{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:32:39Z","timestamp":1793140359734,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750290"],"award-info":[{"award-number":["2024M750290"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12472306"],"award-info":[{"award-number":["12472306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["DUT26GF106"],"award-info":[{"award-number":["DUT26GF106"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["DUT25YG272"],"award-info":[{"award-number":["DUT25YG272"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.talanta.2026.130510","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:02:02Z","timestamp":1787587322000},"page":"130510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Closed-loop dynamic negative pressure cell culture system for real-time quantitative analysis of fibroblast wound healing"],"prefix":"10.1016","volume":"312","author":[{"given":"Chang-Gui","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Zhi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Dong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Qu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Rong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4678-9209","authenticated-orcid":false,"given":"Yong-Jiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.talanta.2026.130510_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/wound.2021.0026","article-title":"Human wound and its burden: updated 2020 compendium of estimates","volume":"10","author":"Sen","year":"2021","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.talanta.2026.130510_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.annepidem.2018.10.005","article-title":"Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies","volume":"29","author":"Martinengo","year":"2019","journal-title":"Ann. Epidemiol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130510_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/wound.2023.0157","article-title":"Negative pressure wound therapy: challenges, novel techniques, and future perspectives","volume":"14","author":"Keenan","year":"2025","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.talanta.2026.130510_bib4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/5584_2023_773","article-title":"Negative-pressure wound therapy: what we know and what we need to know","volume":"1436","author":"Yamashiro","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.talanta.2026.130510_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2026.129752","article-title":"Multifunctional nanozyme systems for combating bacterial infections in wound treatment","volume":"306","author":"Guliy","year":"2026","journal-title":"Talanta"},{"issue":"3","key":"10.1016\/j.talanta.2026.130510_bib6","doi-asserted-by":"crossref","first-page":"e423","DOI":"10.1016\/S2214-109X(19)30547-9","article-title":"Negative pressure wound therapy versus standard treatment in patients with acute conflict-related extremity wounds: a pragmatic, multisite, randomised controlled trial","volume":"8","author":"\u00c4lg\u00e5","year":"2020","journal-title":"Lancet Global Health"},{"issue":"6","key":"10.1016\/j.talanta.2026.130510_bib7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1001\/jama.2020.0059","article-title":"WHIST trial collaborators. Effect of incisional negative pressure wound therapy vs standard wound dressing on deep surgical site infection after surgery for lower limb fractures associated with major trauma: the whist randomized clinical trial","volume":"323","author":"Costa","year":"2020","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.talanta.2026.130510_bib8","article-title":"Negative pressure wound therapy: where are we in 2022?","volume":"6","author":"Quacinella","year":"2023","journal-title":"OTA Int"},{"issue":"13","key":"10.1016\/j.talanta.2026.130510_bib9","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/bjs.9636","article-title":"Systematic review of molecular mechanism of action of negative-pressure wound therapy","volume":"101","author":"Glass","year":"2014","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.talanta.2026.130510_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/17434440.2021.1882301","article-title":"Negative pressure wound therapy: device design, indications, and the evidence supporting its use","volume":"18","author":"Poteet","year":"2021","journal-title":"Expert Rev. Med. Dev."},{"issue":"3","key":"10.1016\/j.talanta.2026.130510_bib11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1055\/s-0041-1731792","article-title":"Negative pressure wound therapy: mechanism of action and clinical applications","volume":"35","author":"Normandin","year":"2021","journal-title":"Semin. Plast. Surg."},{"issue":"11","key":"10.1016\/j.talanta.2026.130510_bib12","doi-asserted-by":"crossref","first-page":"617","DOI":"10.12968\/jowc.2016.25.11.617","article-title":"Biological effects and clinical application of negative pressure wound therapy: a review","volume":"25","author":"Nie","year":"2016","journal-title":"J. Wound Care"},{"issue":"7","key":"10.1016\/j.talanta.2026.130510_bib13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1067\/j.cpsurg.2014.04.001","article-title":"Effect of negative pressure wound therapy on wound healing","volume":"51","author":"Huang","year":"2014","journal-title":"Curr. Probl. Surg."},{"key":"10.1016\/j.talanta.2026.130510_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00238-016-1200-z","article-title":"Negative pressure wound therapy induces early wound healing by increased and accelerated expression of vascular endothelial growth factor receptors","volume":"39","author":"Tanaka","year":"2016","journal-title":"Eur. J. Plast. Surg."},{"issue":"1","key":"10.1016\/j.talanta.2026.130510_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-42634-9","article-title":"Negative pressure wound therapy promotes wound healing of diabetic foot ulcers by up-regulating PRDX2 in wound margin tissue","volume":"13","author":"Tang","year":"2023","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.talanta.2026.130510_bib16","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1524-475X.2007.00287.x","article-title":"Effects of negative pressure wound therapy on fibroblast viability, chemotactic signaling, and proliferation in a provisional wound (fibrin) matrix","volume":"15","author":"McNulty","year":"2007","journal-title":"Wound Repair Regen."},{"issue":"4","key":"10.1016\/j.talanta.2026.130510_bib17","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3892\/etm.2016.3083","article-title":"Negative pressure wound therapy promotes vessel destabilization and maturation at various stages of wound healing and thus influences wound prognosis","volume":"11","author":"Ma","year":"2016","journal-title":"Exp. Ther. Med."},{"issue":"7","key":"10.1016\/j.talanta.2026.130510_bib18","article-title":"Comparison of negative pressure wound therapy with and without instillation of saline in the management of infected wounds","volume":"12","author":"Kim","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.talanta.2026.130510_bib19","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2023.24","article-title":"Molecular mechanisms of action of negative pressure wound therapy: a systematic review","volume":"25","author":"Ravindhran","year":"2023","journal-title":"Expert Rev. Mol. Med."},{"issue":"5","key":"10.1016\/j.talanta.2026.130510_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3892\/ijmm.2024.5427","article-title":"Enhancing diabetic foot ulcer healing: impact of the regulation of the FUS and ILF2 RNA-binding proteins through negative pressure wound therapy","volume":"54","author":"Tang","year":"2024","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.talanta.2026.130510_bib21","article-title":"Comparison of the effects of different negative pressure wound therapy modes-continuous, noncontinuous, and with instillation-on porcine excisional wounds","volume":"13","author":"Lessing","year":"2013","journal-title":"Eplasty"},{"issue":"2","key":"10.1016\/j.talanta.2026.130510_bib22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/PRS.0b013e3181fed52a","article-title":"The influence of low and high pressure levels during negative-pressure wound therapy on wound contraction and fluid evacuation","volume":"127","author":"Borgquist","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"issue":"4","key":"10.1016\/j.talanta.2026.130510_bib23","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1097\/PRS.0b013e31820a63cb","article-title":"Waveform modulation of negative-pressure wound therapy in the murine model","volume":"127","author":"Dastouri","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"issue":"4","key":"10.1016\/j.talanta.2026.130510_bib24","first-page":"44","article-title":"Individualizing the use of negative pressure wound therapy for optimal wound healing: a focused review of the literature","volume":"57","author":"Borgquist","year":"2011","journal-title":"Ostomy\/Wound Manag."},{"issue":"6","key":"10.1016\/j.talanta.2026.130510_bib25","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/iwj.12201","article-title":"Cyclic negative pressure wound therapy: an alternative mode to intermittent system","volume":"12","author":"Lee","year":"2015","journal-title":"Int. Wound J."},{"key":"10.1016\/j.talanta.2026.130510_bib26","article-title":"The effects of variable, intermittent, and continuous negative pressure wound therapy, using foam or gauze, on wound contraction, granulation tissue formation, and ingrowth into the wound filler","volume":"12","author":"Malmsj\u00f6","year":"2012","journal-title":"Eplasty"},{"issue":"7","key":"10.1016\/j.talanta.2026.130510_bib27","doi-asserted-by":"crossref","first-page":"E209","DOI":"10.25270\/wnds\/22085","article-title":"Utilizing international consensus panel recommendations and a clinical decision tree to guide selection of negative pressure wound therapy","volume":"35","author":"Loney","year":"2023","journal-title":"Wounds"},{"issue":"4","key":"10.1016\/j.talanta.2026.130510_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.25270\/wnds\/24109","article-title":"Negative pressure wound therapy using a new pressure monitoring device for wound treatment: results of an animal model","volume":"37","author":"Meng","year":"2025","journal-title":"Wounds"},{"key":"10.1016\/j.talanta.2026.130510_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2023.1080838","article-title":"Comparison of the effects of negative pressure wound therapy and negative pressure wound therapy with instillation on wound healing in a porcine model","volume":"10","author":"Tingting","year":"2023","journal-title":"Front. Surg."},{"key":"10.1016\/j.talanta.2026.130510_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1756798","article-title":"Effects of negative pressure wound therapy on levels of angiopoetin-2 and other selected circulating signaling molecules in patients with diabetic foot ulcer","volume":"2019","author":"Hohendorff","year":"2019","journal-title":"J. Diabetes Res."},{"issue":"1","key":"10.1016\/j.talanta.2026.130510_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10856-022-06709-9","article-title":"Vacuum sealing drainage system combined with an antibacterial jackfruit aerogel wound dressing and 3D printed fixation device for infections of skin soft tissue injuries","volume":"34","author":"Hu","year":"2022","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"5","key":"10.1016\/j.talanta.2026.130510_bib32","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1097\/PRS.0b013e3181bbc829","article-title":"Short periodic applications of the vacuum-assisted closure device cause an extended tissue response in the diabetic mouse model","volume":"124","author":"Scherer","year":"2009","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.talanta.2026.130510_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7920265","article-title":"Enhancement of bone-marrow-derived mesenchymal stem cell angiogenic capacity by NPWT for a combinatorial therapy to promote wound healing with large defect","volume":"2017","author":"Shou","year":"2017","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.talanta.2026.130510_bib34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jmbbm.2015.01.012","article-title":"Combinatorial therapy using negative pressure and varying lithium dosage for accelerated wound healing","volume":"44","author":"Pandit","year":"2015","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"2","key":"10.1016\/j.talanta.2026.130510_bib35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12195-015-0385-8","article-title":"Endothelial cell response under hydrostatic pressure condition mimicking pressure therapy","volume":"8","author":"Yoshino","year":"2015","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.talanta.2026.130510_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2022.105620","article-title":"Influence of advanced wound matrices on observed vacuum pressure during simulated negative pressure wound therapy","volume":"138","author":"Veale","year":"2023","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"1","key":"10.1016\/j.talanta.2026.130510_bib37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10237-020-01377-6","article-title":"A novel system for dynamic stretching of cell cultures reveals the mechanobiology for delivering better negative pressure wound therapy","volume":"20","author":"Katzengold","year":"2021","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130510_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/srt.13262","article-title":"Novel cell culture system for monitoring cells during continuous and variable negative-pressure wound therapy","volume":"29","author":"Yamashiro","year":"2023","journal-title":"Skin Res. Technol."},{"issue":"6","key":"10.1016\/j.talanta.2026.130510_bib39","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/vsu.14101","article-title":"In vitro evaluation of a hybrid negative pressure system for wound therapy","volume":"53","author":"Davey","year":"2024","journal-title":"Vet. Surg."},{"key":"10.1016\/j.talanta.2026.130510_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jtv.2019.12.004","article-title":"Pressure distribution and flow characteristics during negative pressure wound therapy","volume":"29","author":"Biermann","year":"2020","journal-title":"J. Tissue Viability"},{"issue":"23","key":"10.1016\/j.talanta.2026.130510_bib41","doi-asserted-by":"crossref","DOI":"10.1063\/5.0153342","article-title":"High sensitivity multiscale and multitasking terahertz Janus sensor based on photonic spin Hall effect","volume":"122","author":"Sui","year":"2023","journal-title":"Appl. Phys. Lett."},{"issue":"23","key":"10.1016\/j.talanta.2026.130510_bib42","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1364\/OL.476048","article-title":"High sensitivity multitasking non-reciprocity sensor using the photonic spin Hall effect","volume":"47","author":"Sui","year":"2022","journal-title":"Opt Lett."},{"key":"10.1016\/j.talanta.2026.130510_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/TIM.2024.3450104","article-title":"Short-wave infrared Janus metastructure with multitasking of wide-range pressure detection and high-resolution biosensing based on photonic spin Hall effect","volume":"73","author":"Sui","year":"2024","journal-title":"IEEE Trans. Instrum. Meas."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026011665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026011665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:35:43Z","timestamp":1793136943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026011665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":43,"alternative-id":["S0039914026011665"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130510","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Closed-loop dynamic negative pressure cell culture system for real-time quantitative analysis of fibroblast wound healing","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130510","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"130510"}}