocking the hidden depths: Multi-Modal integration of imaging Mass spectrometry-based and molecular imaging techniques","volume":"55","author":"Akbari","year":"2025","journal-title":"Crit. Rev. Anal. Chem."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026008738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026008738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:31:31Z","timestamp":1788827491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026008738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":210,"alternative-id":["S0039914026008738"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130217","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mapping alkaloids with mass spectrometry imaging: Application of spatial distribution in medicinal plants and animal tissues","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130217"}}