{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:31:24Z","timestamp":1793428284246,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3909401"],"award-info":[{"award-number":["2024YFC3909401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2027,3]]},"DOI":"10.1016\/j.talanta.2026.130635","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:19:08Z","timestamp":1790299148000},"page":"130635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Aptamer-engineered signal-loaded MCOFs as a turn-on fluorescent platform for trace detection of immunosuppressants and prognostic biomarkers in serum"],"prefix":"10.1016","volume":"313","author":[{"given":"Jianhua","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoyu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-4955","authenticated-orcid":false,"given":"Maolong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhui","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4307-9441","authenticated-orcid":false,"given":"Li","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.talanta.2026.130635_bib1","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.matt.2020.09.027","article-title":"SARS-CoV-2 RapidPlex: a graphene-based multiplexed telemedicine platform for rapid and low-cost COVID-19 diagnosis and monitoring","volume":"3","author":"Torrente-Rodr\u00edguez","year":"2020","journal-title":"Matter"},{"key":"10.1016\/j.talanta.2026.130635_bib2","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.3390\/s23031482","article-title":"Biomarkers and corresponding biosensors for childhood cancer diagnostics","volume":"23","author":"Gharehzadehshirazi","year":"2023","journal-title":"Sensors"},{"key":"10.1016\/j.talanta.2026.130635_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115488","article-title":"Enzyme-Switch sensors for therapeutic drug monitoring of immunotherapies","volume":"237","author":"Campbell","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130635_bib4","first-page":"1095","article-title":"Microstructured optical fiber-enhanced light\u2013matter interaction enables highly sensitive exosome-based liquid biopsy of breast cancer","volume":"95","author":"Liu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130635_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116603","article-title":"Enzymatic cascade reactors on carbon nanotube transistor detecting trace prostate cancer biomarker","volume":"263","author":"Liu","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130635_bib6","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1021\/acsnano.4c12280","article-title":"Lanthanide metal\u2013organic framework flowers for proteome profiling and biomarker identification in ultratrace biofluid samples","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2026.130635_bib7","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1056\/NEJMoa2401537","article-title":"Axatilimab in recurrent or refractory chronic Graft-versus-Host disease","volume":"391","author":"Wolff","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.talanta.2026.130635_bib8","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2483386","article-title":"Prolonging calcineurin inhibitor therapy post kidney allograft failure: a prospective study","volume":"47","author":"Leal","year":"2025","journal-title":"Ren. Fail."},{"key":"10.1016\/j.talanta.2026.130635_bib9","first-page":"695.e1","article-title":"Association of cyclosporine exposure post-allogeneic hematopoietic cell transplant with graft failure and relapse risk in hematological malignancies","volume":"31","author":"Alnughmush","year":"2025","journal-title":"Transplantation and cellular therapy"},{"key":"10.1016\/j.talanta.2026.130635_bib10","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s12185-024-03913-x","article-title":"Rapid tapering of cyclosporine after allogeneic transplantation for high-risk hematological malignancies","volume":"121","author":"Gomyo","year":"2025","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.talanta.2026.130635_bib11","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/s41409-025-02583-5","article-title":"Pre-transplant inflammation and its associations with acute GvHD and mortality in pediatric allogeneic hematopoietic stem cell transplantation patients","volume":"60","author":"Verbeek","year":"2025","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.talanta.2026.130635_bib12","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1182\/blood-2007-08-106286","article-title":"Biomarkers in newly diagnosed pediatric-extensive chronic graft-versus-host disease: a report from the children's oncology group","volume":"111","author":"Fujii","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.talanta.2026.130635_bib13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/bmt.2013.97","article-title":"Biologic markers of chronic GVHD","volume":"49","author":"Pidala","year":"2014","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.talanta.2026.130635_bib14","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/S2352-3026(23)00342-3","article-title":"Prophylaxis and management of graft-versus-host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European society for blood and marrow transplantation","volume":"11","author":"Penack","year":"2024","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.talanta.2026.130635_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/620682","article-title":"Impact of cyclosporine levels on the development of acute graft versus host disease after reduced intensity conditioning allogeneic stem cell transplantation","volume":"2014","author":"Garc\u00eda Cadenas","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.talanta.2026.130635_bib16","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s12185-016-1936-z","article-title":"Soluble interleukin-2 receptor index predicts the development of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation from unrelated donors","volume":"103","author":"Nakamura","year":"2016","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.talanta.2026.130635_bib17","doi-asserted-by":"crossref","first-page":"33211","DOI":"10.1021\/acsami.5c05773","article-title":"Janus membranes with On-Demand control of droplets used in blood testing and information encryption","volume":"17","author":"Min","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2026.130635_bib18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/01.tp.0000194861.59543.b9","article-title":"Interaction between tacrolimus and omeprazole in a pediatric liver transplant recipient","volume":"81","author":"Moreau","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.talanta.2026.130635_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.10085","article-title":"Exploring the mechanisms of cyclosporine therapy in aplastic anemia: a data-independent acquisition proteomics approach","volume":"39","author":"Guo","year":"2025","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.talanta.2026.130635_bib20","first-page":"832","article-title":"Study on colorimetric sensor array based on enzymatic method for highly selective detection of sarin","volume":"53","author":"Jiang","year":"2025","journal-title":"Chin. J. Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130635_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117586","article-title":"Peptide-based biosensor for real-time monitoring of protease biomarker activity using multi-parametric surface plasmon resonance spectroscopy","volume":"286","author":"Rai","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130635_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117629","article-title":"Multimodal sensing platform based on Fe3O4\/DEX\/PDA@Au(Raman reporters)@Au nanocomposites for sweat biomarkers monitoring","volume":"286","author":"Zhao","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130635_bib23","article-title":"An \"on-off-on\" self-powered biosensor based on enzyme-free amplification for detection of three biomarkers","volume":"285","author":"Zhan","year":"2025","journal-title":"Water Res."},{"key":"10.1016\/j.talanta.2026.130635_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117583","article-title":"Targeted molecular rapid SERS diagnosis in clinical human serum through aptamer origami-collapsed nanofingers chip","volume":"285","author":"Ji","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130635_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117536","article-title":"Catalytic hairpin assembly-powered nanozyme-SERS dual-function sensing system for ultrasensitive detection of gastric precancerous lesions","volume":"283","author":"Zhuang","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130635_bib26","article-title":"Composite surface enhanced Raman scattering substrate of flower-shaped ZIF-67 and Au nanorods for simultaneous detection of creatinine and urea nitrogen","volume":"69","author":"Fu","year":"2025","journal-title":"Surf. Interfaces"},{"key":"10.1016\/j.talanta.2026.130635_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114508","article-title":"An ultrasensitive dual-signal aptasensor based on functionalized Sb@ZIF-67 nanocomposites for simultaneously detect multiple biomarkers","volume":"214","author":"Zhang","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130635_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40820-023-01249-5","article-title":"Advances of electrochemical and electrochemiluminescent sensors based on covalent organic frameworks","volume":"16","author":"Cao","year":"2024","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.talanta.2026.130635_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2023.109249","article-title":"A review of covalent organic frameworks for metal ion fluorescence sensing","volume":"35","author":"Zhen","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.talanta.2026.130635_bib30","article-title":"Specific and magnetic covalent organic framework confined Os nanoclusterzyme for interference-free and ultrasensitive biosensing","volume":"34","author":"Zhou","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.talanta.2026.130635_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.desal.2025.119096","article-title":"Functionalized covalent organic frameworks for rapid and selective extraction of uranium from wastewater through experimental and theoretical studies","volume":"614","author":"Liu","year":"2025","journal-title":"Desalination"},{"key":"10.1016\/j.talanta.2026.130635_bib32","doi-asserted-by":"crossref","first-page":"30664","DOI":"10.1021\/acsami.5c03929","article-title":"Biological Cascade catalysts based on structurally regulated covalent organic framework for intuitive glucose colorimetric sensing","volume":"17","author":"Lu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.talanta.2026.130635_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136593","article-title":"Light-activated bifunctional nanozymes based on three-component covalent organic frameworks for colorimetric and ratiometric fluorescence dual-mode detection of alkaline phosphatase","volume":"422","author":"Hu","year":"2025","journal-title":"Sens. Actuator B-Chem."},{"key":"10.1016\/j.talanta.2026.130635_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jcis.2021.06.077","article-title":"Sulfonic acid functionalized hierarchical porous covalent organic frameworks as a SALDI-TOF MS matrix for effective extraction and detection of paraquat and diquat","volume":"603","author":"Tan","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.talanta.2026.130635_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.141058","article-title":"De novo synthesis of enzyme-embedded covalent organic frameworks (COFs) using deep eutectic solvent: pushing the COF limits","volume":"456","author":"Talekar","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.talanta.2026.130635_bib36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1039\/D3AY01775C","article-title":"Non-immobilized GO-SELEX screening of aptamers against cyclosporine A and its application in a AuNPs colorimetric aptasensor","volume":"16","author":"Yang","year":"2024","journal-title":"Anal. Methods"},{"key":"10.1016\/j.talanta.2026.130635_bib37","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.7314\/APJCP.2014.15.11.4545","article-title":"Clinical significance of joint detection of serum VEGF, SIL-2R and HGF in patients with primary hepatocellular carcinoma before and after percutaneous microwave coagulation therapy","volume":"15","author":"Chen","year":"2014","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.talanta.2026.130635_bib38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jchromb.2004.02.040","article-title":"Simultaneous determination of four immunosuppressants by means of high speed and robust on-line solid phase extraction-high performance liquid chromatography-tandem mass spectrometry","volume":"805","author":"Koal","year":"2004","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.talanta.2026.130635_bib39","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1021\/acs.analchem.8b00780","article-title":"Sensitive rapid fluorescence polarization immunoassay for free mycophenolic acid determination in human serum and plasma","volume":"90","author":"Glahn-Mart\u00ednez","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130635_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2024.124154","article-title":"LC-MS\/MS and EMIT measure the whole blood concentration of cyclosporine A: the two methods yield concordant results within the dynamic range of the latter, but the former shows broader application scenarios","volume":"1240","author":"Zhang","year":"2024","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.talanta.2026.130635_bib41","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0165-2427(94)90074-4","article-title":"Development of a sandwich immunoassay for the detection of soluble ovine IL-2R alpha chain","volume":"42","author":"Verhagen","year":"1994","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.talanta.2026.130635_bib42","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.bios.2018.11.038","article-title":"Improved ELISA for tumor marker detection using electro-readout-mode based on label triggered degradation of methylene blue","volume":"126","author":"Zhang","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.talanta.2026.130635_bib43","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1002\/cbic.201900109","article-title":"A rapid colorimetric sensor for soluble Interleukin-2 receptor \u03b1, based on aptamer-adsorbed AuNP","volume":"20","author":"Jeon","year":"2019","journal-title":"Chembiochem"},{"key":"10.1016\/j.talanta.2026.130635_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116553","article-title":"AGREEprep \u2013 analytical greenness metric for sample preparation","volume":"149","author":"Wojnowski","year":"2022","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.talanta.2026.130635_bib45","doi-asserted-by":"crossref","first-page":"7598","DOI":"10.1039\/D3GC02347H","article-title":"Blue applicability grade index (BAGI) and software: a new tool for the evaluation of method practicality","volume":"25","author":"Manousi","year":"2023","journal-title":"Green Chem."}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026012919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026012919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:40:01Z","timestamp":1793425201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026012919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,3]]},"references-count":45,"alternative-id":["S0039914026012919"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130635","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2027,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aptamer-engineered signal-loaded MCOFs as a turn-on fluorescent platform for trace detection of immunosuppressants and prognostic biomarkers in serum","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130635","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"130635"}}