{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:53:23Z","timestamp":1791276803551,"version":"4.1.0"},"reference-count":147,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.talanta.2026.130583","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:34:24Z","timestamp":1788478464000},"page":"130583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PC","title":["DNA- and aptamer-based biosensors for Alzheimer's disease biomarkers toward clinical translation"],"prefix":"10.1016","volume":"312","author":[{"given":"Yasamin","family":"Pahlavan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0428-822X","authenticated-orcid":false,"given":"Mehran","family":"Nozari-Asbemarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Amani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnaz","family":"Hasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrshad","family":"Aliakbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Khaleghinejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Pahlavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Emami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamideh","family":"Imanzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.talanta.2026.130583_bib1","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/alz.13016","article-title":"Alzheimer's disease facts and figures","volume":"19","author":"Better","year":"2023","journal-title":"Alzheimer's Dement."},{"issue":"10284","key":"10.1016\/j.talanta.2026.130583_bib2","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.talanta.2026.130583_bib3","doi-asserted-by":"crossref","unstructured":"2024 Alzheimer's disease facts and figures. Alzheimer's Dement. 2024;20(5):3708-3821.","DOI":"10.1002\/alz.13809"},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer's disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"6","key":"10.1016\/j.talanta.2026.130583_bib5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/joim.12816","article-title":"Biomarkers for Alzheimer's disease: current status and prospects for the future","volume":"284","author":"Blennow","year":"2018","journal-title":"J. Intern. Med."},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.talanta.2026.130583_bib7","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer's disease: alzheimer's association workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.talanta.2026.130583_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101544","article-title":"Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention","volume":"74","author":"Mahaman","year":"2022","journal-title":"Ageing Res. Rev."},{"issue":"12","key":"10.1016\/j.talanta.2026.130583_bib9","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/alz.12756","article-title":"The Alzheimer's association appropriate use recommendations for blood biomarkers in alzheimer's disease","volume":"18","author":"Hansson","year":"2022","journal-title":"Alzheimer's Dement."},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/jamaophthalmol.2022.4845","article-title":"Ocular biomarkers for Alzheimer disease dementia: an umbrella review of systematic reviews and meta-analyses","volume":"141","author":"Costanzo","year":"2023","journal-title":"JAMA ophthalmology"},{"issue":"13","key":"10.1016\/j.talanta.2026.130583_bib11","doi-asserted-by":"crossref","first-page":"16394","DOI":"10.1021\/acsami.2c21379","article-title":"Dumbbell aptamer sensor based on dual biomarkers for early detection of Alzheimer's disease","volume":"15","author":"Zhou","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"18","key":"10.1016\/j.talanta.2026.130583_bib12","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3390\/cells14181424","article-title":"The diagnostic and therapeutic potential of oligonucleotide aptamers in alzheimer's disease","volume":"14","author":"Katsipis","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.talanta.2026.130583_bib13","article-title":"Ultrasensitive portable aptamer-electrochemical sensor for point-of-care testing of Alzheimer's biomarker amyloid-\u03b2 oligomers","author":"Mao","year":"2025","journal-title":"Bioelectrochemistry"},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s44371-025-00094-2","article-title":"Aptamers and antibodies in optical biosensing","volume":"2","author":"Mpofu","year":"2025","journal-title":"Discover Chemistry"},{"issue":"2","key":"10.1016\/j.talanta.2026.130583_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/10408347.2022.2072678","article-title":"Progress in nanomaterials-based enzyme and aptamer biosensor for the detection of organophosphorus pesticides","volume":"54","author":"Tan","year":"2024","journal-title":"Crit. Rev. Anal. Chem."},{"issue":"9","key":"10.1016\/j.talanta.2026.130583_bib16","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.3390\/s23094184","article-title":"Revolutionizing the early detection of Alzheimer's disease through non-invasive biomarkers: the role of artificial intelligence and deep learning","volume":"23","author":"Vrahatis","year":"2023","journal-title":"Sensors"},{"issue":"9","key":"10.1016\/j.talanta.2026.130583_bib17","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3390\/bios13090840","article-title":"Assessment of the antioxidant capacity of commercial coffee using conventional optical and chromatographic methods and an innovative electrochemical DNA-based biosensor","volume":"13","author":"Morais","year":"2023","journal-title":"Biosensors"},{"issue":"9","key":"10.1016\/j.talanta.2026.130583_bib18","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.1021\/acssensors.5c02453","article-title":"Electrochemical biosensors combined with nanomaterial signal amplification for the detection of alzheimer\u2019s disease biomarkers in blood","volume":"10","author":"Peng","year":"2025","journal-title":"ACS Sens."},{"issue":"7","key":"10.1016\/j.talanta.2026.130583_bib19","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3390\/bios13070742","article-title":"Electrochemical immunosensors developed for amyloid-beta and tau proteins, leading biomarkers of Alzheimer's disease","volume":"13","author":"Sharma","year":"2023","journal-title":"Biosensors"},{"issue":"2","key":"10.1016\/j.talanta.2026.130583_bib20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s41664-023-00277-9","article-title":"Printed biosensors for the detection of Alzheimer's disease based on blood biomarkers","volume":"8","author":"Zeng","year":"2024","journal-title":"Journal of Analysis and Testing"},{"issue":"6","key":"10.1016\/j.talanta.2026.130583_bib21","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/chemosensors13060220","article-title":"Advanced biosensing technologies: leading innovations in alzheimer\u2019s disease diagnosis","volume":"13","author":"Benjamin","year":"2025","journal-title":"Chemosensors"},{"issue":"10","key":"10.1016\/j.talanta.2026.130583_bib22","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3390\/bios15100684","article-title":"Carbon nanomaterial-based electrochemical biosensors for Alzheimer's disease biomarkers: progress, challenges, and future perspectives","volume":"15","author":"\u015eak","year":"2025","journal-title":"Biosensors"},{"issue":"3","key":"10.1016\/j.talanta.2026.130583_bib23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/bios16030161","article-title":"Progress in machine learning-assisted biosensors for alzheimer's disease","volume":"16","author":"Feng","year":"2026","journal-title":"Biosensors"},{"key":"10.1016\/j.talanta.2026.130583_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1031833","article-title":"Biosensors toward behavior detection in diagnosis of alzheimer\u2019s disease","volume":"10","author":"Sun","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.talanta.2026.130583_bib25","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3389\/fpsyt.2020.00432","article-title":"Biomarkers in psychiatry: concept, definition, types and relevance to the clinical reality","volume":"11","author":"Garc\u00eda-Guti\u00e9rrez","year":"2020","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.talanta.2026.130583_bib26","unstructured":"Jesse IA, Caleb NA, Peter GM, Yusuf E, Sani B, Mele M. APPLICATION OF BIOMARKERS IN DRUGS DEVELOPMENT."},{"issue":"6","key":"10.1016\/j.talanta.2026.130583_bib27","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.3390\/jcm9061673","article-title":"Diagnostic biomarkers for Alzheimer's disease using non-invasive specimens","volume":"9","author":"Paraskevaidi","year":"2020","journal-title":"J. Clin. Med."},{"issue":"8","key":"10.1016\/j.talanta.2026.130583_bib28","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2020.02.001","article-title":"The \u03b2-secretase BACE1 in Alzheimer's disease","volume":"89","author":"Hampel","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.talanta.2026.130583_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2020.609073","article-title":"Modulation of \u03b2-amyloid fibril formation in Alzheimer's disease by microglia and infection","volume":"13","author":"Brown","year":"2020","journal-title":"Front. Mol. Neurosci."},{"issue":"7","key":"10.1016\/j.talanta.2026.130583_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13430","article-title":"BACE1: more than just a \u03b2\u2010secretase","volume":"23","author":"Taylor","year":"2022","journal-title":"Obes. Rev."},{"issue":"4","key":"10.1016\/j.talanta.2026.130583_bib31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s12276-022-00754-8","article-title":"\u03b3-Secretase in Alzheimer's disease","volume":"54","author":"Hur","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.talanta.2026.130583_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2024.109468","article-title":"Exploring the therapeutic potential of steroidal alkaloids in managing Alzheimer's disease","author":"Pandey","year":"2024","journal-title":"Steroids"},{"key":"10.1016\/j.talanta.2026.130583_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108614","article-title":"Sequence and structure-based peptides as potent amyloid inhibitors: a review","volume":"695","author":"Mitra","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.talanta.2026.130583_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/biophysica2020010","article-title":"Amyloid-\u03b2 oligomers: multiple moving targets","volume":"2","author":"Shea","year":"2022","journal-title":"Biophysica"},{"issue":"9","key":"10.1016\/j.talanta.2026.130583_bib35","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/aps.2017.28","article-title":"Amyloid beta: structure, biology and structure-based therapeutic development","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.talanta.2026.130583_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-2-22","article-title":"The Alzheimer's disease \u03b2-secretase enzyme, BACE1","volume":"2","author":"Cole","year":"2007","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3233\/JAD-215542","article-title":"Increased serum beta-secretase 1 activity is an early marker of Alzheimer's disease","volume":"87","author":"Nicsanu","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.talanta.2026.130583_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.873811","article-title":"Electrochemical detection of Alzheimer's disease biomarker, \u03b2-secretase enzyme (BACE1), with one-step synthesized reduced graphene oxide","volume":"10","author":"Dey","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"10","key":"10.1016\/j.talanta.2026.130583_bib39","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1093\/brain\/awac181","article-title":"Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology","volume":"145","author":"Morris","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.talanta.2026.130583_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105327","article-title":"Clinical and research application of fluid biomarkers in autosomal dominant Alzheimer's disease and Down syndrome","author":"Carmona-Iragui","year":"2024","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.talanta.2026.130583_bib41","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41582-024-00942-2","article-title":"Biomarker-based staging of Alzheimer disease: rationale and clinical applications","volume":"20","author":"Therriault","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.talanta.2026.130583_bib42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41582-024-00940-4","article-title":"Is Alzheimer disease a disease?","volume":"20","author":"Korczyn","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13024-022-00574-4","article-title":"ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies","volume":"17","author":"Raulin","year":"2022","journal-title":"Mol. Neurodegener."},{"issue":"7","key":"10.1016\/j.talanta.2026.130583_bib44","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1007\/s10571-023-01365-1","article-title":"Roles of apoE4 on the pathogenesis in Alzheimer's disease and the potential therapeutic approaches","volume":"43","author":"Sun","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/1871527322666221226145141","article-title":"Relation between apolipoprotein e in alzheimer's disease and Sars-CoV-2 and their treatment strategy: a review","volume":"23","author":"Ramachandran","year":"2024","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"key":"10.1016\/j.talanta.2026.130583_bib46","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fnagi.2019.00204","article-title":"Role of tau as a microtubule-associated protein: structural and functional aspects","volume":"11","author":"Barbier","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.talanta.2026.130583_bib47","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuroscience.2022.05.023","article-title":"Macromolecular structures and proteins interacting with the microtubule associated tau protein","volume":"518","author":"Jim\u00e9nez","year":"2023","journal-title":"Neuroscience"},{"key":"10.1016\/j.talanta.2026.130583_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105320","article-title":"Microtubule associated proteins as targets for anticancer drug development","volume":"116","author":"Khwaja","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.talanta.2026.130583_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/agt2.70133","article-title":"Illuminating tau aggregates: Multiscale approaches for detection, imaging, and understanding","author":"Bhuskute","year":"2025","journal-title":"Aggregate"},{"issue":"3","key":"10.1016\/j.talanta.2026.130583_bib50","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1007\/s12035-022-03164-z","article-title":"Role of tau in various tauopathies, treatment approaches, and emerging role of nanotechnology in neurodegenerative disorders","volume":"60","author":"Kaur","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.talanta.2026.130583_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2023.1129036","article-title":"Alzheimer's disease as a synaptopathy: evidence for dysfunction of synapses during disease progression","volume":"15","author":"Meftah","year":"2023","journal-title":"Front. Synaptic Neurosci."},{"issue":"9","key":"10.1016\/j.talanta.2026.130583_bib52","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1038\/s41380-024-02501-z","article-title":"Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer's disease","volume":"29","author":"Wang","year":"2024","journal-title":"Mol. Psychiatr."},{"issue":"2","key":"10.1016\/j.talanta.2026.130583_bib53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00018-021-04106-z","article-title":"Microtubule-associated protein tau in murine kidney: role in podocyte architecture","volume":"79","author":"Vall\u00e9s-Saiz","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"10","key":"10.1016\/j.talanta.2026.130583_bib54","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1001\/jamaneurol.2023.2560","article-title":"Increased medial temporal tau positron emission tomography uptake in the absence of amyloid-\u03b2 positivity","volume":"80","author":"Costoya-S\u00e1nchez","year":"2023","journal-title":"JAMA Neurol."},{"issue":"8","key":"10.1016\/j.talanta.2026.130583_bib55","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-024-00988-2","article-title":"Multifaceted roles of APOE in Alzheimer disease","volume":"20","author":"Jackson","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"2","key":"10.1016\/j.talanta.2026.130583_bib56","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3233\/JAD-160836","article-title":"Down syndrome, partial trisomy 21, and absence of Alzheimer's disease: the role of APP","volume":"56","author":"Doran","year":"2017","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib57","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1038\/s41598-021-85062-3","article-title":"Genetic dissection of down syndrome-associated alterations in APP\/amyloid-\u03b2 biology using mouse models","volume":"11","author":"Tosh","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.talanta.2026.130583_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116684","article-title":"Natural products targeting Amyloid-\u03b2 oligomer neurotoxicity in Alzheimer's disease","author":"Gon\u00e7alves","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.talanta.2026.130583_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2024.102585","article-title":"Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an A\u03b2-dependent expression in Alzheimer's disease","volume":"235","author":"Maccioni","year":"2024","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.talanta.2026.130583_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.vibspec.2023.103510","article-title":"Amyloid\u2013\u03b2 pathology in Alzheimer's Disease: a nano delivery approach","volume":"126","author":"Meghana","year":"2023","journal-title":"Vib. Spectrosc."},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib61","first-page":"201","article-title":"Amyloid precursor protein: a regulatory hub in alzheimer's disease","volume":"15","author":"Chen","year":"2024","journal-title":"Aging and Disease"},{"key":"10.1016\/j.talanta.2026.130583_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2023.107213","article-title":"Amyloid-\u03b2: a potential mediator of aging-related vascular pathologies","author":"Khan","year":"2023","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.talanta.2026.130583_bib63","article-title":"Effects of DHA (omega-3 fatty acid) and estradiol on amyloid \u03b2-peptide regulation in the brain","author":"Majou","year":"2023","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib64","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41398-024-03075-8","article-title":"MicroRNAs: pioneering regulators in Alzheimer\u2019s disease pathogenesis, diagnosis, and therapy","volume":"14","author":"Li","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.talanta.2026.130583_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102483","article-title":"DECIPHERING THE ROLE OF miRNAs IN ALZHEIMER'S DISEASE: predictive targeting and pathway modulation-a systematic review","author":"Sharma","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"21","key":"10.1016\/j.talanta.2026.130583_bib66","article-title":"Identification and diagnostic potential of serum microRNAs as biomarkers for early detection of Alzheimer's disease","volume":"15","author":"Han","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.talanta.2026.130583_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.585432","article-title":"microRNA-based biomarkers in Alzheimer's disease (AD)","volume":"14","author":"Zhao","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.talanta.2026.130583_bib68","first-page":"171","article-title":"MICRORNA-BASED mapping","author":"Redhwan","year":"2024","journal-title":"Exploring Molecular Targets to Treat Neurodegenerative Disorders"},{"key":"10.1016\/j.talanta.2026.130583_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126561","article-title":"Insights into role of microRNA in alzheimer's disease: from contemporary research to bedside perspective","author":"Bandakinda","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.talanta.2026.130583_bib70","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3390\/biology12060788","article-title":"MicroRNA (miRNA) complexity in Alzheimer's Disease (AD)","volume":"12","author":"Lukiw","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.talanta.2026.130583_bib71","first-page":"1","article-title":"microRNA pathological mechanisms between parkinson's disease, alzheimer's disease, glaucoma, and macular degeneration","author":"Wang","year":"2023","journal-title":"Expert Rev. Mol. Med."},{"issue":"14","key":"10.1016\/j.talanta.2026.130583_bib72","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.3390\/ijms21145007","article-title":"Serum tau proteins as potential biomarkers for the assessment of Alzheimer's disease progression","volume":"21","author":"Nam","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.talanta.2026.130583_bib73","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s43587-023-00405-1","article-title":"Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies","volume":"3","author":"Montoliu-Gaya","year":"2023","journal-title":"Nat. Aging"},{"issue":"2","key":"10.1016\/j.talanta.2026.130583_bib74","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3233\/JAD-190711","article-title":"Apolipoprotein E facilitates amyloid-\u03b2 oligomer-induced tau phosphorylation","volume":"74","author":"Hou","year":"2020","journal-title":"J. Alzheimers Dis."},{"issue":"11","key":"10.1016\/j.talanta.2026.130583_bib75","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/clinchem\/hvad139","article-title":"Alzheimer disease biomarkers: moving from CSF to plasma for reliable detection of amyloid and tau pathology","volume":"69","author":"Kang","year":"2023","journal-title":"Clinical chemistry"},{"key":"10.1016\/j.talanta.2026.130583_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114278","article-title":"Current trends in blood biomarker detection and imaging for Alzheimer's disease","volume":"210","author":"Hu","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"22","key":"10.1016\/j.talanta.2026.130583_bib77","doi-asserted-by":"crossref","first-page":"12562","DOI":"10.1021\/acs.analchem.7b03837","article-title":"Tandem femto-and nanomolar analysis of two protein biomarkers in plasma on a single mixed antibody monolayer surface using surface plasmon resonance","volume":"89","author":"Kim","year":"2017","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.talanta.2026.130583_bib78","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/14737159.2021.1887732","article-title":"Nanomaterial-based optical and electrochemical biosensors for amyloid beta and tau: potential for early diagnosis of Alzheimer's disease","volume":"21","author":"Phan","year":"2021","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib79","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s44174-024-00180-6","article-title":"Recent advances and applications of graphene-based biosensors for blood-based biomarkers in neurodegenerative diseases","volume":"3","author":"Nazir","year":"2025","journal-title":"Biomedical Materials & Devices"},{"key":"10.1016\/j.talanta.2026.130583_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.120999","article-title":"Electrochemical aptasensors based on the gold nanostructures","volume":"216","author":"Negahdary","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.130583_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113519","article-title":"The role of graphene patterning in field-effect transistor sensors to detect the tau protein for Alzheimer's disease: simplifying the immobilization process and improving the performance of graphene-based immunosensors","volume":"192","author":"Kwon","year":"2021","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib82","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41467-019-13901-z","article-title":"Clinically accurate diagnosis of Alzheimer's disease via multiplexed sensing of core biomarkers in human plasma","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"issue":"39","key":"10.1016\/j.talanta.2026.130583_bib83","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.1039\/C8TB01869C","article-title":"Development of quantum dot-based biosensors: principles and applications","volume":"6","author":"Ma","year":"2018","journal-title":"J. Mater. Chem. B"},{"issue":"58","key":"10.1016\/j.talanta.2026.130583_bib84","first-page":"137","article-title":"The effect of nickel salt source and anion of electrolyte on electro-driven water oxidation activity using nickel hydroxide thin film","volume":"16","author":"Nozari-asbmarz","year":"2021","journal-title":"Applied Chemistry Today"},{"issue":"5","key":"10.1016\/j.talanta.2026.130583_bib85","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/bios13050542","article-title":"Metal oxides nanomaterials and nanocomposite-based electrochemical sensors for healthcare applications","volume":"13","author":"Kannan","year":"2023","journal-title":"Biosensors"},{"issue":"8","key":"10.1016\/j.talanta.2026.130583_bib86","doi-asserted-by":"crossref","DOI":"10.1149\/1945-7111\/acef60","article-title":"Overall water splitting by bio-modification of Fe3O4 with Co\u2013Ni complexes","volume":"170","author":"Amiri","year":"2023","journal-title":"J. Electrochem. Soc."},{"key":"10.1016\/j.talanta.2026.130583_bib87","series-title":"Development of a lab-on-a-chip Microfluidic System for the Detection of C-reactive Protein in Whole Human Blood and an Antibody Biomarker for the Detection of Alzheimer's disease","author":"Pytka","year":"2015"},{"issue":"3","key":"10.1016\/j.talanta.2026.130583_bib88","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s42242-018-0019-9","article-title":"Additive nanomanufacturing of lab-on-a-chip fluorescent peptide nanoparticle arrays for Alzheimer's disease diagnosis","volume":"1","author":"Sun","year":"2018","journal-title":"BioDes. Manuf."},{"issue":"4","key":"10.1016\/j.talanta.2026.130583_bib89","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1039\/D4LC00748D","article-title":"An integrated paper-based microfluidic platform for screening of early-stage Alzheimer's disease by detecting A\u03b242","volume":"25","author":"Duan","year":"2025","journal-title":"Lab Chip"},{"issue":"14","key":"10.1016\/j.talanta.2026.130583_bib90","doi-asserted-by":"crossref","first-page":"7893","DOI":"10.3390\/ijms25147893","article-title":"Nucleic acids-based biomarkers for alzheimer's disease diagnosis and novel molecules to treat the disease","volume":"25","author":"Bivona","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.talanta.2026.130583_bib91","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3390\/bios13110987","article-title":"Alzheimer's disease biomarker detection using field effect transistor-based biosensor","volume":"13","author":"Le","year":"2023","journal-title":"Biosensors"},{"key":"10.1016\/j.talanta.2026.130583_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.122188","article-title":"A review of aptamer-based SERS biosensors: design strategies and applications","volume":"227","author":"Muhammad","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.130583_bib93","article-title":"MicroRNA biosensors for detection of Alzheimer's disease","author":"Vafadar","year":"2025","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.talanta.2026.130583_bib94","article-title":"Recent advances in nanomaterial-based biosensors for Alzheimer's Disease (AD) diagnosis: a review","author":"Liu","year":"2025","journal-title":"Chem. Commun."},{"issue":"10","key":"10.1016\/j.talanta.2026.130583_bib95","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1021\/acs.analchem.4c02619","article-title":"Electrochemical biosensors for the detection of exosomal microRNA biomarkers for early diagnosis of neurodegenerative diseases","volume":"97","author":"Yu","year":"2025","journal-title":"Anal. Chem."},{"issue":"37","key":"10.1016\/j.talanta.2026.130583_bib96","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202302673","article-title":"Functional nanomaterials for the diagnosis of Alzheimer's disease: recent progress and future perspectives","volume":"33","author":"Abdullah","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.talanta.2026.130583_bib97","first-page":"111","article-title":"Biosensors in detection and diagnosis of neurodegenerative diseases","volume":"81","author":"Sahana","year":"2025","journal-title":"SYNERGIES IN HEALING"},{"key":"10.1016\/j.talanta.2026.130583_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2023.108553","article-title":"Electrochemical miRNA-34a-based biosensor for the diagnosis of Alzheimer's disease","volume":"154","author":"Pereira","year":"2023","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.talanta.2026.130583_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.171406","article-title":"High-velocity DNA nanoharvester-enabled ultrasensitive analysis: decoding extracellular vesicles miRNA Assisted by machine learning for grading of Alzheimer'S disease","author":"Cheng","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2026.130583_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115270","article-title":"A dual \u201cturn-on\u201d biosensor based on AIE effect and FRET for in situ detection of miR-125b biomarker in early Alzheimer's disease","volume":"230","author":"Zhang","year":"2023","journal-title":"Biosens. Bioelectron."},{"issue":"4","key":"10.1016\/j.talanta.2026.130583_bib101","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3390\/s21041109","article-title":"A review on biosensors and recent development of nanostructured materials-enabled biosensors","volume":"21","author":"Naresh","year":"2021","journal-title":"Sensors"},{"issue":"5","key":"10.1016\/j.talanta.2026.130583_bib102","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.3390\/s100504541","article-title":"Design strategies for aptamer-based biosensors","volume":"10","author":"Han","year":"2010","journal-title":"Sensors"},{"issue":"8","key":"10.1016\/j.talanta.2026.130583_bib103","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1039\/D0MA00639D","article-title":"Detection and beyond: challenges and advances in aptamer-based biosensors","volume":"1","author":"Yoo","year":"2020","journal-title":"Mater. Adv."},{"issue":"6287","key":"10.1016\/j.talanta.2026.130583_bib104","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/346818a0","article-title":"In vitro selection of RNA molecules that bind specific ligands","volume":"346","author":"Ellington","year":"1990","journal-title":"nature"},{"issue":"6360","key":"10.1016\/j.talanta.2026.130583_bib105","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/355564a0","article-title":"Selection of single-stranded DNA molecules that bind and inhibit human thrombin","volume":"355","author":"Bock","year":"1992","journal-title":"nature"},{"issue":"3","key":"10.1016\/j.talanta.2026.130583_bib106","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0022-2836(91)90509-5","article-title":"Selexion: systematic evolution of ligands by exponential enrichment with integrated optimization by non-linear analysis","volume":"222","author":"Irvine","year":"1991","journal-title":"Journal of molecular biology"},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib107","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3390\/s120100612","article-title":"Aptamers and their biological applications","volume":"12","author":"Song","year":"2012","journal-title":"Sensors"},{"issue":"1","key":"10.1016\/j.talanta.2026.130583_bib108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/28378083.2024.2386517","article-title":"Electrochemical aptamer-based biosensors for disease biomarkers","volume":"1","author":"\u0130nce","year":"2024","journal-title":"Essential Chem"},{"issue":"8","key":"10.1016\/j.talanta.2026.130583_bib109","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/bio.3557","article-title":"Chemiluminescence\u2010based aptasensors for various target analytes","volume":"33","author":"Sun","year":"2018","journal-title":"Luminescence"},{"issue":"11","key":"10.1016\/j.talanta.2026.130583_bib110","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1021\/acs.iecr.2c04437","article-title":"Colorimetric detection of hemoglobin by aptamer-based biosensor","volume":"62","author":"Teniou","year":"2023","journal-title":"Ind. Eng. Chem. Res."},{"issue":"10","key":"10.1016\/j.talanta.2026.130583_bib111","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3390\/bios12100887","article-title":"A sensitive aptamer fluorescence anisotropy sensor for Cd2+ using affinity-enhanced aptamers with phosphorothioate modification","volume":"12","author":"Yu","year":"2022","journal-title":"Biosensors"},{"key":"10.1016\/j.talanta.2026.130583_bib112","doi-asserted-by":"crossref","first-page":"6655","DOI":"10.1007\/s00216-020-02754-x","article-title":"Functional nucleic acid-based fluorescence polarization\/anisotropy biosensors for detection of biomarkers","volume":"412","author":"Bai","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.talanta.2026.130583_bib113","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1007\/s00604-017-2467-x","article-title":"Aptamer-based fluorometric determination of norovirus using a paper-based microfluidic device","volume":"184","author":"Weng","year":"2017","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.talanta.2026.130583_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2021.107902","article-title":"Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment","volume":"55","author":"Qi","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.talanta.2026.130583_bib115","article-title":"Recent advances in aptamer discovery, modification and improving performance","volume":"40","author":"Fallah","year":"2024","journal-title":"Biochem. Biophys. Rep."},{"issue":"5","key":"10.1016\/j.talanta.2026.130583_bib116","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1039\/D4LC00859F","article-title":"Aptamer selection via versatile microfluidic platforms and their diverse applications","volume":"25","author":"Chung","year":"2025","journal-title":"Lab Chip"},{"issue":"8","key":"10.1016\/j.talanta.2026.130583_bib117","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1007\/s12033-024-01256-w","article-title":"Enhanced SELEX platforms for aptamer selection with improved characteristics: a review","volume":"67","author":"Didarian","year":"2025","journal-title":"Mol. Biotechnol."},{"issue":"19","key":"10.1016\/j.talanta.2026.130583_bib118","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1039\/D3SC00439B","article-title":"Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations","volume":"14","author":"Yang","year":"2023","journal-title":"Chem. Sci."},{"issue":"12","key":"10.1016\/j.talanta.2026.130583_bib119","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00604-018-3087-9","article-title":"Voltammetric determination of the Alzheimer's disease-related ApoE 4 gene from unamplified genomic DNA extracts by ferrocene-capped gold nanoparticles","volume":"185","author":"Lu","year":"2018","journal-title":"Microchim. Acta"},{"issue":"14","key":"10.1016\/j.talanta.2026.130583_bib120","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/abcdcb","article-title":"Nanoconstructs as a versatile tool for detection and diagnosis of Alzheimer biomarkers","volume":"32","author":"Gopalan","year":"2021","journal-title":"Nanotechnology"},{"issue":"3","key":"10.1016\/j.talanta.2026.130583_bib121","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1515\/ntrev-2016-0014","article-title":"Noble metal nanoparticles in biosensors: recent studies and applications","volume":"6","author":"Malekzad","year":"2017","journal-title":"Nanotechnol. Rev."},{"issue":"2","key":"10.1016\/j.talanta.2026.130583_bib122","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3390\/mi16020232","article-title":"Nanoparticle-based DNA biosensor: synthesis of novel manganese nanoparticles applied in the development of a sensitive electrochemical double-stranded\/single-stranded DNA biosensor","volume":"16","author":"Ozkan-Ariksoysal","year":"2025","journal-title":"Micromachines"},{"key":"10.1016\/j.talanta.2026.130583_bib123","article-title":"A facile strategy for synthesis of flower-like FeNiS2 nanocomposite via integration of binary metal-organic framework and metal sulfide for enhanced electrocatalytic oxygen evolution reaction","volume":"53","author":"Imanzadeh","year":"2024","journal-title":"Surf. Interfaces"},{"issue":"14","key":"10.1016\/j.talanta.2026.130583_bib124","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.1039\/D5NR00346F","article-title":"Bimetallic Fe (OH) x@ Co0. 8Fe0. 2-MOF\/NF composites as effective electrocatalysts for the production of 2, 5-furandicarboxylic acid from 5-hydroxymethylfurfural","volume":"17","author":"Nozari-Asbemarz","year":"2025","journal-title":"Nanoscale"},{"key":"10.1016\/j.talanta.2026.130583_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.128009","article-title":"Competitive electrochemical immunosensor for trace phosphorylated Tau181 analysis in plasma: toward point-of-care technologies of Alzheimer's disease","volume":"292","author":"Luo","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.130583_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139174","article-title":"Electrochemical cDNA-sensing of miRNA-137 for detection of Alzheimer's disease using CuO and PEI deposited Au-Pd bimetallic nanoparticles","volume":"1318","author":"Rani","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.talanta.2026.130583_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135714","article-title":"Boosting the sensitivity for tau protein detection with a bifunctional nanoenzyme signal amplifier","volume":"410","author":"Tang","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"issue":"5","key":"10.1016\/j.talanta.2026.130583_bib128","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/17415993.2023.2206967","article-title":"Headspace single-drop microextraction combined with nanodrop spectrophotometry for ultra-trace detection of ethanethiol using a suspended drop of AuNPs as a plasmonic sensor","volume":"44","author":"Nozari-Asbemarz","year":"2023","journal-title":"J. Sulfur Chem."},{"key":"10.1016\/j.talanta.2026.130583_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.133656","article-title":"DNAzyme-driven tripedal DNA walker triggered hybridization chain reaction for label-free electrochemical detection of Alzheimer's tau protein","volume":"384","author":"Wei","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.talanta.2026.130583_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136797","article-title":"Internal-driven DNA nanowindmill: multi-fulcrum mediated amplified rolling nanomachine for fast and ultrasensitive electrochemical detection of tau","volume":"423","author":"Cheng","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"issue":"15","key":"10.1016\/j.talanta.2026.130583_bib131","article-title":"Freestanding nanofiber\u2010assembled aptasensor for precisely and ultrafast electrochemical detection of Alzheimer's disease biomarkers","volume":"13","author":"Liu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.talanta.2026.130583_bib132","article-title":"Analysis of Tau-441 protein in clinical samples using rGO\/AuNP nanocomposite-supported disposable impedimetric neuro-biosensing platform: towards Alzheimer's disease detection","volume":"219","author":"Sonu\u00e7","year":"2020","journal-title":"Talanta"},{"issue":"7","key":"10.1016\/j.talanta.2026.130583_bib133","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.3390\/s26072089","article-title":"Electrochemical detection of miR-29a and miR-34a using AuNPs immobilized by a silsesquioxane polyelectrolyte: potential early Alzheimer's disease biomarkers detection","volume":"26","author":"Zinser","year":"2026","journal-title":"Sensors"},{"key":"10.1016\/j.talanta.2026.130583_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125134","article-title":"Ultrasensitive electrochemical detection of amyloid-beta oligomers using double amplification strategy by MXene substrate and covalent organic framework-based probe","volume":"266","author":"Lv","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.talanta.2026.130583_bib135","article-title":"Development of a biosensor for phosphorylated Tau 181 protein detection in Early-stage Alzheimer's disease","volume":"145","author":"Schneider","year":"2022","journal-title":"Bioelectrochemistry"},{"issue":"32","key":"10.1016\/j.talanta.2026.130583_bib136","doi-asserted-by":"crossref","first-page":"17715","DOI":"10.1021\/acs.analchem.5c03015","article-title":"CRISPR\/Cas12a-mediated electrochemical aptasensor for simultaneous determination of Alzheimer's disease biomarkers in human blood","volume":"97","author":"Yuan","year":"2025","journal-title":"Anal. Chem."},{"issue":"8","key":"10.1016\/j.talanta.2026.130583_bib137","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3390\/bios12080564","article-title":"Portable vertical graphene@ Au-based electrochemical aptasensing platform for point-of-care testing of tau protein in the blood","volume":"12","author":"Liu","year":"2022","journal-title":"Biosensors"},{"key":"10.1016\/j.talanta.2026.130583_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341535","article-title":"Electrochemical impedance-based biosensor for label-free determination of plasma P-tau181 levels for clinically accurate diagnosis of mild cognitive impairment and Alzheimer's disease","volume":"1273","author":"Tieu","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.talanta.2026.130583_bib139","article-title":"Self-assembled DNA micelle-GNP for simultaneous detecting miRNAs of Alzheimer's disease via lateral flow assays","author":"Zhu","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"42","key":"10.1016\/j.talanta.2026.130583_bib140","doi-asserted-by":"crossref","first-page":"10088","DOI":"10.1039\/D3TB01502E","article-title":"Magneto-assisted enzymatic DNA walkers for simultaneous electrochemical detection of amyloid-beta oligomers and Tau","volume":"11","author":"Cheng","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"12","key":"10.1016\/j.talanta.2026.130583_bib141","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.3390\/ijms27125176","article-title":"Why sensors fail in biological samples: fouling, blocking, matrix effects and prevention solutions","volume":"27","author":"Lenar","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.talanta.2026.130583_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2025.102892","article-title":"Antifouling zwitterionic coating enhances electrochemical aptamer-based sensors for therapeutic drug monitoring","volume":"66","author":"Duan","year":"2026","journal-title":"Nano Today"},{"issue":"16","key":"10.1016\/j.talanta.2026.130583_bib143","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1039\/D5TB02633D","article-title":"Advances in ultrasensitive detection technologies for blood-based biomarkers of Alzheimer's disease","volume":"14","author":"Mou","year":"2026","journal-title":"J. Mater. Chem. B"},{"issue":"10","key":"10.1016\/j.talanta.2026.130583_bib144","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1039\/D6NA00021E","article-title":"Biomarker-targeted functionalized magnetic nanoparticles: synthesis and aptamer conjugation optimization toward Alzheimer's disease biosensing","volume":"8","author":"Makridis","year":"2026","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.talanta.2026.130583_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140190","article-title":"Self-designed portable dual-mode fluorescence device with custom python-based analysis software for rapid detection via dual-color FRET aptasensor with IoT capabilities","volume":"457","author":"Wang","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.talanta.2026.130583_bib146","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2025.115788","article-title":"Exploring the diagnostic landscape: portable aptasensors in point-of-care testing","volume":"700","author":"Mohan","year":"2025","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.talanta.2026.130583_bib147","article-title":"Portable aptasensor for smartphones using trimetallic PtPdAuNFs and triplex molecular switch for rapid detection of procymidone","volume":"519","author":"Wang","year":"2025","journal-title":"Chem. Eng. J."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026012397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026012397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:29:32Z","timestamp":1791275372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026012397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":147,"alternative-id":["S0039914026012397"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130583","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA- and aptamer-based biosensors for Alzheimer's disease biomarkers toward clinical translation","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130583"}}