{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:55:06Z","timestamp":1790891706568,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018573","name":"Istanbul Medeniyet University","doi-asserted-by":"publisher","award":["2024-GAP-Bili-0003"],"award-info":[{"award-number":["2024-GAP-Bili-0003"]}],"id":[{"id":"10.13039\/100018573","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.talanta.2026.130325","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:26:14Z","timestamp":1784355974000},"page":"130325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Hybrid multispectroscopic-chemometric strategy combined with DLLME for the detection of benzodiazepines in complex beverage matrices"],"prefix":"10.1016","volume":"312","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5306-8852","authenticated-orcid":false,"given":"Busra","family":"Emanetoglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Guzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-550X","authenticated-orcid":false,"given":"Elif","family":"Koyuncu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Nur","family":"Bayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuriye","family":"Akbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2026.130325_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.forsciint.2025.112552","article-title":"A ten-year analysis of drug-facilitated crimes: prevalence and characteristics at a tertiary hospital victim protection center","volume":"374","author":"Anegg","year":"2025","journal-title":"Forensic Sci. Int."},{"issue":"6","key":"10.1016\/j.talanta.2026.130325_bib2","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1111\/1556-4029.70151","article-title":"Drug\u2010facilitated crime: a review of findings between 2019 and 2023","volume":"70","author":"Hessler","year":"2025","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.talanta.2026.130325_bib3","series-title":"Principles of Forensic Toxicology","article-title":"Benzodiazepines","author":"Jufer-Phipps","year":"2020"},{"issue":"4","key":"10.1016\/j.talanta.2026.130325_bib4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1553-2712.1997.tb03557.x","article-title":"Flunitrazepam and its involvement in date or acquaintance rape","volume":"4","author":"Anglin","year":"1997","journal-title":"Acad. Emerg. Med."},{"key":"10.1016\/j.talanta.2026.130325_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2025.1639890","article-title":"Forensic toxicology of benzodiazepines: neuropharmacological effects, analytical challenges, and emerging detection strategies","volume":"7","author":"Irfan Thalib","year":"2025","journal-title":"Frontiers in Toxicology"},{"key":"10.1016\/j.talanta.2026.130325_bib6","series-title":"Toxicological Aspects of Drug-Facilitated Crimes","first-page":"223","article-title":"Case reports in drug-facilitated crimes: from A for Alprazolam to Z for Zopiclone","author":"Dumestre-Toulet","year":"2014"},{"key":"10.1016\/j.talanta.2026.130325_bib7","author":"Katkar"},{"key":"10.1016\/j.talanta.2026.130325_bib8","article-title":"Derivative UV-VIS spectrophotometry in analytical chemistry. (Inside) chern","author":"Kus","year":"1996","journal-title":"Anal. (Warsaw) (C. 41)"},{"issue":"12","key":"10.1016\/j.talanta.2026.130325_bib9","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/bmc.1598","article-title":"Analyses of benzodiazepines and their metabolites in various biological matrices by LC-MS(\/MS)","volume":"25","author":"Nakamura","year":"2011","journal-title":"Biomed. Chromatogr."},{"issue":"1","key":"10.1016\/j.talanta.2026.130325_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1527-3458.2004.tb00003.x","article-title":"Clinical pharmacology, clinical efficacy, and behavioral toxicity of alprazolam: a review of the literature","volume":"10","author":"Verster","year":"2004","journal-title":"CNS Drug Rev."},{"issue":"3","key":"10.1016\/j.talanta.2026.130325_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2165\/00003495-198121030-00001","article-title":"Lorazepam: a review of its clinical: pharmacological properties and therapeutic uses","volume":"21","author":"Ameer","year":"1981","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.talanta.2026.130325_bib12","doi-asserted-by":"crossref","first-page":"91A","DOI":"10.1021\/ac50037a008","article-title":"Derivative and wavelength modulation spectrometry","volume":"51","author":"O'Haver","year":"1979","journal-title":"Anal. Chem."},{"issue":"3","key":"10.1016\/j.talanta.2026.130325_bib13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/jat\/bkv140","article-title":"Comparison of LC\u2013MS-MS and GC\u2013MS analysis of benzodiazepine compounds included in the drug demand reduction urinalysis program","volume":"40","author":"Perez","year":"2016","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.talanta.2026.130325_bib14","article-title":"Benzodiazepine analysis by an improved LC-MS\/MS method illustrates usage patterns in Washington state","volume":"543","author":"Chan","year":"2023","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.talanta.2026.130325_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/ansa.70024","article-title":"Recent advances in liquid chromatography\u2013mass spectrometry (LC\u2013MS) applications in biological and applied sciences","volume":"6","author":"Alanazi","year":"2025","journal-title":"Analytical Science Advances"},{"issue":"1","key":"10.1016\/j.talanta.2026.130325_bib16","article-title":"Analytical methods used for the detection and quantification of benzodiazepines","volume":"2019","author":"Qriouet","year":"2019","journal-title":"J. Anal. Meth. Chemistry"},{"key":"10.1016\/j.talanta.2026.130325_bib17","unstructured":"Matthews, J., Chen, A., & Bedini, F. (n.d.). GC-MS\/MS analysis of benzodiazepines using analyte protectants [Application note]. Thermo Fisher Scientific. https:\/\/cdn.technologynetworks.com\/ep\/pdfs\/gc-msms-analysis-of-benzodiazepines-using-analyte-protectants.pdf (accessed 2026-April-20)."},{"issue":"3","key":"10.1016\/j.talanta.2026.130325_bib18","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3390\/separations13030084","article-title":"Green approaches in forensic Separations-An overview","volume":"13","author":"Brettell","year":"2026","journal-title":"Separations"},{"key":"10.1016\/j.talanta.2026.130325_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117524","article-title":"Comparison of various sample preparation methods for benzodiazepines in terms of the principles of white analytical chemistry","volume":"171","author":"Jain","year":"2024","journal-title":"Trends Anal. Chem."},{"issue":"4","key":"10.1016\/j.talanta.2026.130325_bib20","first-page":"224","article-title":"Recent findings and advancements in the detection of designer benzodiazepines: a brief review","volume":"74","author":"Wu","year":"2023","journal-title":"Arh. Hig. Rada. Toksikol."},{"key":"10.1016\/j.talanta.2026.130325_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.trac.2012.08.012","article-title":"New materials and trends in sorbents for solid-phase extraction","volume":"43","author":"Augusto","year":"2013","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"4","key":"10.1016\/j.talanta.2026.130325_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3390\/separations12040095","article-title":"New trends in the methodologies of determination of benzodiazepine residues in biological samples","volume":"12","author":"Ibarra","year":"2025","journal-title":"Separations"},{"issue":"20","key":"10.1016\/j.talanta.2026.130325_bib23","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.1021\/acs.analchem.4c01328","article-title":"Evolution of green sample preparation: fostering a sustainable tomorrow in analytical sciences","volume":"96","author":"Mart\u00ednez-P\u00e9rez-Cejuela","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130325_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.112354","article-title":"A comparative study of SPE-and DLLME-based methods for the determination of opioids and benzodiazepines in urine samples using LC\u2013MS\/MS","volume":"208","author":"Cliville-Cabre","year":"2025","journal-title":"Microchem. J."},{"issue":"4","key":"10.1016\/j.talanta.2026.130325_bib25","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S1386-1425(03)00300-7","article-title":"Spectrophotometric and fluorimetric determination of diazepam, bromazepam and clonazepam in pharmaceutical and urine samples","volume":"60","author":"Salem","year":"2004","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"issue":"4","key":"10.1016\/j.talanta.2026.130325_bib26","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1208\/s12249-009-9343-x","article-title":"A comparative study of UV-spectrophotometry and first-order derivative UV-spectrophotometry methods for the estimation of diazepam in presence of tween-20 and propylene glycol","volume":"10","author":"Dastidar","year":"2009","journal-title":"AAPS PharmSciTech"},{"issue":"3","key":"10.1016\/j.talanta.2026.130325_bib27","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.4067\/s0717-97072018000304126","article-title":"A review on derivative uv-spectrophotometry analysis of drugs in pharmaceutical formulations and biological samples review","volume":"63","author":"Redasani","year":"2018","journal-title":"J. Chil. Chem. Soc."},{"key":"10.1016\/j.talanta.2026.130325_bib28","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jpba.2018.03.030","article-title":"Determination of benzodiazepines in beverages using green extraction methods and capillary HPLC-UV detection","volume":"154","author":"Piergiovanni","year":"2018","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"4","key":"10.1016\/j.talanta.2026.130325_bib29","first-page":"272","article-title":"UV Spectrophotometric estimation of Alprazolam by second and third order derivative methods in Bulk and Pharmaceutical Dosage form","volume":"8","author":"Rele","year":"2016","journal-title":"J. Chem. Pharmaceut. Res."},{"issue":"11","key":"10.1016\/j.talanta.2026.130325_bib30","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s11094-025-03335-x","article-title":"UV derivative spectroscopy: a comprehensive review for advancement in quantification","volume":"58","author":"Chandarana","year":"2025","journal-title":"Pharm. Chem. J."},{"issue":"4","key":"10.1016\/j.talanta.2026.130325_bib31","first-page":"565","article-title":"Derivative UV spectrophotometry used for the assay of diazepam from human blood plasma","volume":"60","author":"LakissH","year":"2012","journal-title":"FARMACIA"},{"issue":"10","key":"10.1016\/j.talanta.2026.130325_bib32","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/jps.2600671022","article-title":"Fluorescence\u2013TLC densitometric determination of diazepam and other 1, 4-Benzodiazepines in serum","volume":"67","author":"Sun","year":"1978","journal-title":"J. Pharmaceut. Sci."},{"issue":"4","key":"10.1016\/j.talanta.2026.130325_bib33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/0003702820987847","article-title":"Exploration of principal component analysis: deriving principal component analysis visually using spectra","volume":"75","author":"Beattie","year":"2021","journal-title":"Appl. Spectrosc."},{"issue":"3","key":"10.1016\/j.talanta.2026.130325_bib34","doi-asserted-by":"crossref","first-page":"624","DOI":"10.5740\/jaoacint.SGE_Chmielewska","article-title":"Comparative analysis of chiral drugs in view of chemometrics","volume":"95","author":"Chmielewska","year":"2012","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.talanta.2026.130325_bib35","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3389\/fchem.2018.00576","article-title":"Chemometric methods for spectroscopy-based pharmaceutical analysis","volume":"6","author":"Biancolillo","year":"2018","journal-title":"Front. Chem."},{"issue":"3","key":"10.1016\/j.talanta.2026.130325_bib36","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jrs.70062","article-title":"Rapid classification and identification of benzodiazepine drugs utilizing raman spectroscopy combined with PCA\u2010SVM algorithms","volume":"57","author":"Bai","year":"2026","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.talanta.2026.130325_bib37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jpba.2015.02.017","article-title":"Analytical methodologies for the determination of benzodiazepines in biological samples","volume":"113","author":"Persona","year":"2015","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"5","key":"10.1016\/j.talanta.2026.130325_bib38","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1111\/1556-4029.15068","article-title":"Vortex\u2010assisted dispersive liquid\u2013liquid microextraction\u2010gas chromatography (VADLLME\u2010GC) determination of residual ketamine, nimetazepam, and xylazine from drug\u2010spiked beverages appearing in liquid, droplet, and dry forms","volume":"67","author":"Teoh","year":"2022","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.talanta.2026.130325_bib39","series-title":"_R: a Language and Environment for Statistical Computing_","year":"2023"},{"key":"10.1016\/j.talanta.2026.130325_bib40","author":"Taiyun"},{"key":"10.1016\/j.talanta.2026.130325_bib41","article-title":"R package \u2018ggcorrplot\u2019: visualization of a Correlation Matrix using ggplot2'","author":"Kassambara","year":"2022","journal-title":"R package version 0.1.4"},{"issue":"1","key":"10.1016\/j.talanta.2026.130325_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v025.i01","article-title":"FactoMineR: an R package for multivariate analysis","volume":"25","author":"Le","year":"2008","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.talanta.2026.130325_bib43","article-title":"R package \u2018factoextra\u2019: extract and visualize the results of multivariate data analyses","author":"Kassambara","year":"2020","journal-title":"R package version 1.0.7"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026009811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026009811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:01:45Z","timestamp":1790888505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026009811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":43,"alternative-id":["S0039914026009811"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130325","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hybrid multispectroscopic-chemometric strategy combined with DLLME for the detection of benzodiazepines in complex beverage matrices","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130325","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130325"}}