{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:11:46Z","timestamp":1777421506754,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T00:00:00Z","timestamp":1568678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Topics in Companion Animal Medicine"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.tcam.2019.100358","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T11:48:57Z","timestamp":1568202537000},"page":"100358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Borrelia burgdorferi Antibody Test Results in Dogs Administered 4 Different Vaccines"],"prefix":"10.1016","volume":"37","author":[{"given":"Brett A.","family":"Stillman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendon","family":"Thatcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa J.","family":"Beall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lappin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramaswamy","family":"Chandrashekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcam.2019.100358_bib0001","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM198908313210906","article-title":"Lyme disease","volume":"321","author":"Steer","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tcam.2019.100358_bib0002","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pt.2010.01.006","article-title":"Lyme borreliosis in dogs and humans in the USA","volume":"26","author":"Little","year":"2010","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.tcam.2019.100358_bib0003","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/jvim.15085","article-title":"ACVIM consensus update on Lyme borreliosis in dogs and cats","volume":"32","author":"Littman","year":"2018","journal-title":"Vet Intern Med"},{"key":"10.1016\/j.tcam.2019.100358_bib0004","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2460\/javma.1985.186.09.955","article-title":"Borreliosis in dogs from southern Connecticut","volume":"186","author":"Magnarelli","year":"1985","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.tcam.2019.100358_bib0005","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/1756-3305-7-257","article-title":"Canine infection with Dirofilaria immitis, Borrelia burgdorferi, Anaplasma spp., and Ehrlichia spp. in the United States, 2010-2012","volume":"7","author":"Little","year":"2014","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.tcam.2019.100358_bib0006","first-page":"308","article-title":"Utility of an in-office C6 ELISA test kit for determination of infection status of dogs naturally exposed to Borrelia burgdorferi","volume":"3","author":"Levy","year":"2002","journal-title":"Vet Ther"},{"key":"10.1016\/j.tcam.2019.100358_bib0007","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1128\/CVI.00427-09","article-title":"Humoral immune response in dogs naturally infected with Borrelia burgdorferi sensu lato and in dogs after immunization with a Borrelia vaccine","volume":"17","author":"Leschnik","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.tcam.2019.100358_bib0008","first-page":"458","article-title":"Dogs vaccinated with common Lyme disease vaccines do not respond to IR6, the conserved immunodominant region of the VlsE surface protein of Borrelia burgdorferi","volume":"11","author":"O'Connor","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.tcam.2019.100358_bib0009","series-title":"The Immunoassay Handbook","first-page":"623","article-title":"Immunoassay applications in veterinary diagnostics","author":"O'Connor","year":"2013"},{"key":"10.1016\/j.tcam.2019.100358_bib0010","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1053\/j.tcam.2015.12.002","article-title":"SNAP assay technology","volume":"30","author":"O'Connor","year":"2015","journal-title":"Top Companion Anim Med"},{"key":"10.1016\/j.tcam.2019.100358_bib0011","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2460\/javma.245.1.80","article-title":"Performance of a commercially available in-clinic ELISA for detection of antibodies against Anaplasma phagocytophilum, Anaplasma platys, Borrelia burgdorferi, Ehrlichia canis, and Ehrlichia ewingii and Dirofilaria immitis antigen in dogs","volume":"245","author":"Stillman","year":"2014","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.tcam.2019.100358_bib0012","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1128\/IAI.67.12.6702-6706.1999","article-title":"Analysis of antibody response to invariable regions of VlsE, the variable surface antigen of Borrelia burgdorferi","volume":"67","author":"Liang","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.tcam.2019.100358_bib0013","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1128\/CVI.00524-09","article-title":"One-year duration of immunity induced by vaccination with a canine Lyme disease bacterin","volume":"17","author":"LaFleur","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.tcam.2019.100358_bib0014","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/CVI.00340-07","article-title":"Quantitative measurement of C6 antibody following antibiotic treatment of Borrelia burgdorferi antibody-positive nonclinical dogs","volume":"15","author":"Levy","year":"2008","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.tcam.2019.100358_bib0015","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1128\/JCM.38.11.4160-4166.2000","article-title":"Characterization of a Borrelia burgdorferi VlsE invariable region useful in canine Lyme disease serodiagnosis by enzyme-linked immunosorbent assay","volume":"38","author":"Liang","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.tcam.2019.100358_bib0016","doi-asserted-by":"crossref","first-page":"13865","DOI":"10.1073\/pnas.97.25.13865","article-title":"Correlation between plasmid content and infectivity in Borrelia burgdorferi","volume":"97","author":"Purser","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tcam.2019.100358_bib0017","unstructured":"Zoetis, Inc., VANGUARD crLyme, https:\/\/www.zoetisus.com\/products\/dogs\/vanguard-crlyme\/resources\/vanguard-crlyme-efficacy-information.pdf (Accessed April 2019)"},{"key":"10.1016\/j.tcam.2019.100358_bib0018","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/104063879901100309","article-title":"Western immunoblot analysis for distinguishing vaccination and infection status with Borrelia burgdorferi (Lyme disease) in dogs","volume":"11","author":"Gauthier","year":"1999","journal-title":"J Vet Diagn Invest"},{"key":"10.1016\/j.tcam.2019.100358_bib0019","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1128\/JCM.38.7.2628-2632.2000","article-title":"Quantitative approach for the serodiagnosis of canine Lyme disease by the immunoblot procedure","volume":"38","author":"Guerra","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.tcam.2019.100358_bib0020","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1128\/CVI.05653-11","article-title":"Antibodies to Borrelia burgdorferi OspA, OspC, OspF, and C6 antigens as markers for early and late infection in dogs","volume":"4","author":"Wagner","year":"2012","journal-title":"Clin Vac Immun"},{"key":"10.1016\/j.tcam.2019.100358_bib0021","unstructured":"Bushmich S.Veterinary Lyme disease testing at CVMDL. http:\/\/cvmdl.uconn.edu\/testinformation\/Veterinary%20Lyme%20Disease%20Testing.pdf (Accessed April 2019)"}],"container-title":["Topics in Companion Animal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1938973619300959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1938973619300959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:38:12Z","timestamp":1761849492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1938973619300959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":21,"alternative-id":["S1938973619300959"],"URL":"https:\/\/doi.org\/10.1016\/j.tcam.2019.100358","relation":{},"ISSN":["1938-9736"],"issn-type":[{"value":"1938-9736","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Borrelia burgdorferi Antibody Test Results in Dogs Administered 4 Different Vaccines","name":"articletitle","label":"Article Title"},{"value":"Topics in Companion Animal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcam.2019.100358","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100358"}}