{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:31:22Z","timestamp":1791088282446,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Cell Biology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.tcb.2012.11.008","type":"journal-article","created":{"date-parts":[[2012,12,29]],"date-time":"2012-12-29T03:49:55Z","timestamp":1356752995000},"page":"203-209","source":"Crossref","is-referenced-by-count":126,"title":["Epigenetic flexibility in metabolic regulation: disease cause and prevention?"],"prefix":"10.1016","volume":"23","author":[{"given":"Henriette","family":"Kirchner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Osler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Krook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juleen R.","family":"Zierath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tcb.2012.11.008_bib0005","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome - biological and translational implications","volume":"11","author":"Baylin","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.tcb.2012.11.008_bib0010","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1007\/s00125-011-2250-1","article-title":"Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat","volume":"54","author":"Pinney","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.tcb.2012.11.008_bib0015","series-title":"Epigenetic Mechanisms of Gene Regulation","year":"1996"},{"key":"10.1016\/j.tcb.2012.11.008_bib0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrg3142","article-title":"Epigenetics and the environment: emerging patterns and implications","volume":"13","author":"Feil","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tcb.2012.11.008_bib0025","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrn3234","article-title":"Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease","volume":"13","author":"Qureshi","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.tcb.2012.11.008_bib0030","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cmet.2012.01.001","article-title":"Acute exercise remodels promoter methylation in human skeletal muscle","volume":"15","author":"Barres","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.tcb.2012.11.008_bib0035","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1096\/fj.05-4671fje","article-title":"Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle","volume":"20","author":"McGee","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.tcb.2012.11.008_bib0040","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1126\/science.1111098","article-title":"DNA modification mechanisms and gene activity during development","volume":"187","author":"Holliday","year":"1975","journal-title":"Science"},{"key":"10.1016\/j.tcb.2012.11.008_bib0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000130315","article-title":"X inactivation, differentiation, and DNA methylation","volume":"14","author":"Riggs","year":"1975","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.tcb.2012.11.008_bib0050","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature08514","article-title":"Human DNA methylomes at base resolution show widespread epigenomic differences","volume":"462","author":"Lister","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.tcb.2012.11.008_bib0055","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrg2341","article-title":"DNA methylation landscapes: provocative insights from epigenomics","volume":"9","author":"Suzuki","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tcb.2012.11.008_bib0060","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cmet.2009.07.011","article-title":"Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density","volume":"10","author":"Barres","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.tcb.2012.11.008_bib0065","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.yexcr.2011.08.019","article-title":"Evidence for non-CpG methylation in mammals","volume":"317","author":"Yan","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.tcb.2012.11.008_bib0070","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","article-title":"Targeted mutation of the DNA methyltransferase gene results in embryonic lethality","volume":"69","author":"Li","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2012.11.008_bib0075","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2012.11.008_bib0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ng1077","article-title":"Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors","volume":"33","author":"Chen","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tcb.2012.11.008_bib0085","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/ng1330","article-title":"Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer","volume":"36","author":"Suzuki","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tcb.2012.11.008_bib0090","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1093\/nar\/29.22.4598","article-title":"Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation","volume":"29","author":"Nguyen","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.tcb.2012.11.008_bib0095","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1126\/science.1697983","article-title":"5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes","volume":"249","author":"Rideout","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.tcb.2012.11.008_bib0100","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.1210944","article-title":"Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA","volume":"333","author":"He","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.tcb.2012.11.008_bib0105","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.1210597","article-title":"Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.tcb.2012.11.008_bib0110","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2217\/epi.10.57","article-title":"Transgenerational genetic effects","volume":"2","author":"Nelson","year":"2010","journal-title":"Epigenomics"},{"key":"10.1016\/j.tcb.2012.11.008_bib0115","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrg2295","article-title":"Epigenetic events in mammalian germ-cell development: reprogramming and beyond","volume":"9","author":"Sasaki","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.tcb.2012.11.008_bib0120","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cell.2007.02.010","article-title":"Genetic and epigenetic regulators of pluripotency","volume":"128","author":"Surani","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2012.11.008_bib0125","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/adc.71.4.288","article-title":"Role of nutritional programming in determining adult morbidity","volume":"71","author":"Lucas","year":"1994","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.tcb.2012.11.008_bib0130","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2007.01.015","article-title":"The role of chromatin during transcription","volume":"128","author":"Li","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2012.11.008_bib0135","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1101\/gr.5704207","article-title":"The landscape of histone modifications across 1% of the human genome in five human cell lines","volume":"17","author":"Koch","year":"2007","journal-title":"Genome Res."},{"key":"10.1016\/j.tcb.2012.11.008_bib0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.tcb.2012.11.008_bib0145","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2009.06.049","article-title":"Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes","volume":"138","author":"Wang","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2012.11.008_bib0150","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cell.2005.10.025","article-title":"Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex","volume":"123","author":"Keogh","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2012.11.008_bib0155","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1469-7793.2001.00273.x","article-title":"Marathon running increases ERK1\/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle","volume":"536","author":"Yu","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.tcb.2012.11.008_bib0160","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1056\/NEJM197608122950701","article-title":"Obesity in young men after famine exposure in utero and early infancy","volume":"295","author":"Ravelli","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tcb.2012.11.008_bib0165","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1210\/en.2011-1805","article-title":"Minireview: epigenetic programming of diabetes and obesity: animal models","volume":"153","author":"Seki","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.tcb.2012.11.008_bib0170","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.cell.2010.12.008","article-title":"Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals","volume":"143","author":"Carone","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.tcb.2012.11.008_bib0175","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nature09491","article-title":"Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring","volume":"467","author":"Ng","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.tcb.2012.11.008_bib0180","first-page":"2316","article-title":"Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1","volume":"118","author":"Park","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tcb.2012.11.008_bib0185","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.2337\/diabetes.50.10.2279","article-title":"Intrauterine growth retardation leads to the development of type 2 diabetes in the rat","volume":"50","author":"Simmons","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.tcb.2012.11.008_bib0190","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.siny.2004.03.001","article-title":"Maternal constraint of fetal growth and its consequences","volume":"9","author":"Gluckman","year":"2004","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.tcb.2012.11.008_bib0195","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/sj.ejhg.5200859","article-title":"Cardiovascular and diabetes mortality determined by nutrition during parents\u2019 and grandparents\u2019 slow growth period","volume":"10","author":"Kaati","year":"2002","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.tcb.2012.11.008_bib0200","first-page":"E731","article-title":"Persistence of metabolic consequences in the progeny of rats fed a HC formula in their early postnatal life","volume":"269","author":"Vadlamudi","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.tcb.2012.11.008_bib0205","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1126\/science.1089769","article-title":"Control of pancreas and liver gene expression by HNF transcription factors","volume":"303","author":"Odom","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.tcb.2012.11.008_bib0210","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1073\/pnas.1019007108","article-title":"Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets","volume":"108","author":"Sandovici","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tcb.2012.11.008_bib0215","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1101\/gad.1535507","article-title":"Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha","volume":"21","author":"Gupta","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.tcb.2012.11.008_bib0220","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2337\/diabetes.53.4.1141","article-title":"Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes","volume":"53","author":"Silander","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.tcb.2012.11.008_bib0225","doi-asserted-by":"crossref","first-page":"E707","DOI":"10.1152\/ajpendo.00252.2004","article-title":"Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis","volume":"288","author":"Brissova","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tcb.2012.11.008_bib0230","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1172\/JCI21845","article-title":"PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance","volume":"114","author":"Kulkarni","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tcb.2012.11.008_bib0235","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.1093\/hmg\/ddq336","article-title":"DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome","volume":"19","author":"Ollikainen","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.tcb.2012.11.008_bib0240","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/emboj.2011.503","article-title":"DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients","volume":"31","author":"Volkmar","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.tcb.2012.11.008_bib0245","doi-asserted-by":"crossref","first-page":"10604","DOI":"10.1073\/pnas.0500398102","article-title":"Epigenetic differences arise during the lifetime of monozygotic twins","volume":"102","author":"Fraga","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tcb.2012.11.008_bib0250","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ng.286","article-title":"DNA methylation profiles in monozygotic and dizygotic twins","volume":"41","author":"Kaminsky","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.tcb.2012.11.008_bib0255","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.2337\/db11-1653","article-title":"Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes","volume":"61","author":"Nitert","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.tcb.2012.11.008_bib0260","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/jnci\/djj447","article-title":"Epigenetic cancer therapy makes headway","volume":"98","author":"Mack","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.tcb.2012.11.008_bib0265","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00125-008-1018-8","article-title":"Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle","volume":"51","author":"Ronn","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.tcb.2012.11.008_bib0270","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF00403304","article-title":"Poor physical fitness, and impaired early insulin response but late hyperinsulinaemia, as predictors of NIDDM in middle-aged Swedish men","volume":"39","author":"Eriksson","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.tcb.2012.11.008_bib0275","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1210\/en.2008-1035","article-title":"Moderate daily exercise activates metabolic flexibility to prevent prenatally induced obesity","volume":"150","author":"Miles","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.tcb.2012.11.008_bib0280","doi-asserted-by":"crossref","first-page":"985139","DOI":"10.1155\/2011\/985139","article-title":"Maternal behaviors during pregnancy impact offspring obesity risk","volume":"2011","author":"Phelan","year":"2011","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.tcb.2012.11.008_bib0285","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0959-437X(00)00224-0","article-title":"Control of muscle development by dueling HATs and HDACs","volume":"11","author":"McKinsey","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.tcb.2012.11.008_bib0290","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1097-2765(00)00025-3","article-title":"Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases","volume":"6","author":"Lu","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tcb.2012.11.008_bib0295","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1073\/pnas.0337639100","article-title":"Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial function by MEF2 and HDAC5","volume":"100","author":"Czubryt","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tcb.2012.11.008_bib0300","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1172\/JCI31960","article-title":"Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers","volume":"117","author":"Potthoff","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tcb.2012.11.008_bib0305","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nature07777","article-title":"Role of Jhdm2a in regulating metabolic gene expression and obesity resistance","volume":"458","author":"Tateishi","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.tcb.2012.11.008_bib0310","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1440-1681.2006.04362.x","article-title":"Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms","volume":"33","author":"McGee","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.tcb.2012.11.008_bib0315","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.2337\/diabetes.53.5.1208","article-title":"Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle","volume":"53","author":"McGee","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.tcb.2012.11.008_bib0320","doi-asserted-by":"crossref","first-page":"e1002543","DOI":"10.1371\/journal.pgen.1002543","article-title":"An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity","volume":"8","author":"Kuehnen","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.tcb.2012.11.008_bib0325","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00125-007-0916-5","article-title":"Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion","volume":"51","author":"Ling","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.tcb.2012.11.008_bib0330","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1172\/JCI30938","article-title":"Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle","volume":"117","author":"Ling","year":"2007","journal-title":"J. Clin. Invest."}],"container-title":["Trends in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096289241200222X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096289241200222X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T17:50:20Z","timestamp":1562521820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096289241200222X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S096289241200222X"],"URL":"https:\/\/doi.org\/10.1016\/j.tcb.2012.11.008","relation":{},"ISSN":["0962-8924"],"issn-type":[{"value":"0962-8924","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}