{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:06:00Z","timestamp":1791165960686,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Topics in Companion Animal Medicine"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.tcam.2025.100977","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T01:17:51Z","timestamp":1741828671000},"page":"100977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Evaluation of hematologic indices in parvovirus infected dogs with systemic inflammatory response syndrome (SIRS)"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1959-1010","authenticated-orcid":false,"given":"K.","family":"Sevim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.\u00c7.","family":"\u00c7olako\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcam.2025.100977_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104485","article-title":"Assessment of certain biomarkers for predicting survival in response to treatment in dogs naturally infected with canine parvovirus","volume":"149","author":"Eregowda","year":"2020","journal-title":"Microb Pathog"},{"key":"10.1016\/j.tcam.2025.100977_bib0010","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.cvsm.2010.07.007","article-title":"Canine parvovirus","volume":"40","author":"Goddard","year":"2010","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"10.1016\/j.tcam.2025.100977_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-020-02417-0","article-title":"Canine parvovirus: a predicting canine model for sepsis","volume":"16","author":"Alves","year":"2020","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.tcam.2025.100977_bib0014","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1532-950X.1997.tb01699.x","article-title":"Evaluation of the sensitivity and specificity of diagnostic criteria for sepsis in dogs","volume":"26","author":"Hauptman","year":"1997","journal-title":"Veterinary Surg"},{"key":"10.1016\/j.tcam.2025.100977_bib0006","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tvjl.2010.04.009","article-title":"Acute phase proteins: biomarkers of infection and inflammation in veterinary medicine","volume":"185","author":"Eckersall","year":"2010","journal-title":"Veterinary J"},{"key":"10.1016\/j.tcam.2025.100977_bib0036","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12917-018-1427-y","article-title":"Plasma procalcitonin concentrations predict organ dysfunction and outcome in dogs with sepsis","volume":"14","author":"Troia","year":"2018","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.tcam.2025.100977_bib0039","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.theriogenology.2022.09.015","article-title":"The evaluation of SIRS status with hemato-biochemical indices in bitches affected from pyometra and the usefulness of these indices as a potential diagnostic tool","volume":"193","author":"Yazl\u0131k","year":"2022","journal-title":"Theriogenology"},{"key":"10.1016\/j.tcam.2025.100977_bib0011","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/jvim.16972","article-title":"Retrospective evaluation of hematological ratios in canine parvovirosis: 401 cases","volume":"38","author":"Gonz\u00e1lez-Dom\u00ednguez","year":"2024","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.tcam.2025.100977_bib0012","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.3390\/ani12243483","article-title":"Prognostic role of red cell distribution width and other routine clinico-pathological parameters in dogs with acute pancreatitis","volume":"12","author":"Guglielmini","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.tcam.2025.100977_bib0009","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1939-1676.2008.0073.x","article-title":"Prognostic usefulness of blood leukocyte changes in canine parvoviral enteritis","volume":"22","author":"Goddard","year":"2008","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.tcam.2025.100977_bib0019","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.rvsc.2010.02.013","article-title":"Factors affecting the occurrence, duration of hospitalization and final outcome in canine parvovirus infection","volume":"89","author":"Kalli","year":"2010","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.tcam.2025.100977_bib0029","article-title":"Prognostic potential of thrombocyte indices, acute phase proteins, electrolytes and acid-base markers in canine parvovirus infected dogs with systemic inflammatory Response Syndrome","volume":"56\u201357","author":"Paul","year":"2023","journal-title":"Top Companion Anim Med"},{"key":"10.1016\/j.tcam.2025.100977_bib0001","first-page":"1477","article-title":"Clinical and hematological prognostic factors in dogs with parvoviral enteritis and sepsis","volume":"40","author":"Alves","year":"2019","journal-title":"Semina: Ci\u00eancias Agr\u00e1rias"},{"key":"10.1016\/j.tcam.2025.100977_bib0018","first-page":"125","article-title":"The role of immature granulocytes and inflammatory hemogram indices in the inflammation","volume":"3","author":"Incir","year":"2020","journal-title":"Int J Med Biochem"},{"key":"10.1016\/j.tcam.2025.100977_bib0003","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.3390\/ijms23073636","article-title":"Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases","volume":"23","author":"Buonacera","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.tcam.2025.100977_bib0004","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/vec.13159","article-title":"Neutrophil to lymphocyte ratio as a prognostic biomarker in puppies with acute diarrhea","volume":"32","author":"Dinler Ay","year":"2022","journal-title":"J Veterinary Emerg Critic Care"},{"key":"10.1016\/j.tcam.2025.100977_bib0026","first-page":"9","article-title":"Altered neutrophil-to-lymphocyte ratio in sepsis secondary to canine parvoviral enteritis treated with and without an immunomodulator in puppies","author":"Mu\u00f1oz","year":"2022","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.tcam.2025.100977_bib0033","doi-asserted-by":"crossref","first-page":"51","DOI":"10.33988\/auvfd.1075126","article-title":"The impact of peripheral blood cell ratios in dogs with diffuse B-cell small lymphocytic lymphoma treated with CHOP protocol","volume":"71","author":"Sevim","year":"2024","journal-title":"Ankara \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi"},{"key":"10.1016\/j.tcam.2025.100977_bib0040","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4149\/BLL_2021_078","article-title":"Neutrophil-to-lymphocyte ratio, past, present and future perspectives","volume":"122","author":"Zahorec","year":"2021","journal-title":"Bratislava Med J"},{"key":"10.1016\/j.tcam.2025.100977_bib0035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10549-020-05925-7","article-title":"The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype","volume":"185","author":"Tiainen","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.tcam.2025.100977_bib0038","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12885-020-6698-6","article-title":"Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and prognostic nutritional index for predicting clinical outcomes in T1\u20132 rectal cancer","volume":"20","author":"Xia","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tcam.2025.100977_bib0017","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.1158\/1078-0432.CCR-14-0442","article-title":"Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma","volume":"20","author":"Hu","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.tcam.2025.100977_bib0023","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1177\/0961203320929753","article-title":"Predictive value of the neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-neutrophil ratio, and neutrophil-to-monocyte ratio in lupus nephritis","volume":"29","author":"Liu","year":"2020","journal-title":"Lupus"},{"key":"10.1016\/j.tcam.2025.100977_bib0025","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/emermed-2014-204071","article-title":"Neutrophil to lymphocyte count ratio as an early indicator of blood stream infection in the emergency department","volume":"32","author":"Lowsby","year":"2015","journal-title":"Emerg Med J"},{"key":"10.1016\/j.tcam.2025.100977_bib0027","doi-asserted-by":"crossref","DOI":"10.1099\/jmm.0.001360","article-title":"Serum biomarkers to differentiate gram-negative, gram-positive and fungal infection in febrile patients","volume":"70","author":"Niu","year":"2021","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.tcam.2025.100977_bib0022","first-page":"12","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in stroke: a systematic review and meta-analysis","author":"Li","year":"2021","journal-title":"Front Neurol"},{"key":"10.1016\/j.tcam.2025.100977_bib0020","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.amjcard.2016.07.072","article-title":"Relation between neutrophil-to-lymphocyte ratio and index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention","volume":"118","author":"Lee","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.tcam.2025.100977_bib0028","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/TA.0000000000001266","article-title":"Neutrophil-to-lymphocyte ratio in trauma patients","volume":"82","author":"Park","year":"2017","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.tcam.2025.100977_bib0021","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3390\/cancers13061308","article-title":"Neutrophil-to-lymphocyte ratio predicts development of immune-related adverse events and outcomes from immune checkpoint blockade: a case-control study","volume":"13","author":"Lee","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.tcam.2025.100977_bib0008","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10654-018-0472-y","article-title":"The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: the Rotterdam Study","volume":"34","author":"Fest","year":"2019","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.tcam.2025.100977_bib0034","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41598-020-79431-7","article-title":"Neutrophil-to-lymphocyte ratio and mortality in the United States general population","volume":"11","author":"Song","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.tcam.2025.100977_bib0031","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.rvsc.2019.08.028","article-title":"Neutrophil-to-lymphocyte ratio nucleated red blood cells and erythrocyte abnormalities in canine systemic inflammatory response syndrome","volume":"126","author":"Pierini","year":"2019","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.tcam.2025.100977_bib0015","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5326\/JAAHA-MS-6808","article-title":"Utility and prognostic significance of neutrophil-to-lymphocyte ratio in dogs with septic peritonitis","volume":"546","author":"Hodgson","year":"2018","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.1016\/j.tcam.2025.100977_bib0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/vec.13269","article-title":"Evaluation of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in critically ill dogs","volume":"33","author":"Dourmashkin","year":"2023","journal-title":"J Veterinary Emerg Critic Care"},{"key":"10.1016\/j.tcam.2025.100977_bib0032","first-page":"7","article-title":"Are leukocyte and platelet abnormalities and complete blood count ratios potential prognostic markers in canine sepsis?","author":"Pierini","year":"2020","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.tcam.2025.100977_bib0013","doi-asserted-by":"crossref","first-page":"45","DOI":"10.47027\/duvetfd.1100794","article-title":"Hematological status in septic or non septic dogs due to parvoviral enteritis","volume":"15","author":"G\u00fclersoy","year":"2022","journal-title":"Dicle \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi"},{"key":"10.1016\/j.tcam.2025.100977_bib0030","doi-asserted-by":"crossref","first-page":"437","DOI":"10.35229\/jaes.1172262","article-title":"A preliminary study for determination of neutrophil to lymphocyte, monocyte to lymphocyte and platelet to lymphocyte ratios in dogs with Canine Distemper Virus infection","volume":"7","author":"Pekmezci","year":"2022","journal-title":"J Anatolian Environ Animal Sci"},{"key":"10.1016\/j.tcam.2025.100977_bib0016","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1620\/tjem.236.297","article-title":"Systemic immune-inflammation index, based on platelet counts and neutrophil-lymphocyte ratio, is useful for predicting prognosis in small cell lung cancer","volume":"236","author":"Hong","year":"2015","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.tcam.2025.100977_bib0037","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3855\/jidc.17907","article-title":"Diagnostic and prognostic values of immunocyte ratios in patients with sepsis in the intensive care unit","volume":"171","author":"Wu","year":"2023","journal-title":"J Infect Dev Countr"},{"key":"10.1016\/j.tcam.2025.100977_fur1","first-page":"6","article-title":"Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19","volume":"81","author":"Liu","year":"2020","journal-title":"J Infect"}],"container-title":["Topics in Companion Animal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1938973625000303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1938973625000303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T07:24:09Z","timestamp":1748330649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1938973625000303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":40,"alternative-id":["S1938973625000303"],"URL":"https:\/\/doi.org\/10.1016\/j.tcam.2025.100977","relation":{},"ISSN":["1938-9736"],"issn-type":[{"value":"1938-9736","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of hematologic indices in parvovirus infected dogs with systemic inflammatory response syndrome (SIRS)","name":"articletitle","label":"Article Title"},{"value":"Topics in Companion Animal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tcam.2025.100977","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100977"}}