{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:29:36Z","timestamp":1793482176165,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2022203004"],"award-info":[{"award-number":["H2022203004"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Talanta"],"published-print":{"date-parts":[[2027,3]]},"DOI":"10.1016\/j.talanta.2026.130642","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:08:29Z","timestamp":1789830509000},"page":"130642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PB","title":["Leonurus cardiaca L. polysaccharide-stabilized Pd-Au nanozymes for NIR-responsive doxorubicin delivery and combined chemo-chemodynamic-photothermal therapy"],"prefix":"10.1016","volume":"313","author":[{"given":"Ruyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longgang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.talanta.2026.130642_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40164-025-00602-1","article-title":"Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects","volume":"14","author":"Cheng","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130642_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41413-021-00139-z","article-title":"Review of a new bone tumor therapy strategy based on bifunctional biomaterials","volume":"9","author":"Liao","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.talanta.2026.130642_bib3","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.2147\/IJN.S388996","article-title":"Combined photodynamic and photothermal therapy and immunotherapy for cancer treatment: a review","volume":"17","author":"Kong","year":"2022","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.talanta.2026.130642_bib4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13045-022-01304-5","article-title":"Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application","volume":"15","author":"Zhang","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.talanta.2026.130642_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41392-020-0107-0","article-title":"The role of ubiquitination in tumorigenesis and targeted drug discovery","volume":"5","author":"Deng","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"7","key":"10.1016\/j.talanta.2026.130642_bib6","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.7150\/ijbs.79651","article-title":"Crosstalk between N6-methyladenosine (m6A) modification and noncoding RNA in tumor microenvironment","volume":"19","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.talanta.2026.130642_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.159716","article-title":"Regulation of ROS balance in the tumor microenvironment achieves reversal of immune suppression and deep penetration of nanomedicines","volume":"505","author":"Xu","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"14","key":"10.1016\/j.talanta.2026.130642_bib8","doi-asserted-by":"crossref","first-page":"16269","DOI":"10.1021\/acsami.2c01759","article-title":"Broad-band-enhanced plasmonic perovskite solar cells with irregular silver nanomaterials","volume":"14","author":"Wu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.talanta.2026.130642_bib9","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1038\/s41467-021-23737-1","article-title":"Glucose-oxidase like catalytic mechanism of noble metal nanozymes","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.talanta.2026.130642_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.apcatb.2021.120317","article-title":"NIR enhanced peroxidase-like activity of Au@CeO2 hybrid nanozyme by plasmon-induced hot electrons and photothermal effect for bacteria killing","volume":"295","author":"Liu","year":"2021","journal-title":"Appl. Catal., B"},{"key":"10.1016\/j.talanta.2026.130642_bib11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jcis.2023.01.079","article-title":"Oxygen-rich graphene\/ZnO2-Ag nanoframeworks with pH-switchable catalase\/peroxidase activity as O2 nanobubble-self generator for bacterial inactivation","volume":"637","author":"Jannesari","year":"2023","journal-title":"J. Colloid Interface Sci."},{"issue":"1","key":"10.1016\/j.talanta.2026.130642_bib12","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/s41467-024-45668-3","article-title":"Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy","volume":"15","author":"Meng","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.talanta.2026.130642_bib13","article-title":"Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature","volume":"7","author":"Zhu","year":"2016","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.talanta.2026.130642_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202424768","article-title":"Engineering two\u2010dimensional nanomaterials for photothermal therapy","volume":"64","author":"Zhang","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"issue":"11","key":"10.1016\/j.talanta.2026.130642_bib15","article-title":"Multiscale thermal analysis of gold nanostars in 3D tumor spheroids: integrating cellular\u2010level photothermal effects and nanothermometry via X\u2010ray spectroscopy","volume":"14","author":"L\u00f3pez\u2010M\u00e9ndez","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"11","key":"10.1016\/j.talanta.2026.130642_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202206865","article-title":"Thermoresponsive hydrogel\u2010enabled thermostatic photothermal therapy for enhanced healing of bacteria\u2010infected wounds","volume":"10","author":"Fu","year":"2023","journal-title":"Adv. Sci."},{"issue":"35","key":"10.1016\/j.talanta.2026.130642_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202502617","article-title":"Artesunate nanoplatform targets the serine-MAPK axis in cancer\u2010associated fibroblasts to reverse photothermal resistance in triple\u2010negative breast cancer","volume":"37","author":"Zheng","year":"2025","journal-title":"Adv. Mater."},{"issue":"15","key":"10.1016\/j.talanta.2026.130642_bib18","doi-asserted-by":"crossref","first-page":"7546","DOI":"10.7150\/thno.56482","article-title":"Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view","volume":"11","author":"Huang","year":"2021","journal-title":"Theranostics"},{"issue":"13","key":"10.1016\/j.talanta.2026.130642_bib19","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1039\/C4NR07279K","article-title":"Hybridized doxorubicin-Au nanospheres exhibit enhanced near-infrared surface plasmon absorption for photothermal therapy applications","volume":"7","author":"Zhou","year":"2015","journal-title":"Nanoscale"},{"issue":"10","key":"10.1016\/j.talanta.2026.130642_bib20","doi-asserted-by":"crossref","first-page":"12679","DOI":"10.1021\/acsnano.0c01453","article-title":"A hepatocellular carcinoma targeting nanostrategy with hypoxia-ameliorating and photothermal abilities that, combined with immunotherapy, inhibits metastasis and recurrence","volume":"14","author":"Zhou","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.talanta.2026.130642_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.actbio.2023.03.021","article-title":"A biomimetic nanoplatform for precise reprogramming of tumor-associated macrophages and NIR-II mediated antitumor immune activation","volume":"162","author":"Du","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.talanta.2026.130642_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120167","article-title":"Photothermal conversion-coordinated Fenton-like and photocatalytic reactions of Cu2-xSe-Au Janus nanoparticles for tri-combination antitumor therapy","volume":"255","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.talanta.2026.130642_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113098","article-title":"Pt(II) and Au(III) complexes containing schiff-base ligands: a promising source for antitumor treatment","volume":"211","author":"Sun","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.talanta.2026.130642_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.151167","article-title":"Wavelength-equilibrium temperature dual-tunable photothermal convertible materials for temperature-controlled therapy of cancer","volume":"488","author":"Du","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"16","key":"10.1016\/j.talanta.2026.130642_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202110268","article-title":"H2O2 self\u2010producing single\u2010atom nanozyme hydrogels as light\u2010controlled oxidative stress amplifier for enhanced synergistic therapy by transforming \u201ccold\u201d tumors","volume":"32","author":"Zhu","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.talanta.2026.130642_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.canlet.2021.03.018","article-title":"Long non-coding RNAs in the doxorubicin resistance of cancer cells","volume":"508","author":"Ashrafizaveh","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.talanta.2026.130642_bib27","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jcis.2025.02.033","article-title":"Hollow mesoporous Prussian blue nanozymes alleviate doxorubicin-induced cardiotoxicity by restraining oxidative stress associated with Nrf2 signaling","volume":"686","author":"Wang","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.talanta.2026.130642_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.128380","article-title":"Anticancer effects of doxorubicin-conjugated magnetite MXene\/Callicarpa extract on MCF-7 breast cancer cell line","volume":"295","author":"Jabbarzadeh","year":"2025","journal-title":"Talanta"},{"issue":"24","key":"10.1016\/j.talanta.2026.130642_bib29","doi-asserted-by":"crossref","first-page":"8009","DOI":"10.1039\/c2cs35160a","article-title":"Pd-Au bimetallic catalysts: understanding alloy effects from planar models and (supported) nanoparticles","volume":"41","author":"Gao","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.talanta.2026.130642_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2026.125553","article-title":"Construction strategies and detection application progress of colorimetric sensors in polysaccharide-metal nanoparticle composite systems: a review","volume":"388","author":"Zhen","year":"2026","journal-title":"Carbohydr. Polym."},{"issue":"5","key":"10.1016\/j.talanta.2026.130642_bib31","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.7150\/thno.69119","article-title":"Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death","volume":"12","author":"Moon","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.talanta.2026.130642_bib32","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12951-021-00986-2","article-title":"Artificial exosomes for translational nanomedicine","volume":"19","author":"Li","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.talanta.2026.130642_bib33","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.3390\/ijms24032914","article-title":"Optimization of the hemolysis assay for the assessment of cytotoxicity","volume":"24","author":"S\u00e6b\u00f8","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.talanta.2026.130642_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.129878","article-title":"Improved detection of reactive oxygen species by DCFH-DA: new insight into self-amplification of fluorescence signal by light irradiation","volume":"339","author":"Yu","year":"2021","journal-title":"Sens. Actuators, B"}],"container-title":["Talanta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026012981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039914026012981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:11:17Z","timestamp":1793481077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039914026012981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,3]]},"references-count":34,"alternative-id":["S0039914026012981"],"URL":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130642","relation":{},"ISSN":["0039-9140"],"issn-type":[{"value":"0039-9140","type":"print"}],"subject":[],"published":{"date-parts":[[2027,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leonurus cardiaca L. polysaccharide-stabilized Pd-Au nanozymes for NIR-responsive doxorubicin delivery and combined chemo-chemodynamic-photothermal therapy","name":"articletitle","label":"Article Title"},{"value":"Talanta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.talanta.2026.130642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"130642"}}