{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:56:22Z","timestamp":1790891782025,"version":"4.1.0"},"reference-count":123,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.talanta.2026.130331","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T15:16:48Z","timestamp":1784387808000},"page":"130331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Comprehensive advances of microneedle technology in addressing diabetes mellitus and its multisystem complications"],"prefix":"10.1016","volume":"312","author":[{"given":"Huijia","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10397","key":"10.1016\/j.talanta.2026.130331_bib1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global burden of disease study 2021","volume":"402","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-018-4711-2","article-title":"Global trends in diabetes complications: a review of current evidence","volume":"62","author":"Harding","year":"2019","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-021-05585-2","article-title":"Interpreting global trends in type 2 diabetes complications and mortality","volume":"65","author":"Ali","year":"2022","journal-title":"Diabetologia"},{"issue":"16","key":"10.1016\/j.talanta.2026.130331_bib4","article-title":"Gelatin methacryloyl microneedle patches for minimally invasive extraction of skin interstitial fluid","volume":"16","author":"Zhu","year":"2020","journal-title":"Small"},{"issue":"17","key":"10.1016\/j.talanta.2026.130331_bib5","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1039\/D3BM00409K","article-title":"Microneedle-based glucose monitoring: a review from sampling methods to wearable biosensors","volume":"11","author":"Wang","year":"2023","journal-title":"Biomater. Sci."},{"issue":"30","key":"10.1016\/j.talanta.2026.130331_bib6","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1039\/D1TB00880C","article-title":"Biodegradable phenylboronic acid-modified \u03b5-polylysine for glucose-responsive insulin delivery via transdermal microneedles","volume":"9","author":"Shen","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.talanta.2026.130331_bib7","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.ijbiomac.2019.08.007","article-title":"Biopolymer-based biomaterials for accelerated diabetic wound healing: a critical review","volume":"139","author":"Shah","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.talanta.2026.130331_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114412","article-title":"Colorimetric microneedle patches for multiplexed transdermal detection of metabolites","volume":"212","author":"Zhu","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"13","key":"10.1016\/j.talanta.2026.130331_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303511","article-title":"Wearable microneedle patch for colorimetric detection of multiple signature biomarkers in vivo toward diabetic diagnosis","volume":"13","author":"Bao","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"5","key":"10.1016\/j.talanta.2026.130331_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/bios13050537","article-title":"Porous colorimetric microneedles for minimally invasive rapid glucose sampling and sensing in skin interstitial fluid","volume":"13","author":"Zeng","year":"2023","journal-title":"Biosensors"},{"key":"10.1016\/j.talanta.2026.130331_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119782","article-title":"Transdermal colorimetric patch for hyperglycemia sensing in diabetic mice","volume":"237","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"issue":"Pt 3","key":"10.1016\/j.talanta.2026.130331_bib12","article-title":"Glucose detection: in-situ colorimetric analysis with double-layer hydrogel microneedle patch based on polyvinyl alcohol and carboxymethyl chitosan","volume":"277","author":"Yin","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.talanta.2026.130331_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.342152","article-title":"Swellable colorimetric microneedles for glucose detection based on glucose oxidase-like gold nanoparticles","volume":"1288","author":"Li","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2026.130331_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115571","article-title":"Microneedles coated with composites of phenylboronic acid-containing polymer and carbon nanotubes for glucose measurements in interstitial fluids","volume":"238","author":"Han","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130331_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoen.2024.110194","article-title":"A wireless, battery-free microneedle patch with light-cured swellable hydrogel for minimally-invasive glucose detection","volume":"131","author":"Yue","year":"2024","journal-title":"Nano Energy"},{"key":"10.1016\/j.talanta.2026.130331_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116280","article-title":"An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids","volume":"256","author":"Yang","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130331_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115932","article-title":"Impedance-based polymer microneedle patch sensor for continuous interstitial fluid glucose monitoring","volume":"247","author":"Piao","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130331_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116297","article-title":"A self-powered and supercapacitive microneedle continuous glucose monitoring system with a wide range of glucose detection capabilities","volume":"257","author":"Kil","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"6","key":"10.1016\/j.talanta.2026.130331_bib19","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1021\/acssensors.0c00444","article-title":"Surface enhanced raman spectroscopy based biosensor with a microneedle array for minimally invasive in vivo glucose measurements","volume":"5","author":"Ju","year":"2020","journal-title":"ACS Sens."},{"issue":"8","key":"10.1016\/j.talanta.2026.130331_bib20","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1021\/acssensors.2c01033","article-title":"Hydrogel microneedle-assisted assay integrating aptamer probes and fluorescence detection for reagentless biomarker quantification","volume":"7","author":"Zheng","year":"2022","journal-title":"ACS Sens."},{"issue":"7","key":"10.1016\/j.talanta.2026.130331_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202203943","article-title":"Continuous glucose monitoring enabled by fluorescent nanodiamond boronic hydrogel","volume":"10","author":"Zhang","year":"2023","journal-title":"Adv. Sci."},{"issue":"22","key":"10.1016\/j.talanta.2026.130331_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh1765","article-title":"Fluorescent-based biodegradable microneedle sensor array for tether-free continuous glucose monitoring with smartphone application","volume":"9","author":"Sang","year":"2023","journal-title":"Sci. Adv."},{"issue":"29","key":"10.1016\/j.talanta.2026.130331_bib23","article-title":"Fluorescence-amplified origami microneedle device for quantitatively monitoring blood glucose","volume":"35","author":"Li","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.talanta.2026.130331_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116542","article-title":"A wearable microneedle patch incorporating reversible FRET-based hydrogel sensors for continuous glucose monitoring","volume":"262","author":"Hu","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.talanta.2026.130331_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202000307","article-title":"Hydrogel-forming microneedles: current advancements and future trends","volume":"21","author":"Turner","year":"2021","journal-title":"Macromol. Biosci."},{"issue":"10","key":"10.1016\/j.talanta.2026.130331_bib26","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1039\/C9TB02837D","article-title":"Polymer microneedles with interconnected porous structures via a phase inversion route for transdermal medical applications","volume":"8","author":"Liu","year":"2020","journal-title":"J. Mater. Chem. B"},{"issue":"4","key":"10.1016\/j.talanta.2026.130331_bib27","article-title":"Nanozymes with multiple activities: prospects in analytical sensing","volume":"12","author":"Niu","year":"2022","journal-title":"Biosensors (Basel)"},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib28","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1038\/s41467-021-23737-1","article-title":"Glucose-oxidase like catalytic mechanism of noble metal nanozymes","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.talanta.2026.130331_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117891","article-title":"Opportunities and challenges of microneedle electrochemical sensors for interstitial fluid detection","volume":"180","author":"Dong","year":"2024","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"39","key":"10.1016\/j.talanta.2026.130331_bib30","doi-asserted-by":"crossref","first-page":"2404909","DOI":"10.1002\/adfm.202404909","article-title":"Dual-mode sensing chips for wide-range and high-accuracy biomarker detection","volume":"34","author":"He","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"24","key":"10.1016\/j.talanta.2026.130331_bib31","doi-asserted-by":"crossref","first-page":"14269","DOI":"10.1021\/acs.analchem.8b03420","article-title":"Glucose sensing using surface-enhanced raman-mode constraining","volume":"90","author":"Yang","year":"2018","journal-title":"Anal. Chem."},{"issue":"37","key":"10.1016\/j.talanta.2026.130331_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201702243","article-title":"A swellable microneedle patch to rapidly extract skin interstitial fluid for timely metabolic analysis","volume":"29","author":"Chang","year":"2017","journal-title":"Adv. Mater."},{"issue":"3","key":"10.1016\/j.talanta.2026.130331_bib33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41551-025-01477-7","article-title":"Continuous insulin monitoring using an antibody-protecting zwitterionic microneedle patch","volume":"10","author":"GhavamiNejad","year":"2025","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.talanta.2026.130331_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116995","article-title":"High-density microneedle array-based wearable electrochemical biosensor for detection of insulin in interstitial fluid","volume":"271","author":"Dervisevic","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.talanta.2026.130331_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s44222-025-00394-3","article-title":"Integrated hydrogel microneedle aptamer sensor for wearable insulin monitoring","volume":"4","author":"Garg","year":"2025","journal-title":"Nat. Rev. Bioeng."},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-025-03432-9","article-title":"Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives","volume":"23","author":"Li","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"6427","key":"10.1016\/j.talanta.2026.130331_bib37","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1126\/science.aau2277","article-title":"An ingestible self-orienting system for oral delivery of macromolecules","volume":"363","author":"Abramson","year":"2019","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.talanta.2026.130331_bib38","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/s41591-019-0598-9","article-title":"A luminal unfolding microneedle injector for oral delivery of macromolecules","volume":"25","author":"Abramson","year":"2019","journal-title":"Nat. Med."},{"issue":"44","key":"10.1016\/j.talanta.2026.130331_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202104932","article-title":"Magneto-responsive microneedle robots for intestinal macromolecule delivery","volume":"33","author":"Zhang","year":"2021","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj7067","article-title":"Pain-free oral delivery of biologic drugs using intestinal peristalsis-actuated microneedle robots","volume":"10","author":"Gao","year":"2024","journal-title":"Sci. Adv."},{"issue":"33","key":"10.1016\/j.talanta.2026.130331_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202210679","article-title":"Rocket-inspired effervescent motors for oral macromolecule delivery","volume":"35","author":"Cai","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib40","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s13346-021-00938-1","article-title":"A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects","volume":"12","author":"Dhalla","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"issue":"43","key":"10.1016\/j.talanta.2026.130331_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202304276","article-title":"Tumbler-inspired microneedle containing robots: achieving rapid self-orientation and peristalsis-resistant adhesion for colonic administration","volume":"33","author":"Huang","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib44","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1021\/acsnano.6b06892","article-title":"H2O2-Responsive vesicles integrated with transcutaneous patches for glucose-mediated insulin delivery","volume":"11","author":"Hu","year":"2017","journal-title":"ACS Nano"},{"issue":"23","key":"10.1016\/j.talanta.2026.130331_bib45","doi-asserted-by":"crossref","first-page":"20014","DOI":"10.1021\/acsami.8b04484","article-title":"Glucose- and H2O2-Responsive polymeric vesicles integrated with microneedle patches for glucose-sensitive transcutaneous delivery of insulin in diabetic rats","volume":"10","author":"Tong","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"41","key":"10.1016\/j.talanta.2026.130331_bib46","doi-asserted-by":"crossref","first-page":"8200","DOI":"10.1039\/C7TB02082A","article-title":"H2O2-Responsive mesoporous silica nanoparticles integrated with microneedle patches for the glucose-monitored transdermal delivery of insulin","volume":"5","author":"Xu","year":"2017","journal-title":"J. Mater. Chem. B"},{"issue":"3","key":"10.1016\/j.talanta.2026.130331_bib47","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1021\/acsnano.7b08152","article-title":"Core-shell microneedle gel for self-regulated insulin delivery","volume":"12","author":"Wang","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2026.130331_bib48","article-title":"Anti-inflammatory PEGylated bilirubin microneedle patch for diabetes treatment","volume":"39","author":"Kuang","year":"2024","journal-title":"Appl. Mater. Today"},{"issue":"7","key":"10.1016\/j.talanta.2026.130331_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12070606","article-title":"Smart microneedles with porous polymer layer for glucose-responsive insulin delivery","volume":"12","author":"Ullah","year":"2020","journal-title":"Pharmaceutics"},{"issue":"8","key":"10.1016\/j.talanta.2026.130331_bib50","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1007\/s12274-020-3273-z","article-title":"Microneedle-array patch with pH-sensitive formulation for glucose-responsive insulin delivery","volume":"14","author":"Luo","year":"2021","journal-title":"Nano Res."},{"issue":"7","key":"10.1016\/j.talanta.2026.130331_bib51","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1021\/acsbiomaterials.8b00626","article-title":"Microneedles integrated with ZnO quantum-dot-capped mesoporous bioactive glasses for glucose-mediated insulin delivery","volume":"4","author":"Xu","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/biomimetics8010050","article-title":"Glucose-responsive silk fibroin microneedles for transdermal delivery of insulin","volume":"8","author":"Tan","year":"2023","journal-title":"Biomimetics"},{"key":"10.1016\/j.talanta.2026.130331_bib53","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jiec.2024.01.007","article-title":"Glucose-responsive soluble microneedle prepared with \u201cGelatin - hydroxyethylcellulose ethoxylate complex coacervate\u201d for the transdermal drug delivery","volume":"134","author":"George Joy","year":"2024","journal-title":"J. Ind. Eng. Chem."},{"issue":"27","key":"10.1016\/j.talanta.2026.130331_bib54","doi-asserted-by":"crossref","first-page":"8260","DOI":"10.1073\/pnas.1505405112","article-title":"Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery","volume":"112","author":"Yu","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.talanta.2026.130331_bib55","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1021\/acs.nanolett.6b03848","article-title":"Hypoxia and H2O2 dual-sensitive vesicles for enhanced glucose-responsive insulin delivery","volume":"17","author":"Yu","year":"2017","journal-title":"Nano Lett."},{"issue":"14","key":"10.1016\/j.talanta.2026.130331_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201704181","article-title":"Bioresponsive microneedles with a sheath structure for H2O2 and pH cascade-triggered insulin delivery","volume":"14","author":"Zhang","year":"2018","journal-title":"Small"},{"issue":"5","key":"10.1016\/j.talanta.2026.130331_bib57","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1021\/acsbiomaterials.3c00137","article-title":"Microneedles with two-stage glucose-sensitive controlled release for long-term insulin delivery","volume":"9","author":"Wang","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"26","key":"10.1016\/j.talanta.2026.130331_bib58","doi-asserted-by":"crossref","first-page":"31330","DOI":"10.1021\/acsami.3c06483","article-title":"Molecular docking-guided design on glucose-responsive nanoparticles for microneedle fabrication and \"Three-Meal-per-Day\" blood-glucose regulation","volume":"15","author":"Shen","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"10.1016\/j.talanta.2026.130331_bib59","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1631\/jzus.A2300386","article-title":"Preparation and properties of poly(ethylene glycol)-b-poly(3-acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches","volume":"25","author":"Hong","year":"2024","journal-title":"J. Zhejiang Univ. - Sci."},{"issue":"7","key":"10.1016\/j.talanta.2026.130331_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw4357","article-title":"Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs","volume":"5","author":"Wang","year":"2019","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.talanta.2026.130331_bib61","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41551-019-0508-y","article-title":"Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs","volume":"4","author":"Yu","year":"2020","journal-title":"Nat. Biomed. Eng."},{"issue":"48","key":"10.1016\/j.talanta.2026.130331_bib63","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add3197","article-title":"Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs","volume":"8","author":"Yang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.talanta.2026.130331_bib64","article-title":"Glucose-responsive microneedle patch with high insulin loading capacity for prolonged glycemic control in mice and minipigs","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2026.130331_bib65","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jconrel.2024.03.001","article-title":"Glucose-responsive insulin microneedle patches for long-acting delivery and release visualization","volume":"368","author":"He","year":"2024","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.talanta.2026.130331_bib68","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/cnma.202100288","article-title":"Microneedle patch prepared from a hydrogel by a mild method for insulin delivery","volume":"7","author":"Chen","year":"2021","journal-title":"ChemNanoMat"},{"issue":"10","key":"10.1016\/j.talanta.2026.130331_bib69","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1021\/acsbiomaterials.1c01073","article-title":"Cross-linking-density-changeable microneedle patch prepared from a glucose-responsive hydrogel for insulin delivery","volume":"7","author":"Chen","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"13","key":"10.1016\/j.talanta.2026.130331_bib70","doi-asserted-by":"crossref","DOI":"10.1002\/admt.202202124","article-title":"Glucose-responsive microneedle patch with variable crosslinking density and flexible core-shell structure for insulin delivery","volume":"8","author":"Chen","year":"2023","journal-title":"Adv. Mater. Technol."},{"issue":"4","key":"10.1016\/j.talanta.2026.130331_bib71","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1021\/acsami.3c16540","article-title":"Electrostatic-interaction-aided microneedle patch for enhanced glucose-responsive insulin delivery and three-meal-per-day blood-glucose regulation","volume":"16","author":"Shen","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"Pt B","key":"10.1016\/j.talanta.2026.130331_bib72","article-title":"Intelligent microneedle patch based on functionalized alginate and chitosan for long-term self-regulated insulin delivery","volume":"348","author":"Wang","year":"2025","journal-title":"Carbohydr. Polym."},{"issue":"30","key":"10.1016\/j.talanta.2026.130331_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303665","article-title":"\"smart\" matrix microneedle patch made of self-crosslinkable and multifunctional polymers for delivering insulin On-Demand","volume":"10","author":"Liu","year":"2023","journal-title":"Adv. Sci."},{"issue":"28","key":"10.1016\/j.talanta.2026.130331_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202203274","article-title":"Shrinking fabrication of a glucose-responsive glucagon microneedle patch","volume":"9","author":"Wang","year":"2022","journal-title":"Adv. Sci."},{"issue":"10","key":"10.1016\/j.talanta.2026.130331_bib67","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1021\/acs.biomac.2c00878","article-title":"Polymeric microneedle arrays with glucose-sensing dynamic-covalent bonding for insulin delivery","volume":"23","author":"Ye","year":"2022","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.talanta.2026.130331_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2023.112061","article-title":"Preparation of phenylboronic acid-based glucose-responsive hydrogels and microneedles for regulated delivery of insulin","volume":"192","author":"Lu","year":"2023","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.talanta.2026.130331_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.154517","article-title":"Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing","volume":"497","author":"Zhao","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"9","key":"10.1016\/j.talanta.2026.130331_bib75","doi-asserted-by":"crossref","first-page":"2416205","DOI":"10.1002\/adfm.202416205","article-title":"Photothermal\/photodynamic synergistic antibacterial hydrogel dressing with pH\/Glucose dual responsive pirfenidone release for diabetic foot ulcers","volume":"35","author":"Pan","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.talanta.2026.130331_bib76","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.actbio.2023.01.059","article-title":"Porcupine-inspired microneedles coupled with an adhesive back patching as dressing for accelerating diabetic wound healing","volume":"160","author":"Liu","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.talanta.2026.130331_bib77","article-title":"Antibacterial microneedle patch releases oxygen to enhance diabetic wound healing","volume":"24","author":"Sun","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"7","key":"10.1016\/j.talanta.2026.130331_bib78","article-title":"Silk sericin-based ROS-responsive oxygen generating microneedle platform promotes angiogenesis and decreases inflammation for scarless diabetic wound healing","volume":"35","author":"Liu","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"6","key":"10.1016\/j.talanta.2026.130331_bib79","doi-asserted-by":"crossref","first-page":"7725","DOI":"10.1021\/acsami.2c18809","article-title":"Separable microneedles with photosynthesis-driven oxygen manufactory for diabetic wound healing","volume":"15","author":"Zhao","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"15","key":"10.1016\/j.talanta.2026.130331_bib80","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202307585","article-title":"Chlorella-loaded antibacterial microneedles for microacupuncture oxygen therapy of diabetic bacterial infected wounds","volume":"36","author":"Gao","year":"2024","journal-title":"Adv. Mater."},{"issue":"28","key":"10.1016\/j.talanta.2026.130331_bib81","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh1415","article-title":"Self-powered enzyme-linked microneedle patch for scar-prevention healing of diabetic wounds","volume":"9","author":"Zhang","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.talanta.2026.130331_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.148592","article-title":"Mxene-based mild hyperthemia microneedle patch for diabetic wound healing","volume":"481","author":"Gan","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"11","key":"10.1016\/j.talanta.2026.130331_bib83","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1016\/j.apsb.2024.06.014","article-title":"Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing","volume":"14","author":"Zeng","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib84","article-title":"Living microneedle patch with adipose-derived stem cells embedding for diabetic ulcer healing","volume":"33","author":"Ye","year":"2022","journal-title":"Adv. Funct. Mater."},{"issue":"23","key":"10.1016\/j.talanta.2026.130331_bib85","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202210903","article-title":"Bio-inspired adaptable indwelling microneedles for diabetic ulcers treatment","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.talanta.2026.130331_bib86","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.actbio.2024.09.045","article-title":"A biphasic drug-releasing microneedle with ROS scavenging and angiogenesis for the treatment of diabetic ulcers","volume":"189","author":"He","year":"2024","journal-title":"Acta Biomater."},{"issue":"28","key":"10.1016\/j.talanta.2026.130331_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202316742","article-title":"Bio-inspired porous microneedles dwelled stem cells for diabetic wound treatment","volume":"34","author":"Fan","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"14","key":"10.1016\/j.talanta.2026.130331_bib88","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202312499","article-title":"XiaochunBian, ZhiweiLuo, HongwuDu, PeixunZhang, YongqiangWen, double bionic deformable DNA hydrogel microneedles loaded with extracellular vesicles to guide tissue regeneration of diabetes ulcer wound","volume":"34","author":"Zhou","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.talanta.2026.130331_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.152252","article-title":"Dynamic hydrogel-integrated microneedle patch with extracellular vesicles encapsulation for wound healing","volume":"493","author":"Wu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2026.130331_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101630","article-title":"Antibacterial, adhesive, and MSC exosomes encapsulated microneedles with spatio-temporal variation functions for diabetic wound healing","volume":"47","author":"Gan","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.talanta.2026.130331_bib91","first-page":"32","article-title":"Dissolvable microneedle-based wound dressing transdermally and continuously delivers anti-inflammatory and pro-angiogenic exosomes for diabetic wound treatment","volume":"42","author":"Cao","year":"2024","journal-title":"Bioact. Mater."},{"issue":"23","key":"10.1016\/j.talanta.2026.130331_bib92","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300297","article-title":"Multifunctional double-layer and dual drug-loaded microneedle patch promotes diabetic wound healing","volume":"12","author":"Liu","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.talanta.2026.130331_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122574","article-title":"Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS\/NF-\u03baB pathway to regulate macrophage polarization","volume":"345","author":"Liu","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"12","key":"10.1016\/j.talanta.2026.130331_bib94","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1016\/j.apsb.2023.05.032","article-title":"Purpurolide C-based microneedle promotes macrophage-mediated diabetic wound healing via inhibiting TLR4-MD2 dimerization and MYD88 phosphorylation","volume":"13","author":"Liu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.talanta.2026.130331_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118246","article-title":"Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis","volume":"259","author":"Huang","year":"2020","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.talanta.2026.130331_bib96","doi-asserted-by":"crossref","first-page":"Jc27","DOI":"10.7326\/ACPJ202003170-027","article-title":"Cyclical pressurized topical wound oxygen therapy increased healing of refractory diabetic foot ulcers","volume":"172","author":"Liakos","year":"2020","journal-title":"Ann. Intern. Med."},{"issue":"20","key":"10.1016\/j.talanta.2026.130331_bib97","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba4311","article-title":"Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes","volume":"6","author":"Chen","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.talanta.2026.130331_bib98","first-page":"50","article-title":"Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration","volume":"19","author":"Kim","year":"2023","journal-title":"Bioact. Mater."},{"issue":"28","key":"10.1016\/j.talanta.2026.130331_bib99","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202301064","article-title":"Microfluidic templated stem cell spheroid microneedles for diabetic wound treatment","volume":"35","author":"Wu","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.talanta.2026.130331_bib100","article-title":"M2 macrophage-derived exosome-encapsulated microneedles with mild photothermal therapy for accelerated diabetic wound healing","volume":"20","author":"Zeng","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.talanta.2026.130331_bib101","article-title":"Affinity-selected polysaccharide for rhBMP-2-induced osteogenesis via BMP receptor activation","volume":"20","author":"Yu","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.talanta.2026.130331_bib105","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejim.2023.07.005","article-title":"Management of diabetic ketoacidosis","volume":"117","author":"Barski","year":"2023","journal-title":"Eur. J. Intern. Med."},{"issue":"5","key":"10.1016\/j.talanta.2026.130331_bib106","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12050424","article-title":"Feasibility of interstitial fluid ketone monitoring with microneedles","volume":"12","author":"Taylor","year":"2022","journal-title":"Metabolites"},{"issue":"2","key":"10.1016\/j.talanta.2026.130331_bib107","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1021\/acs.analchem.9b05109","article-title":"Microneedle-based detection of ketone bodies along with glucose and lactate: toward real-time continuous interstitial fluid monitoring of diabetic ketosis and ketoacidosis","volume":"92","author":"Teymourian","year":"2020","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.talanta.2026.130331_bib108","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1021\/acssensors.3c02677","article-title":"Continuous ketone monitoring via wearable microneedle patch platform","volume":"9","author":"Moonla","year":"2024","journal-title":"ACS Sens."},{"issue":"32","key":"10.1016\/j.talanta.2026.130331_bib102","article-title":"Multifunctional dopamine-based hydrogel microneedle electrode for continuous ketone sensing","volume":"36","author":"Ausri","year":"2024","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib103","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1021\/acsbiomaterials.4c01787","article-title":"Phycocyanin\/hyaluronic acid microneedle patches loaded with celastrol nanoparticles for synergistic treatment of diabetic nephropathy","volume":"11","author":"Zheng","year":"2025","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.talanta.2026.130331_bib104","first-page":"516","article-title":"Conductive polyphenol microneedles coupled with electroacupuncture to accelerate wound healing and alleviate depressive-like behaviors in diabetes","volume":"44","author":"Hou","year":"2025","journal-title":"Bioact. Mater."},{"issue":"7","key":"10.1016\/j.talanta.2026.130331_bib109","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41581-020-0278-5","article-title":"Genetics of diabetes mellitus and diabetes complications","volume":"16","author":"Cole","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"issue":"12","key":"10.1016\/j.talanta.2026.130331_bib110","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s11892-019-1263-x","article-title":"Crosstalk between lipids and mitochondria in diabetic kidney disease","volume":"19","author":"Ducasa","year":"2019","journal-title":"Curr. Diabetes Rep."},{"issue":"5","key":"10.1016\/j.talanta.2026.130331_bib111","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.ymthe.2024.02.035","article-title":"Gene therapy approaches for obesity-induced adipose neuropathy: device-Targeted AAV-mediated neurotrophic factor delivery to adipocytes in subcutaneous adipose","volume":"32","author":"Blaszkiewicz","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.talanta.2026.130331_bib112","doi-asserted-by":"crossref","first-page":"114839","DOI":"10.1016\/j.matdes.2025.114839","article-title":"ARA290 microneedle patch modulate microglia polarization and mitigate diabetic peripheral neuropathy","volume":"259","author":"Wu","year":"2025","journal-title":"Mater. Des."},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib113","first-page":"1","article-title":"Shrinkage estimation of factor models with global and group-specific factors","volume":"39","author":"Xu","year":"2021","journal-title":"J. Bus. Econ. Stat."},{"key":"10.1016\/j.talanta.2026.130331_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.125536","article-title":"On-skin glucose-biosensing and on-demand insulin-zinc hexamers delivery using microneedles for syringe-free diabetes management","volume":"398","author":"Hsu","year":"2020","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib118","doi-asserted-by":"crossref","DOI":"10.1038\/s41378-020-00224-z","article-title":"Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery","volume":"6","author":"Yang","year":"2020","journal-title":"Microsyst. Nanoeng."},{"issue":"16","key":"10.1016\/j.talanta.2026.130331_bib114","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100827","article-title":"A fully integrated closed-loop system based on mesoporous microneedles-iontophoresis for diabetes treatment","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"issue":"50","key":"10.1016\/j.talanta.2026.130331_bib115","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo6900","article-title":"Masticatory system-inspired microneedle theranostic platform for intelligent and precise diabetic management","volume":"8","author":"Yang","year":"2022","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.talanta.2026.130331_bib116","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1021\/acssensors.2c02863","article-title":"Wearable, sensing-controlled, ultrasound-based microneedle smart system for diabetes management","volume":"8","author":"Luo","year":"2023","journal-title":"ACS Sens."},{"issue":"5","key":"10.1016\/j.talanta.2026.130331_bib119","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1021\/acssensors.1c02337","article-title":"Closed-loop diabetes minipatch based on a biosensor and an electroosmotic pump on hollow biodegradable microneedles","volume":"7","author":"Luo","year":"2022","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2026.130331_bib120","doi-asserted-by":"crossref","DOI":"10.34133\/2022\/9870637","article-title":"A microtube-based wearable closed-loop minisystem for diabetes management","author":"Liu","year":"2022","journal-title":"Research"},{"issue":"3","key":"10.1016\/j.talanta.2026.130331_bib121","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1039\/D2LC00797E","article-title":"A wearable, minimally-invasive, fully electrochemically-controlled feedback minisystem for diabetes management","volume":"23","author":"Liu","year":"2023","journal-title":"Lab Chip"},{"issue":"1","key":"10.1016\/j.talanta.2026.130331_bib122","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41378-024-00663-y","article-title":"A wearable, rapidly manufacturable, stability-enhancing microneedle patch for closed-loop diabetes management","volume":"10","author":"Liu","year":"2024","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.talanta.2026.130331_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113794","article-title":"Dissolving microneedles in transdermal drug delivery: a critical analysis of limitations and translation challenges","volume":"383","author":"Moawad","year":"2025","journal-title":"J. Control. Release"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026009872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026009872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:10:14Z","timestamp":1790889014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026009872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":123,"alternative-id":["S0039914026009872"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130331","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive advances of microneedle technology in addressing diabetes mellitus and its multisystem complications","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130331","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130331"}}