{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:55:49Z","timestamp":1790891749931,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["2022YZ035020"],"award-info":[{"award-number":["2022YZ035020"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009696","name":"Minjiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009696","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021J011039"],"award-info":[{"award-number":["2021J011039"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.talanta.2026.130416","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T06:32:35Z","timestamp":1786084355000},"page":"130416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Self-assembled DNA nanosphere-powered confined-free self-circulating amplifier for high-fidelity microRNA imaging and clinical liquid biopsy"],"prefix":"10.1016","volume":"312","author":[{"given":"Jing","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengxin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-3090","authenticated-orcid":false,"given":"Liqun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9930-8878","authenticated-orcid":false,"given":"Huo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2026.130416_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bios.2025.118066","article-title":"DNA centipede nanowires drive rapid picomolar microRNA detection in cells and serum","volume":"292","author":"Dong","year":"2026","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.talanta.2026.130416_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12967-026-07795-x","article-title":"Exosomal miR-21 mitigates pulmonary hypertension-induced right-heart remodeling by preserves mitochondrial homeostasis","volume":"24","author":"Chang","year":"2026","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.talanta.2026.130416_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/bjbs.2025.15354","article-title":"Influence of reference gene selection on miRNA quantification by RT-qPCR in human placental samples","volume":"82","author":"Sekovanic","year":"2025","journal-title":"Br. J. Biomed. Sci."},{"issue":"38","key":"10.1016\/j.talanta.2026.130416_bib4","doi-asserted-by":"crossref","first-page":"21098","DOI":"10.1021\/acs.analchem.5c04448","article-title":"An RCA-CRISPR-Enhanced SERS platform for ultrasensitive and single-nucleotide-resolved detection of exosomal miRNA-21 in early lung cancer","volume":"97","author":"Teng","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130416_bib5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cej.2024.150764","article-title":"miRNA-Responsive 3D DNA walker nanoprobe for intracellular imaging, cell typing, and clinical diagnostics","volume":"487","author":"Xu","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"36","key":"10.1016\/j.talanta.2026.130416_bib6","doi-asserted-by":"crossref","first-page":"14508","DOI":"10.1021\/acs.analchem.4c02751","article-title":"Novel Self-Powered Biosensor Based on Au Nanoparticles @ Pd Nanorings and Catalytic Hairpin Assembly for Ultrasensitive miRNA-21 Assay","volume":"96","author":"Shen","year":"2024","journal-title":"Anal. Chem."},{"issue":"8","key":"10.1016\/j.talanta.2026.130416_bib7","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s00604-024-06529-4","article-title":"Fluorescent DNA tetrahedral probe with catalytic hairpin self-assembly reaction for imaging of miR-21 and miR-155 in living cells","volume":"191","author":"Wang","year":"2024","journal-title":"Mikrochim. Acta"},{"issue":"4","key":"10.1016\/j.talanta.2026.130416_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/chemosensors13040123","article-title":"A photo-controllable DNAzyme-Based nanosensor for miRNA imaging in living cells","volume":"13","author":"Zhang","year":"2025","journal-title":"Chemosensors"},{"key":"10.1016\/j.talanta.2026.130416_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.154268","article-title":"A self-propelled DNAzyme-mediated cascading entropy-driven catalysis DNA nanodevice for high-efficiency imaging in living cells and mouse bodies under near-infrared light initiation","volume":"496","author":"Chen","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2026.130416_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117947","article-title":"A cascade amplification platform integrating entropy-driven DNA nanomachine with CRISPR\/Cas12a for microRNA-21 and Listeria monocytogenes detection","volume":"290","author":"Ding","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130416_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116149","article-title":"Dual-responsive 3D DNA nanomachines cascaded hybridization chain reactions for novel self-powered flexible microRNA-detecting platform","volume":"252","author":"Wang","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"15","key":"10.1016\/j.talanta.2026.130416_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/asia.202300367","article-title":"Ultrasensitive miRNA detection by AuNP-based 3D DNA walker and catalytic Hairpin Assembly (CHA) Cascade amplification for early cancer diagnosis","volume":"18","author":"Li","year":"2023","journal-title":"Chem. Asian J."},{"issue":"25","key":"10.1016\/j.talanta.2026.130416_bib13","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1039\/D5AY00542F","article-title":"Conditional regulation of HCR for rapid visualization of endogenous miR-21 in cancer cells","volume":"17","author":"Yan","year":"2025","journal-title":"Anal. Methods : Adv. Meth. Appl."},{"issue":"4","key":"10.1016\/j.talanta.2026.130416_bib14","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1039\/D5RA07186K","article-title":"CHA-driven SERS-nanoenzyme sensor for ultra-sensitive diagnosis of gastric precancerous lesions","volume":"16","author":"Huang","year":"2026","journal-title":"RSC Adv."},{"issue":"18","key":"10.1016\/j.talanta.2026.130416_bib15","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1021\/acs.analchem.4c00473","article-title":"Near-infrared light-powered and DNA nanocage-confined catalytic hairpin assembly nanobiosensor with a nucleic acid restriction behavior and reinforced enzymatic resistance for robust imaging assay in live biosystems","volume":"96","author":"Xin","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130416_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115823","article-title":"Movable toehold for leakless self-assembly circuits","volume":"245","author":"Han","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130416_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.microc.2024.110479","article-title":"A leakage-resistant catalytic hairpin assembly for ultrasensitive detection of miRNA-146a in systemic lupus erythematosus","volume":"200","author":"Bao","year":"2024","journal-title":"Microchem. J."},{"issue":"11","key":"10.1016\/j.talanta.2026.130416_bib18","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1021\/acs.analchem.3c05554","article-title":"DNA nanospheres assisted spatial confinement signal amplification for MicroRNA imaging in live cancer cells","volume":"96","author":"Wang","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130416_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.127354","article-title":"Product-induced catalytic amplification strategy based on DNA tetrahedron for detection of miRNA-21 in colorectal cancer","volume":"285","author":"Yu","year":"2025","journal-title":"Talanta"},{"issue":"5","key":"10.1016\/j.talanta.2026.130416_bib20","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1021\/acs.analchem.3c05619","article-title":"Zipper-confined DNA nanoframe for high-efficient and high-contrast imaging of heterogeneous tumor cell","volume":"96","author":"Zhang","year":"2024","journal-title":"Anal. Chem."},{"issue":"Pt 1","key":"10.1016\/j.talanta.2026.130416_bib21","article-title":"An APE1 gated signal amplified biosensor driven by catalytic hairpin assembly for the specific imaging of microRNA in situ","volume":"262","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.talanta.2026.130416_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.125952","article-title":"A dual-core 3D DNA nanomachine based on DNAzyme positive feedback loop for highly sensitive MicroRNA imaging in living cells","volume":"273","author":"Li","year":"2024","journal-title":"Talanta"},{"issue":"1","key":"10.1016\/j.talanta.2026.130416_bib23","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1021\/nn506309d","article-title":"In situ amplification of intracellular microRNA with MNAzyme nanodevices for multiplexed imaging, logic operation, and controlled drug release","volume":"9","author":"Zhang","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2026.130416_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.talanta.2026.129560","article-title":"Harnessing soft DNA nanospheres as a superior alternative to hard nanoparticles for boosting DNAzyme-based colorimetric sensing of lead ions","volume":"304","author":"Yu","year":"2026","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.130416_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jhazmat.2025.137437","article-title":"DNA nanosphere-enhanced DNAzyme system for sensitive and rapid detection of lead contamination in water and living cells","volume":"488","author":"Xu","year":"2025","journal-title":"J. Hazard Mater."},{"issue":"47","key":"10.1016\/j.talanta.2026.130416_bib26","doi-asserted-by":"crossref","first-page":"17303","DOI":"10.1021\/ja906987s","article-title":"Control of DNA strand displacement kinetics using toehold exchange","volume":"131","author":"Zhang","year":"2009","journal-title":"J. Am. Chem. Soc."},{"issue":"39","key":"10.1016\/j.talanta.2026.130416_bib27","doi-asserted-by":"crossref","first-page":"14643","DOI":"10.1021\/acs.analchem.3c02431","article-title":"Versatile DNA balances via adjacent base stacking for homogeneous assay of energy parameters, small molecules, and ribonuclease","volume":"95","author":"Hao","year":"2023","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.talanta.2026.130416_bib28","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.biochi.2008.02.009","article-title":"Molecular crowding effects on structure and stability of DNA","volume":"90","author":"Miyoshi","year":"2008","journal-title":"Biochimie"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026010726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026010726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:08:56Z","timestamp":1790888936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026010726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":28,"alternative-id":["S0039914026010726"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130416","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Self-assembled DNA nanosphere-powered confined-free self-circulating amplifier for high-fidelity microRNA imaging and clinical liquid biopsy","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130416"}}