{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:01:59Z","timestamp":1793318519133,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"am","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02365"],"award-info":[{"award-number":["21H02365"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Topics in Companion Animal Medicine"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.tcam.2022.100756","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T02:27:36Z","timestamp":1672194456000},"page":"100756","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Clinical and Pathological Findings in Fatal Cases of Severe Fever With Thrombocytopenia Syndrome With High Viremia in Cats"],"prefix":"10.1016","volume":"52","author":[{"given":"Aya","family":"Matsuu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Hatai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuro","family":"Hifumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emu","family":"Hamakubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maho","family":"Take","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Momoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Koyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Kamikubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raye","family":"Kamatsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Kurusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruna","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yanaidani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiyo","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcam.2022.100756_bib0001","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1007\/s00705-020-04731-2","article-title":"2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales","volume":"165","author":"Kuhn","year":"2020","journal-title":"Arch Virol"},{"key":"10.1016\/j.tcam.2022.100756_bib0002","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1056\/NEJMoa1010095","article-title":"Fever with thrombocytopenia associated with a novel bunyavirus in China","volume":"364","author":"Yu","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tcam.2022.100756_bib0003","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.3201\/eid1911.130792","article-title":"Severe fever with thrombocytopenia syndrome, South Korea, 2012","volume":"19","author":"Kim","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0004","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/infdis\/jit603","article-title":"The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan","volume":"209","author":"Takahashi","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0005","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3201\/eid2505.181463","article-title":"Endemic severe fever with thrombocytopenia syndrome, Vietnam","volume":"25","author":"Tran","year":"2019","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0006","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/22221751.2019.1710436","article-title":"The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan","volume":"9","author":"Lin","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.tcam.2022.100756_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3201\/eid2001.120532","article-title":"Severe fever with thrombocytopenia syndrome, Shandong Province, China, 2011","volume":"20","author":"Wen","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0008","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3201\/eid2604.191011","article-title":"SFTS epidemiological research group Japan severe fever with thrombocytopenia syndrome, Japan, 2013\u20132017","volume":"26","author":"Kobayashi","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7883\/yoken.67.1","article-title":"A cross-sectional survey of severe fever with thrombocytopenia syndrome virus infection of domestic animals in Laizhou City, Shandong Province, China","volume":"67","author":"Ding","year":"2014","journal-title":"Jpn J Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0010","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.4269\/ajtmh.16-0333","article-title":"Severe fever with thrombocytopenia syndrome virus in humans, domesticated animals, ticks, and mosquitoes, Shaanxi Province, China","volume":"96","author":"Tian","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.tcam.2022.100756_bib0011","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.3201\/eid2409.171667","article-title":"Fatal Tickborne Phlebovirus Infection in Captive Cheetahs, Japan","volume":"24","author":"Matsuno","year":"2018","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2019.06.019","article-title":"Natural severe fever with thrombocytopenia syndrome virus infection in domestic cats in Japan","volume":"236","author":"Matsuu","year":"2019","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.tcam.2022.100756_bib0013","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3390\/v13061142","article-title":"Severe fever with thrombocytopenia syndrome in cats and its prevalence among veterinarian staff members in Nagasaki, Japan","volume":"13","author":"Ando","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.tcam.2022.100756_bib0014","doi-asserted-by":"crossref","first-page":"11990","DOI":"10.1038\/s41598-019-48317-8","article-title":"Severe fever with thrombocytopenia syndrome phlebovirus causes lethal viral hemorrhagic fever in cats","volume":"9","author":"Park","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.tcam.2022.100756_bib0015","series-title":"Severe fever with thrombocytopenia syndrome (SFTS) in Japan, as of June 2019","first-page":"111-112","year":"2019"},{"key":"10.1016\/j.tcam.2022.100756_bib0016","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.3201\/eid2612.191513","article-title":"Direct transmission of severe fever with thrombocytopenia syndrome virus from domestic cat to veterinary personnel","volume":"26","author":"Yamanaka","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0017","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/v13020204","article-title":"Pathological characteristics of a patient with severe fever with thrombocytopenia syndrome (SFTS) infected with SFTS virus through a sick cat's bite","volume":"13","author":"Tsuru","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.tcam.2022.100756_bib0018","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/v13020229","article-title":"Seroprevalence of severe fever with thrombocytopenia syndrome virus in small-animal veterinarians and nurses in the Japanese Prefecture with the highest case load","volume":"13","author":"Kirino","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.tcam.2022.100756_bib0019","doi-asserted-by":"crossref","first-page":"356","DOI":"10.7883\/yoken.JJID.2018.526","article-title":"A case of cat-to-human transmission of severe fever with thrombocytopenia syndrome virus","volume":"72","author":"Kida","year":"2019","journal-title":"Jpn J Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0020","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3201\/eid2704.204148","article-title":"Histopathological characterization of cases of spontaneous fatal feline severe fever with thrombocytopenia syndrome","volume":"27","author":"Sakai","year":"2021","journal-title":"Jpn Emerg Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0021","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1471-2199-10-106","article-title":"Quantitative TaqMan\u00ae real-time PCR assays for gene expression normalisation in feline tissues","volume":"10","author":"Kessler","year":"2009","journal-title":"BMC Mol Biol"},{"key":"10.1016\/j.tcam.2022.100756_bib0022","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1292\/jvms.09-0574","article-title":"An updated nation-wide epidemiological survey of feline immunodeficiency virus (FIV) infection in Japan","volume":"72","author":"Nakamura","year":"2010","journal-title":"J Vet Med Sci"},{"key":"10.1016\/j.tcam.2022.100756_bib0023","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1099\/jgv.0.000866","article-title":"Central and peripheral reservoirs of feline immunodeficiency virus in cats: a review","volume":"98","author":"Eckstrand","year":"2017","journal-title":"J Gen Virol"},{"key":"10.1016\/j.tcam.2022.100756_bib0024","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1172\/JCI129171","article-title":"Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections","volume":"130","author":"Suzuki","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tcam.2022.100756_bib0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1939-1676.1996.tb02017.x","article-title":"Bone marrow cytological findings in 4 dogs and a cat with hemophagocytic syndrome","volume":"10","author":"Walton","year":"1996","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.tcam.2022.100756_bib0026","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/vcp.12015","article-title":"Hemophagocytic syndrome in a cat with multiple myeloma","volume":"42","author":"Dunbar","year":"2013","journal-title":"Vet Clin Pathol"},{"key":"10.1016\/j.tcam.2022.100756_bib0027","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/vcp.12721","article-title":"Royal AB Hemophagocytosis and Histoplasma-like fungal infection in 32 cats","volume":"48","author":"Schaefer","year":"2019","journal-title":"Vet Clin Pathol"},{"key":"10.1016\/j.tcam.2022.100756_bib0028","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1939-165X.2008.00073.x","article-title":"Erythrophagocytic low-grade extranodal T-cell lymphoma in a cat","volume":"37","author":"Carter","year":"2008","journal-title":"Vet Clin Pathol"},{"key":"10.1016\/j.tcam.2022.100756_bib0029","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.2169\/internalmedicine.56.6904","article-title":"Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome","volume":"56","author":"Nakano","year":"2017","journal-title":"Intern Med"},{"key":"10.1016\/j.tcam.2022.100756_bib0030","doi-asserted-by":"crossref","first-page":"592","DOI":"10.11150\/kansenshogakuzasshi.89.592","article-title":"[A fatal case of severe fever with thrombocytopenia syndrome complicated by hemophagocytic lymphohistiocytosis]","volume":"89","author":"Kaneko","year":"2015","journal-title":"Kansenshogaku Zasshi"},{"key":"10.1016\/j.tcam.2022.100756_bib0031","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3349\/ymj.2019.60.6.592","article-title":"Higher fatality for severe fever with thrombocytopenia syndrome complicated by hemophagocytic lymphohistiocytosis","volume":"60","author":"Jung","year":"2019","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.tcam.2022.100756_bib0032","doi-asserted-by":"crossref","unstructured":"Oh HS, Kim M, Lee JO, et al. Hemophagocytic lymphohistiocytosis associated with SFTS virus infection: a case report with literature review. 95:e4476, 2016 https:\/\/doi.org\/10.1097\/MD.0000000000004476","DOI":"10.1097\/MD.0000000000004476"},{"key":"10.1016\/j.tcam.2022.100756_bib0033","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3947\/ic.2016.48.4.338","article-title":"Severe fever with thrombocytopenia syndrome presenting with hemophagocytic lymphohistiocytosis","volume":"48","author":"Lee","year":"2016","journal-title":"Infect Chemother"},{"key":"10.1016\/j.tcam.2022.100756_bib0034","doi-asserted-by":"crossref","unstructured":"Kawaguchi T, Umekita K, Yamanaka A, et al. Impact of C-Reactive protein levels on differentiating of severe fever with thrombocytopenia syndrome from Japanese spotted fever. Open Forum Infect Dis 7:ofaa473. https:\/\/doi.org\/10.1093\/ofid\/ofaa473","DOI":"10.1093\/ofid\/ofaa473"},{"key":"10.1016\/j.tcam.2022.100756_bib0035","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/infdis\/jis472","article-title":"Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients","volume":"206","author":"Gai","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0036","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jiac.2018.07.009","article-title":"Pathophysiology of severe fever with thrombocytopenia syndrome and development of specific antiviral therapy","volume":"24","author":"Saijo","year":"2018","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.tcam.2022.100756_bib0037","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12879-020-05012-8","article-title":"Detection of viral RNA in diverse body fluids in an SFTS patient with encephalopathy, gastrointestinal bleeding and pneumonia: a case report and literature review","volume":"20","author":"Akagi","year":"2020","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0038","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7883\/yoken.JJID.2015.404","article-title":"Ulcerative lesions with hemorrhage in a patient with severe fever with thrombocytopenia syndrome observed via upper gastrointestinal endoscopy","volume":"69","author":"Kaneyuki","year":"2016","journal-title":"Jpn J Infect Dis"},{"key":"10.1016\/j.tcam.2022.100756_bib0039","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.cmi.2017.09.002","article-title":"Severe fever with thrombocytopenia syndrome-associated encephalopathy\/encephalitis","volume":"24","author":"Park","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.tcam.2022.100756_bib0040","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1186\/s12879-021-06627-1","article-title":"Clinical feature of severe fever with thrombocytopenia syndrome (SFTS)-associated encephalitis\/encephalopathy: a retrospective study","volume":"21","author":"Ying","year":"2021","journal-title":"BMC Infect Dis"}],"container-title":["Topics in Companion Animal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1938973622001295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1938973622001295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:40:06Z","timestamp":1761849606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1938973622001295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":40,"alternative-id":["S1938973622001295"],"URL":"https:\/\/doi.org\/10.1016\/j.tcam.2022.100756","relation":{},"ISSN":["1938-9736"],"issn-type":[{"value":"1938-9736","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and Pathological Findings in Fatal Cases of Severe Fever With Thrombocytopenia Syndrome With High Viremia in Cats","name":"articletitle","label":"Article Title"},{"value":"Topics in Companion Animal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcam.2022.100756","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100756"}}