{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:32:49Z","timestamp":1793140369757,"version":"4.5.0"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["YZJJ2024QN47"],"award-info":[{"award-number":["YZJJ2024QN47"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.talanta.2026.130404","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:04:54Z","timestamp":1786374294000},"page":"130404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Surface-enhanced Raman spectroscopy for breast cancer personalized management:From liquid biopsy and intraoperative navigation to therapy monitoring"],"prefix":"10.1016","volume":"312","author":[{"given":"Yue","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.talanta.2026.130404_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.talanta.2026.130404_bib2","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/s41591-025-03502-3","article-title":"Global patterns and trends in breast cancer incidence and mortality across 185 countries","volume":"31","author":"Kim","year":"2025","journal-title":"Nat. Med."},{"issue":"6797","key":"10.1016\/j.talanta.2026.130404_bib3","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"Perou","year":"2000","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.talanta.2026.130404_bib4","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1093\/annonc\/mdr304","article-title":"Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011","volume":"22","author":"Goldhirsch","year":"2011","journal-title":"Ann. Oncol. : official journal of the European Society for Medical Oncology"},{"issue":"8","key":"10.1016\/j.talanta.2026.130404_bib5","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1093\/annonc\/mdy192","article-title":"4th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 4)?","volume":"29","author":"Cardoso","year":"2018","journal-title":"Ann. Oncol. : official journal of the European Society for Medical Oncology"},{"key":"10.1016\/j.talanta.2026.130404_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-pathol-042420-093238","article-title":"Pathogenesis of triple-negative breast cancer","volume":"17","author":"Derakhshan","year":"2022","journal-title":"Annual review of pathology"},{"issue":"Suppl 2","key":"10.1016\/j.talanta.2026.130404_bib7","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.breast.2015.07.008","article-title":"Clinical implications of the intrinsic molecular subtypes of breast cancer","volume":"24","author":"Prat","year":"2015","journal-title":"Breast"},{"issue":"12","key":"10.1016\/j.talanta.2026.130404_bib8","doi-asserted-by":"crossref","first-page":"R605","DOI":"10.1530\/ERC-18-0179","article-title":"Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer","volume":"25","author":"Lamb","year":"2018","journal-title":"Endocr. Relat. Cancer"},{"issue":"3","key":"10.1016\/j.talanta.2026.130404_bib9","first-page":"184","article-title":"Cancer screening in the United States, 2019: a review of current American cancer society guidelines and current issues in cancer screening","volume":"69","author":"Smith","year":"2019","journal-title":"CA Cancer J. Clin."},{"issue":"9","key":"10.1016\/j.talanta.2026.130404_bib10","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/modpathol.2015.74","article-title":"Standardization of pathologic evaluation and reporting of postneoadjuvant specimens in clinical trials of breast cancer: recommendations from an international working group","volume":"28","author":"Provenzano","year":"2015","journal-title":"Mod. Pathol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12967-025-06080-7","article-title":"Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer","volume":"23","author":"Xu","year":"2025","journal-title":"J. Transl. Med."},{"issue":"10","key":"10.1016\/j.talanta.2026.130404_bib12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1089\/pho.2013.9873","article-title":"Raman spectroscopy: new perspectives for its clinical application in diagnosis","volume":"31","author":"Pacheco","year":"2013","journal-title":"Photomed. Laser Surg."},{"issue":"40","key":"10.1016\/j.talanta.2026.130404_bib13","doi-asserted-by":"crossref","first-page":"14390","DOI":"10.1021\/ja904480r","article-title":"Raman spectroelectrochemistry of molecules within individual electromagnetic hot spots","volume":"131","author":"Shegai","year":"2009","journal-title":"J. Am. Chem. Soc."},{"issue":"10","key":"10.1016\/j.talanta.2026.130404_bib14","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1021\/acs.chemrev.7b00668","article-title":"Surface-enhanced raman spectroscopy for bioanalysis: reliability and challenges","volume":"118","author":"Zong","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.talanta.2026.130404_bib15","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1039\/D4CS00090K","article-title":"Surface-enhanced raman spectroscopy in biomedical applications: current status and future trends","volume":"53","author":"Cialla-May","year":"2024","journal-title":"Chem. Soc. Rev."},{"issue":"23","key":"10.1016\/j.talanta.2026.130404_bib16","doi-asserted-by":"crossref","first-page":"13998","DOI":"10.1039\/D5NR01131K","article-title":"Recent advances of metal cluster-based SERS probes for biomedical applications","volume":"17","author":"Sun","year":"2025","journal-title":"Nanoscale"},{"key":"10.1016\/j.talanta.2026.130404_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.117070","article-title":"Cervical cancer screening by biomarker-free Serum-SERS technique: a three-principal-substrate approach","volume":"271","author":"Zhao","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"Pt 1","key":"10.1016\/j.talanta.2026.130404_bib18","article-title":"Advanced artificial intelligence combined with SERS platforms for diagnosis and therapeutic effects of cancer in clinical applications","volume":"348","author":"Bari","year":"2026","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2026.130404_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2022.03.036","article-title":"Exosome detection via surface-enhanced raman spectroscopy for cancer diagnosis","volume":"144","author":"Li","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.talanta.2026.130404_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2026.118621","article-title":"A programmable matrix-robust plasmonic MetaRing biosensor for rapid SERS-based chemotherapeutic response profiling","volume":"304","author":"Fang","year":"2026","journal-title":"Biosens. Bioelectron."},{"issue":"19","key":"10.1016\/j.talanta.2026.130404_bib24","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1002\/anie.201205748","article-title":"Surface-enhanced Raman spectroscopy: concepts and chemical applications","volume":"53","author":"Schl\u00fccker","year":"2014","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.talanta.2026.130404_bib25","doi-asserted-by":"crossref","DOI":"10.1021\/acsnano.4c09483","article-title":"Single-molecule surface-enhanced raman spectroscopy: challenges, opportunities, and future directions","author":"Schmidt","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2026.130404_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121714","article-title":"Surface enhanced Raman scattering substrate for the detection of explosives: construction strategy and dimensional effect","volume":"387","author":"Wu","year":"2020","journal-title":"J. Hazard Mater."},{"issue":"13","key":"10.1016\/j.talanta.2026.130404_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202218799","article-title":"Chemical enhancement and quenching in single-molecule tip-enhanced raman spectroscopy","volume":"62","author":"Yang","year":"2023","journal-title":"Angew Chem. Int. Ed. Engl."},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib29","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41377-023-01271-7","article-title":"Early cancer detection by SERS spectroscopy and machine learning","volume":"12","author":"Shi","year":"2023","journal-title":"Light Sci. Appl."},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib30","article-title":"Research progress in small-molecule detection using aptamer-based SERS techniques","volume":"15","author":"Zheng","year":"2025","journal-title":"Biosensors (Basel)"},{"issue":"11","key":"10.1016\/j.talanta.2026.130404_bib31","doi-asserted-by":"crossref","first-page":"16287","DOI":"10.1021\/acsami.4c17502","article-title":"Surface-enhanced raman spectroscopy for biomedical applications: recent advances and future challenges","volume":"17","author":"Lin","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2026.130404_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140843","article-title":"Ultrasensitive detection of contaminants in milk using a novel NMS-Ag modified water-resistant paper substrate","volume":"461","author":"Su","year":"2024","journal-title":"Food Chem."},{"issue":"27","key":"10.1016\/j.talanta.2026.130404_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301000","article-title":"A ratiometric SERS probe for imaging the macrophage phenotypes in live mice with epilepsy and brain tumor","volume":"12","author":"Duan","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.talanta.2026.130404_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.125797","article-title":"Advances in SERS detection method combined with microfluidic technology for bio-analytical applications","volume":"332","author":"Xu","year":"2025","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"issue":"48","key":"10.1016\/j.talanta.2026.130404_bib35","doi-asserted-by":"crossref","first-page":"16086","DOI":"10.1021\/acs.analchem.1c03807","article-title":"Construction of optimal SERS hotspots based on capturing the spike receptor-binding domain (RBD) of SARS-CoV-2 for highly sensitive and specific detection by a fish model","volume":"93","author":"Huang","year":"2021","journal-title":"Anal. Chem."},{"issue":"23","key":"10.1016\/j.talanta.2026.130404_bib36","doi-asserted-by":"crossref","first-page":"27456","DOI":"10.1021\/acsami.2c05781","article-title":"Phosphonium-Based ionic liquid significantly enhances SERS of cytochrome c on TiO(2) nanotube arrays","volume":"14","author":"Dong","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2026.130404_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2025.104838","article-title":"Plasmonic surgery: SERS-active smart nanotools reshaping intraoperative decision-making and precision therapy","volume":"214","author":"Chen","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.talanta.2026.130404_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2019.111543","article-title":"Telomere elongation-based DNA-catalytic amplification strategy for sensitive SERS detection of telomerase activity","volume":"142","author":"Li","year":"2019","journal-title":"Biosens. Bioelectron."},{"issue":"24","key":"10.1016\/j.talanta.2026.130404_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202500770","article-title":"Wearable SERS-microfluidic patch for real-time in situ monitoring of chiral metabolites in sweat","volume":"21","author":"Pan","year":"2025","journal-title":"Small"},{"issue":"7","key":"10.1016\/j.talanta.2026.130404_bib40","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.1002\/jcp.26379","article-title":"Breast cancer diagnosis: imaging techniques and biochemical markers","volume":"233","author":"Jafari","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.talanta.2026.130404_bib41","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.trecan.2024.10.007","article-title":"Artificial intelligence improves mammography-based breast cancer risk prediction","volume":"11","author":"Ingman","year":"2025","journal-title":"Trends Cancer"},{"issue":"9","key":"10.1016\/j.talanta.2026.130404_bib42","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrclinonc.2017.14","article-title":"Integrating liquid biopsies into the management of cancer","volume":"14","author":"Siravegna","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"Suppl 1","key":"10.1016\/j.talanta.2026.130404_bib43","doi-asserted-by":"crossref","first-page":"9S","DOI":"10.2967\/jnumed.115.157834","article-title":"Clinical diagnosis and management of breast cancer","volume":"57","author":"McDonald","year":"2016","journal-title":"J. Nucl. Med."},{"issue":"48","key":"10.1016\/j.talanta.2026.130404_bib44","article-title":"Peripheral blood inflammatory indexes in breast cancer: a review","volume":"102","author":"Xie","year":"2023","journal-title":"Medicine (Baltim.)"},{"issue":"12","key":"10.1016\/j.talanta.2026.130404_bib45","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13045-024-01591-0","article-title":"LncRNA-encoded peptides in cancer","volume":"17","author":"Zhang","year":"2024","journal-title":"J. Hematol. Oncol."},{"issue":"5","key":"10.1016\/j.talanta.2026.130404_bib47","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/onc.2017.361","article-title":"Circular RNAs in cancer: opportunities and challenges in the field","volume":"37","author":"Kristensen","year":"2018","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.talanta.2026.130404_bib48","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.cell.2014.07.013","article-title":"Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis","volume":"158","author":"Aceto","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.talanta.2026.130404_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114236","article-title":"Highly sensitive and reliable detection of microRNA for clinically disease surveillance using SERS biosensor integrated with catalytic hairpin assembly amplification technology","volume":"208","author":"Weng","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"8","key":"10.1016\/j.talanta.2026.130404_bib50","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1021\/acs.analchem.8b05172","article-title":"Triggerable mutually amplified signal probe based SERS-microfluidics platform for the efficient enrichment and quantitative detection of miRNA","volume":"91","author":"Wang","year":"2019","journal-title":"Anal. Chem."},{"issue":"17","key":"10.1016\/j.talanta.2026.130404_bib52","article-title":"Quantitative and specific detection of exosomal miRNAs for accurate diagnosis of breast cancer using a surface-enhanced raman scattering sensor based on plasmonic head-flocked gold nanopillars","volume":"15","author":"Lee","year":"2019","journal-title":"Small"},{"issue":"23","key":"10.1016\/j.talanta.2026.130404_bib54","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1002\/anie.201902776","article-title":"Functionalized h-BN nanosheets as a Theranostic platform for SERS real-time monitoring of MicroRNA and photodynamic therapy","volume":"58","author":"Liu","year":"2019","journal-title":"Angew. Chem."},{"key":"10.1016\/j.talanta.2026.130404_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113470","article-title":"Surface-enhanced Raman scattering holography chip for rapid, sensitive and multiplexed detection of human breast cancer-associated MicroRNAs in clinical samples","volume":"190","author":"Meng","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130404_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.122735","article-title":"Recent advances in catalytic hairpin assembly signal amplification-based sensing strategies for microRNA detection","volume":"235","author":"Wu","year":"2021","journal-title":"Talanta"},{"issue":"2","key":"10.1016\/j.talanta.2026.130404_bib57","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3390\/biomedicines13020505","article-title":"Advancing breast cancer diagnosis: optimization of raman spectroscopy for urine-based early detection","volume":"13","author":"Andras","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.talanta.2026.130404_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114143","article-title":"Simultaneous dual-targeted monitoring of breast cancer circulating miRNA via surface-enhanced Raman spectroscopy","volume":"207","author":"Kim","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130404_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.129157","article-title":"Label free paper sensor and light driven material for the rapid screening of S100P cancer biomarker in saliva","volume":"300","author":"Alzubaidi","year":"2026","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.130404_bib62","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2147\/IJN.S71811","article-title":"Surface-enhanced Raman spectroscopy of saliva proteins for the noninvasive differentiation of benign and malignant breast tumors","volume":"10","author":"Feng","year":"2015","journal-title":"Int. J. Nanomed."},{"issue":"5","key":"10.1016\/j.talanta.2026.130404_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.24.5.055001","article-title":"Nanoparticle-based assay for detection of S100P mRNA using surface-enhanced Raman spectroscopy","volume":"24","author":"Han","year":"2019","journal-title":"J. Biomed. Opt."},{"issue":"11","key":"10.1016\/j.talanta.2026.130404_bib55","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1046\/j.1365-2036.2003.01577.x","article-title":"Review article: clinic-based testing for Helicobacter pylori infection by enzyme immunoassay of faeces, urine and saliva","volume":"17","author":"Kabir","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib56","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-anchem-061020-123959","article-title":"Saliva diagnostics","volume":"15","author":"Nonaka","year":"2022","journal-title":"Annu. Rev. Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130404_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.343383","article-title":"Determination of multiple analytes in urine using label-free SERS coupled with simple sample pretreatments","volume":"1332","author":"Markina","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2026.130404_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.117875","article-title":"Breast cancer derived exosomes: theragnostic perspectives and implications","volume":"557","author":"Ram Kumar","year":"2024","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib64","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International society for extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"issue":"6","key":"10.1016\/j.talanta.2026.130404_bib65","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.ccell.2016.10.009","article-title":"Extracellular vesicles in cancer: Cell-To-Cell mediators of metastasis","volume":"30","author":"Becker","year":"2016","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.talanta.2026.130404_bib66","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1021\/acssensors.9b00760","article-title":"Label-free nanosensing platform for breast cancer exosome profiling","volume":"4","author":"Ferreira","year":"2019","journal-title":"ACS Sens."},{"issue":"2","key":"10.1016\/j.talanta.2026.130404_bib67","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1021\/acssensors.2c02587","article-title":"Dual-Aptamer-assisted ratiometric SERS biosensor for ultrasensitive and precise identification of breast cancer exosomes","volume":"8","author":"Zhang","year":"2023","journal-title":"ACS Sens."},{"issue":"11","key":"10.1016\/j.talanta.2026.130404_bib68","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1039\/D0TB02894K","article-title":"A magnetic surface-enhanced Raman scattering platform for performing successive breast cancer exosome isolation and analysis","volume":"9","author":"Li","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.talanta.2026.130404_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115493","article-title":"Ti(3)C(2)Tx MXene -facilitated non-selective trapping effect: efficient SERS detection of exosomal PD-L1","volume":"237","author":"Zhou","year":"2023","journal-title":"Biosens. Bioelectron."},{"issue":"19","key":"10.1016\/j.talanta.2026.130404_bib70","doi-asserted-by":"crossref","first-page":"7552","DOI":"10.1021\/acs.analchem.3c00026","article-title":"Machine learning-based label-free SERS profiling of exosomes for accurate fuzzy diagnosis of cancer and dynamic monitoring of drug therapeutic processes","volume":"95","author":"Diao","year":"2023","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib71","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41467-023-37403-1","article-title":"Single test-based diagnosis of multiple cancer types using Exosome-SERS-AI for early stage cancers","volume":"14","author":"Shin","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.talanta.2026.130404_bib72","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1021\/acssensors.4c03051","article-title":"Microcapillary-derived plasmonic-enhanced cluster through the self-assembly process for breast cancer diagnosis","volume":"10","author":"Nguyen","year":"2025","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2026.130404_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.artmed.2022.102276","article-title":"Breast cancer detection using artificial intelligence techniques: a systematic literature review","volume":"127","author":"Nassif","year":"2022","journal-title":"Artif. Intell. Med."},{"issue":"5","key":"10.1016\/j.talanta.2026.130404_bib74","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.ejso.2017.02.002","article-title":"Breast conserving surgery and locoregional control after neoadjuvant chemotherapy","volume":"43","author":"Teshome","year":"2017","journal-title":"Eur. J. Surg. Oncol."},{"key":"10.1016\/j.talanta.2026.130404_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118364","article-title":"SERS studies on normal epithelial and cancer cells derived from clinical breast cancer specimens","volume":"237","author":"Shen","year":"2020","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.talanta.2026.130404_bib76","article-title":"Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"issue":"16","key":"10.1016\/j.talanta.2026.130404_bib77","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1158\/0008-5472.CAN-17-0709","article-title":"Raman-Encoded molecular imaging with topically applied SERS nanoparticles for intraoperative guidance of lumpectomy","volume":"77","author":"Wang","year":"2017","journal-title":"Cancer Res."},{"issue":"40","key":"10.1016\/j.talanta.2026.130404_bib78","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1002\/smll.201601829","article-title":"Multiplexed molecular imaging of fresh tissue surfaces enabled by convection-enhanced topical staining with SERS-Coded nanoparticles","volume":"12","author":"Wang","year":"2016","journal-title":"Small"},{"issue":"11","key":"10.1016\/j.talanta.2026.130404_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/nano8110953","article-title":"A raman imaging approach using CD47 antibody-labeled SERS nanoparticles for identifying breast cancer and its potential to guide surgical resection","volume":"8","author":"Davis","year":"2018","journal-title":"Nanomaterials"},{"issue":"21","key":"10.1016\/j.talanta.2026.130404_bib82","doi-asserted-by":"crossref","first-page":"9058","DOI":"10.1021\/ac102058k","article-title":"Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration","volume":"82","author":"Mohs","year":"2010","journal-title":"Anal. Chem."},{"issue":"33","key":"10.1016\/j.talanta.2026.130404_bib83","doi-asserted-by":"crossref","first-page":"eado2741","DOI":"10.1126\/sciadv.ado2741","article-title":"SERS surgical navigation with postsurgical immunotherapy of local microtumors and distant metastases for improved anticancer outcomes","volume":"10","author":"Wen","year":"2024","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.talanta.2026.130404_bib86","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.biomaterials.2010.10.058","article-title":"Fluorescence-surface enhanced Raman scattering co-functionalized gold nanorods as near-infrared probes for purely optical in vivo imaging","volume":"32","author":"Qian","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.talanta.2026.130404_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122538","article-title":"Sentinel lymph node identification using NIR-II ultrabright Raman nanotags on preclinical models","volume":"308","author":"Deng","year":"2024","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.talanta.2026.130404_bib79","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/cjp2.309","article-title":"CD47 and CD68 expression in breast cancer is associated with tumor-infiltrating lymphocytes, blood vessel invasion, detection mode, and prognosis","volume":"9","author":"Chen","year":"2023","journal-title":"The journal of pathology. Clinical research"},{"issue":"11","key":"10.1016\/j.talanta.2026.130404_bib80","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.21873\/anticanres.17318","article-title":"CD47 and calreticulin expression in breast cancer subtypes and Anti-CD47 inhibitory effects in macrophage-mediated phagocytosis","volume":"44","author":"Chantaraamporn","year":"2024","journal-title":"Anticancer Res."},{"issue":"3","key":"10.1016\/j.talanta.2026.130404_bib84","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1200\/JOP.2016.019992","article-title":"Sentinel lymph Node biopsy for patients with early-stage breast cancer: 2016 American society of clinical oncology clinical practice guideline update summary","volume":"13","author":"Lyman","year":"2017","journal-title":"Journal of oncology practice"},{"issue":"13","key":"10.1016\/j.talanta.2026.130404_bib85","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1200\/JCO.2013.54.1177","article-title":"Sentinel lymph node biopsy for patients with early-stage breast cancer: American society of clinical oncology clinical practice guideline update","volume":"32","author":"Lyman","year":"2014","journal-title":"J. Clin. Oncol. : official journal of the American Society of Clinical Oncology"},{"key":"10.1016\/j.talanta.2026.130404_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126092","article-title":"Surface-enhanced Raman scattering-based identification of breast cancer progression using extracellular vesicles-derived integrin \u03b16\u03b24","volume":"275","author":"Lei","year":"2024","journal-title":"Talanta"},{"issue":"9","key":"10.1016\/j.talanta.2026.130404_bib89","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1021\/acssensors.5c01653","article-title":"A 3D nanofiltration array for direct plasma EV purification with label-free SERS detection toward accurate clinical breast cancer staging","volume":"10","author":"Wang","year":"2025","journal-title":"ACS Sens."},{"key":"10.1016\/j.talanta.2026.130404_bib90","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1039\/C7FD00135E","article-title":"Fast and reproducible iSERS microscopy of single HER2-positive breast cancer cells using gold nanostars as SERS nanotags","volume":"205","author":"Wang","year":"2017","journal-title":"Faraday Discuss."},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib91","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s12951-024-02600-7","article-title":"Combined SERS-Raman screening of HER2-overexpressing or silenced breast cancer cell lines","volume":"22","author":"Spaziani","year":"2024","journal-title":"J Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib92","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1039\/C1NR11243K","article-title":"Fabrication of SERS-Fluorescence dual modal nanoprobes and application to multiplex cancer cell imaging","volume":"4","author":"Lee","year":"2012","journal-title":"Nanoscale"},{"issue":"14","key":"10.1016\/j.talanta.2026.130404_bib93","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.1021\/acs.analchem.1c00188","article-title":"Detection of Estrogen receptor alpha and assessment of fulvestrant activity in MCF-7 tumor spheroids using microfluidics and SERS","volume":"93","author":"Kapara","year":"2021","journal-title":"Anal. Chem."},{"issue":"27","key":"10.1016\/j.talanta.2026.130404_bib94","doi-asserted-by":"crossref","first-page":"16602","DOI":"10.1021\/acsomega.0c01441","article-title":"Mixed-dimensional heterostructure material-based SERS for trace level identification of breast cancer-derived exosomes","volume":"5","author":"Pramanik","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.talanta.2026.130404_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126136","article-title":"Non-invasive screening and subtyping for breast cancer by serum SERS combined with LGB-DNN algorithms","volume":"275","author":"Zhang","year":"2024","journal-title":"Talanta"},{"issue":"3","key":"10.1016\/j.talanta.2026.130404_bib96","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/00037028241297716","article-title":"Evaluation of breast cancer gene type 1 (BRCA1) protein levels in cancer tissue using surface-enhanced raman spectroscopy","volume":"79","author":"Miser-Saliho Lu","year":"2025","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.talanta.2026.130404_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126956","article-title":"Specific isolation and quantification of PD-L1 positive tumor derived exosomes for accurate breast cancer discrimination via aptamer-functionalized magnetic composites and SERS immunoassay","volume":"281","author":"Su","year":"2025","journal-title":"Talanta"},{"issue":"5","key":"10.1016\/j.talanta.2026.130404_bib98","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/FTD.0000000000000628","article-title":"Therapeutic drug monitoring of everolimus in oncology: evidences and perspectives","volume":"41","author":"Falkowski","year":"2019","journal-title":"Ther. Drug Monit."},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30010015","article-title":"Advances in surface-enhanced raman spectroscopy for therapeutic drug monitoring","volume":"30","author":"Lai","year":"2024","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.talanta.2026.130404_bib100","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1021\/acs.analchem.8b04523","article-title":"Ultrasensitive SERS substrate for label-free therapeutic-drug monitoring of paclitaxel and cyclophosphamide in blood serum","volume":"91","author":"Panikar","year":"2019","journal-title":"Anal. Chem."},{"issue":"22","key":"10.1016\/j.talanta.2026.130404_bib101","doi-asserted-by":"crossref","first-page":"7225","DOI":"10.1039\/D0AN01532F","article-title":"Characterisation of estrogen receptor alpha (ER\u03b1) expression in breast cancer cells and effect of drug treatment using targeted nanoparticles and SERS","volume":"145","author":"Kapara","year":"2020","journal-title":"The Analyst"},{"issue":"4","key":"10.1016\/j.talanta.2026.130404_bib102","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.cmet.2022.02.010","article-title":"The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer","volume":"34","author":"Wang","year":"2022","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.talanta.2026.130404_bib103","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/antiox12020240","article-title":"Polysulfide serves as a hallmark of desmoplastic reaction to differentially diagnose ductal carcinoma in situ and invasive breast cancer by SERS imaging","volume":"12","author":"Kubo","year":"2023","journal-title":"Antioxidants"},{"issue":"13","key":"10.1016\/j.talanta.2026.130404_bib104","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.1002\/anie.202015451","article-title":"Dual ratiometric SERS and photoacoustic core-satellite nanoprobe for quantitatively visualizing hydrogen peroxide in inflammation and cancer","volume":"60","author":"Li","year":"2021","journal-title":"Angew. Chem."},{"issue":"44","key":"10.1016\/j.talanta.2026.130404_bib105","doi-asserted-by":"crossref","first-page":"eadz0187","DOI":"10.1126\/sciadv.adz0187","article-title":"Circulating tumor cells as predictive biomarkers in the risk stratification of DCIS: evidence of early dissemination","volume":"11","author":"Nagpal","year":"2025","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.talanta.2026.130404_bib106","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40580-024-00428-3","article-title":"SERS biosensors for liquid biopsy towards cancer diagnosis by detection of various circulating biomarkers: current progress and perspectives","volume":"11","author":"Lyu","year":"2024","journal-title":"Nano Converg."},{"issue":"2","key":"10.1016\/j.talanta.2026.130404_bib107","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1021\/acsami.3c13921","article-title":"Multiplexed surface protein detection and cancer classification using gap-enhanced magnetic-plasmonic core-shell raman nanotags and machine learning algorithm","volume":"16","author":"Rodriguez-Nieves","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"29","key":"10.1016\/j.talanta.2026.130404_bib108","doi-asserted-by":"crossref","first-page":"10375","DOI":"10.1021\/acs.analchem.2c01249","article-title":"Microfluidic Droplet-SERS platform for single-cell cytokine analysis via a cell surface bioconjugation strategy","volume":"94","author":"Cong","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130404_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2023.112832","article-title":"Cyclometalated Ir(III) theranostic molecular probe enabled mitochondria targeted fluorescence-SERS-guided phototherapy in breast cancer cells","volume":"250","author":"Reghukumar","year":"2024","journal-title":"J. Photochem. Photobiol., B"},{"issue":"15","key":"10.1016\/j.talanta.2026.130404_bib110","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1039\/D4AN00151F","article-title":"A self-calibrating flexible SERS substrate incorporating PB@Au assemblies for reliable and reproducible detection","volume":"149","author":"Zhou","year":"2024","journal-title":"The Analyst"},{"key":"10.1016\/j.talanta.2026.130404_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.128100","article-title":"Multimodal triple-mode probe with colorimetric-fluorescence-SERS (CFSERS) for sensitive and quantitative detection of C-reactive protein in clinical diagnostics","volume":"293","author":"Li","year":"2025","journal-title":"Talanta"},{"issue":"13","key":"10.1016\/j.talanta.2026.130404_bib112","doi-asserted-by":"crossref","first-page":"8297","DOI":"10.1021\/acs.chemrev.2c00897","article-title":"The emerging role of raman spectroscopy as an omics approach for metabolic profiling and biomarker detection toward precision medicine","volume":"123","author":"Cutshaw","year":"2023","journal-title":"Chem Rev"},{"key":"10.1016\/j.talanta.2026.130404_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116724","article-title":"Sensitive phenotyping of serum extracellular vesicles on a SERS-microfluidic platform for early-stage clinical diagnosis of ovarian carcinoma","volume":"267","author":"Chen","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"49","key":"10.1016\/j.talanta.2026.130404_bib114","doi-asserted-by":"crossref","first-page":"8915","DOI":"10.1039\/D5CC01038A","article-title":"Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles","volume":"61","author":"Duffield","year":"2025","journal-title":"Chemical communications (Cambridge, England)"},{"issue":"51","key":"10.1016\/j.talanta.2026.130404_bib115","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202207658","article-title":"Machine learning-assisted high-throughput SERS classification of cell secretomes","volume":"19","author":"Plou","year":"2023","journal-title":"Small"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003991402601060X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003991402601060X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:37:41Z","timestamp":1793137061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003991402601060X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":111,"alternative-id":["S003991402601060X"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130404","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surface-enhanced Raman spectroscopy for breast cancer personalized management:From liquid biopsy and intraoperative navigation to therapy monitoring","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"130404"}}