{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:39:35Z","timestamp":1757705975381,"version":"3.30.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Topics in Companion Animal Medicine"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.tcam.2024.100923","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T10:14:30Z","timestamp":1728555270000},"page":"100923","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The peculiar clinical presentation and diagnostic results of a case of widely metastatic cholangiocellular carcinoma in a Siberian Husky dog"],"prefix":"10.1016","volume":"63","author":[{"given":"Hannah","family":"Reichert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Macleod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Sharkey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-1883","authenticated-orcid":false,"given":"Cornelia","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcam.2024.100923_bib0001","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/030098588101800403","article-title":"Canine bile duct carcinoma","volume":"18","author":"Patnaik","year":"1981","journal-title":"Vet Pathol"},{"key":"10.1016\/j.tcam.2024.100923_bib0002","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0021-9975(83)90047-6","article-title":"Canine biliary carcinoma: epidemiological comparisons with man","volume":"93","author":"Hayes","year":"1983","journal-title":"J Comp Pathol"},{"key":"10.1016\/j.tcam.2024.100923_bib0003","series-title":"Tumors of the Liver and Gallbladder. Tumors in Domestic Animals","first-page":"618","author":"Cullen","year":"2017"},{"key":"10.1016\/j.tcam.2024.100923_bib0004","series-title":"Liver and Biliary System. Jubb, Kennedy and Palmer's Pathology of Domestic Animals","first-page":"348","author":"Cullen","year":"2015"},{"key":"10.1016\/j.tcam.2024.100923_bib0005","series-title":"Hepatobiliary System and Exocrine Pancreas. Pathologic Basis of Veterinary Disease","first-page":"454","author":"Brown","year":"2017"},{"key":"10.1016\/j.tcam.2024.100923_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/vrc2.303","article-title":"Computed tomography findings in canine cholangiocellular carcinoma","volume":"10","author":"Tanaka","year":"2022","journal-title":"Vet Rec Case Rep"},{"key":"10.1016\/j.tcam.2024.100923_bib0007","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1748-5827.2003.tb00178.x","article-title":"Immunocytological confirmation of bone marrow metastases in a dog with cholangiocarcinoma","volume":"44","author":"Mischke","year":"2003","journal-title":"J Small Anim Pract"},{"key":"10.1016\/j.tcam.2024.100923_bib0008","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5326\/JAAHA-MS-7199","article-title":"Outcome of localized bile duct carcinoma in six dogs treated with liver lobectomy","volume":"58","author":"Maeda","year":"2022","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.1016\/j.tcam.2024.100923_bib0009","doi-asserted-by":"crossref","first-page":"293","DOI":"10.21037\/jgo.2016.10.01","article-title":"Biliary cancer: intrahepatic cholangiocarcinoma vs. extrahepatic cholangiocarcinoma vs. gallbladder cancers: classification and therapeutic implications","volume":"8","author":"Ahn","year":"2017","journal-title":"J Gastrointest Oncol"},{"key":"10.1016\/j.tcam.2024.100923_bib0010","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2018.01.009","article-title":"Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations","volume":"68","author":"Wardell","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.tcam.2024.100923_bib0011","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","article-title":"Cholangiocarcinoma 2020: the next horizon in mechanisms and management","volume":"17","author":"Banales","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.tcam.2024.100923_bib0012","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/hep.29764","article-title":"Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma","volume":"68","author":"Nepal","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.tcam.2024.100923_bib0013","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/S0140-6736(13)61903-0","article-title":"Cholangiocarcinoma","volume":"383","author":"Razumilava","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.tcam.2024.100923_bib0014","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1053\/j.gastro.2013.10.013","article-title":"Pathogenesis, diagnosis, and management of cholangiocarcinoma","volume":"145","author":"Rizvi","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tcam.2024.100923_bib0015","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s12029-020-00390-3","article-title":"Cholangiocarcinoma: state of the art","volume":"51","author":"Moazzami","year":"2020","journal-title":"J Gastrointest Cancer"},{"key":"10.1016\/j.tcam.2024.100923_bib0016","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1177\/0300985819854439","article-title":"Hepatic myoepithelial carcinoma in a dog: immunohistochemical comparison with other canine hepatic carcinomas","volume":"56","author":"Tsuji","year":"2019","journal-title":"Vet Pathol"},{"key":"10.1016\/j.tcam.2024.100923_bib0017","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1476-5829.2010.00210.x","article-title":"Identification of hepatic stem\/progenitor cells in canine hepatocellular and cholangiocellular carcinoma","volume":"8","author":"Cogliati","year":"2010","journal-title":"Vet Comp Oncol"},{"key":"10.1016\/j.tcam.2024.100923_bib0018","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1354\/vp.38-6-636","article-title":"Immunohistochemical characterization of canine hyperplastic hepatic lesions and hepatocellular and biliary neoplasms with monoclonal antibody hepatocyte paraffin 1 and a monoclonal antibody to cytokeratin 7","volume":"38","author":"Ramos-Vara","year":"2001","journal-title":"Vet Pathol"},{"key":"10.1016\/j.tcam.2024.100923_bib0019","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1354\/vp.36-3-179","article-title":"Coordinate expression of cytokeratins 7 and 20 in feline and canine carcinomas","volume":"36","author":"Espinosa de los Monteros","year":"1999","journal-title":"Vet Pathol"},{"key":"10.1016\/j.tcam.2024.100923_bib0020","first-page":"857","article-title":"Claudin-7 protein differentiates canine cholangiocarcinoma from hepatocellular carcinoma","volume":"25","author":"Jakab","year":"2010","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.tcam.2024.100923_bib0021","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.tvjl.2013.05.027","article-title":"Classification of primary hepatic tumours in the dog","volume":"197","author":"van Sprundel","year":"2013","journal-title":"Vet J"},{"key":"10.1016\/j.tcam.2024.100923_bib0022","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1053\/hupa.2002.130104","article-title":"Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma","volume":"33","author":"Lau","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1016\/j.tcam.2024.100923_bib0023","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/ajcp\/101.3.257","article-title":"The applicability of a keratin 7 monoclonal antibody in routinely Papanicolaou-stained cytologic specimens for the differential diagnosis of carcinomas","volume":"101","author":"Baars","year":"1994","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.tcam.2024.100923_bib0024","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1354\/vp.42-2-140","article-title":"Canine hepatic neuroendocrine carcinoma: an immunohistochemical and electron microscopic study","volume":"42","author":"Patnaik","year":"2005","journal-title":"Vet Pathol"},{"key":"10.1016\/j.tcam.2024.100923_bib0025","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/8756479315573793","article-title":"An overview of small animal veterinary sonography","volume":"31","author":"Albury","year":"2015","journal-title":"J Diagn Med Sonog"},{"key":"10.1016\/j.tcam.2024.100923_bib0026","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1740-8261.2011.01917.x","article-title":"CT characteristics of primary hepatic mass lesions in dogs","volume":"53","author":"Fukushima","year":"2012","journal-title":"Vet Radiol Ultrasound"},{"key":"10.1016\/j.tcam.2024.100923_bib0027","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/vru.12099","article-title":"Triple-phase helical computed tomography in dogs with hepatic masses","volume":"55","author":"Kutara","year":"2014","journal-title":"Vet Radiol Ultrasound"},{"key":"10.1016\/j.tcam.2024.100923_bib0028","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1038\/s41598-020-63220-3","article-title":"Contrast-enhanced ultrasound features of malignant focal liver masses in dogs","volume":"10","author":"Burti","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.tcam.2024.100923_bib0029","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/jvim.12091","article-title":"A comparison of hepatic sonographic features and histopathologic diagnosis in canine liver disease: 138 cases","volume":"27","author":"Kemp","year":"2013","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.tcam.2024.100923_bib0030","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1740-8261.2002.tb01003.x","article-title":"Cellular features of sonographic target lesions of the liver and spleen in 21 dogs and a cat","volume":"43","author":"Cuccovillo","year":"2002","journal-title":"Vet Radiol Ultrasound"},{"key":"10.1016\/j.tcam.2024.100923_bib0031","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1740-8261.2012.01949.x","article-title":"Comparison of abdominal computed tomography and abdominal ultrasound in sedated dogs","volume":"53","author":"Fields","year":"2012","journal-title":"Vet Radiol Ultrasound"},{"key":"10.1016\/j.tcam.2024.100923_bib0032","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/jmri.24810","article-title":"MRI of cholangiocarcinoma","volume":"42","author":"Jhaveri","year":"2015","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.tcam.2024.100923_bib0033","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/vcp.12880","article-title":"The cytologic features of biliary diseases: a retrospective study","volume":"49","author":"Masserdotti","year":"2020","journal-title":"Vet Clin Pathol"},{"key":"10.1016\/j.tcam.2024.100923_bib0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/j.tcam.2019.02.001","article-title":"Hypercalcemia of malignancy in a dog diagnosed with cholangiocellular carcinoma","volume":"35","author":"Mart\u00ednez-Sogues","year":"2019","journal-title":"Top Companion Anim Med"},{"key":"10.1016\/j.tcam.2024.100923_bib0035","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/01.sla.0000251366.62632.d3","article-title":"Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution","volume":"245","author":"DeOliveira","year":"2007","journal-title":"Ann Surg"},{"key":"10.1016\/j.tcam.2024.100923_bib0036","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4143\/crt.2013.45.2.145","article-title":"Two cases of humoral hypercalcemia of malignancy in metastatic cholangiocarcinoma","volume":"45","author":"Lim","year":"2013","journal-title":"Cancer Res Treat"},{"key":"10.1016\/j.tcam.2024.100923_bib0037","first-page":"320","article-title":"Spinal cord infarct as a presentation of cholangiocarcinoma with metastases","volume":"3","author":"Thar","year":"2015","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.tcam.2024.100923_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/964074","article-title":"Postmortem cerebrospinal fluid pleocytosis: a marker of inflammation or postmortem artifact?","volume":"2012","author":"Morris","year":"2012","journal-title":"Int J Pediatr"},{"key":"10.1016\/j.tcam.2024.100923_bib0039","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00534-007-1249-y","article-title":"Carcinomatous meningitis secondary to cholangiocarcinoma without other systemic metastasis","volume":"15","author":"Okamura","year":"2008","journal-title":"J Hepato Biliary Pancreat Surg"}],"container-title":["Topics in Companion Animal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1938973624000783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1938973624000783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T05:10:21Z","timestamp":1733807421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1938973624000783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":39,"alternative-id":["S1938973624000783"],"URL":"https:\/\/doi.org\/10.1016\/j.tcam.2024.100923","relation":{},"ISSN":["1938-9736"],"issn-type":[{"type":"print","value":"1938-9736"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The peculiar clinical presentation and diagnostic results of a case of widely metastatic cholangiocellular carcinoma in a Siberian Husky dog","name":"articletitle","label":"Article Title"},{"value":"Topics in Companion Animal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcam.2024.100923","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100923"}}