{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:08:49Z","timestamp":1785600529942,"version":"3.56.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Topics in Companion Animal Medicine"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.tcam.2022.100694","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T05:23:38Z","timestamp":1657949018000},"page":"100694","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Musladin-Lueke Syndrome in a Dog: Case Report"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-0981","authenticated-orcid":false,"given":"R.K.","family":"Carneiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-7835","authenticated-orcid":false,"given":"G.T.","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5684-0138","authenticated-orcid":false,"given":"R.C.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Amadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3717-0428","authenticated-orcid":false,"given":"T.D.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4373-6539","authenticated-orcid":false,"given":"M.A.R.","family":"Feliciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Alievi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-2485","authenticated-orcid":false,"given":"M.P.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcam.2022.100694_bib0001","doi-asserted-by":"crossref","first-page":"e12817","DOI":"10.1371\/journal.pone.0012817","article-title":"An ADAMTSL2 founder mutation causes musladin-lueke syndrome, a heritable disorder of beagle dogs, featuring stiff skin and joint contractures","volume":"5","author":"Bader","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.tcam.2022.100694_bib0002","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/jvim.14654","article-title":"Clinical phenotype of musladin-lueke syndrome in 2 beagles","volume":"31","author":"Packer","year":"2017","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.tcam.2022.100694_bib0003","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1242\/dmm.017046","article-title":"Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia\u2013a novel mouse model providing insights into geleophysic dysplasia","volume":"8","author":"Hubmacher","year":"2015","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.tcam.2022.100694_bib0004","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajhg.2011.05.012","article-title":"Mutations in the TGFbeta binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias","volume":"89","author":"Le Goff","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tcam.2022.100694_bib0005","first-page":"418","article-title":"Genetic and molecular aspects of acromelic dysplasia","volume":"6","author":"Le Goff","year":"2009","journal-title":"Pediatr Endocrinol Rev"},{"key":"10.1016\/j.tcam.2022.100694_bib0006","series-title":"The New Beagle: A Dog for All Seasons","author":"Musladin","year":"1998"},{"key":"10.1016\/j.tcam.2022.100694_bib0007","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/rda.13231","article-title":"Canine cryptorchidism: An update","volume":"53","author":"Khan","year":"2018","journal-title":"Reprod Domest Anim"},{"key":"10.1016\/j.tcam.2022.100694_bib0008","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1590\/1678-4162-8284","article-title":"Acoustic radiation force impulse (ARFI) elastography of testicular disorders in dogs: preliminary results","volume":"68","author":"Feliciano","year":"2016","journal-title":"Arq Bras Med Vet Zootec"},{"key":"10.1016\/j.tcam.2022.100694_bib0009","first-page":"86","article-title":"Two-dimensional, Doppler and contrast enhanced ultrasonography on testicular evaluation: from man to animal","volume":"38","author":"Souza","year":"2014","journal-title":"Rev Bras Reprod Anim"},{"key":"10.1016\/j.tcam.2022.100694_bib0010","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/ajmg.a.30450","article-title":"Natural history of cardiac involvement in geleophysic dysplasia","volume":"132A","author":"Scott","year":"2005","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.tcam.2022.100694_bib0011","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.matbio.2015.05.004","article-title":"ADAMTS proteins as modulators of microfibril formation and function","volume":"47","author":"Hubmacher","year":"2015","journal-title":"Matrix Biol"},{"key":"10.1016\/j.tcam.2022.100694_bib0012","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/ca.22672","article-title":"Down syndrome-a narrative review with a focus on anatomical features","volume":"29","author":"Arumugam","year":"2015","journal-title":"Clin Anat"},{"key":"10.1016\/j.tcam.2022.100694_bib0013","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/prca.201000121","article-title":"Oxidative stress occurs early in Down syndrome pregnancy: a redox proteomics analysis of amniotic fluid","volume":"5","author":"Perluigi","year":"2011","journal-title":"Proteomics Clin Appl"},{"key":"10.1016\/j.tcam.2022.100694_bib0014","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1590\/1806-9282.63.08.693","article-title":"Smoking and its association with cryptorchidism in Down syndrome","volume":"63","author":"Duarte","year":"2017","journal-title":"Rev Assoc Med Bras"},{"key":"10.1016\/j.tcam.2022.100694_bib0015","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/MOP.0000000000000661","article-title":"Cardiovascular disease in Down syndrome","volume":"30","author":"Versacci","year":"2018","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.tcam.2022.100694_bib0016","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ajhg.2012.08.017","article-title":"An excess of deleterious variants in VEGF-A pathway genes in Down-syndrome-associated atrioventricular septal defects","volume":"91","author":"Ackerman","year":"2012","journal-title":"Am J Hum Genet"}],"container-title":["Topics in Companion Animal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1938973622000678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1938973622000678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:40:23Z","timestamp":1761849623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1938973622000678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":16,"alternative-id":["S1938973622000678"],"URL":"https:\/\/doi.org\/10.1016\/j.tcam.2022.100694","relation":{},"ISSN":["1938-9736"],"issn-type":[{"value":"1938-9736","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Musladin-Lueke Syndrome in a Dog: Case Report","name":"articletitle","label":"Article Title"},{"value":"Topics in Companion Animal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcam.2022.100694","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100694"}}